Abstract: Application of glutamate dehydrogenase GdhA of Peptostreptococcus asaccharolyticus in increasing the yield of poly-?-glutamic acid from Bacillus licheniformis. The glutamate dehydrogenase GdhA of the Bacillus licheniformis WX-02 per se is replaced with the glutamate dehydrogenase derived from the Peptostreptococcus asaccharolyticus by means of homologous recombination, which significantly increases the level of synthesizing the poly-?-glutamic acid for the Bacillus licheniformis, and the yield of the obtained poly-?-glutamic acid from strains is increased at least by more than 20% compared with control strains.

Abstract: A light-emitting diode display panel, a manufacturing method thereof, and an organic light-emitting diode display device are provided. The light-emitting diode display panel includes: a base substrate including a display region and a peripheral region surrounding the display region; a plurality of sub-pixels located in the display region and located at a side of the base substrate; a color-resistance layer located at a side of a second electrode in the sub-pixel away from the base substrate; and a light-blocking structure located in the peripheral region and being an annular structure surrounding the plurality of sub-pixels. The light-blocking structure includes a first light-blocking structure and a second light-blocking structure. The first light-blocking structure includes at least one interval extending in a direction from the display region pointing to the peripheral region. The second light-blocking structure at least fully fills the interval.

Abstract: A device and method for preparing a thermosetting bonded magnet are provided, the device includes a compressed air glue feeding tank and a composite-function mold. A feeding end of the compressed air glue feeding tank is connected to the composite-function mold. The composite-function mold includes a housing, the housing is disposed at an upper end and a lower end of the composite-function mold, and the housing includes a polytetrafluoroethylene upper cover and a polytetrafluoroethylene lower cover; the polytetrafluoroethylene upper cover and the polytetrafluoroethylene lower cover are respectively disposed at the upper end and the lower end of composite-function mold. The method uses a silica gel material as a binder for anisotropic magnets, and the selected raw materials and process are suitable for quickly obtaining a uniform magnet slurry. The curing process is controllable, and there is no organic solvent or heating during the mixing process.

Abstract: A JAK inhibitor may be used in preparation of a medicament. The medicament may be used for preventing and/or treating a disease or condition associated with an antitumor agent in a subject. A pharmaceutical composition may include the JAK inhibitor as may a kit. The JAK inhibitor may include a compound of formula (I) or a pharmaceutically acceptable salt thereof: Q, X, Y, and Z being independently N or C, and R1, R2 and R3 being independently a 5-6-membered aromatic ring, 5-6-membered heteroaromatic ring, 5-6-membered cycloalkyl, 5-6-membered heterocycloalkyl, amino, or amido, the aromatic ring, heteroaromatic ring, cycloalkyl, and/or heterocycloalkyl being optionally substituted by a substituent.

Abstract: Methods for preparing a metallocene-based catalyst composition that can impact the long chain branching of ethylene homopolymers and copolymers produced using the catalyst composition are described. The catalyst composition can be prepared by contacting a metallocene compound, a hydrocarbon solvent, and a first organoaluminum compound for a first period of time to form a metallocene solution, and then contacting the metallocene solution with an activator-support and a second organoaluminum compound for a second period of time to form the catalyst composition.

Abstract: Ethylene-based polymers are characterized by a density from 0.92 to 0.955 g/cm3, a HLMI of less than 35 g/10 min, and a ratio of a number of short chain branches (SCBs) per 1000 total carbon atoms at Mz to a number of SCBs per 1000 total carbon atoms at Mn in a range from 11.5 to 22. These polymers can have a higher molecular weight (HMW) component and a lower molecular weight (LMW) component, in which a ratio of a number of SCBs per 1000 total carbon atoms at Mn of the HMW component to a number of SCBs per 1000 total carbon atoms at Mn of the LMW component is in a range from 10.5 to 22. These ethylene polymers can be produced using a dual catalyst system containing an unbridged metallocene compound with an indenyl group having at least one halogen-substituted hydrocarbyl substituent with at least two halogen atoms, and a single atom bridged metallocene compound with a fluorenyl group and a cyclopentadienyl group.

Abstract: A monocrystalline SiC substrate comprising a first surface and a second surface. The first surface comprises pinning regions and a device region. Each of the pinning regions is configured to provide a potential well which is capable to attract dislocations from a region surrounding said pinning region. The device region is configured to provide a part of the monocrystalline SiC substrate for manufacturing a semiconductor device. The device region is surrounded by the pinning regions, and a density of dislocations in a central portion of the device region is smaller than a density of dislocations in an edge of the device region due to the pinning regions. The pinning regions surrounding the device region attracts dislocations of the device region into the edge portion, so that the density of dislocations in the central portion is reduced. A yield of the semiconductor devices is improved.

Abstract: The present invention discloses an acoustic module waterproof protection mechanism, including an acoustic module arranged in a housing, an acoustic port provided on an outer wall of the housing and communicating with the acoustic module, a waterproof sound-permeable membrane arranged on an inner wall of the housing and covering the acoustic port, the an acoustic module waterproof protection mechanism further includes a waterproof valve assembly embedded in a hole wall of the acoustic port in a stretchable manner, which is used to stretch into the acoustic port to block the acoustic port when an external water pressure is greater than an air pressure in the housing.

Abstract: A model file management method includes that a terminal device receives a storage address of a target model file package from a server and the terminal device obtains the target model file package based on the storage address of the target model file package, where the target model file package is based on a parameter of a model file package locally stored in the terminal device and a parameter of a model file package managed by the server. In an artificial intelligence (AI) field, an application may implement a specific function by using an AI model file. An application is decoupled from an AI model file such that the terminal device performs centralized management on a general model file.

Abstract: An identity certificate may be issued to a blockchain node. The issuance may include issuing a first identity certificate to a first terminal and receiving a second identity certificate issuance request that is from the first terminal. A second identity certificate may be issued to the first terminal, and a third identity certificate issuance request is received from the second terminal. A third identity certificate is issued to the second terminal, so that the second terminal forwards the third identity certificate to the third terminal.

Abstract: The present invention relates to the field of pharmaceutical and chemical engineering, and specifically relates to a weakly acidic microenvironment-sensitive aptamer for tumors, a triptolide conjugate. The conjugate is formed by conjugation between the 14-position hydroxyl group of triptolide and the aptamer via an acetal ester linking bond, which is an acid-sensitive linking bond with a cleavage condition of (pH=3.5-6.5), which is much less pH-sensitive and is more likely to cleave under the tumor microenvironment. Based on the characteristics of the aptamer targeting the highly expressed proteins on the membrane surface of tumor cells, the conjugate delivered triptolide targeted to tumor cells and mediated endocytosis to reach the lysosome; based on the characteristics of the acidic environment of lysosomes, the acetal ester linking bond released intact triptolide in the lysosomal acidic environment, targeting and killing of tumor cells.

Abstract: Described herein are T cells engineered to express a chimeric antigen receptor (CAR), such as an anti-mesothelin CAR alone or in combination with a follicle-stimulating hormone receptor (FSHR) binding domain and/or a dominant negative transforming growth factor-? receptor II (dnTGF?RII) for the treatment of diseases associated with mesothelin expression. Also described are T cells engineered to express a modified T cell receptor (TCR).

Abstract: The present disclosure provides a non-contact fatigue detection system and method based on rPPG. The system and method adopt multi-thread synchronous communication for real-time acquisition and processing of rPPG signal, enabling fatigue status detection. In this setup, the first thread handles real-time rPPG data capture, storage and concatenation, while the second thread conducts real-time analysis and fatigue detection of rPPG data. Through a combination of skin detection and LUV color space conversion, rPPG raw signal extraction is achieved, effectively eliminating interference from internal and external environmental facial noise; Subsequently, an adaptive multi-stage filtering process enhances the signal-to-noise ratio, and a multi-dimensional fusion CNN model ensures accurate detection of respiration and heart rate.

Abstract: A flexible probe for microLED defect detection includes: a flexible base and a flexible circuit film layer. The flexible base includes a flexible substrate and flexible protrusions located on the flexible substrate. A circuit for illuminating a microLED to be detected is provided inside the flexible circuit film layer. The flexible circuit film layer is attached to a surface on a side of the flexible base on which the flexible protrusions are provided, at least a portion of the circuit of the flexible circuit film layer is located on the flexible protrusions, and when the flexible probe for MicroLED defect detection is placed on the MicroLED, the circuit on the flexible protrusions abuts against pins of the MicroLED to be detected and is electrically connected to the pins.

Abstract: The present disclosure provides a method and device for intelligent control of heating furnace combustion based on a big data cloud platform, which relates to the technical field of artificial intelligence control. The method includes: construction of big data cloud platform based on production and operation parameters of the heating furnace; identification of key factors in the production process of the heating furnace by using big data mining technology; independent deployment of traditional heating furnace combustion control systems based on the mechanism model; and integration of cloud platform big data expert knowledge base and the heating furnace combustion intelligent control system.

Abstract: The present disclosure relates to a method and apparatus for interacting with an application program, and an electronic device. The method includes: playing back multimedia content of a target object; and displaying, in a playback page for the multimedia content, an interaction component of the target object. The interactive component comprises: an integrated interactive card and action button. The interactive card is used for describing introductory content of the target object. The introductory content of the target object comprises: the icon of the target object, first basic information of the target object, and extension information of the target object. The action button is used for providing an entry to an interactive page of the target object.

Abstract: Disclosed herein are ethylene-based polymers generally characterized by a melt index of less than 1 g/10 min, a density from 0.93 to 0.965 g/cm3, a CY-a parameter at 190° C. of less than 0.2, an average number of short chain branches per 1000 total carbon atoms of the polymer in a molecular weight range of 400,000 to 600,000 g/mol that is greater than that in a molecular weight range of 40,000 to 60,000 g/mol, and an average number of long chain branches per 1000 total carbon atoms of the polymer in a molecular weight range of 400,000 to 600,000 g/mol that is greater than that in a molecular weight range of 4,000,000 to 6,000,000 g/mol.

Abstract: A preparation method of a Mn-MOF-based cold-adapted nanozyme and a preparation method thereof. The method includes: preparing a Mn(CH3COO)3·2H2O solution by fully dissolving a manganese-containing precursor Mn(CH3COO)3·2H2O in a mixed solution of an alcohol and distilled water; wherein the alcohol is ethanol or methanol; preparing a benzenetricarboxylic acid solution by fully dissolving benzenetricarboxylic acid solid in the mixed solution of the alcohol and distilled water; reacting the Mn(CH3COO)3·2H2O solution with the benzenetricarboxylic acid solution sufficiently using co-precipitation; and centrifuging and removing a supernatant to obtain the MnBTC, where the MnBTC is nano-metal-organic framework (nano-MOF) with a particle size of less than 10 nm.

Abstract: Fluorided silica-coated alumina activator-supports have a bulk density from 0.15 to g/mL, a total pore volume from 0.85 to 2 mL/g, a BET surface area from 200 to 500 m2/g, an average pore diameter from 10 to 25 nm, and from 80 to 99% of pore volume in pores with diameters of greater than 6 nm. Methods of making the fluorided silica-coated alumina activator-supports and using the fluorided silica-coated aluminas in catalyst compositions and olefin polymerization processes also are described. Representative ethylene-based polymers produced using the compositions and processes have a melt index of 0.1 to 10 g/10 min and a density of 0.91 to 0.96 g/cm3, and contain from 70 to 270 ppm solid oxide and from 2 to 18 ppm fluorine.

Abstract: The present invention provides a vertical feeding and wafer inserting integrated machine, comprising a rack and a silicon wafer transfer device provided on the rack; a carrying-transporting water tank for carrying and transporting silicon wafers is provided on one end of the rack; the rack is further provided with a feeding unit for conveying the silicon wafers in the carrying-transporting water tank to a silicon wafer transfer belt a wafer inserting unit for inserting the silicon wafers into wafer baskets is provided on one end, away from the feeding unit, of the silicon wafer transfer device, and a wafer basket arraying mechanism is provided on the other end of the wafer inserting unit; and a washing manipulator for transferring grouped wafer baskets to a washing procedure is further correspondingly provided on the rack.