Abstract: Methods and compositions for the use of CRISPR/Cas9 technology for treating RP1 mutation-associated autosomal dominant Retinitis Pigmentosa (adRP).

Abstract: Provided are an information generation method and apparatus, and an electronic device.

Abstract: An unmanned parking space detection method based on a panoramic surround view is provided. The unmanned parking space detection method adopts a Laplace fusion algorithm to splice images to obtain the panoramic surround view, which effectively realize fusion of the images. By using an image quality evaluation function, complexity of the unmanned parking space detection method is reduced while ensuring a quality of the splicing. The panoramic surround view generated by the present disclosure has a more natural transition in the areas being spliced and fused, and the panoramic surround view display is more complete and beautiful. Compared with conventional machine vision detection technologies, the unmanned parking space detection method adopts a target detection technology for detecting parking space entrance lines and adopts a more lightweight network design to ensure real-time performance of a detection algorithm thereof, which has higher detection accuracy and stronger robustness.

Abstract: Click based contour editing includes detecting a selection input with respect to an image presented on a graphical user interface; designating an area of the image corresponding to the selection input as a region of interest; detecting at least one other selection input on the graphical user interface with respect to the image; determining if the at least one other selection input is within the region of interest or outside of the region of interest; and if the at least one other selection input is within the region of interest, excluding the portion of the image corresponding to the other input; or if the other selection input is outside of the region of interest, including the portion of the image corresponding to an area of the image associated with the other selection input.

Abstract: Methods and compositions for the use of CRISPR/Cas9 technology for treating RP1 mutation-associated autosomal dominant Retinitis Pigmentosa (adRP).

Abstract: Pharmaceutical compositions for the treatment of cancer are provided. In one embodiment the composition comprises Gamitrinib and a MAPK inhibitor selected from the MAPK inhibitor is selected from RAF265, AZD6244, PLX4720, PD0325901, LGX818, MEK162, vemurafenib, trametinib and dabrafenib. Methods of treating cancer are also provided.

Abstract: The present invention relates to methods for assessing one's risk for suffering from severe COVID or long COVID symptoms. Also provided are methods for reducing the risk of developing severe COVID and/or long COVID symptoms.

Abstract: Click based contour editing includes detecting a selection input with respect to an image presented on a graphical user interface; designating an area of the image corresponding to the selection input as a region of interest; detecting at least one other selection input on the graphical user interface with respect to the image; determining if the at least one other selection input is within the region of interest or outside of the region of interest; and if the at least one other selection input is within the region of interest, excluding the portion of the image corresponding to the other input; or if the other selection input is outside of the region of interest, including the portion of the image corresponding to an area of the image associated with the other selection input.

Abstract: One or more implementations of the present specification provide an invoice access method and apparatus based on a blockchain, and an electronic device. The method includes: generating first ciphertext data by encrypting plaintext data of the target invoice based on a first key corresponding to an invoice issuer; generating second ciphertext data by encrypting the plaintext data of the target invoice based on a second key corresponding to an invoice receiver; adding the first ciphertext data and an user identifier of the invoice issuer to the blockchain as related to one another; and adding the second ciphertext data and an user identifier of the invoice receiver to the blockchain as related to one another.

Abstract: Described herein are systems, methods, and instrumentalities associated with automatic image annotation. The annotation may be performed based on one or more manually annotated first images of an object and a machine-learned (ML) model trained to extract first features from the one or more first images. To automatically annotate a second, un-annotated image of the object, the ML model may be used to extract second features from the second image, determine information that may be indicative of the characteristics of the object in the second image based on the first and second features, and generate an annotation of the object for the second image using the determined information. The images may be obtained from various sources including, for example, sensors and/or medical scanners, and the object of interest may include anatomical structures such as organs, tumors, etc. The annotated images may be used for multiple purposes including machine learning.

Abstract: A positioning method performed at a server includes: receiving, at a frequency, arrival time information from a plurality of readers; determining, according to the arrival time information, that the tag is in a sensing auxiliary region of a positioning region; sending a first control command to one of the readers, so that the tag activates an inertial sensor thereof according to the first control command; receiving, from the reader, position information of the tag in the sensing auxiliary region obtained by the inertial sensor; determining, according to the position information of the tag in the sensing auxiliary region, a first motion trajectory of the tag in the sensing auxiliary region; and determining, according to the first motion trajectory, whether the tag enters one of the first regions.

Abstract: A method, a device, and a program product for backing up data in the Internet of Things (IoT) is disclosed. An IoT system includes an IoT manager and a plurality of IoT devices. In response to receiving a registration request for registering an IoT device among a plurality of IoT devices with an IoT manager, a signature public key is received from the IoT device. Atomic data associated with the IoT device is received that includes a signature generated by using a signature private key corresponding to the signature public key. The signature is verified based on the signature public key. In response to the signature being successfully verified, a backup data package for backup is generated based on the atomic data. Accordingly, data may be backed up in the IoT with higher performance, thereby improving the security and reliability of the entire IoT.

Abstract: Systems and methods for ossification center detection (OCD) and bone age assessment (BAA) may be provided. The method may include obtaining a bone age image of a subject. The method may include generating a normalized bone age image by preprocessing the bone age image. The method may include determining, based on the normalized bone age image, positions of a plurality of ossification centers using an ossification center localization (OCL) model. The method may include estimating, based on the normalized bone age image and information related to the positions of the plurality of ossification centers, a bone age of the subject using a bone age assessment (BAA) model.

Abstract: Embodiments of the present specification disclose methods, apparatuses, and devices for transferring data assets based on a blockchain. One method includes: obtaining usage demand information of a data requestor for using original data, wherein the usage demand information indicates a demand of the data requestor for performing computations based on the original data; sending a usage authorization request for the original data to a data owner of the original data based on a decentralized identifier (DID) corresponding to the original data; receiving confirmation information of the usage authorization request from the data owner; processing the original data based on the usage demand information to obtain a processing result; transmitting the processing result to the data requestor; and generating a verifiable claim (VC) for recording usage information of the original data.

Abstract: Methods and compositions for treating and/or preventing a bacterial infection in a subject are provided, in which the subject is administered a fecal sample obtained from a donor subject via fecal microbiota transplantation (FMT). The fecal sample contains bacteriophages that target the bacteria causing the infection. In some embodiments, the fecal sample containing the bacteriophages can be obtained from a donor subject who previously had the same infection but is now cured.

Abstract: Embodiments of the present disclosure relate to a method, a device, and a computer program product for managing virtual machine upgrade. Provided is a method for managing virtual machine upgrade, including: determining, based on a received upgrade file for a virtual machine, a state of the virtual machine; and controlling, based on determining that the state indicates the virtual machine not being accessible via a network, installation of the upgrade file on the virtual machine via a virtual machine agent or a virtual machine manager, the virtual machine agent being capable of modifying a virtual disk of the virtual machine. Through the embodiments of the present disclosure, the installation of the upgrade file on the virtual machine can be realized when the virtual machine is not accessible via the network, whilst simplifying the virtual machine configuration and reducing the network bandwidth occupancy.

Abstract: Embodiments of the present disclosure provide methods, electronic devices and computer program products for accessing data. A method comprises receiving, at a first device, a file system operation request for accessing target data, the target data being stored at a second device after being pre-processed, and the first device providing a file system interface for data stored at the second device; forwarding the file system operation request to the second device, such that the target data is restored at the second device; receiving the restored target data from the second device; and providing the target data as a response to the file system operation request. Embodiments of the present disclosure allow users to access backup data stored after being pre-processed through normal file system operations and can achieve high data access performance.

Abstract: Pharmaceutical compositions for the treatment of cancer are provided. In one embodiment the composition comprises Gamitrinib and a MAPK inhibitor selected from the MAPK inhibitor is selected from RAF265, AZD6244, PLX4720, PD0325901, LGX818, MEK162, vemurafenib, trametinib and dabrafenib. Methods of treating cancer are also provided.

Abstract: The disclosure provides methods of deaminating adenosine and cytosine bases in a target nucleic acid sequence in an USH2A gene comprising contacting the USH2A gene with a base editor in association with a guide RNA (gRNA). In some aspects, base editing is used to restore US2HA function by disrupting a splice site in the USH2A gene sequence to induce skipping of an exon containing a mutation, while in other embodiments, base editing is used to restore US2HA function by correcting a point mutation e.g., in an exon) so as to correct mutations. The disclosure also provides complexes of adenosine base editors and guide RNAs, and complexes of cytidine base editors and guide RNAs. The disclosure further provides pharmaceutical compositions and cells comprising these complexes. The disclosure also provides vectors encoding these complexes, base editors, and gRNAs. In some embodiments, the methods and compositions provided herein are used to treat Usher syndrome and autosomal recessive retinitis pigmentosa (arRP).

Abstract: A three-dimensional printing kit can include a polymeric build material including thermoplastic elastomeric particles having a D50 particle size from about 2 ?m to about 150 ?m, and a fusing agent. The fusing agent can include water, from about 5 wt % to about 40 wt % lower alkyldiol organic co-solvent, and a radiation absorber to generate heat from absorbed electromagnetic radiation.