Abstract: A polypeptide or protein directional modification method based on sulfhydryl-alkenyl azide coupling is provided. The method uses a sulfhydryl group-containing compound and a compound containing alkenyl azide group as reactants to generate an amino acid containing ?-carbonyl sulfide, a polypeptide containing ?-carbonyl sulfide and a protein bioconjugate containing ?-carbonyl sulfide, thereby achieving a chemical modification. The method is mild in conditions and wide in solvent selectivity, a reaction temperature is in a range of 37 degrees Celsius (° C.) to 40° C., and a reaction time is in a range of 10 minutes to 48 hours. The method is promising in preparing functional polypeptides or functional proteins, protein labeling, and biological medicine.

Abstract: A short-travel nanoscale motion stage and a method for measuring thermally-related hysteresis data are provided. A stator unit of a left two-pole electromagnet and stator units of two inchworm motors are fixed on a right side surface of a left foundation frame, and an active unit of the left two-pole electromagnet and actives of the two inchworm motors are fixed on a left side surface of a stage moving component. An active unit of a right two-pole electromagnet is fixed on a right side surface of the stage moving component, while a stator unit of the right two-pole electromagnet is fixed on a left side surface of a right foundation frame. The stage moving component is fixedly mounted on a guide sleeve of an aerostatic guideway. Each of the stator units of the left and right two-pole electromagnets has an eddy current sensor and a hall sensor fixed therein.

Abstract: This application provides a polymer current collector, a preparation method thereof, and a secondary battery, battery module, battery pack, and apparatus associated therewith. The polymer current collector provided in this application includes polymer film layers, where the polymer film layers include a first polymer film layer and a second polymer film layer, a resistivity of the first polymer film layer is denoted as ?1, a resistivity of the second polymer film layer is denoted as ?2, and the current collector satisfies ?1>?2. The polymer current collector in this application can induce to deposit of lithium metal from a low conductivity side to a high conductivity side, avoiding risks of depositing lithium ions on the surface of the current collector and thereby increasing cycle life of lithium metal batteries.

Abstract: The invention relates to the technical field of battery materials and discloses a cobalt-free layered nickel-manganese cathode material and a preparation method and application thereof. The chemical formula of the cobalt-free layered nickel-manganese cathode material is LiaNixMnyMezO2@Mb, and Me is at least one selected from the group consisting of Zr, Al, W, Sr, Ti and Mg; M is at least one selected from the group consisting of Al2O3, CeO2, TiO2, Yb2O3, Nb2O5, La2O3, WO3, titanium sol, aluminum sol, titanium-aluminum sol, aluminum isopropoxide, butyl titanate, aluminum dihydrogen phosphate or lithium tungstate. The present invention achieves a shallow coating through high temperature calcination followed by metal oxide coating, which is beneficial to prevent the material from microcracks expansion caused by the material structure and internal stress change during the charging-discharging cycles.

Abstract: The invention relates to the field of battery materials, and discloses a cathode material precursor and a preparation method and application thereof. The chemical formula of the cathode material precursor is NixCoyMnz(OH)2, wherein 0.2?x?1, 0?y?0.5, 0?z?0.6, and 0.8?x+y+z?1. The cathode material precursor is in a shape of a stack of lamellae, and has a particle size broadening factor K, where K?0.85. In the invention, the preparation process of the precursor is effectively controlled and adjusted by the controlled crystallization method combined with Lamer nucleation and growth theoretical model. The prepared precursor has morphology characteristics of concentrated particle size distribution and high proportion of {010} active crystal plane family, and has capacity retention up to 91.33% at a rate of 20C.

Abstract: A secondary battery includes a positive electrode plate. that includes a positive current collector, a first positive active material layer distributed on one side of the positive current collector, and a second positive active material layer distributed on an other side of the positive current collector and a negative electrode plate that includes a negative current collector, a first negative active material layer distributed on one side of the negative current collector and opposite to the second positive active material layer, and a second negative active material layer distributed on an other side of the negative current collector. A resistance of the first positive active material layer is R1, a resistance of the second positive active material layer is R2, a resistance of the first negative active material layer is R3, a resistance of the second negative active material layer is R4.

Abstract: A connection assembly for prefabricated components provided herein includes two C-shaped groove members and an H-shaped connection member. The C-shaped groove members are each provided with a component connecting part for fixedly connecting with a component, the H-shaped connection member includes a middle web and two side flanges, notches of the C-shaped groove members are in clearance fit with the web, and the side flanges are in stop fit with inverted edges of the C-shaped groove members when the H-shaped connection member is inserted between the C-shaped groove members. The C-shaped groove members and/or the H-shaped connection member are each provided with wedge members, and the wedge members have wedge surfaces for guiding the two C-shaped groove members to be fastened oppositely.

Abstract: The present disclosure relates to a method and a composition comprising an esterase for enzymatic surface modification of a polyester. The present disclosure also relates to a method of degradation or hydrolysis of an insoluble plant material.

Abstract: The present disclosure provides a display substrate, a display panel including the display substrate, and an electronic device. The display substrate includes: a base substrate; a transistor on the base substrate, wherein the transistor includes a first gate layer; a signal line located on the base substrate and configured to transmit an electrical signal; and a conductive isolation portion located between the transistor and the signal line adjacent to the transistor in a direction parallel to the base substrate, wherein the conductive isolation portion is electrically connected with a DC source signal on the display substrate.

Abstract: This application discloses a battery unit. The battery unit includes a housing, at least one cell, and a buffer. The at least one cell is accommodated in the housing, the buffer is disposed corresponding to a side wall of the cell, and the buffer is provided with an accommodating cavity. A periphery of the accommodating cavity includes at least one packaging structure, the packaging structure includes at least one level of packaging region with a predetermined length. When pressure in the accommodating cavity exceeds packaging strength of the packaging structure, the packaging region is opened to form a buffer space that communicates with the accommodating cavity, reducing influence caused by swelling of the cell.

Abstract: An embodiment method of network node operation includes indicating, by a first network node, to a first UE, a first number of REs in a first set of RBs for a first reference signal, transmitting, by the first network node, to the first UE, the first reference signal in accordance with the first number of REs and a first precoding in a first subframe, receiving, by the first network node, from the first UE, a report indicating a first MCS in accordance with a level of signal and interference measured by the first UE, wherein the measurement is restricted to the first reference signal, and transmitting, by the first network node, a first data with the indicated first MCS and the first precoding in a second subframe, the first data being transmitted on a second number of REs in the first set of RBs in the second subframe.

Abstract: The present invention relates to the technical field of medicines, and relates to a polyethylene glycol conjugated drug, a preparation method therefor and the use thereof. In particular, the present invention relates to a polyethylene glycol conjugated drug as shown in formula I or a pharmaceutically acceptable salt thereof. The present invention also relates to a method for preparing the polyethylene glycol conjugated drug or the pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the polyethylene glycol conjugated drug or the pharmaceutically acceptable salt thereof, and the use thereof in the preparation of a drug.

Abstract: A strong FXR small-molecule agonist, and a preparation method therefor and use thereof, the structure of the agonist being represented by formula (I), are provided. In the formula, each substituent is as defined in the description and the claims. The compound provided has the advantages of high FXR agonist activity, simple synthesis, easily available raw materials and the like, and can be used for preparing medicines for treating FXR related diseases.

Abstract: One or more computer processors obtain an initial subnetwork at a target sparsity and an initial pruning mask from a pre-trained self-supervised learning (SSL) speech model. The one or more computer processors finetune the initial subnetwork, comprising: the one or more computer processors zero out one or more masked weights in the initial subnetwork specified by the initial pruning mask; the one or more computer processors train a new subnetwork from the zeroed out subnetwork; the one or more computer processors prune one or more weights of lowest magnitude in the new subnetwork regardless of network structure to satisfy the target sparsity. The one or more computer processors classify an audio segment with the finetuned subnetwork.

Abstract: In described examples, a device mounted on a substrate includes an encapsulant. In at least one example, an encapsulant barrier is deposited along a scribe line, along which the substrate is singulatable. To encapsulate one or more terminals of the substrate, an encapsulant is deposited between the encapsulant barrier and an edge of the device parallel to the encapsulant barrier.

Abstract: A polyethylene glycol conjugate drug synergist, a preparation method therefor, and use thereof, specifically relating to a polyethylene glycol conjugate drug synergist as shown in formula I or a pharmaceutically acceptable salt thereof, a preparation method for the polyethylene glycol conjugate drug synergist or the pharmaceutically acceptable salt thereof, an intermediate for preparing the polyethylent glycol conjugate drug synergist or the pharmaceutically acceptable salt thereof, a composition containing the polyethylene glycol conjugate drug synergist or the pharmaceutically acceptable salt thereof, and use of the polyethylene glycol conjugate drug synergist or the pharmaceutically acceptable salt thereof in preparation of a drug.

Abstract: Provided is a urate oxidase preparation. The urate oxidase preparation includes polyethylene glycol-modified urate oxidase as an active ingredient and a buffer reagent as an excipient.

Abstract: Embodiments of the present disclosure disclose a shift register unit, a driving method thereof, and a device. The shift register unit includes an input circuit, a node control circuit, a first control output circuit, a second control output circuit and an output circuit. By providing the first control output circuit and the second control output circuit, the first control output circuit and the second control output circuit may operate alternately, so that the first control output circuit and the second control output circuit may have time for characteristics recovery respectively, thus improving the service life and output stability of the shift register unit.

Abstract: Provided is a method for preparing a polyethylene glycol-modified urate oxidase, at least 11 of the following amino acid sites of the polyethylene glycol-modified urate oxidase have a PEG modification: T1, K3, K4, K30, K35, K76, K79, K97, K112, K116, K120, K152, K179, K222, K231, K266, K272, K285, K291, and K293, and the preparation method includes: performing a coupling reaction between urate oxidase and polyethylene glycol, wherein the polyethylene glycol is provided in the form of an acidic solution, and a molar ratio of the urate oxidase to the polyethylene glycol is 1: (56 to 94), to obtain the polyethylene glycol-modified urate oxidase.

Abstract: A secondary battery and a preparation method thereof, and a battery module, battery pack, and apparatus containing a secondary battery are provided. In some embodiments, the secondary battery includes a positive electrode plate, a negative electrode plate, and an electrolyte, where the positive electrode plate includes a positive electrode current collector and a positive electrode film layer that is disposed on at least one surface of the positive electrode current collector and that includes a positive electrode active material, and the negative electrode plate includes a negative electrode current collector and a negative electrode film layer that is disposed on at least one surface of the negative electrode current collector and that includes a negative electrode active material; and the positive electrode active material includes a first material and a second material.