Abstract: A power supply system is disclosed that includes a first interleaved power supply, a second interleaved power supply, and a common electromagnetic interference filter. The common electromagnetic interference filter is configured to provide DC power from a DC power source to both the first interleaved power supply and the second interleaved power supply. In one example, the common electromagnetic interference filter comprises a localized filter stage configured to receive DC power from the DC power source, and a distributed filter stage configured to receive DC power from the localized filter stage. The distributed filter stage includes a first set of common mode capacitors electrically connected to and physically proximate input power lines of the first interleaved power supply, and a second set of common mode capacitors electrically connected to and physically proximate input power lines of the second interleaved power supply.

Abstract: A power conversion system is disclosed that provides multiphase power, including phase voltages for each phase of the multiphase power. The system comprises a plurality of inverters that generate PWM output voltages based on PWM control signals. A plurality of inductive components is configured to receive the PWM output voltages to generate the phase voltages. The PWM output voltages cause circulating current flows through the inductive components. A voltage controller is employed that is responsive to the phase voltages to generate voltage modulation signals corresponding to the phase voltages. A plurality of current sharing channels are respectively associated with each of the plurality of inductive components and are configured generate current sharing modulation signals in response to the circulating current flows. The PWM control signals are generated based on modulation signals obtained by combining the current sharing modulation signals and voltage modulation signals.

Abstract: The invention provides siRNA compositions that interfere with viral replication in respiratory viral infections, including respiratory syncytial virus and avian influenza A, including the H5N1 strain. The invention further provides uses of the siRNA compositions to inhibit expression of viral genes in respiratory virus-infected cells, and to uses in the treatment of respiratory virus infections in a subject. Generally the invention provides polynucleotide that includes a first nucleotide sequence of 15 to 30 bases that targets the genome of a respiratory syncytial virus or an influenza A virus, a complement thereof, a double stranded polynucleotide or a hairpin polynucleotide. Additionally the invention provides vectors, cells and pharmaceutical compositions containing siRNA sequences.

Abstract: The invention provides siRNA compositions that interfere with viral replication in respiratory viral infections, including respiratory syncytial virus and avian influenza A, including the H5N1 strain. The invention further provides uses of the siRNA compositions to inhibit expression of viral genes in respiratory virus-infected cells, and to uses in the treatment of respiratory virus infections in a subject. Generally the invention provides polynucleotide that includes a first nucleotide sequence of 15 to 30 bases that targets the genome of a respiratory syncytial virus or an influenza A virus, a complement thereof, a double stranded polynucleotide or a hairpin polynucleotide. Additionally the invention provides vectors, cells and pharmaceutical compositions containing siRNA sequences.

Abstract: Methods and compositions are provided for down regulation of target gene expression in vivo by RNA interference. The methods are useful for target discovery and validation of gene-based drug development, and for treatment of human diseases.