Abstract: The invention relates to a method of preventing, inhibiting, arresting or reversing tumorigenesis in a cell as well as a method of inducing apoptosis in a tumor cell. The method includes increasing the amount and/or the activity of a DACT protein, or a functional fragment thereof, in the cell. Also provided is a pharmaceutical composition that comprises a compound of general formula (I), wherein A is CH or N, R1, R4 and R5 are independent from each other H, an aliphatic group, an alicyclic group, an aromatic group, an arylaliphatic group, and an arylalicyclic group comprising 0-3 heteroatoms. The heteroatoms may be N, O, S, or Si. R4 and R5 may optionally be linked so as to define an aliphatic hydrocarbyl bridge. R2 is H or a halogen such as F, Cl, Br or L. R3 is H, F, Cl or an aliphatic or arylaliphatic group that includes 1-8 main chain carbon atoms and 0-3 heteroatoms. The pharmaceutical composition also comprises a histone deacetylase inhibitor.

Abstract: A method of treating cancer by inhibiting expression of ubiquitin associated and SH3 domain containing B (UBASH3B) gene or by inhibiting the activity of UBASH3B protein or a functional variant thereof.

Abstract: Disclosed are nano multilayer film of electrical field modulation type, a field effect transistor of electrical field modulation type, an electrical field sensor of switch type, and a random access memory of electrical field drive type, for obtaining an electro-resistance effect in an electrical field modulation multilayer film at room temperature. The nano multilayer film comprises in succession from bottom to top a bottom layer (102), a substrate (101), a bottom layer (103), a functional layer (104), a buffer layer (105), an insulation layer (106), an intermediate conductive layer (107), and a cap layer (108), and the buffer layer (107) and the insulation layer (106) can be selectively added as required when the intermediate conductive layer (107) is a magnetic metal, a magnetic alloy or a magnetic metal composite layer.

Abstract: A flexure for a suspension of a head gimbal assembly includes a substrate layer, a dielectric layer formed thereon, a conducting layer formed on the dielectric layer, and an insulating cover layer covered on the conducting layer, wherein at least one window is configured at a surface of the insulating cover layer thereby a portion of the conducting layer is exposed, and an antistatic adhesive is adhered to at least one side wall of the window and contacted with the conducting layer. The new structure of the flexure can avoid or eliminate electro-static discharges enduringly without dipping water. A head gimbal assembly and a disk drive unit with the same, a manufacturing method for the flexure are also disclosed.

Abstract: A flexure for a suspension of a head gimbal assembly includes a substrate layer, a dielectric layer formed thereon, a conducting layer formed on the dielectric layer, and an insulating cover layer covered on the conducting layer, wherein at least one window is configured at a surface of the insulating cover layer thereby a portion of the conducting layer is exposed, and an antistatic adhesive is adhered to at least one side wall of the window and contacted with the conducting layer. The new structure of the flexure can avoid or eliminate electro-static discharges enduringly without dipping water. A head gimbal assembly and a disk drive unit with the same, a manufacturing method for the flexure are also disclosed.

Abstract: The invention generally provides gypsum-containing slurries including stucco, naphthalenesulfonate dispersant, and pregelatinized starch. The naphthalenesulfonate dispersant is present in an amount of about 0.1%-3.0% by weight based on the weight of dry stucco. The pregelatinized starch is present in an amount of at least about 0.5% by weight up to about 10% by weight of pregelatinized starch by weight based on the weight of dry stucco in the formulation. Other slurry additives can include trimetaphosphate salts, accelerators, binders, paper fiber, glass fiber, and other known ingredients. The invention also comprises the gypsum-containing products made with such slurries, for example, gypsum wallboard, and a method of making gypsum wallboard.

Abstract: A reduced weight, reduced density gypsum panel that includes high expansion vermiculite with fire resistance capabilities that are at least comparable to (if not better than) commercial fire rated gypsum panels with a much greater gypsum content, weight and density.

Abstract: The present disclosure relates to the field of information technology, and in particular, to a block storage-based data processing method, apparatus, and system. The block storage-based data processing method provided in embodiments of the present disclosure is applied in a system including at least two storage nodes, each storage node including a CPU, a cache medium, and a non-volatile storage medium, and the cache medium in all the storage nodes forming a cache pool. According to the method, after receiving a data operation request sent by a client, a service processing node sends the data operation request to a corresponding storage node in the system according to a logical address carried in the data operation request, so that the data operation request is processed in the cache medium of the storage node under control of the CPU of the storage node.

Abstract: A method of preparing a reduced weight, reduced density gypsum panel that includes high expansion vermiculite with fire resistance that meet or exceed one or more industry standard fire tests.

Abstract: Disclosed are various embodiments for employing spillover tables to improve performance of data store updates. A request to update a data field is received, and if an exclusive lock on a data table cannot be obtained, the request is placed in a spillover table until the exclusive lock can be obtained. If the request causes a constraint on the data field to be violated or causes the data field to move closer to the constraint, the request is not placed in the spillover table. A spillover task can collapse entries in the spillover table into the data store when an exclusive lock can be obtained.

Abstract: The invention provides a set gypsum-containing product having increased resistance to permanent deformation and a method for preparing it comprising forming a mixture of a calcium sulfate material, water, and an appropriate amount of one or more enhancing materials chosen from condensed phosphoric acids, each of which comprises 2 or more phosphoric acid units; and salts or ions of condensed phosphates, each of which comprises 2 or more phosphate units. The mixture is then maintained under conditions sufficient for the calcium sulfate material to form a set gypsum material.

Abstract: The invention generally provides gypsum-containing slurries including stucco, naphthalenesulfonate dispersant, and pregelatinized starch. The naphthalenesulfonate dispersant is present in an amount of about 0.1%-3.0% by weight based on the weight of dry stucco. The pregelatinized starch is present in an amount of at least about 0.5% by weight up to about 10% by weight of pregelatinized starch by weight based on the weight of dry stucco in the formulation. Other slurry additives can include trimetaphosphate salts, accelerators, binders, paper fiber, glass fiber, and other known ingredients. The invention also comprises the gypsum-containing products made with such slurries, for example, gypsum wallboard, and a method of making gypsum wallboard.

Abstract: The present technology relates to a method of treating cancer by sensitizing human tumours to DNA damaging therapies through activating FBXO32 expression. Transactivation of FBXO32 through the inhibition of EZH2, a histone methyltransferase, decreases p21 protein induction which results in the sensitization of human tumours to chemotherapy. The method further provides a prognostic method to determine if a combination treatment would be effective.

Abstract: Polymerization of siloxane is improved using a gypsum-based slurry that includes stucco, Class C fly ash, magnesium oxide and an emulsion of siloxane and water. This slurry is used in a method of making water-resistant gypsum articles that includes making an emulsion of siloxane and water, then combining the slurry with a dry mixture of stucco, magnesium oxide and Class C fly ash. The slurry is then shaped as desired and the stucco is allowed to set and the siloxane polymerizes. The resulting product is useful for making a water-resistant gypsum panel having a core that includes interwoven matrices of calcium sulfate dihydrate crystals and a silicone resin, where the interwoven matrices have dispersed throughout them a catalyst comprising magnesium oxide and components from a Class C fly ash.

Abstract: The invention provides a set gypsum-containing product having increased resistance to permanent deformation and a method for preparing it comprising forming a mixture of a calcium sulfate material, water, and an appropriate amount of one or more enhancing materials chosen from condensed phosphoric acids, each of which comprises 2 or more phosphoric acid units; and salts or ions of condensed phosphates, each of which comprises 2 or more phosphate units. The mixture is then maintained under conditions sufficient for the calcium sulfate material to form a set gypsum material.

Abstract: The invention generally provides gypsum-containing slurries including stucco, naphthalenesulfonate dispersant, and pregelatinized starch. The naphthalenesulfonate dispersant is present in an amount of about 0.1%-3.0% by weight based on the weight of dry stucco. The pregelatinized starch is present in an amount of at least about 0.5% by weight up to about 10% by weight of pregelatinized starch by weight based on the weight of dry stucco in the formulation. Other slurry additives can include trimetaphosphate salts, accelerators, binders, paper fiber, glass fiber, and other known ingredients. The invention also comprises the gypsum-containing products made with such slurries, for example, gypsum wallboard, and a method of making gypsum wallboard.

Abstract: We describe a method of determining whether a cancer cell is likely to be resistant to treatment by an mTOR inhibitor. The method may comprise detecting PPP2R2B (GenBank Accession Number: NM_18167) in or of the cell. It may, alter-natively, or in addition, comprise detecting PDK1 (GenBank Accession Number: NM_002613), in or of the cell. The method may comprise detecting methylation of the PPP2R2B promoter in or of the cell. It may comprise detecting the expression and/or activity of PPP2R2B in or of the cell. It may comprise detecting PDK1 mediated Myc phosphorylation activity.

Abstract: A method and an apparatus for controlling a distributed automation system, wherein the method comprises determining global constraint rules according to the cooperative relationships between function blocks in the distributed automation system, and establishing a mathematical model based on Membrane Calculus, performing the instantiation of the established mathematical model based on Membrane Calculus according to an executor corresponding to each of the function blocks in the distributed automation system, so as to produce control logics for output to the distributed automation system. If disturbance information is received from the distributed automation system, altering the parameters of the instantiation of the mathematical model based on Membrane Calculus are altered using the disturbance information, so as to produce control logics for outputting to said distributed automation system.

Abstract: A cementitious article and a method of making a cementitious article are disclosed. The cementitious article comprises a cementitious component that comprises a polyvinyl acetate type polymer, a monobasic phosphate, and optionally boric acid. Cementitious articles, such as board, are prepared such that the polyvinyl acetate type polymer, the monobasic phosphate, and optionally boric acid can be present in the cementitious core, and/or in dense layers if present. The concentration of the polyvinyl acetate type polymer, monobasic phosphate, and optionally boric acid in the cementitious article can increase from a central region A to peripheral regions B and C, respectively. In some embodiments, the polyvinyl acetate type polymer is a polyvinyl alcohol and the monobasic phosphate is monoammonium phosphate.

Abstract: The invention provides a light weight composite gypsum board including a foamed low density set gypsum core, a top non-foamed (or reduced-foamed) bonding high density layer and a bottom non-foamed (or reduced-foamed) bonding high density layer, a top cover sheet bonded to the foamed low density set gypsum core by the top non-foamed (or reduced-foamed) bonding high density layer, and a bottom cover sheet bonded to the foamed low density set gypsum core by the bottom non-foamed (or reduced-foamed) bonding high density layer. The foamed low density set gypsum core is prepared having a density of less than about 30 pcf using soap foam in the gypsum-containing slurry. The combination of components provide a composite gypsum board having light weight and high strength.