Patents by Inventor Qi Han

Qi Han has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted lactams as inhibitors of A? protein production
    Patent number: 7390802
    Abstract: This invention relates to novel lactams of Formula (I): having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A?-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to ?-amyloid production such as Alzheimer's disease and Down's Syndrome.
    Type: Grant
    Filed: January 19, 2007
    Date of Patent: June 24, 2008
    Assignee: Bristol-Myers Squibb Pharma Corporation
    Inventors: Qi Han, Hong Liu, Richard E. Olson, Michael G. Yang
  • MEMORY ACCESS CONTROLLER AND METHOD THEREOF
    Publication number: 20080034139
    Abstract: A memory access controller that improves SDRAM access performance with the enhanced AHB bus protocol includes at least one memory access master for issuing a memory access instruction including an HLEN signal that represents the burst length of the transmitting data; and a memory access controller for controlling the access to the memory on the basis of the HLEN signal generated by the memory access master.
    Type: Application
    Filed: July 30, 2007
    Publication date: February 7, 2008
    Applicant: FREESCALE SEMICONDUCTOR, INC.
    Inventors: Qi Han, Yan Xiao
  • Substituted lactams as inhibitors of A? protein production
    Patent number: 7276495
    Abstract: This invention relates to novel lactams of Formula (I): having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A?-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to ?-amyloid production such as Alzheimer's disease and Down's Syndrome.
    Type: Grant
    Filed: December 6, 2004
    Date of Patent: October 2, 2007
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Qi Han, Hong Liu, Richard E. Olson, Michael G. Yang
  • Substituted lactams as inhibitors of Abeta protein production
    Publication number: 20070173491
    Abstract: This invention relates to novel lactams of Formula (I): having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A?-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to ?-amyloid production such as Alzheimer's disease and Down's Syndrome.
    Type: Application
    Filed: January 19, 2007
    Publication date: July 26, 2007
    Applicant: BRISTOL-MYERS SQUIBB PHARMA COMPANY
    Inventors: Qi Han, Hong Liu, Richard Olson, Michael Yang
  • Guanidine mimics as factor Xa inhibitors
    Patent number: 7235575
    Abstract: The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein rings D-E represent guanidine mimics, which are useful as inhibitors of factor Xa.
    Type: Grant
    Filed: August 5, 2005
    Date of Patent: June 26, 2007
    Assignee: Bristol Myers Squibb Company
    Inventors: Patrick Y. Lam, Charles G. Clark, Celia Dominguez, John M. Fevig, Qi Han, Renhua Li, Donald J P Pinto, James R. Pruitt, Mimi L. Quan
  • Substituted lactams as inhibitors of Abeta protein production
    Publication number: 20060211679
    Abstract: This invention relates to novel lactams of Formula (I): having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A?-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to ?-amyloid production such as Alzheimer's disease and Down's Syndrome.
    Type: Application
    Filed: February 6, 2006
    Publication date: September 21, 2006
    Applicant: BRISTOL-MYERS SQUIBB PHARMA COMPANY
    Inventors: Qi Han, Hong Liu, Richard Olson, Michael Yang
  • Guanidine mimics factor Xa inhibitors
    Patent number: 6958356
    Abstract: The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein rings D-E represent guanidine mimics, which are useful as inhibitors of factor Xa.
    Type: Grant
    Filed: March 13, 2002
    Date of Patent: October 25, 2005
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Patrick Y. Lam, Charles G. Clark, Celia Dominguez, John M. Fevig, Amy Qi Han, Renhua Li, Donald J. Pinto, James R. Pruitt, Mimi L. Quan
  • Substituted lactams as inhibitors of Abeta protein production
    Publication number: 20050234039
    Abstract: This invention relates to novel lactams of Formula (I): having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A?-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to ?-amyloid production such as Alzheimer's disease and Down's Syndrome.
    Type: Application
    Filed: December 6, 2004
    Publication date: October 20, 2005
    Inventors: Qi Han, Hong Liu, Richard Olson, Michael Yang
  • Guanidine mimics as factor Xa inhibitors
    Patent number: 6906070
    Abstract: The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein rings D-E represent guanidine mimics, which are useful as inhibitors of factor Xa.
    Type: Grant
    Filed: August 8, 2001
    Date of Patent: June 14, 2005
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Patrick Y. Lam, Charles G. Clark, Celia Dominguez, John M. Fevig, Qi Han, Renhua Li, Donald J. P. Pinto, James R. Pruitt, Mimi L. Quan
  • Substituted lactams as inhibitors of A? protein production
    Patent number: 6900199
    Abstract: This invention relates to novel lactams of Formula (I): having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A?-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to ?-amyloid production such as Alzheimer's disease and Down's Syndrome.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: May 31, 2005
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Qi Han, Hong Liu, Richard E. Olson, Michael G. Yang
  • Nitrogen containing heterobicycles as factor Xa inhibitors
    Patent number: 6858616
    Abstract: The present application describes nitrogen containing heterobicyclics and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.
    Type: Grant
    Filed: April 26, 2002
    Date of Patent: February 22, 2005
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: John M. Fevig, Joseph Cacciola, Charles G. Clark, Qi Han, Patrick Yuk Sun Lam, Donald J. P. Pinto, James R. Pruitt, Mimi L. Quan, Karen A. Rossi
  • Substituted lactams as inhibitors of Abeta protein production
    Publication number: 20040138201
    Abstract: This invention relates to novel lactams of Formula (I): 1
    Type: Application
    Filed: October 14, 2003
    Publication date: July 15, 2004
    Inventors: Qi Han, Hong Liu, Richard E. Olson, Michael G. Yang
  • Imidazolidinones and their related derivatives as hepatitis C virus NS3 protease inhibitors
    Patent number: 6727366
    Abstract: The present invention relates generally to a novel class of imidazolidinones of Formula (I): that are useful as serine protease inhibitors, and more particularly as Hepatitis C virus NS3 protease inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.
    Type: Grant
    Filed: December 12, 2001
    Date of Patent: April 27, 2004
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Amy Qi Han, Peter W. Glunz
  • Imidazo-heterobicycles as factor xa inhibitors
    Publication number: 20040038980
    Abstract: The present application describes imidazo-heterobicycles of formulas I and III: 1
    Type: Application
    Filed: August 15, 2003
    Publication date: February 26, 2004
    Inventors: Patrick Y. Lam, Charles G. Clark, Qi Han, Thomas E. Richardson
  • Imidazo-heterobicycles as factor Xa inhibitors
    Patent number: 6673810
    Abstract: The present application describes imidazo-heterobicycles of formulas I and III: or pharmaceutically acceptable salt or prodrug forms thereof. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
    Type: Grant
    Filed: July 3, 2001
    Date of Patent: January 6, 2004
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Patrick Y. Lam, Charles G. Clark, Qi Han, Thomas E. Richardson
  • Substituted lactams as inhibitors of A&bgr; protein production
    Patent number: 6632812
    Abstract: This invention relates to novel lactams of Formula (I): having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A&bgr;-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to &bgr;-amyloid production such as Alzheimer's disease and Down's Syndrome.
    Type: Grant
    Filed: April 11, 2001
    Date of Patent: October 14, 2003
    Assignee: Dupont Pharmaceuticals Company
    Inventors: Qi Han, Hong Liu, Richard E. Olson, Michael G. Yang
  • Inhibitors of factor Xa with a neutral P1 specificity group
    Patent number: 6602895
    Abstract: The present application describes inhibitors of factor Xa with a neutral P1 specificity group of formula I: or pharmaceutically acceptable salt forms thereof, wherein R and E may be groups such as methoxy and halo.
    Type: Grant
    Filed: May 16, 2002
    Date of Patent: August 5, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert A. Galemmo, Jr., Celia Dominguez, John M. Fevig, Qi Han, Patrick Y. Lam, Donald J. P. Pinto, James R. Pruitt, Mimi L. Quan
  • Thrombin or factor Xa inhibitors
    Patent number: 6602871
    Abstract: This invention relates generally to inhibitors of trypsin-like serine protease enzymes, especially factor Xa or thrombin, pharmaceutical compositions containing the same, and methods of using the same as anticoagulant agents for treatment and prevention of thromboembolic disorders.
    Type: Grant
    Filed: December 4, 2001
    Date of Patent: August 5, 2003
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Patrick Y. S. Lam, Charles G. Clark, John M. Fevig, Robert A. Galemmo, Qi Han, Irina C. Jacobson, Renhau Li, Donald J. P. Pinto, Ruth R. Wexler
  • Amino lactam sulfonamides as inhibitors of A-beta protein production
    Publication number: 20030130251
    Abstract: This invention relates to novel lactams having the Formula (I): 1
    Type: Application
    Filed: November 4, 2002
    Publication date: July 10, 2003
    Inventors: Lorin A. Thompson, Amy Qi Han
  • Imidazolidinones and their related derivatives as hepatitis C virus NS3 protease inhibitors
    Publication number: 20030100768
    Abstract: The present invention relates generally to a novel class of imidazolidinones of Formula (I): 1
    Type: Application
    Filed: December 12, 2001
    Publication date: May 29, 2003
    Inventors: Amy Qi Han, Peter W. Glunz