Patents by Inventor Qi Han

Qi Han has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of factor Xa with a neutral P1 specificity group
    Publication number: 20030092740
    Abstract: The present application describes inhibitors of factor Xa with a neutral P1 specificity group of formula I: 1
    Type: Application
    Filed: May 16, 2002
    Publication date: May 15, 2003
    Inventors: Robert A. Galemmo, Celia Dominguez, John M. Fevig, Qi Han, Patrick Y. Lam, Donald J.P. Pinto, James R. Pruitt, Mimi L. Quan
  • Benzimidazolinones, benzoxazolinones, benzopiperazinones, indanones, and derivatives thereof as inhibitors of factor Xa
    Patent number: 6552042
    Abstract: The present application describes inhibitors of factor Xa of formula I: or pharmaceutically acceptable salt forms thereof, wherein W, W1, W2, and W3 may be N or C and J, Ja, and Jb combine to form a substituted carbocycle or heterocycle.
    Type: Grant
    Filed: January 29, 2001
    Date of Patent: April 22, 2003
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Qi Han, Celia Dominguez, Eugene C. Amparo, Jeongsook M. Park, Mimi L. Quan, Karen A. Rossi
  • Nitrogen containing heteroaromatics as factor Xa inhibitors
    Patent number: 6548512
    Abstract: The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is N or NH and D may be C(═NH)NH2, which are useful as inhibitors of factor Xa.
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: April 15, 2003
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Donald Joseph Phillip Pinto, James Russell Pruitt, Joseph Cacciola, John Matthew Fevig, Qi Han, Michael James Orwat, Mimi Lifen Quan, Karen Anita Rossi
  • Nitrogen containing heterobicycles as factor Xa inhibitors
    Publication number: 20030069237
    Abstract: The present application describes nitrogen containing heterobicyclics and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.
    Type: Application
    Filed: April 26, 2002
    Publication date: April 10, 2003
    Inventors: John M. Fevig, Joseph Cacciola, Charles G. Clark, Qi Han, Patrick Yuk Sun Lam, Donald J.P. Pinto, James R. Pruitt, Mimi L. Quan, Karen A. Rossi
  • Novel guanidine mimics factor Xa inhibitors
    Publication number: 20030069258
    Abstract: The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: 1
    Type: Application
    Filed: March 13, 2002
    Publication date: April 10, 2003
    Inventors: Patrick Y. Lam, Charles G. Clark, Celia Dominguez, John M. Fevig, Amy Qi Han, Renhua Li, Donald J. Pinto, James R. Pruitt, Mimi L. Quan
  • Amino lactam sulfonamides as inhibitors of A&bgr; protein production
    Patent number: 6503901
    Abstract: This invention relates to novel lactams having the Formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A&bgr;-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to &bgr;-amyloid production such as Alzheimer's disease and Down's Syndrome.
    Type: Grant
    Filed: October 7, 2000
    Date of Patent: January 7, 2003
    Assignee: Bristol Myers Squibb Pharma Company
    Inventors: Lorin Andrew Thompson, Amy Qi Han
  • Imidazo-heterobicycles as factor Xa inhibitors
    Publication number: 20030004167
    Abstract: The present application describes imidazo-heterobicycles of formulas I and III: 1
    Type: Application
    Filed: July 3, 2001
    Publication date: January 2, 2003
    Inventors: Patrick Y. Lam, Charles G. Clark, Qi Han, Thomas E. Richardson
  • Thrombin or factor Xa inhibitors
    Publication number: 20020115854
    Abstract: This invention relates generally to inhibitors of trypsin-like serine protease enzymes, especially factor Xa or thrombin, pharmaceutical compositions containing the same, and methods of using the same as anticoagulant agents for treatment and prevention of thromboembolic disorders.
    Type: Application
    Filed: December 4, 2001
    Publication date: August 22, 2002
    Inventors: Patrick Y.S. Lam, Charles G. Clark, John M. Fevig, Robert A. Galemmo, Qi Han, Irina C. Jacobson, Renhau Li, Donald J.P. Pinto, Ruth R. Wexler
  • Nitrogen containing heterobicycles as factor Xa inhibitors
    Patent number: 6413980
    Abstract: The present application describes nitrogen containing heterobicyclics and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: July 2, 2002
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: John M. Fevig, Joseph Cacciola, Charles G. Clark, Qi Han, Patrick Yuk Sun Lam, Donald J.P. Pinto, James R. Pruitt, Mimi L. Quan, Karen A. Rossi
  • Thrombin or factor Xa inhibitors
    Patent number: 6403583
    Abstract: This invention relates generally to inhibitors of trypsin-like serine protease enzymes, especially factor Xa or thrombin, pharmaceutical compositions containing the same, and methods of using the same as anticoagulant agents for treatment and prevention of thromboembolic disorders.
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: June 11, 2002
    Inventors: Patrick Y. S. Lam, Charles G. Clark, John M. Fevig, Robert A. Galemmo, Qi Han, Irina C. Jacobson, Renhau Li, Donald J. P. Pinto, Ruth R. Wexler
  • Inhibitors of factor Xa with a neutral P1 specificity group
    Patent number: 6403620
    Abstract: The present application describes inhibitors of factor Xa with a neutral P1 specificity group of formula I: or pharmaceutically acceptable salt forms thereof, wherein R and E may be groups such as methoxy and halo.
    Type: Grant
    Filed: September 10, 1999
    Date of Patent: June 11, 2002
    Inventors: Robert A. Galemmo, Jr., Celia Dominguez, John M. Fevig, Qi Han, Patrick Y. Lam, Donald J. P. Pinto, James R. Pruitt, Mimi L. Quan
  • Novel guanidine mimics as factor Xa inhibitors
    Publication number: 20020025963
    Abstract: The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: 1
    Type: Application
    Filed: August 8, 2001
    Publication date: February 28, 2002
    Inventors: Patrick Y. Lam, Charles G. Clark, Celia Dominguez, John M. Fevig, Qi Han, Renhua Li, Donald Jp Pinto, James R. Pruitt, Mimi L. Quan
  • Substituted lactams as inhibitors of A beta protein production
    Publication number: 20020025955
    Abstract: This invention relates to novel lactams of Formula (I): 1
    Type: Application
    Filed: April 11, 2001
    Publication date: February 28, 2002
    Inventors: Qi Han, Hong Liu, Richard E. Olson, Michael G. Yang
  • Guanidine mimics as factor Xa inhibitors
    Patent number: 6339099
    Abstract: The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein rings D—E represent guanidine mimics, which are useful as inhibitors of factor Xa.
    Type: Grant
    Filed: June 18, 1998
    Date of Patent: January 15, 2002
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Patrick Y. Lam, Charles G. Clark, Celia Dominguez, John M. Fevig, Qi Han, Renhua Li, Donald J. P. Pinto, James R. Pruitt, Mimi L. Quan
  • Benzimidazolinones, benzoxazolinones, benzopiperazinones, indanones, and derivatives thereof as inhibitors of factor Xa
    Publication number: 20010021775
    Abstract: The present application describes inhibitors of factor Xa of formula I: 1
    Type: Application
    Filed: January 29, 2001
    Publication date: September 13, 2001
    Inventors: Qi Han, Celia Dominguez, Eugene Amparo, Jeongsook Park, Mimi L. Quan, Karen A. Rossi
  • Benzimidazolinones, benzoxazolinones, benzopiperazinones, indanones, and derivatives thereof as inhibitors of factor Xa
    Patent number: 6207697
    Abstract: The present application describes inhibitors of factor Xa of formula I: or pharmaceutically acceptable salt forms thereof, wherein W, W1, W2, and W3 may be N or C and J, Ja, and Jb combine to form a substituted carbocycle or heterocycle.
    Type: Grant
    Filed: September 8, 1998
    Date of Patent: March 27, 2001
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Qi Han, Celia Dominguez, Eugene C. Amparo, Jeongsook M. Park, Mimi L. Quan, Karen A. Rossi
  • Amidinoindoles, amidinoazoles, and analogs thereof
    Patent number: 6043257
    Abstract: The present application describes amidinoindoles, amidinoazoles, and analogs thereof of formula I: ##STR1## wherein W, W.sup.1, W.sup.2, and W.sup.3 are selected from CH and N, provided that one of W.sup.1 and W.sup.2 is C(C(.dbd.NH)NH.sub.2) and at most two of W, W.sup.1, W.sup.2, and W.sup.3 are N and one of J.sup.a and J.sup.b is substituted by --(CH.sub.2).sub.n --Z--A--B, which are useful as inhibitors of factor Xa or thrombin.
    Type: Grant
    Filed: October 21, 1998
    Date of Patent: March 28, 2000
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Celia Dominguez, Qi Han, Daniel Emmett Duffy, Jeongsook Maria Park, Mimi Lifen Quan, Karen Anita Rossi, Ruth Richmond Wexler
  • Nitrogen containing heteroaromatics as factor Xa inhibitors
    Patent number: 6020357
    Abstract: The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is N or NH and D may be C(.dbd.NH)NH.sub.2, which are useful as inhibitors of factor Xa.
    Type: Grant
    Filed: December 22, 1997
    Date of Patent: February 1, 2000
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Donald Joseph Phillip Pinto, James Russell Pruitt, Joseph Cacciola, John Matthew Fevig, Qi Han, Michael James Orwat, Mimi Lifen Quan, Karen Anita Rossi
  • Inhibitors of factor Xa with a neutral P1 specificity group
    Patent number: 5998424
    Abstract: The present application describes inhibitors of factor Xa with a neutral P1 specificity group of formula I: ##STR1## or pharmaceutically acceptable salt forms thereof, wherein R and E may be groups such as methoxy and halo.
    Type: Grant
    Filed: June 18, 1998
    Date of Patent: December 7, 1999
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Robert A. Galemmo, Jr., Celia Dominguez, John M. Fevig, Qi Han, Patrick Y. Lam, Donald J. P. Pinto, James R. Pruitt, Mimi L. Quan
  • Amidinoindoles, amidinoazoles, and analogs thereof
    Patent number: 5886191
    Abstract: The present application describes amidinoindoles, amidinoazoles, and analogs thereof of formula I: ##STR1## wherein W, W.sup.1, W.sup.2, and W.sup.3 are selected from CH and N, provided that one of W.sup.1 and W.sup.2 is C(C(.dbd.NH)NH.sub.2) and at most two of W, W.sup.1, W.sup.2, and W.sup.3 are N and one of J.sup.a and J.sup.b is substituted by --(CH.sub.2).sub.n --Z--A--B, which are useful as inhibitors of factor Xa or thrombin.
    Type: Grant
    Filed: August 18, 1997
    Date of Patent: March 23, 1999
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Celia Dominguez, Qi Han, Daniel Emmett Duffy, Jeongsook Maria Park, Mimi Lifen Quan, Karen Anita Rossi, Ruth Richmond Wexler