Abstract: Systems for packet handling over a network, the systems including a client device configured to communicate over a network, the client device further including a Multi Tenant Module-Client module (MTM-Client module) having processor-readable instructions to direct at least one client device processor to determine whether a packet is a Synchronize packet and, if so, the MTM-Client module opens a pair of streams with consecutive stream IDs to communicate over the network, and the first stream of the pair carries a 5-tuple and metadata for the communication from the client device, and the second stream of the pair carries the TCP packet for the communication from the client device.

Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocycles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

Abstract: A method and apparatus of a device that manages a video telephony call is described. In an exemplary embodiment, the device receives a heads-up of a network event from a network service of a device. The device further determines that the network event that is due to a local disruption of a network component of the device. In addition, and in response to the determination, the device adjusts a target delay of the video telephony call.

Abstract: The present disclosure provides for compounds of the general Formula (I) wherein R1a, R1b, R2, R3, R4, R5, R6, R7, R8, and Ring A have any of the values defined in the specification, and pharmaceutically acceptable salts thereof.

Abstract: Systems for packet handling over a network, the systems including a client device configured to communicate over a network, the client device further including a Multi Tenant Module-Client module (MTM-Client module) having processor-readable instructions to direct at least one client device processor to determine whether a packet is a Synchronize packet and, if so, the MTM-Client module opens a pair of streams with consecutive stream IDs to communicate over the network, and the first stream of the pair carries a 5-tuple and metadata for the communication from the client device, and the second stream of the pair carries the TCP packet for the communication from the client device.

Abstract: Systems for packet handling over a network, the systems including a client device configured to communicate over a network, the client device further including a Multi Tenant Module-Client module (MTM-Client module) having processor-readable instructions to direct at least one client device processor to determine whether a packet is a Synchronize packet and, if so, the MTM-Client module opens a pair of streams with consecutive stream IDs to communicate over the network, and the first stream of the pair carries a 5-tuple and metadata for the communication from the client device, and the second stream of the pair carries the TCP packet for the communication from the client device.

Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocycles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

Abstract: The present disclosure provides for compounds of the general Formula (I) wherein R1a, R1b, R2, R3, R4, R5, R6, R7, R8, and Ring A have any of the values defined in the specification, and pharmaceutically acceptable salts thereof.

Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

Abstract: Systems and methods for providing alternate deal structures are disclosed. A method may include: receiving an application for a loan having a loan structure comprising loan parameters from a dealer or an individual; retrieving data for the individual from a third party data source; decisioning the initial loan structure using the parameters and the cached data; returning an approval for the initial loan structure and an interest rate for the initial loan structure to the dealer or the individual; generating additional loan structures, each having a plurality of different parameters; decisioning the additional loan structures using the different parameters and the cached data; ranking the additional loan structures with the interest rate for each additional loan structure; returning approval and the interest rate for the ranked loan structures to the dealer or the individual; and receiving acceptance of the initial loan structure or one of the additional loan structures.

Abstract: The present disclosure provides for compounds of the general Formula (I) wherein R1a, R1b, R2, R3, R4, R5, R6, R7, R8, and Ring A have any of the values defined in the specification, and pharmaceutically acceptable salts thereof.

Abstract: Systems for packet handling over a network, the systems including a client device configured to communicate over a network, the client device further including a Multi Tenant Module—Client module (MTM-Client module) having processor-readable instructions to direct at least one client device processor to determine whether a packet is a Synchronize packet and, if so, the MTM-Client module opens a pair of streams with consecutive stream IDs to communicate over the network, and the first stream of the pair carries a 5-tuple and metadata for the communication from the client device, and the second stream of the pair carries the TCP packet for the communication from the client device.

Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

Abstract: The present disclosure provides neuroprotective compounds along with their use in treating disease such as Parkinson's disease (PD). The compounds can be used as inhibitors for Parthanatos Associated AIF (apoptosis-inducing factor) Nuclease (PAAN), also known as macrophage migration inhibitor factor (MIF).

Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

Abstract: The present invention relates to novel compounds of formula (I), process for preparation of the same and composition comprising these compounds.

Abstract: A computing system is configured to securely boot different operating systems. The computing system includes one or more processors, a first memory device storing a first firmware element for booting a first operating system, a second memory device storing a second firmware element for booting a second operating system, a first security module configured to provide authentication for booting the first operating system, and a second security module configured to provide authentication for booting the second operating system. The computing system is configured such that, when the first security module is connected to the one or more processors, either the first operating system or the second operating system is selected for booting based on a selection signal, and when the first security module is not connected to the one or more processors, the second operating system is selected for booting.

Abstract: The present invention relates to novel compounds of formula (I), process for preparation of the same and composition comprising these compounds.