Abstract: A method and apparatus of a device that manages a video telephony call is described. In an exemplary embodiment, the device receives a heads-up of a network event from a network service of a device. The device further determines that the network event that is due to a local disruption of a network component of the device. In addition, and in response to the determination, the device adjusts a target delay of the video telephony call.

Abstract: The present disclosure provides for compounds of the general Formula (I) wherein R1a, R1b, R2, R3, R4, R5, R6, R7, R8, and Ring A have any of the values defined in the specification, and pharmaceutically acceptable salts thereof.

Abstract: Systems for packet handling over a network, the systems including a client device configured to communicate over a network, the client device further including a Multi Tenant Module-Client module (MTM-Client module) having processor-readable instructions to direct at least one client device processor to determine whether a packet is a Synchronize packet and, if so, the MTM-Client module opens a pair of streams with consecutive stream IDs to communicate over the network, and the first stream of the pair carries a 5-tuple and metadata for the communication from the client device, and the second stream of the pair carries the TCP packet for the communication from the client device.

Abstract: Systems for packet handling over a network, the systems including a client device configured to communicate over a network, the client device further including a Multi Tenant Module-Client module (MTM-Client module) having processor-readable instructions to direct at least one client device processor to determine whether a packet is a Synchronize packet and, if so, the MTM-Client module opens a pair of streams with consecutive stream IDs to communicate over the network, and the first stream of the pair carries a 5-tuple and metadata for the communication from the client device, and the second stream of the pair carries the TCP packet for the communication from the client device.

Abstract: Performance of a substitute upstream processing component is tested, in order to determine whether that performance is sufficient to support a downstream processing component, within an autonomous driving system, in place of an existing upstream processing component. The existing upstream processing component and the substitute upstream processing component are mutually interchangeable in so far as they provide the same form of outputs interpretable by the downstream processing component, such that either upstream processing component may be used without modification to the downstream processing component. A direct or indirect metric-based comparison is formulated in terms of the resulting performance of the downstream processing component.

Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocycles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

Abstract: The present disclosure provides for compounds of the general Formula (I) wherein R1a, R1b, R2, R3, R4, R5, R6, R7, R8, and Ring A have any of the values defined in the specification, and pharmaceutically acceptable salts thereof.

Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

Abstract: A system and method for automatic optimization of user engagement on a digital platform is provided. The method comprises generating, a set of tokens for a gamified challenge on the digital platform. The method thereafter leads to associating token(s) from the set of tokens with a set of levels of the gamified challenge. Further the method encompasses providing to user(s) via the digital platform, action item(s) at least to enable the user(s) to retrieve token(s) from the set of tokens and to permit the user(s) to transition to a next level from a current level. Further the method comprises determining for each level, a probability of retrieving the token(s) by the user(s). The method thereafter encompasses automatically controlling, a number of users permitted to transition to the next level from the current level based on the determined probability, to automatically optimize the user engagement on the digital platform.

Abstract: Systems and methods for providing alternate deal structures are disclosed. A method may include: receiving an application for a loan having a loan structure comprising loan parameters from a dealer or an individual; retrieving data for the individual from a third party data source; decisioning the initial loan structure using the parameters and the cached data; returning an approval for the initial loan structure and an interest rate for the initial loan structure to the dealer or the individual; generating additional loan structures, each having a plurality of different parameters; decisioning the additional loan structures using the different parameters and the cached data; ranking the additional loan structures with the interest rate for each additional loan structure; returning approval and the interest rate for the ranked loan structures to the dealer or the individual; and receiving acceptance of the initial loan structure or one of the additional loan structures.

Abstract: The present disclosure provides for compounds of the general Formula (I) wherein R1a, R1b, R2, R3, R4, R5, R6, R7, R8, and Ring A have any of the values defined in the specification, and pharmaceutically acceptable salts thereof.

Abstract: Systems for packet handling over a network, the systems including a client device configured to communicate over a network, the client device further including a Multi Tenant Module—Client module (MTM-Client module) having processor-readable instructions to direct at least one client device processor to determine whether a packet is a Synchronize packet and, if so, the MTM-Client module opens a pair of streams with consecutive stream IDs to communicate over the network, and the first stream of the pair carries a 5-tuple and metadata for the communication from the client device, and the second stream of the pair carries the TCP packet for the communication from the client device.

Abstract: The present disclosure relates to a method for deploying an intelligent edge cluster model includes checking an application requirement and a key performance indicator at a first edge node, dynamically assigning a first resource from the resources in the virtual resource pool of the intelligent edge cluster model to the first edge node, instructing a command to another edge node to assign one or more resources to the first edge node. In particular, the intelligent edge cluster model includes edge nodes and master controller having corresponding one or more resources combined to form the virtual resource pool.

Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

Abstract: The present disclosure provides neuroprotective compounds along with their use in treating disease such as Parkinson's disease (PD). The compounds can be used as inhibitors for Parthanatos Associated AIF (apoptosis-inducing factor) Nuclease (PAAN), also known as macrophage migration inhibitor factor (MIF).

Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

Abstract: The present invention generally relates to a self-charging system for electric vehicles comprises at least one gearbox comprises an input end and an output end mechanically coupled to one of the wheels of a vehicle to the input end to generate a rotational energy with an increased output of one of the torque or speed (RPM) to the output end; an auxiliary generator connected to the output end of the at least one gearbox to convert the rotational energy into electrical energy; a controller equipped with a maximum power point tracker to produce maximum power output; and a charger controller coupled to the maximum power point tracker to charge a batter of the vehicle upon limiting electric current rate of the power output to protect against electrical overload, overcharging, and overvoltage.

Abstract: The present disclosure provides a method for providing a white box transponder (132). The method includes a step of receiving the plurality of user inputs (104) from an orchestrator (102) at a programmable photonic switch mode system (108). The method includes another step of receiving the real-time data from an optical line system (122). The method includes yet another step of computing a run-time mode of operation based on the plurality of user inputs (104), the real-time data from the optical line system (122), a complete path computation information, and the network dimensioning data with facilitation of the programmable photonic switch mode application (110). The complete path computation information is received from a path computation engine (120). The method includes yet another step of sending the computed run-time mode of operation to the white box transponder (132) for dynamically configuring the white box transponder (132).

Abstract: The present disclosure provides a system for providing a plurality of data models for a networking device. The system includes a network operating system and a plurality of data model engine modules. The network operating system stores the plurality of data models. Each of the plurality of data model engine modules corresponds to a specific data model from the plurality of data models in the network operating system. In addition, the plurality of data models is used by the networking device simultaneously in real-time. Further, the networking device is a white box hardware device. Furthermore, the networking device includes one or more transponders, one or more switches, and one or more routers. Moreover, the plurality of data models includes one or more vendor neutral data models, one or more open data models, and one or more vendor proprietary data models.

Abstract: Systems and methods for performing authentication may include encrypting, by a server computing system, a question based on a first password associated with a user and based on successful verification of user identification to generate an encrypted question; transmitting, by the server computing system, the encrypted question to a user computing system; receiving, by the server computing system, an encrypted response from the user computing system, the encrypted response associated with the encrypted question; decrypting, by the server computing system, the encrypted response based on the first password to generate a response; and establishing, by the server computing system, a login session with the user computing system based on successful verification of the response.