Abstract: Provided herein are methods and compositions relating to glucagon-like peptide-1 receptor (GLP1R) libraries having nucleic acids encoding for a scaffold comprising a GLP1R binding domain. Libraries described herein include variegated libraries comprising nucleic acids each encoding for a predetermined variant of at least one predetermined reference nucleic acid sequence. Further described herein are protein libraries generated when the nucleic acid libraries are translated. Further described herein are cell libraries expressing variegated nucleic acid libraries described herein.

Abstract: A white light interferometric fiber-optic gyroscope based on a rhombic optical path difference bias structure includes a laser, a rhombic optical path difference bias structure, a fiber coil and a photodetector. The white light interferometric fiber-optic gyroscope adopts an all-fiber structure to simplify the complexity of a gyroscope system and reduce the overall cost. A white light interferometric demodulation algorithm is used to realize linear output of rotation rate signals.

Abstract: Provided herein are methods and compositions relating to CD3 libraries having nucleic acids encoding for a scaffold comprising a CD3 domain. CD3 libraries described herein encode for immunoglobulins such as antibodies.

Abstract: Provided is a method for determining whether a fetus has chromosomal aneuploidy, the method comprising: the method comprises: (1) obtaining nucleic acid sequencing data from a pregnant woman sample; (2) determining a fetal fraction of the pregnant woman sample and an estimated fraction by a predetermined chromosome based on the nucleic acid sequencing data; (3) determining a first feature based on a difference between the estimated fraction by a chromosome to be tested and the estimated fraction by a second comparison chromosome, and determining a second feature based on a difference between the estimated fraction by the chromosome to be tested and the fetal fraction; and (4) determining whether the fetus has an aneuploidy for the chromosome to be tested based on the first feature and the second feature by using corresponding data of control sample, wherein the control sample comprises a positive sample and a negative sample, the positive sample has an aneuploidy for the chromosome to be tested, and the negat

Abstract: Compositions and methods for detecting molecule-molecule interactions are provided. The methods employ a prokaryotic ubiquitin-like protein (Pup) and a Pup ligase that is coupled to one of the molecules. When the Pup ligase is brought to proximity to the other molecule by virtue of the molecule-molecule interaction, the Pup ligase can conjugate the Pup to a lysine residue on the other molecule. As such conjugation can be easily detected, this method allows easy identification of the molecule-molecule interaction.

Abstract: A device for support of an organ ex vivo comprises a chamber with a first engagement feature. A support structure includes a second engagement feature. The first and second engagement features may be engaged so that the chamber body is carried by the support structure for rotation. The chamber body comprises first and second chamber components. In a first orientation of the chamber body, the first chamber component provides support for a first surface of the organ, and the second chamber component is removable so that a second surface of the organ is exposed to manipulation from outside the chamber body. In a second orientation of the chamber body, the second chamber component provides support for the second surface of the organ, and the first chamber component is removable so that the first surface of the organ is exposed to manipulation from outside the chamber body.

Abstract: The present disclosure belongs to the field of automobile chassis suspension system tests, and provides fatigue test equipment for an automobile chassis simulation road test. The fatigue test equipment can simultaneously test the simulation road test fatigue durability of automobile chassis parts such as the wheel and suspension system and the like, ensures that a test state of the tested wheel and suspension system is close to a real automobile state, and simulates and reproduces a load which an automobile chassis bears in the real road running process in a laboratory.

Abstract: The present disclosure belongs to the technical field of tests of wheels and automobile chassis suspension systems, and provides a transmission shaft automatic connection and disengagement device and test equipment. An input shaft drives a transmission shaft to rotate through a second connection shaft, a ratchet assembly, a first connection shaft and an output shaft so as to apply an acceleration torque, gears of the input shaft and the first connection shaft can be completely engaged and completely separated through extension and retraction of piston rods of a first group of air cylinders and a second group of air cylinders so as to achieve an effect that when a driving shaft needs to perform driving, a power system gets involved, and after driving is completed, the power system is cut off, and through the ratchet assembly, the transmission shaft can be prevented from driving a motor to work in reverse.

Abstract: Provided herein are methods and compositions relating to TIGIT libraries having nucleic acids encoding for a scaffold comprising a TIGIT domain. TIGIT libraries described herein encode for immunoglobulins such as antibodies.

Abstract: Various example embodiments for supporting communication network management may be configured to support communication network management based on various policies which may include one or more static rule-based policies (e.g., a rule-based resource management policy) and one or more machine learning (ML) based policies (e.g., an ML-based resource management policy). Various example embodiments for supporting communication network management may be configured to support communication network management based on evaluation and selection of policies to be applied for supporting communication network management. Various example embodiments for supporting communication network management may be configured to support communication network management based on regulation of network management actions generated based on selected policies before application of the network management actions to the communication network.

Abstract: A method and device for controlling a distributed direct current power supply system are provided in embodiments of this disclosure. The method includes: acquiring a direct current busbar current of the distributed direct current power supply system; acquiring, according to the direct current busbar current and a rated capacity of a power conversion unit in the distributed direct current power supply system, a quantity of power conversion units that meets a power requirement of a load; and adjusting, according to the quantity of power conversion units, power conversion units that are turned on in the distributed direct current power supply system. The device is used to implement the method.

Abstract: A method and apparatus for determining stripe consistency, including an operation node that obtains n groups of CRC data blocks corresponding to a target stripe, where the target stripe includes n first data blocks, the n first data blocks include k original data blocks and m EC data blocks of the k original data blocks, the n groups of CRC data blocks are respective CRC data blocks of n groups of second data blocks, one group of second data blocks includes m transformation results obtained by performing m times of EC transformation on one first data block, both k and m are positive integers, and n=m+k.

Abstract: The disclosure discloses an inhomogeneous sample equalization method and system for a product assembly process. The method includes the following steps of: A: calculating a similarity among different samples; B: constructing a fuzzy compatibility matrix S for representing the similarity among all the samples, and constructing a fuzzy compatibility space X with different granule layers through the fuzzy compatibility matrix S; C: based on a granular calculating mode, screening out a granule layer with a maximum comprehensive value of an information increment and the similarity among the samples from the fuzzy compatible space X to serve as an optimal granule layer; and D: carrying out equalization processing on the sample of the optimal granule layer.

Abstract: Provided herein are methods and compositions relating to adenosine A2A receptor libraries having nucleic acids encoding for a scaffold comprising an adenosine A2A binding domain. adenosine A2A receptor libraries described herein encode for immunoglobulins such as antibodies.

Abstract: A mini subwoofer double drive low-frequency vibrator includes a base, an upper cover, a side cover, a flexible printed circuit, a coil, a magnetic body, a counterweight, a spring piece, an internal welding piece, an external welding piece, an insulating tape, and a buffer. The magnetic body and the coil includes a symmetrical double-driving structure at both upper and lower part to mutually offset components in a non-vibration direction of an electromagnetic force and cancel vibration noises. The spring piece adopts a V-shape structure to increase an effective length of a deformation zone and to make a response frequency even lower. Two V-shape springs are distributed symmetrically in a center, making an operation more stable. The buffer is adopted to enhance service life, for fear of a spring damage caused by high circuit voltage.

Abstract: A method for network function discovery in a communication network is provided. The method includes receiving a discovery request from a first network function NF to request one or more NF instance of a first group type for a first subscriber. The discovery request may include a first group type identifier of the first group type. The method may further include determining one or more group identifier for one or more groups of NF instances managing the first subscriber. The one or more groups of NF instances are of the first group type and one or more other group types. The method may further include sending a discovery response to the first network function, including the one or more group identifiers and addressing information to reach the one or more groups of NF instances.

Abstract: The embodiments is an unmanned aerial vehicle. The unmanned aerial vehicle includes: an airframe; and a fixed-wing assembly and a rotor assembly, both replaceably connected to the airframe. The fixed-wing assembly is connected to the airframe to form a vertical take-off and landing fixed-wing unmanned aerial vehicle and the rotor assembly is connected to the airframe to form a multi-rotor unmanned aerial vehicle, thereby implementing an unmanned aerial vehicle that can switch between the vertical take-off and landing fixed-wing unmanned aerial vehicle and the multi-rotor unmanned aerial vehicle.

Abstract: A device for support of an organ ex vivo comprises a chamber with a first engagement feature. A support structure includes a second engagement feature. The first and second engagement features may be engaged so that the chamber body is carried by the support structure for rotation. The chamber body comprises first and second chamber components. In a first orientation of the chamber body, the first chamber component provides support for a first surface of the organ, and the second chamber component is removable so that a second surface of the organ is exposed to manipulation from outside the chamber body. In a second orientation of the chamber body, the second chamber component provides support for the second surface of the organ, and the first chamber component is removable so that the first surface of the organ is exposed to manipulation from outside the chamber body.

Abstract: The disclosure relates to a polycrystalline diamond compact including a cemented carbide substrate and a diamond layer, with the diamond layer disposed at the top face of cemented carbide substrate, there are at least two continuous varying cambered convex ridges at the end face of the diamond layer, each cambered convex ridge extending from the edge of the end face to the center of end face, with the width of each continuous varying cambered convex ridge increasing gradually from the edge of the end face to the center of the end face. Both ploughing effect and the fracture drilling property of the PDC cutting face with each continuous varying cambered convex ridge are improved, the cutting resistance during drilling is reduced and thus the rate of penetration of the PDC bit is increased. A drilling bit with the polycrystalline diamond compact disposed at the end thereof is provided in the disclosure.

Abstract: A two-position eight-way valve, including a valve body, a sliding column, and a control mechanism. The valve body is provided with an accommodating space having an opening. The control mechanism is connected to the opening. Provided on a sidewall of the accommodating space are a first through hole, a second through hole, a third through hole, a fourth through hole, a fifth through hole, a sixth through hole, a seventh through hole, and an eighth through hole allowing the accommodating space to be in communication with the external environment. The sliding column is provided within the accommodating space and is connected to the control mechanism.