Abstract: Embodiments of the instant disclosure relate to novel antiviral compositions and methods for treating viral infections. In accordance with these embodiments, antiviral compositions can include at least one mRNA encoding for a TRIM7 protein encapsulated into a lipid nanoparticle (LNP). In other embodiments, methods of making antiviral compositions are disclosed as well as methods of administering a composition having at least one mRNA encoding for a TRIM7 protein encapsulated into LNP into a subject.

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: In an aspect of the disclosure, a method, a computer-readable medium, and an apparatus are provided. The apparatus may be a first UE. The first UE transmits a plurality of reference signals (RSs) using a plurality of transmission beams on a sidelink. The first UE receives, from a second UE, a beam report carried on a Physical Sidelink Feedback Channel (PSFCH). The beam report indicates beam qualities generated by the second UE based on measurements of the plurality of RSs. The first UE selects a transmission beam and a reception beam based on the beam qualities. The first UE establishes a sidelink communication with the second UE using the selected transmission beam and the selected reception beam on the sidelink.

Abstract: In an aspect of the disclosure, a method, a computer-readable medium, and an apparatus are provided. The apparatus may be a UE. The UE transmits a plurality of reference signals (RSs) using a plurality of transmission beams on a sidelink. The UE receives a beam report from a second UE. The beam report indicates a selected transmission beam from the plurality of transmission beams. The beam report also indicates a selected reception beam of the second UE. The selected transmission beam and the selected reception beam are based on measurements of the transmitted RSs. The UE establishes a sidelink communication with the second UE using the selected transmission beam and the selected reception beam on the sidelink.

Abstract: In some aspects, the present disclosure provides compositions of lipid nanoparticles useful for the delivery of large RNAs including mRNAs. These compositions may include a cationic ionizable lipid, a phospholipid, a PEGylated lipid, and a steroid including using less of a cationic ionizable lipid than compositions with shorter nucleic acids. These compositions may be used to treat a disease or disorder for which the delivery of an mRNA is therapeutically effective.

Abstract: Embodiments of the instant disclosure relate to novel antiviral compositions and methods for treating viral infections. In accordance with these embodiments, antiviral compositions can include at least one mRNA encoding for a TRIM7 protein encapsulated into a lipid nanoparticle (LNP). In other embodiments, methods of making antiviral compositions are disclosed as well as methods of administering a composition having at least one mRNA encoding for a TRIM7 protein encapsulated into LNP into a subject.

Abstract: Described herein are compositions, kits, and methods for potent delivery to a cell of a subject. The cell can be of a particular cell type, such as a basal cell, a ciliated cell, or a secretory cell. In some cases, the cell can be a lung cell of a particular cell type. Also described herein are pharmaceutical compositions comprising a therapeutic or prophylactic agent assembled with a lipid composition. The lipid composition can comprise an ionizable cationic lipid, a phospholipid, and a selective organ targeting lipid. Further described herein are high-potency dosage forms of a therapeutic or prophylactic agent formulated with a lipid composition.

Abstract: A nonstick cooking utensil with a pure inorganic structural layer and a manufacturing method thereof are provided. The cooking utensil includes a base layer and a pure inorganic structural layer, where the pure inorganic structural layer is formed by spraying inorganic particles on an inner surface of the base layer; the inorganic particles in the pure inorganic structural layer form a connected pore structure; the pure inorganic structural layer includes at least three inorganic structural sub-layers; the at least three inorganic structural sub-layers are sequentially stacked on the inner surface of the base layer according to sizes of the inorganic particles; the inorganic particles in the inorganic structural sub-layer adjacent to the base layer have a largest size; and in a direction away from the base layer, the sizes of the inorganic particles in the multiple inorganic structural sub-layers decrease sequentially.

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: Described herein are compositions, kits, and methods for potent delivery to a ceil of a subject. The cell can be of a particular cell type, such as a basal cell. In some cases, the cell can be a lung cell of a particular cell type. Also described herein are pharmaceutical compositions comprising a therapeutic or prophylactic agent assembled with a lipid composition. Tire lipid composition can comprise an ionizable cationic lipid, and a selective organ targeting lipid. The lipid composition can further comprise a phospholipid. Further described herein are high-potency intravenous dosage forms of a therapeutic or prophylactic agent formulated with a lipid composition.

Abstract: A UE obtains a channel occupancy time (COT) for a set of resources on a sidelink (SL) in an unlicensed spectrum through a channel access procedure. The UE determines whether a frequency division multiplexing (FDM) transmission scheme is utilized for a SL transmission on the sidelink in the COT. The UE selects a cyclic prefix extension (CPE) starting position prior to an initial symbol containing the SL transmission. The UE selects the default CPE starting position as the CPE starting position when the FDM transmission scheme is utilized. The UE randomly selects the CPE starting position from a subset of a set of all candidate CPE starting positions based on an L1 priority of the SL transmission when the FDM transmission scheme is not utilized. The UE transmits a CPE at the selected CPE starting position and performs the SL transmission after the CPE transmission.

Abstract: In an aspect of the disclosure, a method, a computer-readable medium, and an apparatus are provided. The apparatus may be a UE. The UE obtains a number (N) of transmissions of a sidelink synchronization signal block (S-SSB) with repetitions in a frequency domain. The UE obtains a gap in the frequency domain between two adjacent transmissions of the N transmissions. The UE maps the N S-SSBs into N sets of resources in which two adjacent sets are separated by the gap. The N sets of resources overlap in time domain. The UE performs the N transmissions of the S-SSB using the N sets of resources.

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: Apparatus and methods are provided for sidelink (SL) transmission in SL unlicensed frequency bands (SL-U). In one novel aspect, one and/or multiple starting symbols within a slot is supported for SL-U to start a transmission. In one embodiment, the physical sidelink control channel (PSCCH) is configured to be transmitted on each starting symbol within a slot. In another embodiment, only physical sidelink shared channel (PSSCH) is transmitted on the starting symbols other than the first starting symbol within a slot. In one novel aspect, PSCCH is transmitted within one sub-channel. In one embodiment, the PSCCH is transmitted on a fixed subchannel of each RB set of the occupied BWP. In another embodiment, the PSCCH is transmitted on a fixed subchannel of one preconfigured RB set. In another novel aspect, the UE sets the CAPC value to be one for the physical sidelink feedback channel (PSFCH).

Abstract: Apparatus and methods are provided RLF detection for SL-U transceiving. In one novel aspect, HARQ-based RLF detection and/or LBT-based RLF detection is performed for SL-U RLF. HARQ based SL-U RLF procedure increases DTX for each PSSCH or PSCCH and disregards detected DTX on PSFCH or increases DTX for each PSFCH absence. In one embodiment, a DTX threshold value is modified. In one embodiment, the LBT based RLF procedure detects and reports an LBT failure for an RB set by the PHY layer; determines a consistent LBT (C-LBT) for the RB set based on a C-LBT threshold at the MAC layer and determines an RLF when all configured RB sets for the SL connection is determined to be C-LBT. In another novel aspect, multiple PSFCH occasions are configured for one PSSCH/PSCCH at a consecutive symbol level, a non-consecutive symbol level, a consecutive slot level or a non-consecutive slot level.

Abstract: Apparatus and methods are provided for SL-U resource allocation and usage. In one novel aspect, one or two candidate starting symbols are configured. In one embodiment, the candidate starting symbols are preconfigured for AGC or a repetition of PSCCH/PSSCH data. In one embodiment, CAPC value is mapped from a PQI with a bitmap or a mapping table. The CAPC value is mapped from the PQI based on one or more elements comprising a resource type, a default priority level, a packet delay budget (PDB) requirement, and packet data error rate. In one novel aspect, multi-consecutive-slot (MCSt) resources are reserved for SL-U by applying one or more resource selection rules, comprising selecting, by a MAC layer, resources excluded by a PHY layer in an exclusion step, increasing one or more selection thresholds comprising a resource exclusion RSRP threshold, a remaining resource portion after resource exclusion threshold, and a RSRP threshold.

Abstract: Various solutions for enhancements on sidelink (SL) over unlicensed spectrum (SL-U) communication are described. An apparatus may operate in a first transmission mode for an SL-U communication with a peer apparatus. The apparatus may determine that a condition associated with the SL-U communication is met. The apparatus may stay in the first transmission mode or switch from the first transmission mode to a second transmission mode for the SL-U communication responsive to the determining.

Abstract: Apparatus and methods are provided for sidelink synchronization signal pattern in the unlicensed frequency bands (SL-U). In one novel aspect, the UE, configured one or more SL resource pools, determines an applicability of the occupied channel bandwidth (OCB), and configures OCB-compliance SL synchronization signal block (S-SSB) based on the OCB requirement, wherein the OCB-compliance S-SSB is included in or excluded from the one or more SL resource pools to the meet the OCB requirements. In one embodiment, the S-SSB is excluded from the SL resource pool and the S-SSB is transmitted repeatedly in the frequency domain multiple times or transmitted interlaced in frequency domain based on the OCB requirement. In one embodiment, the SL synchronization signal blocks are included in the SL resource pool and are multiplexed with other transmissions in the frequency domain multiplexed (FDM) mode or time domain multiplexed (TDM) mode.

Abstract: Examples pertaining to power control of sidelink (SL) on unlicensed spectrum (SL-U) in mobile communications are described. A user equipment (UE) communicates in a SL-U. The UE performs a transmit power control (TPC) such that a power spectral density (PSD) limit is not exceeded in communicating in the SL-U.