Abstract: The present invention relates to a process for producing succinic anhydride by maleic anhydride hydrogenation, comprising (1) feeding a maleic anhydride solution and a hydrogen raw material respectively to a first-stage hydrogenation reactor from an upper liquid-phase feed port and a top gas-phase feed port of the first-stage hydrogenation reactor for a first-stage hydrogenation reaction to obtain a first-stage hydrogenation product; (2) feeding the first-stage hydrogenation product to a second-stage hydrogenation reactor for a second-stage hydrogenation reaction to obtain a second-stage hydrogenation product, optionally, before entering the second-stage hydrogenation reactor, subjecting the first-stage hydrogenation product to a first-stage gas-liquid separation to obtain a first-stage gas phase and a first-stage liquid phase, and then feeding the first-stage gas phase and the first-stage liquid phase respectively from a top gas-phase feed port and an upper liquid-phase feed port of the second-stage hydrogen

Abstract: Provided is a process including: determining, based on a machine learning model, a measure of outcome success for a set of job requisitions, the machine learning model trained to determine measures of outcome success for job requisitions based on a set of job requisition training data, and the set of job requisition training data comprising: a set of historical job requisitions; and job outcomes for the set of historical job requisitions; ranking, based on the measure of outcome success, the set of job requisitions to generate a ranked set of job requisitions; and providing, to a job candidate, one or more job requisitions of the ranked set of job requisitions for selection of a job requisition for application by the job candidate.

Abstract: In one example in accordance with the present disclosure, an additive manufacturing system is described. The additive manufacturing system includes a build material deposition device to form a plastically deformable three-dimensional (3D) object by depositing layers of a thermoplastic build material to form a body of the plastically deformable 3D object. The additive manufacturing system also includes a heat channel forming device to form heat channels within the plastically deformable 3D object which heat channels, responsive to an applied stimulus, are to soften adjacent regions of the body. The additive manufacturing system also includes a fusing system to selectively harden layers of thermoplastic build material to form the plastically deformable 3D object.

Abstract: Various methods of reshaping and recycling thermoset polymers and composites containing thermoset polymers are provided. The methods involve the bond exchange reaction of exchangeable covalent bonds in the polymer matrix with a suitable small molecule solvent in the presence of a catalyst. In some aspects, the methods are applied to a carbon fiber reinforced polymer or a thermoset polymer where the thermoset polymer matrix includes a plurality of ester bonds. Using a small molecule alcohol, the methods provide for recycling one or both of the carbon fiber and the polymer, for welding two surfaces, or for repairing a damaged surface in the materials.

Abstract: Various methods of reshaping and recycling thermoset polymers and composites containing thermoset polymers are provided. The methods involve the bond exchange reaction of exchangeable covalent bonds in the polymer matrix with a suitable small molecule solvent in the presence of a catalyst. In some aspects, the methods are applied to a carbon fiber reinforced polymer or a thermoset polymer where the thermoset polymer matrix includes a plurality of ester bonds. Using a small molecule alcohol, the methods provide for recycling one or both of the carbon fiber and the polymer, for welding two surfaces, or for repairing a damaged surface in the materials.

Abstract: Provided is a protein comprising an antibody or antigen-binding fragment and an interleukin molecule operably linked to the antibody or antigen-binding fragment. The antibody or antigen-binding fragment specifically binds to an immune checkpoint protein. The interleukin molecule is IL-10.

Abstract: Various methods of reshaping and recycling thermoset polymers and composites containing thermoset polymers are provided. The methods involve the bond exchange reaction of exchangeable covalent bonds in the polymer matrix with a suitable small molecule solvent in the presence of a catalyst. In some aspects, the methods are applied to a carbon fiber reinforced polymer or a thermoset polymer where the thermoset polymer matrix includes a plurality of ester bonds. Using a small molecule alcohol, the methods provide for recycling one or both of the carbon fiber and the polymer, for welding two surfaces, or for repairing a damaged surface in the materials.

Abstract: Provided herein is related generally to the field of molecular biology and growth factor regulation. More specifically, provided herein are methods useful for treating cancer patient using c-Met inhibitor based on the identification of an increased c-Met expression and at least one c-Met gene alteration, e.g. c-Met mutation, c-Met fusion gene and c-Met gene amplification.

Abstract: Provided herein are methods of treating cancer in a patient with a tyrosine kinase inhibitor. The method comprises: a) measuring the expression level of a protein kinase in a sample obtained from the patient; b) comparing the expression level of the protein kinase to a corresponding reference expression level; c) determining a likelihood of the patient being responsive to the tyrosine kinase inhibitor; and d) treating the patient whose expression level of the protein kinase indicates that the patient will be responsive with the tyrosine kinase inhibitor.

Abstract: Various methods of reshaping and recycling thermoset polymers and composites containing thermoset polymers are provided. The methods involve the bond exchange reaction of exchangeable covalent bonds in the polymer matrix with a suitable small molecule solvent in the presence of a catalyst. In some aspects, the methods are applied to a carbon fiber reinforced polymer or a thermoset polymer where the thermoset polymer matrix includes a plurality of ester bonds. Using a small molecule alcohol, the methods provide for recycling one or both of the carbon fiber and the polymer, for welding two surfaces, or for repairing a damaged surface in the materials.

Abstract: Various methods of reshaping and recycling thermoset polymers and composites containing thermoset polymers are provided. The methods involve the bond exchange reaction of exchangeable covalent bonds in the polymer matrix with a suitable small molecule solvent in the presence of a catalyst. In some aspects, the methods are applied to a carbon fiber reinforced polymer or a thermoset polymer where the thermoset polymer matrix includes a plurality of ester bonds. Using a small molecule alcohol, the methods provide for recycling one or both of the carbon fiber and the polymer, for welding two surfaces, or for repairing a damaged surface in the materials.

Abstract: Various methods of reshaping and recycling thermoset polymers and composites containing thermoset polymers are provided. The methods involve the bond exchange reaction of exchangeable covalent bonds in the polymer matrix with a suitable small molecule solvent in the presence of a catalyst. In some aspects, the methods are applied to a carbon fiber reinforced polymer or a thermoset polymer where the thermoset polymer matrix includes a plurality of ester bonds. Using a small molecule alcohol, the methods provide for recycling one or both of the carbon fiber and the polymer, for welding two surfaces, or for repairing a damaged surface in the materials.

Abstract: An information transmission apparatus for logging while drilling comprises a hollow drilling rod and at least one cable. The drilling rod comprises at least one first drilling rod member and at least one second drilling rod member spliced to each other alternately. The first drilling rod member comprises a through hole, and the second drilling rod member comprises a stepped hole. The cable comprises a fixed end, a connected end, and a folded portion connect the fixed end to the connected end. Each of the cables is fixed in the stepped hole through a fixed end or is connected to a connected end of an adjacent cable. The connected end may be stretched along the stepped hole, and stretched through the through hole to be electrically connected to a logging instrument or a fixed end of the adjacent cable. The apparatus provides protection for a cable through a hollow drilling rod, thereby improving the transmission reliability.

Abstract: The present invention provides an immuno-deficient animal useful as an animal model for a human disease associated with a first mutation of a target gene, wherein the animal comprises (a) a first human xenograft comprising the target gene comprising the first mutation; (b) a second human xenograft comprising the target gene but lacking the first mutation, wherein the first human xenograft and second human xenograft are isogenic. Also provided here are methods of producing the animal model and methods of using such animal model.

Abstract: The present invention relates to compounds having at least one (substituted phenyl)-propenal moiety. The compounds are useful in treating a subject suffering from an androgen receptor-associated medical condition, e.g., inflammation, acne, alopecia, hirsutism, wound, Spinal and Bulbar Muscular Atrophy (SBMA, Kennedy's Disease), unwanted immune response, immune disorder, or cancer.

Abstract: The present disclosure relates to a system and method of managing the use of power in a computing system including for example a wearable computer such as a smart watch. The computing device may include a policy agent implementing one or more stored power management policies relating to download parameters for photos or other content based in part on remaining battery life in the computing device. The stored policies indicate the size reduction for image or media files to be downloaded to the computing device.

Abstract: The present invention includes methods and compositions useful for treating and preventing skin disorders, hair loss and other skin disorders. The compositions include an ARD enhancer in combination with a second compound or composition. In some embodiments the second compound is at least one of a bactericide, an antibiotic, an anti-microbial peptide, Vitamin A, a Vitamin A derivative, a retinoid, an anti-inflammatory compound, and anti-androgen compounds.

Abstract: The present invention includes methods and compositions useful for treating and preventing skin disorders, hair loss and other skin disorders. The compositions include an ARD enhancer in combination with a second compound or composition. In some embodiments the second compound is at least one of a bactericide, an antibiotic, an anti-microbial peptide, Vitamin A, a Vitamin A derivative, a retinoid, an anti-inflammatory compound, and anti-androgen compounds.

Abstract: The present invention relates to compounds having at least one (substituted phenyl)-propenal moiety. The compounds are useful in treating a subject suffering from an androgen receptor-associated medical condition, e.g., inflammation, acne, alopecia, hirsutism, wound, Spinal and Bulbar Muscular Atrophy (SBMA, Kennedy's Disease), unwanted immune response, immune disorder, or cancer.