Abstract: Disclosed is a compound which is 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentaazaheptacyclo[27.7.1.14,7.011,15.016,21.020,24.030,35]octatriaconta-1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaene-23-carboxylic acid (Formula I) and enantiomers and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions of 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentaazaheptacyclo[27.7.1.14,7.011,15.016,21.020,24.030,35]octatriaconta-1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaene-23-carboxylic acid, and enantiomers and pharmaceutically acceptable salts thereof, and methods of treating cancer with such compounds and compositions.

Abstract: The present invention provides an oligodeoxy nucleotide for preparing drugs for inhibiting tumor growth and an application thereof. The core sequence of the oligodeoxy nucleotide is TTYSGGAAWT, wherein Y is C or T; S is C or G; and W is A or T. The oligodeoxy nucleotide above further comprises an antisense strand and a modified type thereof. The oligodeoxy nucleotide according to the present invention plays a role of inhibiting the tumor growth in vitro and vivo, and is expected to be used for preparing drugs for inhibiting tumor growth, with high specificity and high inhibition ratio.

Abstract: The present invention provides an oligodeoxy nucleotide for preparing drugs for inhibiting tumor growth and an application thereof. The core sequences of the oligodeoxy nucleotide is TTTCSCGCS, wherein S is C or G. The oligodeoxy nucleotide above further comprises an antisense strand and a modified type thereof. The oligodeoxy nucleotide according to the present invention plays a role of inhibiting the tumor growth in vitro and vivo, and is expected to be used for preparing drugs for inhibiting tumor growth, with high specificity and high inhibition ratio.

Abstract: The present invention provides an oligodeoxy nucleotide for preparing drugs for inhibiting tumor growth and an application thereof. The core sequence of the oligodeoxy nucleotide is RGGGAHTTYCS, wherein R is G or A; H is A or C or T; Y is C or T; S is C or G. The oligodeoxy nucleotide above further comprises an antisense strand and a modified type thereof. The oligodeoxy nucleotide according to the present invention plays a role of inhibiting the tumor growth in vitro and vivo, and is expected to be used for preparing drugs for inhibiting tumor growth, with high specificity and high inhibition ratio.

Abstract: A preparation method of a Decoy nucleic acid cationic liposome carrier including: (1) mixing dioleoyl phosphoethanolamine and (2,3-dioleoyl-propyl)-trimethylamine in a mass ratio of 4:1 to 1:4, and adding an organic solvent to obtain a mixed solution through dissolution; (2) completely evaporating the organic solvent in the mixed solution obtained in step (1), dissolving the remaining solid fraction by using an HEPES buffer solution, firstly hydrating the solution for 30 to 60 min, and then ultrasonically processing the solution for 30 to 60 min; (3) filtering the mixed system obtained after processing in the step (2) by a membrane of 0.4 to 0.8 ?m, then filtering the mixed system by a membrane of 0.03 to 0.2 ?m, and preparing uniformly to distributed blank liposome with small grain size; and (4) mixing the blank liposome with protamine and Decoy nucleic acid according to a mass ratio of (50 to 120):(10 to 20):1, and incubating for 12 to 24 h at the temperature of 2° C. to 8° C.

Abstract: A method for synthesizing florfenicol comprises the steps of cyclization, selective reduction, fluorination, ring opening, deprotection, acylation, esterification with sulfonic acids, epimerization and hydrolysis. Florfenicol is prepared by successively purifying, selectively reducing, and epimerizing chiral (R)-amino ketones. This improves atom economy, reduces waste water pollution and accordingly reduces costs for treating waste water and pollution to the environment, thus lowering costs and simplifying the process. Furthermore, triethylamine hydrofluoride is used as a fluorinating reagent, resulting in improved safety, because of the use of liquid reaction conditions as compared to gaseous reaction conditions, and reduced corrosion to the reaction equipment.

Abstract: Provided herein are pyranonaphthoquinone compounds and methods of using pyranonaphthoquinone compounds. The method of using the pyranonaphthoquinone compounds includes selectively inhibiting 4E-BP1 phosphorylation by administering at least one pyranonaphthoquinone or pyranonaphthoquinone analog to a subject in need thereof.

Abstract: A converter circuit includes an inverter and a controller. The inverter is configured to receive an input voltage and to convert the input voltage into a primary-side alternating-current (AC) voltage in a first inversion mode or a second inversion mode. Each of a first switch unit and a second switch unit in the inverter includes switches. When the converter circuit works in the first inversion mode, the controller controls switches of the first switch unit and the second switch unit to cooperatively switch on and switch off periodically according to an output voltage corresponding to the primary-side AC voltage. When the converter circuit works in the second inversion mode, the controller controls the first switch unit to operate independently, in which the switches of the first switch unit switch on and switch off periodically.

Abstract: The present disclosure provides a power supply system and a method for supplying power. The power supply system includes an isolating circuit and a first converting circuit. The isolating circuit includes an input terminal and an output terminal. The input terminal of the isolating circuit is configured to connect with a second input source and receive the alternating current or direct current outputted from the second input source. The first converting circuit includes an input terminal and an output terminal. The input terminal of the first converting circuit is configured to connect with a first input source and the output terminal of the isolating circuit. The first converting circuit is configured to convert electricity to output the direct current.

Abstract: A converter circuit includes an inverter and a controller. The inverter is configured to receive an input voltage and to convert the input voltage into a primary-side alternating-current (AC) voltage in a first inversion mode or a second inversion mode. Each of a first switch unit and a second switch unit in the inverter includes switches. When the converter circuit works in the first inversion mode, the controller controls switches of the first switch unit and the second switch unit to cooperatively switch on and switch off periodically according to an output voltage corresponding to the primary-side AC voltage. When the converter circuit works in the second inversion mode, the controller controls the first switch unit to operate independently, in which the switches of the first switch unit switch on and switch off periodically.

Abstract: Methods and materials for reducing organ transplant rejection or minimizing ischemia or ischemia/reperfusion injury in a subject are described. The methods include administering a fat emulsion before or after the organ transplant or before, at the onset of, or after the ischemic event.

Abstract: A method in a call information server for a two-way radio system includes accessing, by the server, group list information associating the plurality of subscriber units with one or more groups; receiving, at the server, updates related to presence information, availability information, and the group list information; and confirming, by the server, for each particular subscriber unit indicated in a particular group list as forming a particular group, the particular subscriber unit's participation in a particular group call to the particular group, as a function of the presence information, the availability information, and the group list information. A call information server and a two-way radio system are also disclosed.

Abstract: A method for controlling a resonant DC/DC power converting circuit is provided. The resonant DC/DC power converting circuit having a converter output and a converter input comprises at least two converters having similar structures and outputs connected in parallel as said converter output, and a controller. Each converter comprises a full-bridge inverter unit and a resonant unit. The full-bridge inverter unit is configured with at least four switches. The resonant unit is coupled with said full-bridge inverter unit. The controller outputs two groups of driving control signals to drive four switches in said two converters respectively. The method comprises: making said two converters operate at the same frequency and interleave with preset phase shift; and making two of driving control signals in one group interleave with preset angle to reduce output current of said converter corresponding controlled thereby, when output currents of said two converters are not approximately equal.

Abstract: A control unit is selected from a plurality of narrowband mobile stations also forming an ad-hoc network. The control unit is configured to control and manage a narrowband trunking operation via the ad-hoc network. The control unit receives a call request over a narrowband control channel from a first mobile station, assigns a pair of narrowband traffic channels for a call associated with the call request, chooses two mobile stations from the plurality of mobile stations to act as a narrowband repeater for the call, the pair including a respective receiver mobile station and a respective transmitter mobile station, informs the repeater mobile stations of the assignment and of the assigned traffic channels for the call, and grants the call request over the narrowband control channel. The grant includes an indication of the assigned traffic channels on which the repeater mobile stations can be located for the call.

Abstract: The present invention discloses a new florfenicol synthesizing method. The method synthesizes florfenicol products meeting requirements of the Drug Administration by a series of combinations of cyclization, selective reduction, fluorinated open ring, deprotection and acylation, hydroxyl sulfoacid esterified configuration converting reaction, hydrolysis reaction and the like. The synthesizing method of the present invention utilizing chiral amine closed-ring aziridine three-membered ring uses a physical separation method to repeatedly purify chiral aminoketone of high yield obtaining single R configuration, and uses selective reduction and converts the configuration to obtain florfenicol, greatly improving atom economy, while avoiding waste water pollution caused by the existing process, and greatly reducing costs for treating waste water and reducing pollution to the environment, thus lowering costs and simplifying the process.

Abstract: The present invention discloses a capsule endoscope and a method to prevent the capsule from being covered by a residue or mucous in a patient's digestive tract. The capsule endoscope comprises an improved surface, preventing a residue or mucous to adhere onto the surface of the capsule, and in the unlikely event that a residue or a mucous is collected by the capsule the improved surface can allow an easy and successful clean before an image is taken.

Abstract: A method for controlling a resonant DC/DC power converting circuit is provided. The resonant DC/DC power converting circuit having a converter output and a converter input comprises at least two converters having similar structures and outputs connected in parallel as said converter output, and a controller. Each converter comprises a full-bridge inverter unit and a resonant unit. The full-bridge inverter unit is configured with at least four switches. The resonant unit is coupled with said full-bridge inverter unit. The controller outputs two groups of driving control signals to drive four switches in said two converters respectively. The method comprises: making said two converters operate at the same frequency and interleave with preset phase shift; and making two of driving control signals in one group interleave with preset angle to reduce output current of said converter corresponding controlled thereby, when output currents of said two converters are not approximately equal.

Abstract: A method and computer program product for defining a first subnet for a first end portion of a physical network. The first subnet includes: a first NIC IP address, a first gateway IP address, and a first logical path connecting the first NIC IP address and the first gateway IP address. A second subnet is defined for a second end portion of the physical network. The second subnet includes: a second NIC IP address, a second gateway IP address, and a second logical path connecting the second NIC IP address and the second gateway IP address. A supernet is defined for a central portion of the physical network. The first subnet is coupled to the second subnet via the supernet to enable point-to-point routing of data through the physical network.

Abstract: A control unit is selected from a plurality of narrowband mobile stations also forming an ad-hoc network. The control unit is configured to control and manage a narrowband trunking operation via the ad-hoc network. The control unit receives a call request over a narrowband control channel from a first mobile station, assigns a pair of narrowband traffic channels for a call associated with the call request, chooses two mobile stations from the plurality of mobile stations to act as a narrowband repeater for the call, the pair including a respective receiver mobile station and a respective transmitter mobile station, informs the repeater mobile stations of the assignment and of the assigned traffic channels for the call, and grants the call request over the narrowband control channel. The grant includes an indication of the assigned traffic channels on which the repeater mobile stations can be located for the call.

Abstract: A power factor correction converter and a control method are disclosed. A power factor correction converter includes a power conversion module, a capacitor, a third switch unit, and a fourth switch capacitor. The power conversion module includes a first switch, a second switch, a first switch unit, a second switch unit, and an inductor. The first switch is coupled to a first input terminal. The second switch is coupled to a second input terminal. The first switch is coupled between an output terminal and the first switch. The second switch is coupled between the output terminal and the second switch. The inductor is coupled between the first and the second switch unit. The capacitor is coupled to the output terminal. The third switch unit is coupled between the second input terminal and the capacitor. The fourth switch unit is coupled between the first input terminal and the capacitor.