Abstract: A concurrent rebuild list indicates RAID extents to be concurrently rebuilt in response to a physical drive failure. When rebuilding of a RAID extent in the list completes, a next RAID extent to add to the list is selected that has a lowest relatedness score in a candidate set of RAID extents. The relatedness score indicates an amount of limitation with regard to concurrently rebuilding the candidate RAID extent in combination with the RAID extents remaining in the concurrent rebuild list. The relatedness score may be a sum of a weighted write score indicating limits on concurrent write operations when rebuilding a candidate RAID extent in combination with the RAID extents remaining in the concurrent rebuild list, and a read score indicating limits on concurrent read operations when rebuilding the candidate RAID extent in combination with the RAID extents remaining in the concurrent rebuild list.

Abstract: Isolated or recombinant anti-LGR4 monoclonal antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer.

Abstract: Graph-based detection systems and techniques are provided to identify potential malicious lateral movement paths. System and security events may be used to generate a network connection graph and detect remote file executions and/or other detections, for use in tracking malicious lateral movement across a computer network, such as a compromised computer network. Lateral movement determination across a computer network may be divided into two subproblems: forensic analysis and general detection. With forensic analysis, given a malicious node, possible lateral movement leading into or out of the node is identified. General detection identifies previously unknown malicious lateral movement on a network using a remote file execution detector, and/or other detectors, and a rare path anomaly detection algorithm.

Abstract: Embodiments of the present disclosure provide a method and apparatus for data access in a storage system. The solution divides local cache of each of the plurality of controllers in the storage system into dedicated area and shared area, wherein the shared area is uniformly addressed to form a global shared address space. Accordingly, a controller can access and utilize local cache that originally belongs to other controllers, so as to improve cache utilization rate of the storage system. The plurality of controllers in the storage system has a high-speed communication interface therebetween. The solution of the present disclosure enables a controller to utilize cache resources of other controllers in the storage system, so as to achieve the purpose of coordinating cache resources in the storage system.

Abstract: A composition and method for detecting the ability of a compound to modulate the activity of LGR4, LGR5, or LGR6 receptors in a cell. LGR4, LGR5, and LGR6 are capable of activating the Wnt/?-catenin signaling system which plays essential roles in embryonic development and in the self-renewal and maintenance of adult stem cells.

Abstract: Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:

Abstract: Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:

Abstract: A system and method for limiting the impact of an unstable wavelength on other wavelengths in a reconfigurable optical add/drop multiplexer (ROADM) network are disclosed. The method generally comprises measuring optical channel power at prescribed time intervals; for each measurement of channel power falling outside a predefined threshold, recording a threshold crossing event; comparing the recorded threshold crossing events to stored criteria indicative of an unstable wavelength channel; and removing an unstable wavelength from the ROADM network if the threshold crossing events exceed the stored criteria.

Abstract: Methods and compositions comprising tryptophan hydroxylase inhibitors are disclosed. Particular methods are directed at reducing or avoiding serotonin-mediated adverse effects associated with some drugs.

Abstract: Methods are disclosed for treating ulcerative colitis and related diseases and disorders, which comprise inhibiting tryptophan hydroxylase (TPH) in patients in need thereof.

Abstract: Methods and compounds are disclosed for affecting gastrointestinal motility and gastric emptying, which comprise inhibiting tryptophan hydroxylase (TPH) in patients in need thereof

Abstract: Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:

Abstract: A system and method for limiting the impact of an unstable wavelength on other wavelengths in a reconfigurable optical add/drop multiplexer (ROADM) network are disclosed. The method generally comprises measuring optical channel power at prescribed time intervals; for each measurement of channel power falling outside a predefined threshold, recording a threshold crossing event; comparing the recorded threshold crossing events to stored criteria indicative of an unstable wavelength channel; and removing an unstable wavelength from the ROADM network if the threshold crossing events exceed the stored criteria.

Abstract: Methods and compounds are disclosed for affecting gastrointestinal motility and gastric emptying, which comprise inhibiting tryptophan hydroxylase (TPH) in patients in need thereof.

Abstract: Methods are disclosed for treating serotonin-mediated diseases and disorders, which comprise inhibiting tryptophan hydroxylase (TPH) in patients in need thereof.

Abstract: Methods and compositions comprising tryptophan hydroxylase inhibitors are disclosed. Particular methods are directed at reducing or avoiding serotonin-mediated adverse effects associated with some drugs.

Abstract: Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:

Abstract: A new neuromedin U receptor, designated NMUR2 has been found, which is involved in modulation of feeding behavior in mammals. Ligands of this receptor are able to modulate eating, and weight gain. Amino acid sequences of the human and rat forms, as well as their nucleic acid sequences are given.

Abstract: An isolated nucleic acid molecule is disclosed which encodes a novel human uncoupling protein (UCP3), and related recombinant expression vectors, recombinant host cells and substantially purified forms of the UCP3 protein. The isolated nucleic acid and proteins disclosed herein will be useful in methods associated with identifying compounds which modulate energy expenditure and body weight regulation, as well as effecting diseases such as obesity and diabetes as well as mitochondria-associated hypermetabolism. Additionally, the isolated nucleic acids of the present ivention are candidates for gene therapy of a mammalian host, including humans.

Abstract: DNA encoding a novel human GABAB receptor subunit, HG20, as well as the protein encoded by the DNA, is provided. Also provided is DNA encoding a novel murine GABAB receptor subunit, GABABR1a, as well as the protein encoded by the DNA. Heterodimers of HG20 protein and GABABR1a protein that form a functional GABAB receptor are disclosed. Methods of identifying agonists and antagonists of the GABAB receptor are also provided.