Abstract: The present invention provides a novel pan-RAF kinase inhibitor, comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug thereof. The present invention also provides a use or method of the compound of formula (I) in the treatment or prevention of a disorder related to the activity of RAF and/or RAS kinase.

Abstract: Provided herein are friction reducer formulations including a formate salt and an inverting surfactant, and methods of manufacturing such formulations. Methods of using the friction reducer formulations, such as for treating subterranean formations, are also provided.

Abstract: A mechanism is provided in a data processing system for refining lesion contours with combined active contour and inpainting. The mechanism receives an initial segmented medical image having organ tissue including a set of object contours and a contour to be refined. The mechanism inpaints object voxels inside all contours of the set. The mechanism calculates an updated contour around the contour to be refined based on the in-painted object voxels to form an updated segmented medical image. The mechanism determines whether the updated segmented medical image is improved compared to the initial segmented medical image. The mechanism keeps the updated segmented medical image responsive to the updated segmented medical image being improved.

Abstract: Provided are a display substrate and a manufacturing method thereof, and a display apparatus. The display substrate includes: a display area and a peripheral area surrounding the display area. The display substrate includes: a base substrate, and a light emitting structure layer, a color filter layer, a first flat layer and an optical layer disposed on the base substrate; the color filter layer is located on one side of the light emitting structure layer away from the base substrate, the first flat layer is located on one side of the color filter layer away from the base substrate, and the optical layer is located on one side of the first flat layer away from the base substrate and is configured to collect light emitted from the color filter layer.

Abstract: A mechanism is provided for seed relabeling for seed-based slice-wise lesion segmentation. The mechanism receives a lesion mask for a three-dimensional medical image volume. The lesion mask corresponds to detected lesions in the medical image volume and wherein each detected lesion has a lesion contour. The mechanism generates a distance map for a given two-dimensional slice in the medical image volume based on the lesion mask. The distance map comprises a distance to a lesion contour for each voxel of the given two-dimensional slice. The mechanism performs local maxima identification to select a set of local maxima from the distance map such that each local maximum has a value greater than its immediate neighbor points. The mechanism performs seed relabeling based on the distance map and the set of local maxima to generate a set of seeds. Each seed represents a center of a distinct component of a lesion contour.

Abstract: A lesion detection and classification artificial intelligence (AI) pipeline comprising a plurality of trained machine learning (ML) computer models is provided. First ML model(s) process an input volume of medical images (VOI) to determine whether VOI depicts a predetermined amount of an anatomical structure. The AI pipeline determines whether criteria, such as a predetermined amount of an anatomical structure of interest being depicted in the input volume, are satisfied by output of the first ML model(s). If so, lesion processing operations are performed including: second ML modal(s) processing the VOI to detect lesions which correspond to the anatomical structure of interest; third ML model(s) performing lesion segmentation and combining of lesion contours associated with a same lesion; and fourth ML models processing the listing of lesions to classify the lesions. The AI pipeline outputs the listing of lesions and the classifications for downstream computing system processing.

Abstract: Provided are a display substrate and a preparation method thereof, and a display device. The display substrate includes a base substrate, a light-emitting element disposed on the base substrate, and an encapsulation layer disposed on the light-emitting element, the display substrate further comprises a driving circuit connected with the light-emitting element and configured to drive the light-emitting element, the driving circuit comprises a driving transistor which comprises an active layer located inside the base substrate; the encapsulation layer comprises a first gradient layer and a second gradient layer stacked along a direction away from the base substrate, a content of oxygen element in the first gradient layer gradually decreases, and a content of carbon element in the second gradient layer gradually increases along the direction away from the base substrate.

Abstract: A mechanism is provided to implement a trained machine learning computer model for determining z-wise lesion connectivity. The mechanism identifies, for a given slice in a three-dimensional medical image, a first lesion in the given slice and a second lesion in an adjacent slice in the three-dimensional medical image. The mechanism determines a first intersect value between the first lesion and the second lesion with respect to the first lesion and determines a second intersect value between the first lesion and the second lesion with respect to the second lesion. The mechanism determines whether the first lesion and the second lesion belong to the same three-dimensional lesion based on the first and second intersect values.

Abstract: Provided are a method for controlling an oxygen provider and a portable device. The method includes: acquiring measurement data at a patient side; determining an oxygen demand volume and an output pattern of an oxygen provider based on the acquired measurement data and a desired oxygen fraction ratio; and controlling the oxygen provider with the oxygen demand volume and the output pattern. With the method or device for controlling an oxygen provider, oxygen with an amount that actually needed by a patient is provided to produce the blended gas to be delivered to the patient, and the blended gas delivered to the patient are regulated according to the output pattern to guarantee the blended gas is delivered in synchronization with the inspiration of the patient, so that a therapeutic effect is achieved with a lower oxygen consumption amount.

Abstract: Disclosed are a display panel, a manufacturing method thereof, and a display device. The display panel includes a base substrate and sub-pixels thereon. At least one sub-pixel includes: a light emitting element including a first electrode, a luminous functional layer and a second electrode sequentially stacked, the first electrode being closer to the base substrate than the second electrode; a metal reflective layer, between the base substrate and the first electrode; a silicon nitride layer, between the first electrode and the metal reflective layer, and including a first via hole through which the first electrode is connected with the metal reflective layer; a driving circuit including a driving transistor and a storage capacitor between the base substrate and the metal reflective layer, the driving transistor including a gate electrode connected with the storage capacitor, and source and drain electrodes, one of which is connected with the metal reflective layer.

Abstract: A light emitting diode includes a pixel unit. The pixel unit may include a first sub-pixel configured to emit white light. The first sub-pixel may include a first microcavity adjustment layer, a scattering layer, a first transparent electrode layer, a first emitting layer, and a first semi-transparent electrode layer. The scattering layer includes a plurality of patterns formed on a surface of the scattering layer. The scattering layer may be configured to reduce color cast of the first sub-pixel to be less than about 0.025 at viewing angles in a range of about ?50 degree to +50 degree.

Abstract: An approach to recommending corrective action to computing system event errors. The approach may include generating a textual description of an event error. The approach may include transforming the textual description into feature vectors with a domain-specific word embedding module. The approach may also include generating a recommendation to correct the event error based on an analysis of the feature vectors. Additionally, the recommendation may be presented for verification.

Abstract: The embodiment of the present application relates to the field of battery, and in particular relates to a battery, an electric apparatus, and a method for producing a battery. The battery of the present application includes: a battery cell; a box body configured for accommodating the battery cell and comprising a sleeve, and a first end cover and a second end cover for sealing both ends of the sleeve in a height direction respectively; a first insulating member, at least part of the first insulating member being located between the first end cover and the battery cell; and a second insulating member, at least part of the second insulating member being located between the second end cover and the battery cell; where an inner wall of the sleeve is provided with a fixing portion configured to fix the first insulating member and the second insulating member.

Abstract: Systems, computer-implemented methods, and computer program products that facilitate synthetic system fault generation are provided. According to an embodiment, a system can comprise a processor that executes the following computer-executable components stored in a non-transitory computer readable medium: a generator component that employs a trained artificial intelligence (AI) model to generate a synthetic system fault, represented as a combination of discrete parameters and continuous parameters that define a system state; and a fault assembler component that analyzes the synthetic system fault and generates textual content corresponding to the synthetic system fault.

Abstract: A display panel includes a substrate, a planarization layer disposed at a side of the substrate being provided with partitioning slots to form driving areas in an array; a first electrode layer on the planarization layer having first electrodes; wherein orthographic projections of the first electrodes on the planarization layer are within the driving areas; each of the first electrodes includes a planar center portion and an edge portion, the edge portion includes a planarization portion surrounding the center portion and a slope portion connected between the center portion and the planarization portion; a pixel definition layer on the planarization layer that exposes part of the center portion; a light-emitting functional layer covering the pixel definition layer, the center portion being exposed by the pixel definition layer and the planarization layer and a second electrode covering the light-emitting functional layer.

Abstract: A light-emitting diode includes a light-transmissive substrate, a light-emitting unit disposed on the light-transmissive substrate, an insulating layer, a first electrode and a second electrode. The insulating layer includes a first insulating portion and a second insulating portion which respectively cover an upward surface and a lateral surface of the light-emitting unit. The first and second electrodes are separately disposed on the insulating layer. At least one of the first and second electrodes extends on the first insulating portion and over a juncture between the first insulating portion and the second insulating portion.

Abstract: A display panel and a manufacturing method thereof, and an electronic device are provided. The display panel includes a substrate, an array structure layer and a light-emitting structure layer disposed on the substrate. The substrate includes a transistor, the array structure layer includes a first conductive post, a connecting electrode and a second conductive post, the light-emitting structure layer includes a first electrode, an organic light-emitting layer and a second electrode, the first electrode is located on one side of the organic light-emitting layer close to the substrate, and the second electrode is located on one side of the organic light-emitting layer away from the substrate. The first electrode includes a first sub-electrode, a second sub-electrode and a third sub-electrode.

Abstract: A catalyst including an amorphous matrix of a metallic glass including iron and phosphorous; wherein when the catalyst performs a catalytic reaction with a reactant, the metallic glass catalyst activates at least some of the reactant, and at least a portion of the catalyst at a surface of the metallic glass matrix transforms to a surface layer including a material property different from that of the metallic glass matrix being covered by the surface layer; and wherein the surface layer is arranged to maintain an amorphous structure of the metallic glass matrix and to facilitate the catalytic reaction to occur at the surface layer.

Abstract: A tightly combined GPS/BDS carrier differential positioning method is provided.

Abstract: Embodiments of the present invention provide methods, computer program products, and systems. Embodiments of the present invention can dynamically determine one or more endpoints to fulfill a user request. Embodiments of the present invention can select the dynamically determined one or more endpoints as the one or more endpoints that fulfill the user request. Embodiments of the present invention can execute the selected one or more endpoints to fulfill the user request.