Abstract: Anti-PD-1 antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancers and autoimmune diseases.

Abstract: The present invention relates to Provided are compounds of Formula (I): wherein R1, R2, X, Ring A, Ring B, and Ring C are as defined herein. Compounds of Formula (I) are useful as inhibitors of DNA-PK. Also provided are pharmaceutical compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various diseases, conditions, and disorders.

Abstract: The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: The present invention provides an anti-C5aR antibody and a preparation method and use thereof. The anti-C5aR antibody comprises one or more of the followings: a heavy chain CDR1, heavy chain CDR2 or heavy chain CDR3 of a heavy chain variable region of an anti-C5aR antibody, and one or more of the followings: a light chain CDR1, light chain CDR2 or light chain CDR3 of a light chain variable region of the anti-C5aR antibody. The anti-C5aR antibody has a high affinity to human C5aR protein and can block the binding of the C5aR protein to a C5a, thus downregulating or switching off a corresponding signaling pathway, stopping C5a directed migration of a neutrophil in vitro and inhibiting chemotaxis of the neutrophil.

Abstract: Provided herein are anti-PD-L1 antibodies and antigen-binding fragments thereof. Also provided are nucleic acids encoding the antibodies, compositions containing the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancer, infectious diseases and autoimmune diseases.

Abstract: An electrical energy router includes cascaded submodules. Each submodule of the cascaded submodules includes a rectifying stage and an isolating stage. The rectifying stage includes a structure of a neutral point clamped full bridge. The isolating stage includes a DC-DC converter, which includes a primary side, a secondary side and a transformer. The primary side includes a structure of a neutral point clamped half bridge. A DC side of the neutral point clamped half bridge is connected to a DC bus line of the rectifying stage.

Abstract: Techniques for data synchronization involve obtaining a first bitmap about a first storage device, the first storage device including a group of storage areas, a bit in the first bitmap indicating whether data in a corresponding storage area of a first size in the group of storage areas is to be synchronized to a second storage device. The technique further involves, in response to a configuration of the first storage device being changed, determining a second size of a storage area in the group of storage areas. The technique further involves converting the first bitmap into a second bitmap based on the first size and the second size. In addition, the technique further involves synchronizing data from the first storage device to the second storage device based on the second size and the second bitmap.

Abstract: A modified nano graphite, a polymer composite material of the modified nano graphite, and use of the polymer composite material in a high temperature and high salinity oil reservoir.

Abstract: The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: A band-stop filter comprises: a housing having a top wall, a bottom wall and at least one side wall, the housing defining an internal cavity; a signal input port and a signal output port that are respectively disposed on one of the at least one side wall; a resonating element that is disposed in the internal cavity and includes a top, a bottom, and a side; and a transmission line that is disposed in the internal cavity and coupled between the signal input port and the signal output port, the transmission line comprising a coupling section that is coupled to the resonating element, wherein the coupling section is configured to surround more than half of the side of the resonating element and not directly contact the housing and the resonating element.

Abstract: A composite temperature resistance gel plugging agent, a preparation method thereof and Fuse thereof in profile control and water plugging of ultra-deep oil reservoirs.

Abstract: Disclosed herein is a close-cell structured stent which is composed of curved struts that intersect at a crossing angle of 90 to 170 degrees in the longitudinal direction. Methods for making the stent, use of the stent as a vascular stent, an esophagus stent, an intestine stent, a bile conduct stent, or a urinary tract stent, and use of the stent in the manufacture of stent graft for the treatment of abdominal aortic aneurysms are also provided. The stent has both excellent longitudinal flexibility and radial strength.

Abstract: Disclosed herein is a close-cell structured stent which is composed of curved struts that intersect at a crossing angle of 90 to 170 degrees in the longitudinal direction. Methods for making the stent, use of the stent as a vascular stent, an esophagus stent, an intestine stent, a bile conduct stent, or a urinary tract stent, and use of the stent in the manufacture of stent graft for the treatment of abdominal aortic aneurysms are also provided. The stent has both excellent longitudinal flexibility and radial strength.

Abstract: A novel preparation method for the anti-gout drug Lesinurad, and a key intermediate thereof. The method comprises the following reaction steps: 1) the compound of formula II undergoing a substitution reaction with R3—SH in the presence of a first solvent and a first alkali to generate a mixture containing the compound of formula III and the compound of formula IV; 2) adding a second alkali and R3X to the resulting mixture for a reaction to obtain the compound of formula III, wherein: R represents a cyclopropane group, a halogen, a triflate group, a mesylate group or a tosylate group, preferably a cyclopropane group; R3 represents —COCH3, a benzyl group or —CH2R4, wherein R4 represents a methyl acetate group, an ethyl acetate group, —C(O)OC2H5, —C(O)OCH3, —CN, —CH2OH or a phenyl group substituted with one or more of a C1-C6 alkyl group and a halogen; X represents a halogen.

Abstract: A smart tourniquet for self-administering a medication is provided. When a patient needs to inject themselves with a medication, intravenously, called an “infusion,” the patient wears the smart tourniquet around their arm and tightens the device. While the patient is using the smart tourniquet, the device automatically records the date and time of the infusion, called a “timestamp”. The patient can also use the device to record the dosage or “number of units” taken at the time of the infusion. The smart tourniquet can store the timestamp as well as other related information as a record. At a later time, the patient can recall prior records on the smart tourniquet itself. The smart tourniquet can also be synchronized with an application and the records can be downloaded for review by the patient, nurse or doctor to render accurate and timely care.

Abstract: Techniques for data synchronization involve obtaining a first bitmap about a first storage device, the first storage device including a group of storage areas, a bit in the first bitmap indicating whether data in a corresponding storage area of a first size in the group of storage areas is to be synchronized to a second storage device. The technique further involves, in response to a configuration of the first storage device being changed, determining a second size of a storage area in the group of storage areas. The technique further involves converting the first bitmap into a second bitmap based on the first size and the second size. In addition, the technique further involves synchronizing data from the first storage device to the second storage device based on the second size and the second bitmap.

Abstract: Techniques for data replication involve: in response to a first source state machine associated with a source file system being booted up, booting up a second source state machine associated with the source file system, the first source state machine performing a first operation for resizing a first storage area of data for replication from the source file system; transmitting a resizing message from the second source state machine to a destination file system, to enable the destination file system to perform a second operation for resizing a second storage area for storing the data to be replicated into the destination file system; and in response to the first operation and the second operation being successfully performed, enabling the data for replication from the source file system to be replicated into the destination file system.

Abstract: The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: The present disclosure relates to a method and apparatus for controlling interface display. The method includes: determining whether or not a first interface switching condition is satisfied in a case where a first display interface of an application is being displayed; and switching the first display interface being displayed at present to a second display interface of the application in a case where the first interface switching condition is satisfied, wherein the first display interface is associated with authentic user information, and the second display interface is associated with virtual user information. Examples of the present disclosure enable quick interface switching and thus provide the user with more convenience and improved experience in using the terminal device.

Abstract: A terminal includes: a metal housing; a frame surrounds the metal housing; and a metal antenna radiator arranged between the metal housing and the frame, surrounding the metal housing, and having a first end coupled with a feed source through a matching circuit and a second end grounded.