Publication number: 20250042857
Abstract: The present invention relates to an SOS1 inhibitor with a pyrido-fused-six-membered ring structure, a preparation method therefor, and use thereof. The SOS1 inhibitor has the structural formula shown in formula (I) and an inhibitory activity on SOS1, and can be used to treat head and neck cancer, lung cancer, a mediastinal tumor, a gastrointestinal tumor, prostate cancer, testicular cancer, a gynecological tumor, breast cancer, renal and bladder cancer, an endocrine tumor, soft tissue sarcoma, osteosarcoma, rhabdomyosarcoma, mesothelioma, skin cancer, a peripheral nerve tumor, a central nervous system tumor, lymphoma, leukemia, Noonan syndrome, cardio-facio-cutaneous syndrome, and hereditary gingival fibromatosis and a related syndrome thereof.
Type:
Application
Filed:
September 28, 2022
Publication date:
February 6, 2025
Applicant:
HAIHE BIOPHARMA CO., LTD.
Inventors:
Dongsheng LI, Shanyun GAO, Cailu LIU, Yalei CAI, Maozhi YANG, Wangyang TU, Bing YU, Qing XIE, Yixiang ZHANG, Leping LI