Abstract: The present invention relates to a pharmaceutical combination which comprises (a) a phosphatidylinositol 3-kinase inhibitor or pharmaceutically acceptable salt thereof, and (b) at least one c-Met receptor tyrosine kinase inhibitor or pharmaceutically acceptable salt thereof, for simultaneous, separate or sequential administration for the treatment of a proliferative disease, particularly a c-Met dependent proliferative disease; a pharmaceutical composition comprising such combination; a method of treating a subject having a proliferative disease comprising administration of said combination to a subject in need thereof; use of such combination for the treatment of proliferative disease; and a commercial package comprising such combination.

Abstract: A pixel circuit includes a trench etched into a front side surface of a semiconductor substrate. The trench includes a bottom surface etched along a <100> crystalline plane and a tilted side surface etched along a <111> crystalline plane that extends between the bottom surface and the front side surface. A floating diffusion is disposed in the semiconductor substrate beneath the bottom surface of the trench. A photodiode is disposed in the semiconductor substrate beneath the tilted side surface of the trench and is separated from the floating diffusion. The photodiode is configured to photogenerate image charge in response to incident light. A tilted transfer gate is disposed over at least a portion of the bottom surface and at least a portion of the tilted side surface of the trench. The tilted transfer gate is configured to transfer the image charge from the photodiode to the floating diffusion.

Abstract: An electrical connector includes: a housing; and plurality terminal groups held on the housing, each terminal group including a pair of signal terminals, a first shielding sheet for shielding the pair of signal terminals on at least one side, and a second shielding sheet for shielding the signal terminals on at least another side; wherein the first shielding sheet and the second shielding sheet of each terminal group are electrically connected, and the first shielding sheet of one of the terminal groups is electrically connected to the second shielding sheet of an adjacent terminal group.

Abstract: An information handling system includes a first device having a first data communication interface connected to a first socket area of a socket. A second device includes a second data communication interface connected to a second socket area of the socket. A host processor includes a third data communication interface connected to a third socket area of the socket. When an interposer is installed into the socket in a first orientation, the interposer connects the first data communication interface to the third data communication interface. When the interposer is installed into the socket in a second orientation, the interposer connects the first data communication interface to the second data communication interface.

Abstract: The present invention relates to the field of quantum communication, especially a quantum key distribution device that can be configured with multiple protocols. It uses the simplified Faraday-Michelson interference ring in combination with the intensity modulator to perform timestamp encoding in a chopping manner. The phase modulation is completed with a Sagnac ring device composed of a single-polarization phase modulator, a polarization beam splitter and a Faraday rotator, so as to achieve the purpose of composite encoding and decoding, thus realizing a quantum key distribution device which can be configured with multiple protocols and multiple decoy state schemes. This device can be compatible with multiple protocols including BB84 protocol, the reference frame-independent protocol, the six-state protocol and SARG protocol and is characterized with polarization-independent phase modulation and low system complexity.

Abstract: A pharmaceutical combination comprising an ALK inhibitor, in free form or a pharmaceutically acceptable salt thereof, and a SHP2 inhibitor, in free form or a pharmaceutically acceptable salt thereof, and optionally a pharmaceutically acceptable carrier, for simultaneous or sequential administration; the uses of such combination in the treatment of proliferative diseases; and methods of treating a subject suffering from a proliferative disease comprising administering a therapeutically effective amount of such combination.

Abstract: Provided is a mobile water quality monitoring platform for a fishpond, belonging to the technical field of water quality monitoring devices. The mobile water quality monitoring platform for a fishpond includes a floating body, a first rotating shaft and a second rotating shaft are disposed on the floating body, the first rotating shaft is rotatably disposed on the floating body through two first support plates, two second support plates are vertically disposed on the floating body, an elongated chute hole is horizontally disposed on two second support plates respectively, both ends of the second rotating shaft are inserted into two chute holes respectively, the first rotating shaft and the second rotating shaft are connected through a connecting rod mechanism, a driving mechanism that enables the first rotating shaft and the second rotating shaft to rotate simultaneously is disposed on the connecting rod mechanism.

Abstract: A method and a system for recommending a target garment matching an inputted garment. The method includes: extracting attributes from text description and image of the inputted garment to obtain extracted attributes; querying a knowledge graph using the extracted attributes to obtain matched attributes; retrieving candidate products from a garment pool using the matched attributes; extracting features from the inputted garment and the candidate products; determining the target garment from the candidate products based on grading scores between the features of the inputted garment and the features of the candidate products; and recommending the target garment. The knowledge graph includes nodes corresponding to type of clothes, category of clothes, attribute keys, values of attribute keys, context keys, values of context keys, combination of the values of the attribute keys and the type of clothes, and combination of the value of the attribute keys and the category of clothes.

Abstract: An active feedback control method for a quantum communication system based on machine learning is disclosed. In the transmission process of a quantum key distribution system, the present invention uses a pre-trained double-layer LSTM network to predict, according to a real-time ambient temperature, humidity and laser light intensity fluctuation, as well as voltage changes in the past moment, a zero-phase voltage value of a phase modulator at a receiving end at the next moment, and updates the network at a fixed time interval, so that the LSTM network can accurately predict for a long time, ensuring that the quantum key distribution system operates stably and efficiently for a long time. The present invention greatly improves the transmission efficiency of the quantum key distribution system by method of active prediction and feedback control.

Abstract: Circuit integrated with voice wake-up function, television and voice control method. The circuit integrated with voice wake-up function comprises television mainboard and far-field voice module. The far-field voice module comprises: microphone unit for collecting voice simulation signal; analog-digital conversion unit for converting voice simulation signal to digital signal; main control unit for processing converted digital signal and outputting same to television mainboard; and voice wake-up unit for processing voice simulation signal and outputting wake-up signal to television mainboard. Microphone unit is connected to analog-digital conversion unit and voice recognition unit, respectively; analog-digital conversion unit is connected to main control unit and television mainboard, respectively; and television mainboard is connected to main control unit and voice wake-up unit, respectively.

Abstract: In accordance with one embodiment, a fan controller operates in a standard mode when main power is provided to the power supply unit in which speed of the fan is controlled in response to a primary pulse width modulation (PWM) signal from a power controller. A loss of the main power to the power supply unit may be detected at a logic circuit, which provides a secondary PWM signal to the fan controller in response to the loss of the main power. In certain embodiments, the fan controller is operated in a power loss mode in response to the secondary PWM signal to direct the speed of the fan to a low-power consumption target speed.

Abstract: The present invention provides a puncture support, including a support body and a soft support coating covering the outside of the support body, wherein a needle insertion channel is provided inside the support body. During use, the puncture support is fixedly connected to an ultrasonic probe by using the hard support body, and the soft support coating attached to the support body is in contact with a human body. Because the support coating is made of a soft material, people feel soft with reduced foreign body sensation when in contact with the support coating. In addition, the support body is made of a hard material, so that the puncture support can be firmly installed, ensuring safety. Therefore, the puncture support can be firmly and reliably installed like an existing puncture support, and also increases the comfort level of the product by taking user feelings into account.

Abstract: The present disclosure provides a return gas prevention device for a drainage pipe, belonging to the technical field of drainage pipes. The device realizes two functions of water seal and a check valve simultaneously, as well as prevents gas channeling in a drainage process.

Abstract: A pixel array includes a semiconductor substrate, a plurality of isolation layer segments, and a plurality of photodiodes. Each of the plurality of isolation layer segments extends through the semiconductor substrate in a first direction. Each of the plurality of isolation layer segments encloses a portion of the semiconductor substrate in a plane perpendicular to the first direction. The plurality of isolation layer segments form a grid that defines a plurality of isolated sections of the semiconductor substrate. The plurality of isolated sections of the semiconductor substrate include the portions of the semiconductor substrate. Each of the photodiodes is formed in a respective one of the plurality of isolated sections of the semiconductor substrate.

Abstract: An image sensor includes a substrate. An array of photodiodes is disposed in the substrate. A plurality of spacers is arranged in a spacer pattern. At least one spacer of the plurality of spacers has an aspect ratio of 18:1 or greater. A buffer layer is disposed between the substrate and the spacer pattern. An array of color filters is disposed in the spacer pattern.

Abstract: A pixel includes a semiconductor substrate, a photodiode region, a floating diffusion region, and a dielectric layer. The substrate has a top surface forming a trench lined by the dielectric layer, and having a trench depth relative to a planar region of the top surface. The photodiode region is in the substrate and includes a bottom photodiode section beneath the trench and a top photodiode section adjacent to the trench, adjoining the bottom photodiode section, and extending toward the planar region to a photodiode depth less than the trench depth. The floating diffusion region is adjacent to the trench and has a junction depth less than the trench depth. A top region of the dielectric layer is between the planar region and the junction depth. A bottom region of the dielectric layer is between the photodiode depth and the trench depth, and thicker than the top region.

Abstract: The present invention provides a biopsy needle and a puncture biopsy apparatus. The biopsy needle includes: an inner needle assembly, including a first plug-in portion plugged in with a fastener; an outer needle assembly, including a second plug-in portion plugged in with the fastener; and the fastener, including a third plug-in portion plugged in with the first plug-in portion, and a fourth plug-in portion plugged in with the second plug-in portion. According to the biopsy needle and the puncture biopsy apparatus provided in the present invention, the biopsy needle can be assembled and disassembled in a simple and fast way, helping reduce preparation time and preparation work for a surgery, thereby improving surgery efficiency.

Abstract: A device includes a photodiode, a floating diffusion region, a transfer gate, and a channel region. The photodiode is disposed in a semiconductor material. The photodiode is coupled to generate charge in response to incident light. The floating diffusion region is disposed in the semiconductor material. The transfer gate is disposed between the photodiode and the floating diffusion region. The channel region associated with the transfer gate is in the semiconductor material proximate to the transfer gate. The transfer gate is coupled to transfer the charge from the photodiode to the floating diffusion region through the channel region in response to a transfer signal coupled to be received by the transfer gate. The transfer gate includes a plurality of fin structures that extend into the semiconductor material and the photodiode.

Abstract: A device includes a photodiode, a floating diffusion region, a transfer gate, and a channel region. The photodiode is disposed in a semiconductor material. The photodiode is coupled to generate charges in response to incident light. The photodiode has a substantially uniform doping profile throughout a depth of the photodiode in the semiconductor material. The floating diffusion region is disposed in the semiconductor material. The transfer gate is disposed between the photodiode and the floating diffusion region, wherein the transfer gate includes a plurality of fin structures. The channel region associated with the transfer gate is in the semiconductor material proximate to the transfer gate. The transfer gate is coupled to transfer the charge from the photodiode to the floating diffusion region through the channel region in response to a transfer signal coupled to be received by the transfer gate.

Abstract: The present disclosure belongs to the technical field of power generators, and in particular relates to a marine support column structure with power generation function. The support column structure solves technical problems that existing marine power generators can only generate power with single energy and have few functions and so on. The marine support column structure with power generation function includes a column body. The support column structure of the present disclosure is capable of generating power with sea wind and waves, and is further capable of serving as a guardrail.