Patents by Inventor Qingyun Liu

Qingyun Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200283445
    Abstract: A dihydropyrimidine compound and use as a medicament, especially application as a medicament used for treating and preventing hepatitis B, specifically, is a compound having Formula (I) or (Ia), or a stereisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, wherein the variables of the formulas are as defined in the specification; and also includes the use of the compound having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof as a medicament, especially use as a medicament for treating and preventing hepatitis B.
    Type: Application
    Filed: October 17, 2018
    Publication date: September 10, 2020
    Applicant: SUNSHINE LAKE PHARMA CO., LTD.
    Inventors: Xinchang LIU, Qingyun REN, Guanghua YAN, Siegfried GOLDMANN, Yingjun ZHANG
  • Publication number: 20200270230
    Abstract: Disclosed are a class of ?-opioid receptor agonists and a preparation method therefor and the use thereof in the field of medicine, belonging to the field of medicinal chemistry. The ?-opioid receptor agonists significantly increase the selectivity for a G protein signaling pathway, and not only can exhibit excellent pharmacodynamic effects, but also significantly improve safety.
    Type: Application
    Filed: September 17, 2018
    Publication date: August 27, 2020
    Inventors: Xin Xu, Zhen Zhang, Yunfei Li, Liming Zhang, Fengying Guo, Qingyun Jiang, Dongsheng Li, Linli Zhang, Jinqian Song, Lei Liu, Qiang Liu, Jing Su, Yijin Wang, Jian Ge
  • Publication number: 20200263500
    Abstract: The invention discloses an anti-rotating device of non-rotating sleeve. The anti-rotating device is connected with the non-rotating sleeve in such way so that the anti-rotating device can transmit circumferential acting force to the non-rotating sleeve, thus the non-rotating sleeve are prevented from rotating, the anti-rotating device comprises an anti-rotating member and a resilient member, the anti-rotating member can move in a generally radial direction of the non-rotating sleeve, and the resilient member acts on the anti-rotating member and provides acting force being substantially radially outward for the anti-rotating member.
    Type: Application
    Filed: March 2, 2018
    Publication date: August 20, 2020
    Applicant: Institute of Geology and Geophysics, Chinese Academy of Sciences
    Inventors: Qingbo LIU, Qingyun DI, Tsili WANG, Wenxuan CHEN, Jiansheng DU, Yongyou YANG, Xinzhen HE, Linfeng HONG, Qijun XIE
  • Publication number: 20200263503
    Abstract: A hybrid rotary guiding device, includes: rotating shaft, the rotating shaft is used to drive the head of a drill tool to rotate, the rotating shaft includes an upper shaft portion, a lower shaft portion, and a steerable portion, a separation distance exists between the upper shaft portion and the lower shaft portion in the axial direction, the upper shaft portion and the lower shaft portion are steerably connected by the steerable portion; the upper shaft portion is installed with at least three first hydraulic mechanisms, and the lower shaft portion is installed with at least three second hydraulic mechanisms, the second hydraulic mechanism is adapted to drive a pushing member against the wall of the well to guide the head of a drill tool, the first hydraulic mechanism and the second hydraulic mechanism are configured so that the first hydraulic mechanism can drive the second hydraulic mechanism to drive the pushing member.
    Type: Application
    Filed: March 2, 2018
    Publication date: August 20, 2020
    Applicant: Institute of Geology and Geophysics, Chinese Academy of Sciences
    Inventors: Qingbo LIU, Qingyun DI, Tsili WANG, Wenxuan CHEN, Jiansheng DU, Yongyou YANG, Xinzhen HE, Linfeng HONG, Qijun XIE
  • Patent number: 10729781
    Abstract: Isolated or recombinant anti-LGR4 monoclonal antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: August 4, 2020
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Qingyun Liu, Xing Gong, Kendra Carmon
  • Publication number: 20200224498
    Abstract: An embodiment of the present disclosure provides a multi-path combined high-low voltage plasma drilling method, a drill bit for drilling and a drill bit apparatus for drilling. The drilling method comprises: disposing a plurality of mutually independent plasma generators on a plasma drill bit, wherein the plasma generators are independently connected to a plasma power source on the ground through wires; allowing each of the plasma generators to eject high-frequency pulsed plasma arc under the control of its corresponding combined high-low voltage pulse power source on the ground; ejecting the high-frequency pulsed plasma arc onto a wall of a drilling well, forming impulsive high temperature thermal shock stress inside the rocks on the wall of the drilling well; and breaking the rocks under the shock of thermal stress to form rock debris.
    Type: Application
    Filed: January 6, 2020
    Publication date: July 16, 2020
    Inventors: Yonghong LIU, Qiang SUN, Qingyun LI, Renjie JI, Baoping CAI, Xiaopeng LI, Yancong HAN, Peng LIU, Xinlei WU, Hang DONG, Fan ZHANG
  • Publication number: 20200217143
    Abstract: The present disclosure provides a multi-path combined high-low voltage plasma rock-breaking drill bit, drill bit apparatus and drilling method. The multi-path combined high-low voltage plasma rock-breaking drill bit comprises: a drill bit body, insulators, plasma generators, drilling fluid outlets, plasma integrated pipelines, a drilling fluid pipe; wherein a plurality of plasma generators are distributed on the same drill bit body; the axis of the plasma generator and the axis of the drill bit body form a certain included angle; each of the plasma generators is independently connected to the ground through its respective plasma integrated pipeline and operates independently; and drilling fluid flows out of the drilling fluid outlets, takes away the heat generated by the operation of the plasma generators, thereby cooling the plasma generators.
    Type: Application
    Filed: January 6, 2020
    Publication date: July 9, 2020
    Inventors: Yonghong LIU, Qiang SUN, Qingyun LI, Renjie JI, Baoping CAI, Xiaopeng LI, Yancong HAN, Peng LIU, Dege LI, Xinlei WU, Fan ZHANG
  • Publication number: 20200217140
    Abstract: An embodiment of the present disclosure provides a multi-path combined high-low voltage plasma drilling power source and drilling system. The multi-path combined high-low voltage plasma drilling power source comprises a high-voltage DC circuit, low-voltage DC circuits, high-voltage breakdown modules and an upper computer; wherein the high-voltage DC circuit is connected with the low-voltage DC circuits through cables; the low-voltage DC circuits and the high-voltage breakdown modules simultaneously supply power to plasma generators through cables; the upper computer monitors the low-voltage DC circuits in real time; and the same power source comprises a plurality of low-voltage DC circuits and high-voltage breakdown modules.
    Type: Application
    Filed: January 2, 2020
    Publication date: July 9, 2020
    Inventors: Yonghong LIU, Qiang SUN, Qingyun LI, Renjie JI, Baoping CAI, Xiaopeng LI, Yancong HAN, Hang DONG, Xinlei WU, Peng LIU, Dege LI
  • Patent number: 10693268
    Abstract: The present disclosure relates to a conductive slip ring for logging while drilling (LWD) instrument. The present disclosure utilizes a mechanical conductive slip ring to solve the problems of transmission of electric power and signals between two structures that have relative rotation, and the conductive slip ring has a simple structure, doesn't involve any complex circuit, and has low cost and high reliability. With the conductive slip ring in the present disclosure, there is no power transmission efficiency problem or signal transmission error rate problem. The conductive slip ring has high temperature-resistant, pressure-proof, and vibration-roof abilities, and can be applied widely.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: June 23, 2020
    Assignee: INSTITUTE OF GEOLOGY AND GEOPHYSICS CHINESE ACADEMY OF SCIENCES
    Inventors: Xinzhen He, Qingyun Di, Wenxuan Chen, Jiansheng Du, Qingbo Liu
  • Publication number: 20200190909
    Abstract: A rotary guiding device comprises a rotating shaft, the rotating shaft is used to drive a tool head to rotate, and the rotating shaft includes at least one steerable portion; a first non-rotating body and a second non-rotating body, the first non-rotating body and the second non-rotating body are substantially in a non-rotating state in a circumferential direction thereof relative to the rotating shaft when the rotating shaft drives the tool head to rotate; a guide driving mechanism, the guide driving mechanism is configured to connect the first non-rotating body and the second non-rotating body, the guide driving mechanism is adapted to generate a substantially axial driving force to change the relative direction between the first non-rotating body and the second non-rotating body, thereby changing the orientation of the tool head.
    Type: Application
    Filed: March 2, 2018
    Publication date: June 18, 2020
    Applicant: INSTITUTE OF GEOLOGY AND GEOPHYSICS, CHINESE ACADEMY OF SCIENCES
    Inventors: Qingbo LIU, Qingyun DI, Tsili WANG, Wenxuan CHEN, Jiansheng DU, Yongyou YANG, Xinzhen HE, Linfeng HONG, Qijun XIE
  • Publication number: 20200133587
    Abstract: Techniques manage a redundant array of independent disks. In such a technique, an instruction to expand the RAID is received, the RAID being formed by a first group of storage devices and including a first group of RAID extents. A second group of RAID extents created on a second group of storage devices and logical units are created on the second group of RAID extents. In response to receiving an indication for a failure of the creation of the second group of RAID extents or the logical units, a notification is generated for indicating a failure of the expansion of the RAID without triggering a shuffling operation, the shuffling operation causing storage extents in the first and second groups of RAID extents to be distributed in the first and second groups of storage devices.
    Type: Application
    Filed: September 27, 2019
    Publication date: April 30, 2020
    Inventors: Qingyun Liu, Jian Gao, Tianshu Sun, Sihang Xia, Changyu Feng
  • Publication number: 20200115381
    Abstract: A dihydropyrimidine compound and a pharmaceutical application thereof, especially the application used for treating and preventing HBV diseases. Specifically, a compound having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof, wherein the variables of the formulas are as defined in the specification. Also, use of the compound having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof as a medicine, especially for treating and preventing HBV diseases.
    Type: Application
    Filed: June 25, 2018
    Publication date: April 16, 2020
    Applicant: NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED
    Inventors: Qingyun REN, Xinchang LIU, Jianzhou HUANG, Yingjun ZHANG, Siegfried GOLDMANN
  • Publication number: 20200113879
    Abstract: A fused tricyclic compound and use thereof as a medicament, in particular as a medicament for the treatment and/or prevention of hepatitis B. Specifically, a compound having Formula (I) or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, wherein each variate is as defined in specification. The compound also includes a Formula (I) or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof as a medicament, especially as a medicament for the treatment and/or prevention of hepatitis B.
    Type: Application
    Filed: June 2, 2018
    Publication date: April 16, 2020
    Applicants: SUNSHINE LAKE PHARMA CO., LTD., NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED
    Inventors: Xinchang LIU, Qingyun REN, Jianzhou HUANG, Zhimin XIONG, Jinfeng XIONG, You LI, Yang LIU, Zhifu ZOU, Guanghua YAN, Siegfried GOLDMANN, Yingjun ZHANG
  • Patent number: 10619478
    Abstract: The present disclosure provides a device for power transmission and signal transfer between the stator and the rotor of a screw drilling tool. The present disclosure can replace the wireless communication technique between the rotary steering tool and the integrated MWD/LWD, omit the upper mud generator above the rotary steering tool, and thereby realize power transmission and signal transfer between the stator and the rotor of the screw drilling tool.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: April 14, 2020
    Assignee: INSTITUTE OF GEOLOGY AND GEOPHYSICS CHINESE ACADEMY OF SCIENCES
    Inventors: Xinzhen He, Qingyun Di, Wenxuan Chen, Jiansheng Du, Qingbo Liu, Yongyou Yang
  • Publication number: 20200087986
    Abstract: A rotary guiding device based on radial driving force, comprising: a rotating shaft, the rotating shaft is used to drive a tool head to rotate, the rotating shaft includes an upper shaft portion, a lower shaft portion, and a steerable portion, the upper shaft portion and the lower shaft portion are steerably connected by the steerable portion;a non-rotating body mounted on the upper shaft portion, the non-rotating body is substantially non-rotating with respect to the rotating shaft in the circumferential direction when the rotating shaft rotationally drives the tool head, the lower shaft portion includes a rib portion that coincides at least partially in the axial direction with the non-rotating body, the non-rotating body includes at least three hydraulic driving mechanisms uniformly distributed along its circumferential direction, the three hydraulic driving mechanisms are adapted to controllably generate radial drive forces respectively, the radial driving forces acts on the rib portion that is overlapped
    Type: Application
    Filed: March 2, 2018
    Publication date: March 19, 2020
    Applicant: Institute of Geology and Geophysics, Chinese Academy of Sciences
    Inventors: Qingbo LIU, Qingyun DI, Tsili WANG, Wenxuan CHEN, Jiansheng DU, Yongyou YANG, Xinzhen HE, Linfeng HONG, Qijun XIE
  • Publication number: 20200067247
    Abstract: The present disclosure relates to a conductive slip ring for logging while drilling (LWD) instrument. The present disclosure utilizes a mechanical conductive slip ring to solve the problems of transmission of electric power and signals between two structures that have relative rotation, and the conductive slip ring has a simple structure, doesn't involve any complex circuit, and has low cost and high reliability. With the conductive slip ring in the present disclosure, there is no power transmission efficiency problem or signal transmission error rate problem. The conductive slip ring has high temperature-resistant, pressure-proof, and vibration-roof abilities, and can be applied widely.
    Type: Application
    Filed: August 29, 2019
    Publication date: February 27, 2020
    Applicant: Institute of Geology And Geophysics, Chinese Academy Of Sciences
    Inventors: Xinzhen He, Qingyun Di, Wenxuan Chen, Jiansheng Du, Qingbo Liu
  • Publication number: 20200003049
    Abstract: The present disclosure provides a device for power transmission and signal transfer between the stator and the rotor of a screw drilling tool. The present disclosure can replace the wireless communication technique between the rotary steering tool and the integrated MWD/LWD, omit the upper mud generator above the rotary steering tool, and thereby realize power transmission and signal transfer between the stator and the rotor of the screw drilling tool.
    Type: Application
    Filed: August 29, 2019
    Publication date: January 2, 2020
    Inventors: Xinzhen He, Qingyun Di, Wenxuan Chen, Jiansheng Du, Qingbo Liu, Yongyou Yang
  • Publication number: 20200003928
    Abstract: The disclosure pertains to the field of exploration based on electromagnetic method, and in particular relates to a method and device for surface-borehole transient electromagnetic detection, aiming at solving the problem that the loop source device cannot effectively detect the high-resistance layer. The device according to the disclosure includes grounded conductor wires as emission sources and underground receiving devices as receiving sources; wherein the grounded conductor wires are arranged on the ground; an existing borehole on the ground or an existing underground roadway is used, and receiving probes are arranged point by point in the borehole direction or in the horizontal direction of the roadway; the grounded conductor wires are composed of three sets of grounded conductor wires, wherein two sets of the grounded conductor wires are arranged in parallel with each other and perpendicular to the third set of the grounded conductor wires.
    Type: Application
    Filed: July 2, 2018
    Publication date: January 2, 2020
    Applicant: Institute of Geology and Geophysics, Chinese Academy of Sciences
    Inventors: Guoqiang Xue, Shucai Liu, Zhihai Jiang, Weiying Chen, Jianhua Yue, Qingyun Di
  • Publication number: 20190391293
    Abstract: The present invention relates to a correction method for transient electromagnetic method-based prediction of water-bearing structure ahead of tunnel wall, which pertains to the technical field of transient electromagnetic sounding method. The correction method includes a method for eliminating effects of transition process in a reception probe and a method of using earth conductivity to eliminate effects of transition process. By using the correction technique, more accurate information about the location, size and shape of the object in front of the tunnel wall can be obtained, which is of great significance to the study of the fine water-bearing geological structure.
    Type: Application
    Filed: June 20, 2018
    Publication date: December 26, 2019
    Applicant: Institute of Geology and Geophysics, Chinese Acade my of Sciences
    Inventors: Guoqiang XUE, Xiu LI, Bin LIU, Huaifeng SUN, Qingyun DI, Dongyang HOU
  • Patent number: 10505954
    Abstract: Graph-based detection systems and techniques are provided to identify potential malicious lateral movement paths. System and security events may be used to generate a network connection graph and detect remote file executions and/or other detections, for use in tracking malicious lateral movement across a computer network, such as a compromised computer network. Lateral movement determination across a computer network may be divided into two subproblems: forensic analysis and general detection. With forensic analysis, given a malicious node, possible lateral movement leading into or out of the node is identified. General detection identifies previously unknown malicious lateral movement on a network using a remote file execution detector, and/or other detectors, and a rare path anomaly detection algorithm.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: December 10, 2019
    Assignee: Microsoft Technology Licensing, LLC
    Inventors: Jack Wilson Stokes, III, Robert James Mead, Tim William Burrell, Ian Hellen, John Joseph Lambert, Weidong Cui, Andrey Marochko, Qingyun Liu