Abstract: A system of one or more computers can be configured to facilitate the design of a service. The disclosed system may operate to add a process block to a service design structure for the service. The process block is provided to a trained AI/ML process prediction model. The trained AI/ML process prediction model suggests one or more further process blocks for addition to the service design structure based, at least in part, on the addition of the process block to the service design structure. In certain embodiments, a process block is selected from the suggested one or more further process blocks and added to the service design structure. Other embodiments of this aspect of the disclosure include corresponding computer systems, apparatus, and computer programs recorded on one or more computer storage devices, each configured to perform the actions of the methods.

Abstract: A network device organizes packets into various queues, in which the packets await processing. Queue management logic tracks how long certain packet(s), such as a designated marker packet, remain in a queue. Based thereon, the logic produces a measure of delay for the queue, referred to herein as the “queue delay.” Based on a comparison of the current queue delay to one or more thresholds, various associated delay-based actions may be performed, such as tagging and/or dropping packets departing from the queue, or preventing addition enqueues to the queue. In an embodiment, a queue may be expired based on the queue delay, and all packets dropped. In other embodiments, when a packet is dropped prior to enqueue into an assigned queue, copies of some or all of the packets already within the queue at the time the packet was dropped may be forwarded to a visibility component for analysis.

Abstract: Delivery and monitoring of Emergency Alert System (EAS) media files via router computing devices using redirection responses is disclosed herein. In one embodiment, a router computing device receives an EAS notification from a server computing device. The EAS notification received by the router computing device includes an EAS media file manifest Universal Resource Locator (URL) of an EAS media file to be pushed to subscribers. Upon receiving the EAS notification, the router computing device intercepts an Internet Protocol (IP) streaming content request from a client computing device that is communicatively coupled to the router computing device, and transmits a redirection response message that includes the EAS media file manifest URL to the client computing device. Upon receiving the redirection response message from the router computing device, the client computing device is redirected from any currently streaming media to the EAS media file manifest URL.

Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

Abstract: A system and a method are disclosed for managing information technology (IT) infrastructure. Client devices interact with applications of an enterprise that may be hosted in data centers of the enterprise or as software as a service (SaaS) applications. An IT management system receives session information from client devices. The session information describes interactions of client devices with applications, for example, response time of applications for each interaction. The IT management system analyzes the session information received from various client devices to identify issues with IT infrastructure. The IT management system generates warning messages describing the issues identified and sends them for review, for example, by a system administrator.

Abstract: A system and method for automatic optimization of user engagement on a digital platform is provided. The method comprises generating, a set of tokens for a gamified challenge on the digital platform. The method thereafter leads to associating token(s) from the set of tokens with a set of levels of the gamified challenge. Further the method encompasses providing to user(s) via the digital platform, action item(s) at least to enable the user(s) to retrieve token(s) from the set of tokens and to permit the user(s) to transition to a next level from a current level. Further the method comprises determining for each level, a probability of retrieving the token(s) by the user(s). The method thereafter encompasses automatically controlling, a number of users permitted to transition to the next level from the current level based on the determined probability, to automatically optimize the user engagement on the digital platform.

Abstract: Systems and methods for providing alternate deal structures are disclosed. A method may include: receiving an application for a loan having a loan structure comprising loan parameters from a dealer or an individual; retrieving data for the individual from a third party data source; decisioning the initial loan structure using the parameters and the cached data; returning an approval for the initial loan structure and an interest rate for the initial loan structure to the dealer or the individual; generating additional loan structures, each having a plurality of different parameters; decisioning the additional loan structures using the different parameters and the cached data; ranking the additional loan structures with the interest rate for each additional loan structure; returning approval and the interest rate for the ranked loan structures to the dealer or the individual; and receiving acceptance of the initial loan structure or one of the additional loan structures.

Abstract: The present disclosure provides for compounds of the general Formula (I) wherein R1a, R1b, R2, R3, R4, R5, R6, R7, R8, and Ring A have any of the values defined in the specification, and pharmaceutically acceptable salts thereof.

Abstract: Systems for packet handling over a network, the systems including a client device configured to communicate over a network, the client device further including a Multi Tenant Module—Client module (MTM-Client module) having processor-readable instructions to direct at least one client device processor to determine whether a packet is a Synchronize packet and, if so, the MTM-Client module opens a pair of streams with consecutive stream IDs to communicate over the network, and the first stream of the pair carries a 5-tuple and metadata for the communication from the client device, and the second stream of the pair carries the TCP packet for the communication from the client device.

Abstract: The present disclosure relates to a method for deploying an intelligent edge cluster model includes checking an application requirement and a key performance indicator at a first edge node, dynamically assigning a first resource from the resources in the virtual resource pool of the intelligent edge cluster model to the first edge node, instructing a command to another edge node to assign one or more resources to the first edge node. In particular, the intelligent edge cluster model includes edge nodes and master controller having corresponding one or more resources combined to form the virtual resource pool.

Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

Abstract: The present disclosure provides neuroprotective compounds along with their use in treating disease such as Parkinson's disease (PD). The compounds can be used as inhibitors for Parthanatos Associated AIF (apoptosis-inducing factor) Nuclease (PAAN), also known as macrophage migration inhibitor factor (MIF).

Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

Abstract: The present invention generally relates to a self-charging system for electric vehicles comprises at least one gearbox comprises an input end and an output end mechanically coupled to one of the wheels of a vehicle to the input end to generate a rotational energy with an increased output of one of the torque or speed (RPM) to the output end; an auxiliary generator connected to the output end of the at least one gearbox to convert the rotational energy into electrical energy; a controller equipped with a maximum power point tracker to produce maximum power output; and a charger controller coupled to the maximum power point tracker to charge a batter of the vehicle upon limiting electric current rate of the power output to protect against electrical overload, overcharging, and overvoltage.

Abstract: The present disclosure provides a method for providing a white box transponder (132). The method includes a step of receiving the plurality of user inputs (104) from an orchestrator (102) at a programmable photonic switch mode system (108). The method includes another step of receiving the real-time data from an optical line system (122). The method includes yet another step of computing a run-time mode of operation based on the plurality of user inputs (104), the real-time data from the optical line system (122), a complete path computation information, and the network dimensioning data with facilitation of the programmable photonic switch mode application (110). The complete path computation information is received from a path computation engine (120). The method includes yet another step of sending the computed run-time mode of operation to the white box transponder (132) for dynamically configuring the white box transponder (132).

Abstract: The present disclosure provides a system for providing a plurality of data models for a networking device. The system includes a network operating system and a plurality of data model engine modules. The network operating system stores the plurality of data models. Each of the plurality of data model engine modules corresponds to a specific data model from the plurality of data models in the network operating system. In addition, the plurality of data models is used by the networking device simultaneously in real-time. Further, the networking device is a white box hardware device. Furthermore, the networking device includes one or more transponders, one or more switches, and one or more routers. Moreover, the plurality of data models includes one or more vendor neutral data models, one or more open data models, and one or more vendor proprietary data models.

Abstract: Systems and methods for performing authentication may include encrypting, by a server computing system, a question based on a first password associated with a user and based on successful verification of user identification to generate an encrypted question; transmitting, by the server computing system, the encrypted question to a user computing system; receiving, by the server computing system, an encrypted response from the user computing system, the encrypted response associated with the encrypted question; decrypting, by the server computing system, the encrypted response based on the first password to generate a response; and establishing, by the server computing system, a login session with the user computing system based on successful verification of the response.

Abstract: The present disclosure provides a method for dynamically allocating an optical channel. The method includes receiving a user input request from a user. In addition, the method includes receiving an OLS spectrum data of the optical channel. Further, the method includes computing one or more configuration parameters for a predefined pair of transponders of one or more transponders based on the user input request and the OLS spectrum data. Furthermore, the method includes configuring the one or more configuration parameters on the predefined pair of transponders of the one or more transponders. Moreover, the user is associated with the one or more transponders. The user input request is associated with the predefined pair of transponders of the one or more transponders. The user input request includes parameters for the optical channel allocation on the predefined pair of transponders.

Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

Abstract: The present disclosure provides system to configure one or more photonics components using a method. The method includes a first step to initialize a photonic abstraction interface driver at a photonic abstraction system. In addition, the method includes another step to call a node detection function at the photonic abstraction system. Further, the method includes yet another step to call a plurality of application programming interfaces (APIs) at the photonic abstraction system. Furthermore, the method includes yet another step to de-initialize the photonic abstraction interface driver at the photonic abstraction system. Moreover, the photonic abstraction interface driver is initialized by a photonic abstraction interface host. Also, the photonic abstraction interface host and the photonic abstraction interface driver are layers of a photonic abstraction interface (PAI). Also, the photonic abstraction interface driver translates the photonic abstraction interface (PAI) into a plurality of shared libraries.