Abstract: The compositions and methods of the invention provide compositions and methods for preferential targeting of tissues to delivery therapeutic or diagnostic agents. For example, such compounds are useful in the treatment of joint disorders those affecting articulating joints, e.g., injury-induced osteoarthritis as well as autoimmune diseases affecting joint tissue such as rheumatoid arthritis.

Abstract: A torque wrench includes a body portion which as a room and a working member is assembled in the room. The working member includes a rod and a working head protruding from the body portion. A torque sensor is connected to the rod of the working member. A release unit is located in the room of the body portion and movably connected to the rod of the working member. A torque setting unit is located in the room to apply a set torque to the release unit. A controller is connected to the torque wrench and electrically connected to the torque sensor and the torque setting unit. When a force applied to the working member exceeds the set torque, the torque setting unit drives the release unit, causing the working member to be free of force.

Abstract: A socket includes a first section and a second section. The first section is to be connected with a tool. The second section includes an outer face, and a mounting hole is axially defined through the second section and communicates through the first section. The mounting hole includes multiple recesses and multiple sides defined in the inner periphery thereof. The multiple recesses and the multiple sides are located alternatively with each other. Each recess includes a rounded corner formed radially in the inner portion thereof. A triangular groove is formed axially and centrally in each side. The angle between two insides of each groove is smaller than 90 degrees. A rusted or damaged bolt head is engaged with either the rounded corners or the grooves so as to be effectively rotated.

Abstract: Methods supporting a Quality of Service (QoS) update during a Handover (HO) procedure are disclosed herein. More specifically, methods performed by a Radio Access Network (RAN) node and a Core Network (CN) node for supporting a QoS update during an HO are provided. The methods disclosed herein can facilitate flexible New Generation (NG)-RAN (NG-RAN) deployment with a mixture of NG-RAN nodes capable or incapable of supporting additional parameters in an HO procedure. The methods also make it possible to provide smooth NG-RAN software updates between different software releases.

Abstract: Systems, methods, and instrumentalities are disclosed relating to intra prediction of a video signal based on mode-dependent subsampling. A block of coefficients associated with a first sub block of a video block, one or more blocks of coefficients associated with one or more remaining sub blocks of the video block, and an indication of a prediction mode for the video block may be received. One or more interpolating techniques, a predicted first sub block, and the predicted sub blocks of the one or more remaining sub blocks may be determined. A reconstructed first sub block and one or more reconstructed remaining sub blocks may be generated. A reconstructed video block may be formed based on the prediction mode, the reconstructed first sub block, and the one or more reconstructed remaining sub blocks.

Abstract: Example embodiments disclose a scalpel rod assembly of an ultrasonic scalpel. The scalpel rod assembly includes a scalpel rod, an inner tube, and a support ring; the inner tube is sleeved outside the scalpel rod; the support ring includes a first support body, the first support body is provided on the inner wall of the inner tube, and a first protrusion protrudes from the first support body in a direction away from the inner tube until the first protrusion abuts against the scalpel rod.

Abstract: A direct-contact, spray-assisted, evaporation and condensation, DCSEC system includes a heating block configured to receive and heat up seawater; plural evaporation and condensation stages, wherein n is a natural number, each stage being configured to generate water vapors through flash evaporation; an evaporation only stage connected to a last stage of the plural evaporation and condensation stages, the evaporation only stage configured to receive a brine from the last stage n of the plural evaporation and condensation stages; an input/output block configured to receive the brine from the evaporation only stage and to discharge it outside the system, and also to receive cooling water; and a pressure-swing regeneration block fluidly connected to the evaporation only stage to receive the water vapors and to generate a hot vapor, which is provided to the heating block for heating the seawater.

Abstract: A method, UE, and computer programs are provided where the UE has multiple universal subscriber identity modules. Information is received from a first PLMN indicating there is one of mobile terminating (MT) signaling or data in the first PLMN while the UE is in a second PLMN. Responsive to receiving the information, a service request is sent to an AMF node of the second PLMN. A radio resource control (RRC) connection release is received from a RAN node in response to sending the service request. Responsive to receiving the RRC connection release, the second PLMN is left to be in the first PLMN.

Abstract: Methods and apparatus are described herein related to improving the sound quality of a bone conduction speaker. The sound quality of the bone conduction speaker is adjusted in the sound generation, sound transferring, and sound receiving of the bone conduction speaker by designing vibration generation manners and vibration transfer structures.

Abstract: The present disclosure relates to a bone conduction speaker and its compound vibration device. The compound vibration device comprises a vibration conductive plate and a vibration board, the vibration conductive plate is set to be the first torus, where at least two first rods inside it converge to its center; the vibration board is set as the second torus, where at least two second rods inside it converge to its center. The vibration conductive plate is fixed with the vibration board; the first torus is fixed on a magnetic system, and the second torus comprises a fixed voice coil, which is driven by the magnetic system. The bone conduction speaker in the present disclosure and its compound vibration device adopt the fixed vibration conductive plate and vibration board, making the technique simpler with a lower cost; because the two adjustable parts in the compound vibration device can adjust both low frequency and high frequency area, the frequency response obtained is flatter and the sound is broader.

Abstract: The present disclosure presents blockchain-based cyber security management systems and related methods. One such method comprises obtaining cyber intelligence input data from a cyber defender computing device, wherein the cyber defender computing device manages network security of a network, wherein the cyber intelligence input data identifies a cyber attacker or a victim of a cyber attack on the network; executing one or more Cyber Security Management (CSM) functions with the cyber intelligence input data received from the cyber defender computing device and cyber data stored in the blockchain ledger, wherein the cyber data stored in the blockchain ledger provides details on a cyber attack on a network that is managed by another cyber defender computing device; and outputting an alert to the cyber defender computing device with a potential cyber attacker or potential victim of the cyber attack on the network managed by the cyber defender computing device.

Abstract: A multiphase buck converter that includes smart two-phase power stages for reducing switching losses. Each of the smart power stages includes a first high side switch, a second high side switch, a first low side switch, a second low side switch, a switching capacitor, a first inductor, and a second inductor. The exemplary multiphase buck converter includes two such smart power stages and a multiphase controller for generating PWM signals for driving the two smart power stages synchronously.

Abstract: A speaker comprises a housing, a transducer residing inside the housing, and at least one sound guiding hole located on the housing. The transducer generates vibrations. The vibrations produce a sound wave inside the housing and cause a leaked sound wave spreading outside the housing from a portion of the housing. The at least one sound guiding hole guides the sound wave inside the housing through the at least one sound guiding hole to an outside of the housing. The guided sound wave interferes with the leaked sound wave in a target region. The interference at a specific frequency relates to a distance between the at least one sound guiding hole and the portion of the housing.

Abstract: This disclosure provides improved RNA molecules, including mRNA molecules that can be produced by in vitro transcription and are suitable for in vivo transfection using an appropriate delivery vehicle, such as a lipid nanoparticle (LNP) or targeted lipid nanoparticle (tLNP). The improved RNA include particular combinations of 5? untranslated region (UTR) and 3? UTR, particular 3? UTRs, or particular open reading frame sequences. Also provided herein are compositions of the LNP, or tLNP with an antibody as a targeting moiety, such as anti-CD8 antibodies that are used as targeting moiety.

Abstract: Provided is a gene target region enrichment method and a kit. The method comprises (1) amplifying fragmented DNA comprising a target region by means of a specific probe so as to obtain a captured-extension product, wherein the specific probe comprises a sequence complementary to the target region of the fragmented DNA, and the 3? terminal nucleotide of the specific probe is modified to prevent a ligation reaction at the 3? terminal of the specific probe; and (2) linking the 3? terminal of the captured-extension product obtained in step (1) to linker DNA to obtain a ligation product.

Abstract: Systems and methods for handling a wireless device in a Configuration Management (CM)-Connected state with Radio Resource Control (RRC) Inactive state are provided. In some embodiments, a method for performing a mobility transfer from a Fifth Generation network to an Evolved Packet System (EPS) network includes a 5G network node: receiving, from an EPS network node, a context request for context associated with a User Equipment (UE); determining data forwarding information associated with the UE; and sending, to the EPS network node, a context response comprising context information associated with the UE and data forwarding information associated with the UE. In this way, packet losses will be minimized leading to improved end user performance.

Abstract: A method of interpreting a digit-to-digit gesture based on roll values for a wrist-wearable device is disclosed. The method includes, receiving an indication at a first point in time that a user donning the wrist-wearable device is providing a digit-to-digit gesture in which one of the user's digits touches another of the user's digits without contacting the display of the wearable device. The method further includes, in accordance with a determination that the digit-to-digit gesture is provided while data indicates that the wrist-wearable device has a first roll value, causing a target device in communication with the wearable device to perform a first input command and receiving another indication at a second point in time that is after the first point in time that the user is providing the digit-to-digit gesture again, causing the target device to perform a second input command that is distinct from the first input command.

Abstract: An example method includes a method performed by a wireless device for sending a message relating to location services. The method includes establishing a user plane connection with a location management function, and sending a message relating to location services to the location management function using the user plane connection.

Abstract: The embodiments of the present disclosure provide a near-field communication control method, device, and display device. The near-field communication control device is applied to a display device. The display device includes a display panel, a near-field communication coil and a display control circuit, wherein the display panel includes a plurality of display periods, and each display period includes a field blanking phase and an effective display phase, the near-field communication control device includes: a first receiving circuit configured to receive a synchronization signal output from the display control circuit, wherein the display panel displays an image during the effective display phase under the control of the synchronization signal; and a driving circuit configured to output a driving signal to the near-field communication coil during the field blanking phase, according to the synchronization signal.