Patents by Inventor Qian-Sheng Yu

Qian-Sheng Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Highly selective butyrylcholinesterase inhibitors for the treatment and diagnosis of Alzheimer's disease and dementias
    Publication number: 20020094999
    Abstract: The present disclosure relates to the discovery that highly selective butyrylcholinesterase inhibitors can prevent or treat cognitive impairments associated with aging or Alzheimer's disease. A preferred butyrylcholinesterase inhibitor is cymserine.
    Type: Application
    Filed: February 7, 2002
    Publication date: July 18, 2002
    Inventors: Nigel H. Greig, Qian-Sheng Yu, Arnold Brossi, Timothy T. Soncrant, Marvin Hausman
  • Highly selective butyrylcholinesterase inhibitors for the treatment and diagnosis of alzheimer's disease and dementias
    Patent number: 6410747
    Abstract: A method for preventing or treating cognitive impairments associated with aging or Alzheimer's disease which comprises treating a patient at risk for having the cognitive impairment with an effective amount of a highly selective butyrylcholinesterase inhibitor.
    Type: Grant
    Filed: June 17, 1999
    Date of Patent: June 25, 2002
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Nigel H. Greig, Qian-Sheng Yu, Arnold Brossi, Timothy T. Soncrant, Marvin Hausman
  • Optically active 5-oxygenated (3S)-1,3-dimethyloxindole-3-acetic acids
    Patent number: 5310935
    Abstract: The synthesis of optically active 5-oxygenated (3S)-1,3-dimethyloxindole-3-acetic acids ##STR1## and their use in the synthesis of optically active (3aS-cis)-eseroline and (3aS-cis)-N.sup.1 -benzylnoreseroline, which are important intermediates in the synthesis of compounds related to (3aS-cis)-physostigmine and carbamate analogs, and of (3aS-cis)-N.sup.1 -benzylnor- and N.sup.1 -norphysostigmine and their carbamate analogs.
    Type: Grant
    Filed: June 30, 1992
    Date of Patent: May 10, 1994
    Assignee: Pharmagroup International
    Inventors: Arnold Brossi, Danilo C. Massari, Qian-Sheng Yu
  • Carbamates related to (-)-physostigmine as cholinergic agents
    Patent number: 4900748
    Abstract: Highly potent analogs of (-)-physostigmine are provided which are potent inhibitors of acetylcholinesterase and butyrylcholinesterase. These compounds are useful in treatment of glaucoma, Alzheimer's disease, myasthenia gravis, and organophosphate poisoning.
    Type: Grant
    Filed: March 4, 1988
    Date of Patent: February 13, 1990
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Arnold Brossi, Qian-Sheng Yu, John R. Atack, Stanley I. Rapoport