Abstract: Embodiments of the present disclosure provide methods, electronic devices and computer program products for accessing data. A method comprises receiving, at a first device, a file system operation request for accessing target data, the target data being stored at a second device after being pre-processed, and the first device providing a file system interface for data stored at the second device; forwarding the file system operation request to the second device, such that the target data is restored at the second device; receiving the restored target data from the second device; and providing the target data as a response to the file system operation request. Embodiments of the present disclosure allow users to access backup data stored after being pre-processed through normal file system operations and can achieve high data access performance.

Abstract: Pharmaceutical compositions for the treatment of cancer are provided. In one embodiment the composition comprises Gamitrinib and a MAPK inhibitor selected from the MAPK inhibitor is selected from RAF265, AZD6244, PLX4720, PD0325901, LGX818, MEK162, vemurafenib, trametinib and dabrafenib. Methods of treating cancer are also provided.

Abstract: The disclosure provides methods of deaminating adenosine and cytosine bases in a target nucleic acid sequence in an USH2A gene comprising contacting the USH2A gene with a base editor in association with a guide RNA (gRNA). In some aspects, base editing is used to restore US2HA function by disrupting a splice site in the USH2A gene sequence to induce skipping of an exon containing a mutation, while in other embodiments, base editing is used to restore US2HA function by correcting a point mutation e.g., in an exon) so as to correct mutations. The disclosure also provides complexes of adenosine base editors and guide RNAs, and complexes of cytidine base editors and guide RNAs. The disclosure further provides pharmaceutical compositions and cells comprising these complexes. The disclosure also provides vectors encoding these complexes, base editors, and gRNAs. In some embodiments, the methods and compositions provided herein are used to treat Usher syndrome and autosomal recessive retinitis pigmentosa (arRP).

Abstract: A three-dimensional printing kit can include a polymeric build material including thermoplastic elastomeric particles having a D50 particle size from about 2 ?m to about 150 ?m, and a fusing agent. The fusing agent can include water, from about 5 wt % to about 40 wt % lower alkyldiol organic co-solvent, and a radiation absorber to generate heat from absorbed electromagnetic radiation.

Abstract: Embodiments of the present specification disclose matching methods, apparatuses, and devices based on trusted asset data. One method comprises: analyzing trusted asset data of a first entity to obtain asset description information of the first entity, wherein the trusted asset data is stored on a trusted device; obtaining service information of a plurality of second entities; determining target service information that matches the first entity based on the asset description information and the service information; and sending the target service information to the first entity.

Abstract: Embodiments of the present disclosure provide a method, device and computer program product for backing up data. The method comprises obtaining a data attribute of specific data to be backed up from a client to a server, a resource utilization rate at the client, and a network condition between the client and the server. The method further comprises setting, based on the data attribute, the resource utilization rate and the network condition, a plurality of parameters for performing stream backup, wherein the plurality of parameters at least comprises a concurrent number of stream transmission and a concurrent number of data parsing. The method further comprises parsing, according to the set plurality of parameters, the specific data and backing up the specific data from the client to the server.

Abstract: The present invention provides for compositions and methods for treating long COVID symptoms or reducing the risk of developing such symptoms.

Abstract: Embodiments of the present specification disclose identity registration methods, apparatuses, and devices. One method comprising: identifying description information from a user for a secure application configured to obtain trusted data to be installed; retrieving installation package data corresponding to the secure application based on the description information; installing the secure application in a trusted execution environment (TEE) based on the installation package data; and adding the description information to a digital identity document of the user recorded on a blockchain.

Abstract: Embodiments of the present disclosure relate to a method for data backup. The method includes obtaining an attribute value associated with a backup task to be run, the backup task being used for backing up data on a client terminal to a server through a network, the attribute value including a value of at least one of an attribute of the client terminal, an attribute of the server, and an attribute of the network; determining, based on the attribute value, the number of threads to be used to perform the backup task on the client terminal; and causing the client terminal to perform the backup task using the number of threads to back up the data.

Abstract: Embodiments of the present specification disclose data processing methods, apparatuses, devices, and media. One method includes the following: receiving a data use request; determining data to be used based on the data use request; determining one or more approvers of the data to be used; sending an approval instruction to the one or more approvers, wherein the approval instruction instructs the one or more approvers to approve the data use request; receiving feedback data from the one or more approvers; and determining that the data use request is approved if the feedback data satisfies a predetermined condition.

Abstract: A method, electronic device, and computer readable medium for managing a backup system is disclosed. The method includes acquiring a state of the backup system. The backup system includes a backup server and at least one backup client terminal, the backup server using multiple threads to back up data from the at least one backup client terminal to a persistent storage device via a buffer. The method also includes determining a reward score corresponding to the state of the backup system and determining configuration information for the backup system based on the state and the reward score of the backup system. The configuration information indicating at least one of the number of the multiple threads and the size of the buffer. The number of writing threads and the size of the buffer for the persistent storage device may be dynamically adjusted based on the state of the backup system.

Abstract: Embodiments of the present disclosure relate to a method for storage management, an electronic device, and a computer program product. According to an exemplary implementation of the present disclosure, a method for storage management includes: generating, at a client, a first backup block for recovering first target data, the client backing up the first target data to a first server and backing up metadata of the first target data to a second server, and the client together with at least one other client and the second server maintaining the same backup chain which includes at least one backup block; adding the first backup block to the backup chain maintained by the client; and distributing the first backup block to the at least one other client and the second server to add the first backup block to the backup chain maintained by the at least one other client and the second server. Therefore, the storage security can be improved.

Abstract: Embodiments of the present disclosure provide a method, device, and computer program product for managing a backup system. The method comprises obtaining a state of a backup system, wherein the backup system comprises a plurality of backup servers and a plurality of backup clients, the plurality of backup servers is communicatively coupled to the plurality of backup clients via a network, and wherein at least one backup server from the plurality of backup servers is configured to back up data of at least one backup client allocated from the plurality of backup clients to the at least one backup server, determining a reward score corresponding to the state of the backup system and, determining, based on the state of the backup system and the reward score, configuration information for the backup system, the configuration information indicating allocation of the plurality of backup clients to the plurality of backup servers.

Abstract: Methods, systems, and devices, including computer programs encoded on a computer storage medium are provided for combined dynamic causal modeling and biophysics modeling of brain function. In particular, the disclosed methods of modeling brain function can be used to integrate brain function measurements by two or more methods, such as functional neuroimaging and electrophysiology. Sequential model fitting is used to improve modeling accuracy to generate a more comprehensive model of brain neuronal circuitry.

Abstract: Embodiments of the present specification disclose data processing methods, apparatuses, and devices. A method can include: obtaining data use authorization information sent by a data requester; verifying the data use authorization information; in response to successfully verifying the data use authorization information, sending data authorized to be accessed by the data use authorization information to the data requester, wherein the data is obtained from a trusted institution and is stored in trusted hardware; and storing, on a blockchain associated with a blockchain network, a data sending record for the data.

Abstract: Systems and methods for ossification center detection (OCD) and bone age assessment (BAA) may be provided. The method may include obtaining a bone age image of a subject. The method may include generating a normalized bone age image by preprocessing the bone age image. The method may include determining, based on the normalized bone age image, positions of a plurality of ossification centers using an ossification center localization (OCL) model. The method may include estimating, based on the normalized bone age image and information related to the positions of the plurality of ossification centers, a bone age of the subject using a bone age assessment (BAA) model.

Abstract: A method, a device, and a program product for backing up data in the Internet of Things (IoT) is disclosed. An IoT system includes an IoT manager and a plurality of IoT devices. In response to receiving a registration request for registering an IoT device among a plurality of IoT devices with an IoT manager, a signature public key is received from the IoT device. Atomic data associated with the IoT device is received that includes a signature generated by using a signature private key corresponding to the signature public key. The signature is verified based on the signature public key. In response to the signature being successfully verified, a backup data package for backup is generated based on the atomic data. Accordingly, data may be backed up in the IoT with higher performance, thereby improving the security and reliability of the entire IoT.

Abstract: Embodiments of the present specification disclose data processing methods, apparatuses, and devices. One method comprises: obtaining an acquisition request for target data of a data owner; determining a trusted application (TAPP) for generating the target data based on decentralized identifier document (DID Doc) information of the data owner in response to the acquisition request; sending, to the TAPP, a target data generation request to use the TAPP to process data of the data owner obtained from a trusted institution; and receiving a processing result from the TAPP in response to the target data generation request.

Abstract: A method for operating a machine tool having a battery and an electric motor which is designed to rotationally drive an output shaft that can be coupled to a tool is described, a control device for actuating the electric motor and a device for determining a parameter being provided, it being possible for the machine tool to be operated in a first operating mode and a second operating mode, and the control device transferring the machine tool from the first operating mode into the second operating mode if the parameter determined by the device exceeds or falls below a defined threshold value. The electric motor (3) is controlled in the second operating mode by an amperage profile comprising current pulses (10, 10?, 11), a level a maximum amperage (A1, A1?, A2) of the current pulses (10, 10?, 11) being varied depending on an actual charge status of the battery (2). A machine tool that can be operated using a method of this kind is also described.

Abstract: A method for operating a machine tool having a battery and an electric motor which is designed to rotationally drive an output shaft that can be coupled to a tool, is described, a control device for actuating the electric motor and a device for determining a parameter being provided. The machine tool can be operated in a first operating mode and a second operating mode, the machine tool being transferred from the first operating mode into the second operating mode if the parameter determined by the device exceeds or falls below a defined threshold value. In the second operating mode, the electric motor is controlled by an amperage profile, the amperage profile comprising first current pulses (10) and second current pulses (11). The level of a maximum amperage (A1) of the first current pulses (10) is greater than the level of a maximum amperage (A2) of the second current pulses (11). A machine tool that can be operated using a method of this kind is also described.