Abstract: Provided herein are compounds, compositions, and methods useful for inhibiting protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), and for treating related diseases, disorders and conditions favorably responsive to PTPN1 or PTPN2 inhibitor treatment, e.g., a cancer or a metabolic disease.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

Abstract: The present invention provides an aqueous dispersion as a biobased binder and an aqueous coating composition comprising such aqueous dispersion and showing balanced stain resistance, freeze-thaw stability, and anti-clogging properties.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

Abstract: The invention discloses biomarkers associated with residual feed intake of growing chickens in growing period and application thereof, which belongs to the field of poultry breeding technology. These biomarkers include one or multiple components of 13(S)-HOTrE, 20-carboxy-LTB4, Traumatic acid, 15-deoxy-delta-12,14-PGJ2, LysoPC(20:2(11Z,14Z)), phosphorycholine, Sphingosine, malic acid, D-4?-Phosphopantothenate, and Spermidine. The invented biomarkers can realize the identification of the residual feed intake, which has high sensitivity and specificity, and is expected to become a new method for the identification of the residual feed intake.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

Abstract: The present invention provides an antimicrobial coating composition comprising (i) a polymer emulsion and (ii) from 20 ppm to 6000 ppm, by dry weight based on total dry weight of the coating composition, a silver, and the polymer emulsion comprises, as polymerized units, (a) ethylenically unsaturated nonionic monomers, and (b) from 0.01% to 20%, by dry weight based on total dry weight of the polymer emulsion, heterocyclic group-containing monomers.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.

Abstract: Disclosed are a benzonitric heterocyclic compound, a preparation method therefor and the use thereof. Provided in the present invention is a benzonitric heterocyclic compound represented by formula I, or a pharmaceutically acceptable salt thereof, which can be used as a histone deacetylase inhibitor, has a selective inhibitory effect on HDAC6, and has characteristics such as a high efficiency, low toxicity and ideal pharmacokinetic properties.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

Abstract: Provided herein are compounds, compositions, and methods useful for inhibiting protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), and for treating related diseases, disorders and conditions favorably responsive to PTPN1 or PTPN2 inhibitor treatment, e.g., a cancer or a metabolic disease.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

Abstract: The present application relates to the technical field of lifting equipment, and provides a traction machine and a lifting equipment. The traction machine includes traction pulleys, traction ropes driven by the traction pulleys and fixed pulleys for changing directions of the traction ropes. The fixed pulley is provided with a sensor sensing member rotating with the fixed pulley, a traction machine sensor is arranged beside the fixed pulley; the traction machine sensor is configured to detect a rotation speed of the sensor sensing member, and send the rotation speed to a controller of the traction machine; the controller controls a rotation of the traction pulley according to detected data of the traction machine sensor. Since this kind of traction machine is provided with the sensor sensing member and the traction machine sensor, it is capable of detecting whether the traction machine has an abnormal operation, and stopping the traction machine immediately in an abnormal state.

Abstract: An aqueous polymer dispersion and an aqueous coating composition comprising such aqueous polymer dispersion that shows good F/T stability and satisfactory anti-clogging properties and provides coatings with good hydrophobic stain resistance.

Abstract: A stable aqueous dispersion of multi-stage polymeric particles comprising a polymer and an oligomer, and an aqueous freeze-thaw stable coating composition comprising the aqueous dispersion providing coatings made therefrom with acceptable scrub resistance.

Abstract: An aqueous polymer composition comprising an acetoacetoxy functional polymer, a metal pyrithione compound, and TEMPO and/or its derivative, showing less yellowing.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.