Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: Embodiments of the instant disclosure relate to novel antiviral compositions and methods for treating viral infections. In accordance with these embodiments, antiviral compositions can include at least one mRNA encoding for a TRIM7 protein encapsulated into a lipid nanoparticle (LNP). In other embodiments, methods of making antiviral compositions are disclosed as well as methods of administering a composition having at least one mRNA encoding for a TRIM7 protein encapsulated into LNP into a subject.

Abstract: The present disclosure relates to the technical field of Internet, and provides a user registration method, a user login method and a device corresponding thereto. In these methods, a passport or the user card records identity information of the autonomous identity of a user, and the user can use the passport or the user card to access an application website, which is unlike the conventional method of performing the accessing through the account and the password. Moreover, the present disclosure further implements a series of mechanisms from the application to the use, concerning the passport and the user card.

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: A visualized surgical assembly is provided, characterized in that the visualized surgical assembly includes a disposable drainage tube and a functional tube for providing visualization function, the disposable drainage tube and the functional tube are connected detachable along the axial of the tube body, and the functional tube is provided with a self-destructive part for cutting the disposable drainage tube. A corresponding endoscope is also provided. The visualized surgical assembly is a combination structure of the disposable drainage tube and the functional tube which can provide visualization function. The disposable drainage tube can removable connect with the functional tube, and the functional tube can be repeated disinfection, which can reduce the cost and avoid the risk of cross infection.

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: The invention discloses a detection method for radial deformation of flexspline of harmonic reducer under installation eccentricity state, taking the center of wave generator as the origin, the reference coordinate system is established in the method, and the offset between the center of wave generator and the pivotal center of rotary table is calculated by measuring the standard circle coaxial with the wave generator; the radial deformation function and the offset of wave generator under eccentricity state are taken to the theoretical ellipse eccentricity mathematical model to obtain the parameters of the actual ellipse; the offset and ellipse parameters are taken into the radial runout correction model of the flexspline to obtain the correction model under eccentricity state; the flexspline deformation function is measured and the correction model is taken to obtain the radial deformation function of the flexspline under standard state.

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: Disclosed herein are novel HDAC inhibitors. The HDAC inhibitors may be used in methods of treating cancer. The HDAC inhibitors may be used in methods of treating a neurological disorder.

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: The present disclosure relates to assays, including but not limited to, leukocyte adhesive function assays (LAFA), devices and/or methods of using such assays. The present disclosure also relates to the uses of the disclosed embodiment in diagnostic, analytic and/or prognostic applications, particularly for diagnostic, analytic and/or prognostic applications in relation to diseases associated with abnormal host immune responses.

Abstract: Disclosed are a blockchain system and a consensus method for use in a miner node in a blockchain system. A specific embodiment of the method includes: acquiring a lower-limit accumulative unused duration; executing, in a trusted execution environment associated with the miner node, a bookkeeping right determination operation including: determining a current accumulative unused duration for the miner node; determining whether the current accumulative unused duration is more than the lower-limit accumulative unused duration; and, in response to the determination that the current accumulative unused duration is more than the lower-limit accumulative unused duration, determining that the miner node has won a bookkeeping right, and updating the current accumulative unused duration with a difference between the current accumulative unused duration and the lower-limit accumulative unused duration. This embodiment allows for reduced electric power consumption in a blockchain system.

Abstract: The present disclosure provides a method and a device for recognizing a text segmentation position. The method includes: receiving a continuous voice message inputted by a user, and recognizing the continuous voice message to generate a text message corresponding to the continuous voice message; analyzing the text message to determine an interval position, and sequentially inserting a sentence end and sentence begin sign at each interval position; calculating a segmentation value corresponding to the sentence end and sentence begin sign inserted at a present interval position according to a preset algorithm; and determining whether the segmentation value is greater than a preset threshold, and determining the present interval position as a segmentation position when the segmentation value is greater than the preset threshold.

Abstract: In some aspects, the present disclosure provides compositions of lipid nanoparticles useful for the delivery of large RNAs including mRNAs. These compositions may include a cationic ionizable lipid, a phospholipid, a PEGylated lipid, and a steroid including using less of a cationic ionizable lipid than compositions with shorter nucleic acids. These compositions may be used to treat a disease or disorder for which the delivery of an mRNA is therapeutically effective.

Abstract: The present disclosure proposes a method and an apparatus for converting English speech information into a text. The method may include: receiving the English speech information inputted by a user, determining a target speech recognition model according to a preset algorithm, and identifying original phonemes of the English speech information by applying the target speech recognition model; performing a matching on the original phonemes by applying a phonetic model generated by pre-training English texts and a preset probability model, and determining a target phoneme matched successfully; and acquiring a target English text corresponding to the target phoneme, and displaying the target English text on a speech conversion textbox.