Abstract: A method for preparing a nitrogen-containing polycyclic fused ring compound of formula I, and an intermediate thereof are provided. By this method, the compound of formula I can be produced on an industrial scale without column chromatography separation, purification steps such as silica gel column chromatography, or hydrogen. In addition, the preparation method effectively uses positional isomers IIIA and IIIB, and improves the yield of a target product from being adversely influenced by discarding positional isomer IIIA.

Abstract: An unmanned parking space detection method based on a panoramic surround view is provided. The unmanned parking space detection method adopts a Laplace fusion algorithm to splice images to obtain the panoramic surround view, which effectively realize fusion of the images. By using an image quality evaluation function, complexity of the unmanned parking space detection method is reduced while ensuring a quality of the splicing. The panoramic surround view generated by the present disclosure has a more natural transition in the areas being spliced and fused, and the panoramic surround view display is more complete and beautiful. Compared with conventional machine vision detection technologies, the unmanned parking space detection method adopts a target detection technology for detecting parking space entrance lines and adopts a more lightweight network design to ensure real-time performance of a detection algorithm thereof, which has higher detection accuracy and stronger robustness.

Abstract: Disclosed are a core-shell structure membrane scale inhibitor and a preparation method therefor, wherein the core-shell structure membrane scale inhibitor has a core emulsion obtained via emulsion polymerization, and a shell structure obtained via ultraviolet-light grafting functional monomers. The preparation method has first preparing a core by using an emulsion polymerization process, adding a reactive photo-initiator in the later stage of polymerization, so that the reactive photo-initiator is grafted on the surface of the core, and finally initiating the polymerization of functional monomers by means of ultraviolet light to obtain a core-shell structure membrane scale inhibitor. The surface structure of the core is modified, such that a large number of ionizable groups are grafted on the surface thereof, and thus, a large number of scaling ions such as Ca2+, Mg2+ and Al3+ can be adsorbed.

Abstract: The present disclosure relates to the technical field of medical equipment, and discloses an articulating endoscopic cutter stapler and universal assembly for stapling, comprising a proper, wherein the surface of the proper is slidably connected with a reset ring and formed with a slot, the surface of the reset ring is provided with a sliding pin which is placed into the slot, and a safety pin is arranged at one end of the surface of the proper. The present disclosure can better control the anvil assembly to improve the stability of stapler during suturing of wound and to improve the quality of surgical suturing. The angle of suturing assembly of stapler can also be adjusted to the specific position of the wound, so that the range of application of stapler can be extended.

Abstract: In one aspect, a preparation method for ferric phosphate includes the following steps: (a) feeding a ferrous sulfate solution and a phosphate solution including hydrogen peroxide simultaneously into a first reactor for mixing and reacting to obtain nucleated ferric phosphate; wherein a molar ratio of iron element to phosphorus element in the feeding process is 1:1, and a stirring speed is 500-600 r/min; (b) discharging the nucleated ferric phosphate to a second reactor for growth to obtain amorphous ferric phosphate slurry, and post-processing the amorphous ferric phosphate slurry to obtain the high tap density ferric phosphate; wherein a stirring speed is 120-150 r/min. The first reactor is a small-volume reactor, and the second reactor is a large-volume reactor.

Abstract: This invention relates to the field of genetic molecular breeding, specifically to a pig 50K liquid-phase chip based on multiple single nucleotide-polymorphism and its application. The probe design of the chip in this invention takes into account the distribution of captured SNP loci across the genome, the polymorphism of the loci, the quality of mSNP markers, and other issues, effectively avoiding problems such as uneven marker density and poor polymorphism. It also considers the quality of mSNP markers and the issue of linkage disequilibrium among mSNP markers. While adhering to the basic principles of liquid-phase chip design, genomic regions with moderate linkage disequilibrium between markers were selected, generating more SNP markers with high genotyping quality and moderate linkage disequilibrium within the probe region with the target loci. The mSNP liquid-phase chip of this invention expands the detectable number of SNPs to 1.

Abstract: The present disclosure provides a two-stage cavitation generator for organic wastewater treatment, including a shrouded impeller, a stator, and a rotor. The shrouded impeller includes a front cover plate, blades, and a rear cover plate. Several blades are evenly distributed between the front cover plate and the rear cover plate. A working surface of the blade is an arc surface, and a back of the blade protrudes locally, so that a flow channel between the back of the blade and a working surface of its adjacent blade is narrowed locally, forming a throat structure. An outlet of the shrouded impeller is provided with the stator and the rotor, and the stator is located at an outer edge of the front cover plate and fixed on an inner wall of a volute. The rotor is mounted on the rear cover plate.

Abstract: A light-emitting substrate includes a base, a first conductive pattern layer disposed on the base and a second conductive pattern layer disposed on a side of the first conductive pattern layer away from the base. The first conductive pattern layer includes first signal lines. The second conductive pattern layer includes lamp bead pads. The lamp bead pads include first lamp bead pads and at least one second lamp bead pad. A vertical projection of each first lamp bead pad on the base at least partially overlaps with a vertical projection of a first signal line on the base. A vertical projection of each second lamp bead pad on the base is outside vertical projections of the first signal lines on the base. A distance between a first lamp bead pad and the base is substantially the same as a distance between a second lamp bead pad and the base.

Abstract: A backplane, a backlight source, an illumination device and a displaying device. The backplane comprises a substrate; a first metal trace layer disposed on one surface of the substrate; an insulating layer disposed on a side, away from the substrate, of the first metal trace layer; a second metal trace layer disposed on a side, away from the substrate, of the insulating layer, an overlapping area existing between an orthographic projection of the second metal trace layer on the substrate and an orthographic projection of the first metal trace layer on the substrate; and a barrier layer disposed between the first metal trace layer and the second metal trace layer, an orthographic projection of the barrier layer on the substrate covering the overlapping area, and the barrier layer being used for preventing metals in the first metal trace layer and the second metal trace layer from growing towards each other.

Abstract: A virus lysis and nucleic acid preservation solution is disclosed, including the following components: isopropanol or ethyl alcohol, guanidinium chloride, tri (hydroxymethyl) aminomethane hydrochloride, and ethylenediaminetetraacetic acid. Furthermore, a kit including the virus lysis and nucleic acid preservation solution, a method for preserving viral nucleic acid, and a method for extracting a viral nucleic acid are also provided. The virus lysis and nucleic acid preservation solution of the present invention has the functions of lysing virus and preserving nucleic acid in the lysed virus samples, and it is compatible with lysis buffers, wash buffers, elution buffers, etc. in all kinds of viral nucleic acid extraction kit commonly available in the market.

Abstract: A composite electrochromic material, a preparation method therefor and an application thereof, the material comprising a core layer, a skin layer having an electrochromic function, and a light-transmitting protective layer formed by a flexible polymer material, that are arranged in sequence. The material of the core layer comprises a fluid conductive mixture, which comprises liquid metal and carboxylated carbon nanotubes. The preparation method comprises: carrying out spinning by co-extrusion using a three-channel nozzle to form hollow double-layer fibers each having a skin layer and a protective layer as well as a cavity, injecting the conductive mixture into the cavity of the hollow double-layer fiber. The material has excellent deformation ability, stable and sensitive color changing function, and a controllable deformation degree. The material has a stable color changing function even in the case of severe defomation, good fatigue resistance, and is suitable for the preparation of intelligent textiles.

Abstract: Click based contour editing includes detecting a selection input with respect to an image presented on a graphical user interface; designating an area of the image corresponding to the selection input as a region of interest; detecting at least one other selection input on the graphical user interface with respect to the image; determining if the at least one other selection input is within the region of interest or outside of the region of interest; and if the at least one other selection input is within the region of interest, excluding the portion of the image corresponding to the other input; or if the other selection input is outside of the region of interest, including the portion of the image corresponding to an area of the image associated with the other selection input.

Abstract: Methods and compositions for the use of CRISPR/Cas9 technology for treating RP1 mutation-associated autosomal dominant Retinitis Pigmentosa (adRP).

Abstract: Pharmaceutical compositions for the treatment of cancer are provided. In one embodiment the composition comprises Gamitrinib and a MAPK inhibitor selected from the MAPK inhibitor is selected from RAF265, AZD6244, PLX4720, PD0325901, LGX818, MEK162, vemurafenib, trametinib and dabrafenib. Methods of treating cancer are also provided.

Abstract: The present invention relates to methods for assessing one's risk for suffering from severe COVID or long COVID symptoms. Also provided are methods for reducing the risk of developing severe COVID and/or long COVID symptoms.

Abstract: Click based contour editing includes detecting a selection input with respect to an image presented on a graphical user interface; designating an area of the image corresponding to the selection input as a region of interest; detecting at least one other selection input on the graphical user interface with respect to the image; determining if the at least one other selection input is within the region of interest or outside of the region of interest; and if the at least one other selection input is within the region of interest, excluding the portion of the image corresponding to the other input; or if the other selection input is outside of the region of interest, including the portion of the image corresponding to an area of the image associated with the other selection input.

Abstract: One or more implementations of the present specification provide an invoice access method and apparatus based on a blockchain, and an electronic device. The method includes: generating first ciphertext data by encrypting plaintext data of the target invoice based on a first key corresponding to an invoice issuer; generating second ciphertext data by encrypting the plaintext data of the target invoice based on a second key corresponding to an invoice receiver; adding the first ciphertext data and an user identifier of the invoice issuer to the blockchain as related to one another; and adding the second ciphertext data and an user identifier of the invoice receiver to the blockchain as related to one another.

Abstract: Described herein are systems, methods, and instrumentalities associated with automatic image annotation. The annotation may be performed based on one or more manually annotated first images of an object and a machine-learned (ML) model trained to extract first features from the one or more first images. To automatically annotate a second, un-annotated image of the object, the ML model may be used to extract second features from the second image, determine information that may be indicative of the characteristics of the object in the second image based on the first and second features, and generate an annotation of the object for the second image using the determined information. The images may be obtained from various sources including, for example, sensors and/or medical scanners, and the object of interest may include anatomical structures such as organs, tumors, etc. The annotated images may be used for multiple purposes including machine learning.

Abstract: A positioning method performed at a server includes: receiving, at a frequency, arrival time information from a plurality of readers; determining, according to the arrival time information, that the tag is in a sensing auxiliary region of a positioning region; sending a first control command to one of the readers, so that the tag activates an inertial sensor thereof according to the first control command; receiving, from the reader, position information of the tag in the sensing auxiliary region obtained by the inertial sensor; determining, according to the position information of the tag in the sensing auxiliary region, a first motion trajectory of the tag in the sensing auxiliary region; and determining, according to the first motion trajectory, whether the tag enters one of the first regions.