Abstract: Provided in the present application are an antibody-drug conjugate, and a preparation method therefor and the use thereof. The antibody drug conjugate has a structure as represented by the formula Ab-[M-L-E-D]x, and the drug is selected from an anti-tubulin agent, a DNA intercalator, a DNA topoisomerase inhibitor and a RNA polymerase inhibitor. The prepared antibody-drug conjugate has a better drug-to-antibody ratio, and has a good targeted killing effect on colon cancer and non-small cell lung cancer (for example, lung adenocarcinoma).

Abstract: A data analytics device for application monitoring includes an application-monitor manager engine to receive configuration files from a cloud server and to generate monitoring rules for a number of monitors. A data-processing engine is coupled to the application-monitor manager engine and the monitors and coordinates activities of the plurality of monitors. The monitors are embedded in a user space and a kernel of a host operating system, and the monitoring rules for the monitors are generated based on the configuration files.

Abstract: The present invention relates to a chemical coupling linker and use thereof, and a bioactive conjugate prepared by the chemical coupling linker. The present invention also relates to use of the bioactive conjugate in the preparation of a drug for the prevention or treatment of tumor diseases.

Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.

Abstract: A fluid and power provision apparatus is provided. The apparatus includes a power provision device and a pump assembly. The pump assembly includes a motor, a transmission system, a piston assembly, and a collar assembly. The piston assembly includes a piston sleeve, a piston, and a piston arm operably coupled to the piston and the transmission system to transmit energy from the motor to articulate the piston within the piston sleeve. The collar assembly forms a collar plenum, a first flowpath, and a second flowpath. The piston sleeve extends at least in part into the collar plenum. The first flowpath extends in fluid communication from the collar plenum to a fluid supply outlet. The second flowpath extends in fluid communication from an interior of the apparatus to the first flowpath.

Abstract: The present invention provides an electrostatic charge detecting packaging device comprising a carrier, multiple dies, and multiple electrostatic-charge-sensitive components; the carrier has a surface; the dies are mounted on the surface of the carrier; and the electrostatic-charge-sensitive components are mounted on the surface of the carrier; since an electrostatic voltage tolerance of each of the electrostatic-charge-sensitive components is lower than an electrostatic voltage tolerance of each of the dies, accumulated electrostatic charges are more likely to discharge towards the electrostatic-charge-sensitive components than towards the dies, and as such, by electrically testing whether the electrostatic-charge-sensitive components are functioning normally when packaging the dies, the present invention allows personnel to debug for knowing which packaging steps exactly cause more serious problems that lead to damaging electrostatic discharges in the dies.

Abstract: A circuit for driving a light-emitting diode (LED) load and a direct current to direct current (DC-DC) converter includes a first sampling sub-circuit, a driving circuit. The first sampling sub-circuit is configured to generate a current signal representing a load current of the LED load. The driving circuit is configured to receive a brightness adjustment signal and a frequency adjustment signal; generate a first control signal, based on the current signal and the brightness adjustment signal, for controlling an output current of the DC-DC converter; and generate a second control signal, based on the frequency adjustment signal, for controlling a switching frequency of the LED load.

Abstract: A method enables a user to bypass a pass code, such as personal identification number (PIN), when performing an authentication process between a client device and a gateway/broker of a virtual desktop infrastructure (VDI) provided by a virtualized computing environment. A customized operating system (OS) of the client device includes pre-installed certificates and keys that are used in the authentication process and which are protected by the PIN. Through a public interface, a client device may perform the authentication process without requiring the user to manually enter the PIN.

Abstract: Example methods and apparatus for providing voice alignment are described. One example method including: obtaining an original voice and a test voice, the test voice is a voice generated after the original voice is transmitted over a communications network; performing loss detection and/or discontinuity detection on the test voice, the loss detection is used to determine whether the test voice has a voice loss compared with the original voice, and the discontinuity detection is used to determine whether the test voice has voice discontinuity compared with the original voice; and aligning the test voice with the original voice based on a result of the loss detection and/or the discontinuity detection, to obtain an aligned original voice and an aligned test voice, the result of the loss detection and/or the discontinuity detection is used to indicate a manner of aligning the test voice with the original voice.

Abstract: The present invention is directed to compositions of bimatoprost, processes of preparing these compositions, devices comprising these compositions, and methods of lowering intraocular pressure.

Abstract: Signaling analysis methods and apparatus are provided to obtain a to-be-detected signaling flow that includes N pieces of signaling. First feature construction is performed on a message type and an information element that are included in each of the N pieces of signaling to obtain a first feature sequence. The first feature sequence includes N first feature vectors which are in a one-to-one correspondence with the N pieces of signaling. The first feature sequence is input to a first signaling anomaly detection model to perform anomaly detection processing. A first anomaly detection result is produced indicating that the to-be-detected signaling flow is normal or abnormal. In this way, an anomaly caused due to an information element error can be covered. The method and the apparatus can be multiplexed between different protocols.

Abstract: A horizontal-vertical drain board-flocculation vacuum preloading sediment treatment method, including (1) electro-osmotic electrodes disposed on the top and bottom of each reinforcing bar of the reinforced frame; (2) after the sediment is blown to the bottommost layer of vacuum preloading tank, the support is fitted over each reinforced frame, and the clips are fastened; (3) the transverse drain board passes through the support, one end of transverse drain board is connected to a curved tube; (4) repeat Step 2 and Step 3 until the sediment is blown to the surface layer of vacuum preloading tank; (5) a vertical drain board is arranged vertically between two adjacent rows of reinforced frames; (6) the curved tube is connected to the first junction block through the second junction block, and then the geotextile and sealing film are laid, the vacuum pump and power supply are switched on at last.

Abstract: Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

Abstract: A circuit for driving a light-emitting diode (LED) load and a direct current to direct current (DC-DC) converter includes a first sampling sub-circuit, a driving circuit. The first sampling sub-circuit is configured to generate a current signal representing a load current of the LED load. The driving circuit is configured to receive a brightness adjustment signal and a frequency adjustment signal; generate a first control signal, based on the current signal and the brightness adjustment signal, for controlling an output current of the DC-DC converter; and generate a second control signal, based on the frequency adjustment signal, for controlling a switching frequency of the LED load.

Abstract: Embodiments of the present disclosure relate to a method, a device and a computer program product for managing backup data. The method comprises receiving a first request from a user for managing backup data on a first virtual machine management platform. The method further comprises sending a second request comprising a user identifier and a platform identifier to a backup server. The method further comprises receiving, from the backup server, a first virtual machine identifier of the first virtual machine used by the user on the second virtual machine management platform and backup records corresponding to the first virtual machine identifier. The method further comprises determining, based on the first virtual machine identifier, whether a second virtual machine matched with the first virtual machine is present in the first virtual machine management platform.

Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.

Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.

Abstract: A horizontal-vertical drain board-flocculation vacuum preloading sediment treatment method, including (1) electro-osmotic electrodes disposed on the top and bottom of each reinforcing bar of the reinforced frame; (2) after the sediment is blown to the bottommost layer of vacuum preloading tank, the support is fitted over each reinforced frame, and the clips are fastened; (3) the transverse drain board passes through the support, one end of transverse drain board is connected to a curved tube; (4) repeat Step 2 and Step 3 until the sediment is blown to the surface layer of vacuum preloading tank; (5) a vertical drain board is arranged vertically between two adjacent rows of reinforced frames; (6) the curved tube is connected to the first junction block through the second junction block, and then the geotextile and sealing film are laid, the vacuum pump and power supply are switched on at last.

Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.