Qianqian Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
Abstract: The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)- or cis (Z)-butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxic agent, and/or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.
Abstract: A method of generating protein-induced pluripotent stem cells by delivering bacterially expressed reprogramming proteins into nuclei of starting somatic cells using the QQ-protein transduction technique, repeating several cell reprogramming cycles for creating reprogrammed protein-induced pluripotent stem cells, moving the reprogrammed cells into a feeder-free medium for expansion, and expanding and passaging the reprogrammed cells in a whole dish for generating homogeneous piPS cells. Also provided are the piPS cells formed using this method and uses thereof.
Abstract: The present disclosure provides a wet etching machine and an etching method. The wet etching machine including an etching chamber in which at least two etching layers are disposed. The etching layers are successively overlapped with each other from up to down, and each etching layer includes a first transfer carrier for receiving and transferring a substrate to be etched and a spraying apparatus disposed right above the first transfer carrier for spraying etching solution. When the total etching time is needed to be longer than the transfer time of the substrate without stopping the substrate, the present disclosure can solve the problems in the prior art of causing the takt time decreased due to the stopping time of the substrate is required to be increased or causing the area of the facility increased due to the number of the etching chambers connected in series is required to be increased.
Abstract: A method of locating a microphone, a device of locating a microphone and a system of locating a microphone. The method includes: determining an initial position of the microphone located in front of a light outgoing surface of a display screen; determining a target position of the microphone; determining a first displacement of the microphone in a direction perpendicular to the light outgoing surface of the display screen based on the target position and the initial position; determining a second displacement of the microphone in a direction parallel with the light outgoing surface of the display screen based on the target position and the initial position; and controlling the microphone to move to the target position based on the first displacement and the second displacement.
June 14, 2019
April 30, 2020
Qianqian HU, Chendong XIE, Weihan LI, Ya MENG
Abstract: Disclosed is a continuous feeding mechanism including a transfer mechanism, wherein the transfer mechanism includes a rotatable indent roller circumferentially provided with a plurality of blanking grooves; a post pin is arranged in each blanking groove; the post pin is connected with a spring; the spring is arranged towards the interior of the indent roller; and the post pin can move along the blanking grooves; a feeding box, wherein the bottom of the feeding box is hollow, and the bottom is arranged above the indent roller or the bottom is fixedly connected with the indent roller; the continuous feeding mechanism is arranged above one side of the transfer mechanism; and an electromagnetic heating mechanism which includes a supporting frame, wherein the transfer mechanism is arranged in the supporting frame, and an electromagnetic coil is circumferentially arranged outside the supporting frame.
December 23, 2019
April 30, 2020
Changhe LI, Mingzheng LIU, Ji CHE, Sanqiang ZHANG, Yanbin ZHANG, Dongzhou JIA, Cai WANG, Weidong XIE, Qianqian ZHAO, Mingchuang KANG, Enhao LIU, Zhaohua LI, Yali HOU
Abstract: The present invention discloses a ducted bidirectional tidal current power station system, mainly consisting of a bidirectional tidal current power generation device, a dam, an open sea, an inland sea, a duct, and an opening/closing gate. The bidirectional tidal current power generation device is installed in the duct on the bottom of the dam. Openings, respectively communicated with the open sea and the inland sea, are formed at two ends of the duct, and an opening/closing gate is arranged at each of the two openings. By the ducted bidirectional tidal current power station system of the present invention, the cost of marine construction, operation and maintenance of the tidal current power generation device in an open sea area is saved, and the complex structure of the power generation device in the tidal power station and the cost of strict construction of auxiliary devices and runners are avoided.
Abstract: A device and a method for detecting main acoustic indexes of multi-beam sonar pertaining to the field of hydrographic surveying and charting technology. The device includes a rotating device and a lifting gear installed in an anechoic tank. The bottom of the rotating device is equipped with a multi-beam sonar that has its rotating plane perpendicular to the direction of track line and transmits signals along the horizontal direction. A standard hydrophone is equipped at the bottom of the lifting gear, and is connected with a signal collector. The device utilizes the standard hydrophone to receive the pulse signals transmitted by the multi-beam sonar and employs the multi-beam sonar to receive the standard sound source signals, designs the detection process for data collection for analysis and research, thereby achieving the detection of the frequency, source level and beam angle of multi-beam sonar.
January 16, 2018
Date of Patent:
April 28, 2020
SHANDONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
Fanlin Yang, Xiankun Wang, Donghui Li, Qianqian Li, Bo Shi, Dong Jing, Xiushan Lu, Xiaodong Cui
Abstract: The present invention is related to novel cytotoxic agents, derivatives of Amanita toxins of Formula (I), wherein , - - - , R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, L, m, n and Q are defined herein, the preparation and the therapeutic uses in the targeted treatment of cancers, autoimmune disorders, and infectious diseases.
Abstract: A conjugation of a cytotoxic drug to a cell-binding molecule with a bis-linker (dual-linker) as shown in Formula (I). Bis-linkage methods of making a conjugate of a cytotoxic drug/molecule to a cell-binding agent in a specific manner are also described, as well as application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease. wherein “” is an optional bond; X, Y, Z1, and Z2 are a functional group; m1 and n are a integer; L1 and L2 are a linker.
April 6, 2017
March 5, 2020
Hangzhou DAC Biotech Co., Ltd.
Robert Yongxin ZHAO, Yuanyuan HUANG, Qingliang YANG, Shun GAI, Hangbo YE, Linyao ZHAO, Chengyu YANG, Yifang XU, Huihui GUO, Minjun CHAO, Qianqian TONG, Wenjun LI, Xiang CAI, Xiaomai ZHOU, Hongsheng XIE, Junxiang JIA, Haifeng ZHU, Zhixiang GUO, Shuihong GAO, Chunyan WANG, Chen LIN, Yanlei YANG, Zhicang YE, Jie PENG, Jun XU, Xiaotao ZUO, Qingyu SU
Abstract: Methods for treating a subject in need thereof are provided which include administering a pharmaceutical composition comprising a protein transduction reagent-modified reprogramming protein to the subject, wherein the protein transduction reagent is non-covalently bound to the reprogramming protein and wherein the protein transduction reagent comprises a cation reagent and a lipid. According to aspects, such methods provide delivery of protein-transduction reagent-modified reprogramming proteins to cancer cells, such as tumor cells, as well as diseased cells of diseased tissues and provide in vivo conversion of diseased cells into normal cells via protein-induced in situ cell reprogramming without administration of nucleic acids to the subject.
Abstract: Embodiments of the present disclosure provide an array substrate and a manufacturing method thereof, a display panel, and a display apparatus. The array substrate includes: a base substrate; a first conductive layer on a side of the base substrate; the first insulating layer on a side of the first conductive layer away from the base substrate; and a second conductive layer on a side of the first insulating layer away from the first conductive layer. The array substrate includes a pixel region and a signal input region, and a portion of the first insulating layer in the pixel region has a thickness less than that of a portion of the first insulating layer in the signal input region.
Abstract: This disclosure provides an image distance sensor and a manufacture method thereof, as well as a ranging device. The image distance sensor includes a semiconductor substrate, and an image sensing unit and a distance sensing unit formed on the semiconductor substrate. The image sensing unit and the distance sensing unit are formed in a same manufacture process.
Abstract: A protein transduction method for efficiently delivery of exogenous proteins into mammalian cells is invented, which has the capability of targeting different cellular compartments and protection from degradation of the delivered proteins from cellular proteases. A composition for treat proteins has cation reagents, lipids and enhancers in a carrier. The method can be used in a number of ways including: production of large quantities of properly folded, post-translationally modified proteins using mammalian cell machinery a in-cell fluorescence spectroscopy and imaging using small molecule fluorophores and a in-cell NMR spectroscopy using living mammalian cells. The method permits cell biology at atomic resolution that is physiologically and pathological relevant and permits protein therapy to treat human diseases. The method can also be used to deliver exogenous protein inside mammalian cells, wherein the exogenous proteins follow a similar secretion pathway as that of the endogenous protein.
Abstract: A protein transduction method for efficiently delivery of exogenous proteins into mammalian cells is invented, which has the capability of targeting different cellular compartments and protection from degradation of the delivered proteins from cellular proteases. A composition for treat proteins has cation reagents, lipids and enhancers in a carrier. The method can be used in a number of ways including: production of large quantities of properly folded, post-translationally modified proteins using mammalian cell machinery, a in-cell fluorescence spectroscopy and imaging using small molecule fluorophores and a in-cell NMR spectroscopy using living mammalian cells. The method permits cell biology at atomic resolution that is physiologically and pathological relevant and permits protein therapy to treat human diseases. The method can also be used to deliver exogenous protein inside mammalian cells, wherein the exogenous proteins follow a similar secretion pathway as that of the endogenous protein.