Abstract: Nucleic acid sequences encoding chimeric polypeptides that exhibit enhanced cellulase activities are disclosed herein. These nucleic acids may be expressed in hosts such as fungi, which in turn may be cultured to produce chimeric polypeptides. Also disclosed are chimeric polypeptides and their use in the degradation of cellulosic materials.

Abstract: The disclosure provides a semi-submersible offshore platform with columns having an enlarged base on the bottom of each column with pontoons coupled between the columns. The enlarged column base can be at least as high as a height of the pontoon and on at least embodiment can be about 50% of the draft of the platform. The enlarged base can change a current flow shape around the base and columns for lower VIM. An outside corner of the base can be trimmed at an angle. Alternatively, the lower portions of the columns can be extended horizontally outward to form an effectively enlarged base having similar characteristics. In some embodiments, the pontoon volume can be reduced inversely proportional to the base enlargement to have comparable total buoyancy.

Abstract: The invention relates to Salmonella typhi Ty21a comprising core-linked Shigella dysenteriae serotype 1 O-specific polysaccharide (O-Ps) and DNA encoding O antigen biosynthesis, said DNA selected from the group consisting of: a) the DNA sequence set out in any one of SEQ ID NOs: 1 and 2 and species homologs thereof; b) DNA encoding Shigella dysenteriae serotype 1 polypeptides encoded by any one of SEQ ID NOs: 1 and 2, and species homologs thereof; and c) DNA encoding a O antigen biosynthesis gene product that hybridizes under moderately stringent conditions to the DNA of (a) or (b); and related sequences, compositions of matter, vaccines, methods of using, and methods of making.

Abstract: An electrostatic discharge (ESD) protection circuit is coupled between first and second pads to protect an internal circuit therebetween. Under a normal operating condition, a voltage on the first pad is higher than that on the second pad. The ESD protection circuit includes a substrate of a first conductivity type; first well of a second conductivity type in the substrate, wherein the first well is coupled to the first pad; a snapback device housed in the first well; and a diode string in the substrate, connected in series with the snapback device and separated from the first well, wherein the serially connected diode string and snapback device is connected between the first pad and the second pad. With the isolation from the first well, the holding voltage of the ESD protection circuit can be tuned by adjusting the number of diodes in the diode string without using a guard ring.

Abstract: The disclosure provides a semi-submersible offshore platform with columns having an enlarged base on the bottom of each column with pontoons coupled between the columns. The enlarged column base can be at least as high as a height of the pontoon and on at least embodiment can be about 50% of the draft of the platform. The enlarged base can change a current flow shape around the base and columns for lower VIM. An outside corner of the base can be trimmed at an angle. Alternatively, the lower portions of the columns can be extended horizontally outward to form an effectively enlarged base having similar characteristics. In some embodiments, the pontoon volume can be reduced inversely proportional to the base enlargement to have comparable total buoyancy.

Abstract: An electrostatic discharge (ESD) protection circuit connecting to an input pad is configured to dissipate an ESD current. The circuit has a substrate of a first conductivity type, a first well of a second conductivity type in the substrate, and a second well of the first conductivity type in the first well. The circuit further has a diode device having a first end of the first conductivity type electrically coupled to the input pad and a second end of the second conductivity type in the second well. Moreover, the protection circuit has a first doped region of the second conductivity type in the first well electrically connecting to the input pad, and a second doped region of the first conductivity type in the substrate electrically coupled to the ground. The circuit also has a channel formed between the input pad and the second doped region to provide an ESD current discharge.

Abstract: The invention relates to Salmonella typhi Ty21a comprising core-linked Shigella dysenteriae serotype 1 O-specific polysaccharide (O-Ps) and DNA encoding O antigen biosynthesis, said DNA selected from the group consisting of: a) the DNA sequence set out in any one of SEQ ID NOs: 1 and 2 and species homologs thereof; b) DNA encoding Shigella dysenteriae serotype 1 polypeptides encoded by any one of SEQ ID NOs: 1 and 2, and species homologs thereof; and c) DNA encoding a O antigen biosynthesis gene product that hybridizes under moderately stringent conditions to the DNA of (a) or (b); and related sequences, compositions of matter, vaccines, methods of using, and methods of making.

Abstract: Nucleic acid molecules encoding chimeric cellulase polypeptides that exhibit improved cellulase activities are disclosed herein. The chimeric cellulase polypeptides encoded by these nucleic acids and methods to produce the cellulases are also described, along with methods of using chimeric cellulases for the conversion of cellulose to sugars such as glucose.

Abstract: The present invention relates to linker molecules that readily conjugate cellular recognition ligand at one end and drug payload at the other, and are useful in treating or preventing cancer, an autoimmune disease, an inflammatory condition, a central nervous system disorder or an infection.

Abstract: A method for manufacturing an oriented silicon steel product with high magnetic-flux density comprises the following procedures: 1) smelting and casting, wherein the oriented silicon steel is composed of, by weight, 0.035˜0.065% of C, 2.9˜4.0% of Si, 0.05˜0.20% of Mn, 0.005˜0.01% of S, 0.015˜0.035% of Al, 0.004˜0.009% of N, 0.005˜0.090% of Sn, 0.200˜0.800% of Nb, the rest being Fe; and after being smelted, molten steel is secondarily refined and continuous casted into steel slabs; 2) hot rolling; 3) normalizing; 4) cold rolling; 5) decarburization annealing; 6) MgO coating; 7) high temperature annealing: said sheets are firstly heated to 700˜900° C. and then secondarily heated to 1200° C. at temperature rise rate of 9˜17° C./hr and maintained at 1200° C. for 20 hr; 8) coating an insulation layer.

Abstract: A method for installing peripheral software drivers including storing a first identifier for a peripheral device meant for compatible operation with an information handling system (IHS) in the non-volatile memory of the basic input/output system (BIOS) of the IHS, matching the peripheral device represented by the first identifier with compatible driver releases represented by a second identifier, sorting the compatible driver releases by priority and installing a highest priority driver release on the IHS.

Abstract: An ESD protection device including second P-type wells, first P+-type doped regions, first N+-type doped regions and a P-type substrate having a first P-type well, an N-type well and an N-type deep well is provided. The second P-type wells are disposed in the N-type deep well. The first P+-type doped regions and the first N+-type doped regions are respectively disposed in the first P-type well, the N-type well and the second P-type wells in alternation. The first P+-type doped region in the N-type well and the N-type deep well are electrically connected to the first connection terminal. The doped regions in the first P-type well and the P-type substrate are electrically connected to the second connection terminal. The second P-type wells and the first N+-type doped regions therein form a diode string connected in series between the first N+-type doped region of the N-type well and the second connection terminal.

Abstract: The disclosure provides an offshore platform and related method, having: a floating structure, a truss assembly coupled to the floating structure, and a heave plate coupled to the truss assembly. The floating structure includes a pontoon adapted to be disposed at least partially below a surface of water in which the offshore platform is disposed; and at least three vertically extending columns coupled to the pontoon, the columns having a larger lateral dimension than the pontoon coupled to the column, creating a pontoon offset portion. The truss assembly includes at least three separated walls of trusses slidably coupled to the columns, each truss wall having at least two vertically disposed truss legs, each truss leg being slidably coupled to a column at the pontoon offset portion independently from a truss leg of an adjacent wall; and cross-bracing between the truss legs of each of the truss walls.

Abstract: The disclosure provides a tension leg platform (“TLP”) with a plurality of buoyant pontoons suitable for highly disturbed seas that can expand the stability of the tension leg platform by extending at least one buoyant pontoon beyond an intersection of two pontoons. In at least one embodiment, the location of the column can be decoupled from the customary end of the pontoon. The tendons can be located at the ends of the pontoons extending beyond the intersection. In some embodiments, such as four-column TLPs, the pontoons can be extended orthogonally relative to an adjacent pontoon. The extending pontoon increases a buoyancy of the pontoon, increases a pitch stability of the TLP, and increases quayside stability. The extended pontoon can be structurally intersected with the adjacent pontoon to strengthen the extended pontoon and reduce the failure mode of such structure.

Abstract: An electrostatic discharge protection device electrically connected between a pad and an internal circuit is provided and includes a capacitor, a first resistor, a voltage-drop element and an NMOS transistor. A first end of the capacitor is electrically connected to the pad. A first end of the first resistor is electrically connected to a second end of the capacitor, and a second end of the first resistor is electrically connected to ground. The NMOS transistor and the voltage-drop element are connected in series between the pad and the ground, a gate of the NMOS transistor is electrically connected to the second end of the capacitor, and a bulk of the NMOS transistor is electrically connected to the ground.

Abstract: A semiconductor device, an electrostatic discharge protection device and manufacturing method thereof are provided. The electrostatic discharge protection device includes a gate, a gate dielectric layer, an N-type source region, an N-type drain region, an N-type doped region and a P-type doped region. The gate dielectric layer is disposed on a substrate. The gate is disposed on the gate dielectric layer. The N-type source region and the N-type drain region are disposed in the substrate at two sides of the gate, respectively. The N-type doped region is disposed in the N-type drain region and connects to the top of the N-type drain region. The P-type doped region is disposed under the N-type drain region and connects to the bottom of the N-type drain region.

Abstract: Apparatus and methods for producing a drop from a Drop on demand (DOD) dispenser, the drop having a radius that is much smaller than the radius of the nozzle that expels the drop. Generally, the Ohnesorge number is less than about 0.1. Various embodiments of the invention are found within a four dimensional space defined in terms of the Ohnesorge number, the Weber number, the actuation frequency, and the initial conditions.

Abstract: The disclosure provides a semi-submersible offshore platform with columns having an enlarged base on the bottom of each column with pontoons coupled between the columns. The enlarged column base can be at least as high as a height of the pontoon and on at least embodiment can be about 50% of the draft of the platform. The enlarged base can change a current flow shape around the base and columns for lower VIM. An outside corner of the base can be trimmed at an angle. Alternatively, the lower portions of the columns can be extended horizontally outward to form an effectively enlarged base having similar characteristics. In some embodiments, the pontoon volume can be reduced inversely proportional to the base enlargement to have comparable total buoyancy.

Abstract: Compositions and methods for protecting a susceptable host against an infection of Shigella sonnei are disclosed. Such compositions and methods are useful for protecting the host against bacillary dysentery and shigellosis.

Abstract: The disclosure provides an offshore platform and related method, having: a floating structure, a truss assembly coupled to the floating structure, and a heave plate coupled to the truss assembly. The floating structure includes a pontoon adapted to be disposed at least partially below a surface of water in which the offshore platform is disposed; and at least three vertically extending columns coupled to the pontoon, the columns having a larger lateral dimension than the pontoon coupled to the column, creating a pontoon offset portion. The truss assembly includes at least three separated walls of trusses slidably coupled to the columns, each truss wall having at least two vertically disposed truss legs, each truss leg being slidably coupled to a column at the pontoon offset portion independently from a truss leg of an adjacent wall; and cross-bracing between the truss legs of each of the truss walls.