Abstract: A TRAIL cell-penetrating peptide (CPPs)-like mutant MuR6 and a preparation method and the application thereof. The amino acid sequence of the mutant is SEQ ID NO: 2. The mutant selectively transforms the amino acid coding sequence of No. 114-119 of the outer fragment of the TRAIL wild-type protein cell membrane from VRERGP to RRRRRR, i.e., mutates valine into arginine on the 114th coding sequence, glutamic acid into arginine on the 116th coding sequence, glycine into arginine on the 118th coding sequence and proline into arginine on the 119th coding sequence, turning the coding sequence of N-terminal of the mutant protein into that of six arginines and making it a protein containing CPPs-like structure. Having a superior therapeutic effect on different types of tumor, the TRAIL mutant is a new generation of high-efficient drug for inducing tumor apoptosis of much potential.

Abstract: A manufacturing method for a substrate for an LCD panel includes providing a substrate, and applying photoresist techniques to form a first wiring layer on the substrate and patterning the first wiring layer to form a first laminating layer. An insulating layer and a semiconductor film are also formed and the semiconductor film is patterned to form a second laminating layer. A second wiring layer is formed and patterned to create a third laminating layer, a passivation layer, and a conductive film, and the conductive film is patterned to form a pixel electrode and a fourth laminating layer. The first, second, third, and fourth laminating layers stack together to form the necessary spacer. A color filter substrate with a constant gap is held between the insulating layer and the first laminating layer, and between the passivation layer and the third laminating layer.

Abstract: Nucleic acid sequences encoding chimeric polypeptides that exhibit enhanced cellulase activities are disclosed herein. These nucleic acids may be expressed in hosts such as fungi, which in turn may be cultured to produce chimeric polypeptides. Also disclosed are chimeric polypeptides and their use in the degradation of cellulosic materials.

Abstract: An electrical connector includes a first body, multiple first conducting terminals and multiple second conducting terminals received in the first body, a first fixing block, and a second fixing block. Each first conducting terminal has a first extending portion, and a first welding portion extending downward from the first extending portion. Each second conducting terminal has a second extending portion, and a second welding portion extending downward from the second extending portion. The first extending portions and the second extending portions are disposed in a front and back manner. The first extending portions are insert injection molded at the first fixing block. The second extending portions are insert injection molded at the second fixing block. The first fixing block and the second fixing block cooperatively position the first welding portions and the second welding portions. A stacked electrical connector formed by two or more of the electrical connectors.

Abstract: The presently disclosed subject matter provides anti-miRNAs for the treatment of diseases associated with atherogenesis and methods of treatment, and diagnosis and/or prognosis of these diseases using lipoprotein-associated miRNAs.

Abstract: The invention mainly relates to the field of genetic engineering drugs, in particular to a mutant cDNA sequence obtained by mutating valine at position 114, glutamate at position 116, glycine at position 118, proline at position 119 and glutamine at position 120 in an amino acid sequence at positions 114-281 of an extracellular fragment of a wild-type TRAIL protein respectively into arginines, so as to allow amino acids at positions 114-121 of the TRAIL protein to form a 8-consecutive arginine sequence, and then by gene synthesis and PCR mutation and splicing; and the TRAIL mutant has excellent therapeutic effect for a variety of tumors of different types, and is a new generation of promising drug for highly efficiently inducing tumor cell apoptosis.

Abstract: A manufacturing method for a substrate for an LCD panel includes providing a substrate, and applying photoresist techniques to form a first wiring layer on the substrate and patterning the first wiring layer to form a first laminating layer. An insulating layer and a semiconductor film are also formed and the semiconductor film is patterned to form a second laminating layer. A second wiring layer is formed and patterned to create a third laminating layer, a passivation layer, and a conductive film, and the conductive film is patterned to form a pixel electrode and a fourth laminating layer. The first, second, third, and fourth laminating layers stack together to form the necessary spacer. A color filter substrate with a constant gap is held between the insulating layer and the first laminating layer, and between the passivation layer and the third laminating layer.

Abstract: A silicon device, has a plurality of crystalline silicon regions. One crystalline silicon region is a doped crystalline silicon region. Deactivating some or all of the dopant atoms in the doped crystalline silicon region is achieved by introducing hydrogen atoms into the doped 5 crystalline silicon region, whereby the hydrogen coulombicly bonds with some or all of the dopant atoms to deactivate the respective dopant atoms. Deactivated dopant atoms may be reactivated by heating and illuminating the doped crystalline silicon region to break at least some of the dopant-hydrogen bonds while maintaining conditions to create a high concentration of neutral hydrogen atoms whereby 10 some of the hydrogen atoms diffuse from the doped crystalline silicon region without rebinding to the dopant atoms.

Abstract: The invention relates to Salmonella typhi Ty21a comprising core-linked Shigella dysenteriae serotype 1 O-specific polysaccharide (O-Ps) and DNA encoding O antigen biosynthesis, said DNA selected from the group consisting of: a) the DNA sequence set out in any one of SEQ ID NOs: 1 and 2 and species homologs thereof; b) DNA encoding Shigella dysenteriae serotype 1 polypeptides encoded by any one of SEQ ID NOs: 1 and 2, and species homologs thereof; and c) DNA encoding a O antigen biosynthesis gene product that hybridizes under moderately stringent conditions to the DNA of (a) or (b); and related sequences, compositions of matter, vaccines, methods of using, and methods of making.

Abstract: An array substrate of an LCD includes a substrate, a first wiring layer, a semiconductor film, an insulating layer, a second wiring layer, a passivation layer, a conductive film, and a spacer. The first wiring layer is patterned to a gate line, a gate electrode, and a first laminating layer. The semiconductor film is patterned to a channel layer and a second laminating layer. The second wiring layer is patterned to a source line, a source electrode, a drain electrode, and a third laminating layer. The conductive film is patterned to a pixel electrode and a fourth laminating layer. The spacer is a laminating structure at least includes the first, second, third, fourth laminating layers. A portion of insulating layer overlaps with the first laminating layer, and a portion of passivation layer overlaps with the third laminating layer.

Abstract: A method is provided for the processing of a device having a crystalline silicon region containing an internal hydrogen source. The method comprises: i) applying encapsulating material to each of the front and rear surfaces of the device to form a lamination; ii) applying pressure to the lamination and heating the lamination to bond the encapsulating material to the device; and iii) cooling the device, where the heating step or cooling step or both are completed under illumination.

Abstract: A wireless power transfer system including a driver coil array, a hexagonally-packed transmitter mat, a receiver coil, and a load coil for powering a medical implant. The magnetically coupled resonance between two isolated parts is established by an array of primary coils and a single small secondary coil to create a transcutaneous power link for implanted devices as moving targets. The primary isolated part includes a driver coil array magnetically coupled to a mat of hexagonally packed primary coils. Power is injected by the driver coils into the transmitter coils in the transmitter mat to maintain resonance in the presence of losses and power drawn by the receiver coil from the magnetic field. The implanted secondary isolated part includes a receiver coil magnetically coupled to a load coil. A rectification/filter system is connected to the load coil supplying DC power to the electronic circuits of the implant.

Abstract: The invention mainly relates to the field of genetic engineering drugs, in particular to a mutant cDNA sequence obtained by mutating valine at position 114, glutamate at position 116, glycine at position 118, proline at position 119 and glutamine at position 120 in an amino acid sequence at positions 114-281 of an extracellular fragment of a wild-type TRAIL protein respectively into arginines, so as to allow amino acids at positions 114-121 of the TRAIL protein to form a 8-consecutive arginine sequence, and then by gene synthesis and PCR mutation and splicing; and the TRAIL mutant has excellent therapeutic effect for a variety of tumors of different types, and is a new generation of promising drug for highly efficiently inducing tumor cell apoptosis.

Abstract: An ESD structure, including a first conductive type substrate, a second conductive type well region in the substrate, first/second doped regions (the first type), fourth to sixth doped regions (second conductive type), and first/second gates, is provided. The first/second doped regions are respectively disposed in the well region and the substrate. The first/second gates are on the substrate surface with no well region below. A third doped region is between the first and second gates in the substrate. The fourth doped region is in the substrate and on one side of the first/second gates. The fifth doped region is in the substrate, extends into the well region, and on another side of the first/second gates. The first doped region is located between the fifth and sixth doped region. The first/sixth doped regions and the first gate are connected. The fourth/second doped region and the second gate are connected.

Abstract: The disclosure provides a semi-submersible offshore platform with columns having an enlarged base on the bottom of each column with pontoons coupled between the columns. The enlarged column base can be at least as high as a height of the pontoon and on at least embodiment can be about 50% of the draft of the platform. The enlarged base can change a current flow shape around the base and columns for lower VIM. An outside corner of the base can be trimmed at an angle. Alternatively, the lower portions of the columns can be extended horizontally outward to form an effectively enlarged base having similar characteristics. In some embodiments, the pontoon volume can be reduced inversely proportional to the base enlargement to have comparable total buoyancy.

Abstract: Compositions and methods for protecting a susceptible host against an infection of Shigella sonnei are disclosed. Such compositions and methods are useful for protecting the host against bacillary dysentery and shigellosis.

Abstract: An electrical connector includes a first body, multiple first conducting terminals and multiple second conducting terminals received in the first body, a first fixing block, and a second fixing block. Each first conducting terminal has a first extending portion, and a first welding portion extending downward from the first extending portion. Each second conducting terminal has a second extending portion, and a second welding portion extending downward from the second extending portion. The first extending portions and the second extending portions are disposed in a front and back manner. The first extending portions are insert injection molded at the first fixing block. The second extending portions are insert injection molded at the second fixing block. The first fixing block and the second fixing block cooperatively position the first welding portions and the second welding portions. A stacked electrical connector formed by two or more of the electrical connectors.

Abstract: Techniques disclosed herein describe methods for achieving resource affinity and scalability in dynamic environments by calculating the modulus of a numeric request identifier against a fixed selection of numbers. Using the proposed techniques yields a numeric request identifier and resource identifier combination that ensures a given resource possesses the unique state applicable to that user's request. Using a fixed selection of numbers thus maintains resource affinity while achieving scalability as resources are added to or subtracted from a pool of resources.

Abstract: The invention relates to Salmonella typhi Ty21a comprising core-linked Shigella dysenteriae serotype 1 O-specific polysaccharide (O-Ps) and DNA encoding O antigen biosynthesis, said DNA selected from the group consisting of: a) the DNA sequence set out in any one of SEQ ID NOs: 1 and 2 and species homologs thereof; b) DNA encoding Shigella dysenteriae serotype 1 polypeptides encoded by any one of SEQ ID NOs: 1 and 2, and species homologs thereof; and c) DNA encoding a O antigen biosynthesis gene product that hybridizes under moderately stringent conditions to the DNA of (a) or (b); and related sequences, compositions of matter, vaccines, methods of using, and methods of making.

Abstract: Compositions and methods for protecting a susceptible host against an infection of Shigella sonnei are disclosed. Such compositions and methods are useful for protecting the host against bacillary dysentery and shigellosis.