Abstract: Described herein are compounds that can arrest mitotic cells and their use in the treatment of disorders such as cancers.

Abstract: Provided are a porous silicone resin and a light-weight flexible flame-retardant composite material, belonging to the technical field of nano-porous materials. The porous silicon resin is prepared from a porous silicon resin precursor solution by means of curing and drying processes. The porous silicone resin precursor solution includes a flame retardant, a surfactant, a siloxane monomer, a catalyst, an auxiliary agent and a solvent. The porous silicone resin precursor solution is obtained by firstly dissolving the flame retardant and the surfactant in the solvent, and then adding the siloxane monomer, the catalyst and the auxiliary agent and mixing them uniformly. The porous silicone resin and the light-weight flexible flame-retardant composite material prepared therefrom have the excellent properties of high porosity, high flame retardancy, high elasticity and high strain.

Abstract: A voltage regulator having a multiple of main stages and at least one accelerated voltage regulator (AVR) bridge is provided. The main stages may respond to low frequency current transients and provide DC output voltage regulation. The AVR bridges are switched much faster than the main stages and respond to high frequency current transients without regulating the DC output voltage. The AVR bridge frequency response range can overlap with the main stage frequency response range, and the lowest frequency to which the AVR bridges respond may be set lower than the highest frequency to which the main stages respond.

Abstract: There is provided a light emitting device, for example a grow-light, comprising: a first solid-state light source that generates blue light with a blue photon flux; and a second solid-state light source that generates red light with a red photon flux; wherein a ratio of the blue photon flux to red photon flux is from about 1:3 to about 3:1. It may be that the broadband blue light substantially matches at least one of: the absorption peak wavelength of chlorophyll-a; the absorption peak wavelength of chlorophyll-b; and the absorption peak wavelength of carotenoid.

Abstract: A method for selection of a core network. The method which can be performed by a first network node comprises receiving a message for a terminal device from a second network node. The message can enable the first network node to determine a category of the terminal device. The method further comprises selecting a core network for the terminal device based at least in part on the category of the terminal device. The terminal device can be served by a dedicated core network selected for the terminal device adaptively, so that network configuration and resource efficiency can be improved.

Abstract: Disclosed herein are glucosyltransferases with modified amino acid sequences. Such engineered enzymes exhibit improved alpha-glucan product yields and/or lower leucrose yields, for example. Further disclosed are reactions and methods in which engineered glucosyltransferases are used to produce alpha-glucan.

Abstract: A multi-phase buck-boost converter includes a first half-bridge circuit, a second half-bridge circuit, a third half-bridge circuit, and a control circuit. The first half-bridge circuit is coupled to a first inductor terminal. The second half-bridge circuit is coupled to a second inductor terminal. The third half-bridge circuit is coupled to a third inductor terminal, a system voltage terminal, and a battery terminal. The control circuit is coupled to the first half-bridge circuit, the second half-bridge circuit, and the third half-bridge circuit. The control circuit is configured to transition the first half-bridge circuit, the second half-bridge circuit, and the third half-bridge circuit from operation in a buck mode to operation in a buck-boost mode based on an off-time of the first half-bridge being less than a particular time.

Abstract: In certain aspects, disclosed herein are methods of treating cancer in a subject, comprising administration to the subject of (1) one or more glucocorticoid receptor agonists and (2) one or more inhibitors of calcineurin. In some embodiments, the administration of the one or more glucocorticoid receptor agonists and the one or more inhibitors of calcineurin results in restoration of contact inhibition, increased formation of intercellular junctions, reduced cell proliferation, and/or increased vacuolization of cells growing in multilayer zones. Included herein are methods for identification of novel compounds that restore contact inhibition in cancer cells.

Abstract: The embodiment of the present disclosure discloses a method, an electronic device, and a storage medium for a ship route optimization. The method for the ship route optimization considers a dynamic feature of a multi-functional emergency rescue ship and an interference effect caused by an airflow, uses a movement model with kinematics non-holonomic constraints, such as a ship total cost assessment function to simulate the movement of the ship, and based on a sparrow search algorithm, learns how to apply the algorithm to a route plan of the emergency rescue ship. The method can improve the ship route optimization algorithm, improve an accuracy and practical applicability of a calculated plan. The method can effectively and accurately locate obstacles and hidden reefs, and consider effects of an airflow and a non-holonomic constraint effect, so as to make the route planning of the ship more efficient and intelligent.

Abstract: The technology is generally directed to a coordinated power throttling mechanism for a payload using power provided by a rack such that the rack power does not exceed a threshold amount for greater than a predetermined period of time. The coordinated power throttling mechanism includes the rack providing a power throttling signal to the payload and the payload executing the power throttling upon detection of the throttling signal. The payload may detect the throttling signal and, after a delay, execute the power throttling. The delay may ensure that all payloads within the rack have detected the power throttling signal.

Abstract: A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein R1, R2, R3, R4, R5, and n are as defined herein.

Abstract: Disclosed in the present disclosure are a lithium adsorbent and a preparation method therefor. The lithium adsorbent has a porous structure, and includes an aluminum-based lithium adsorbent active material and a hydrophilic binder; and the lithium adsorbent has an average pore diameter ranging from 1 nm to 10 nm, a pore volume ranging from 0.65 ml/g to 0.8 ml/g, and a specific surface area ranging from 400 m2/g to 600 m2/g. The lithium adsorbent of the present disclosure has a specific average pore size ranging from 1 nm to 10 nm, lithium ions have a diameter of 0.3 nm, and the pore size of the lithium adsorbent of the present disclosure is three times or more greater than the diameter of the ions so that the lithium ions can quickly enter and exit pores.

Abstract: Provided are novel fully human monoclonal antibodies that bind to human LAG-3. It also provides the methods of hybridoma generation using humanized rats, the nucleic acid molecules encoding the anti-LAG-3 antibodies, expression vectors and host cells used for the expression of anti-LAG-3 antibodies. The invention further provides the methods for validating the function of antibodies in vitro. The antibodies of invention provide a potent agent for the treatment of multiple cancers via modulating human immune function.

Abstract: A communication system comprises a set of specialized backend servers 100 and groups of terminals (210, 220) connected through the Internet. Users of the communication system can make video calls and share text messages, images and video clips through the terminals (210, 220). The terminals in this system are organized into private terminal groups 200 of varying sizes. Each group has only one controller terminal 210 and one or more display terminals 220. Both types of terminals provide an easy-to-use graphic user interface for the user to access the communication services provided by the system. Communication and information sharing between any display terminals must be pre-authorized by their controllers. This communication system, while ensuring security and privacy, addresses the needs of caregiver groups that include caregiver professionals, family members and care receivers, to facilitate private conference calls, information sharing and caring activity coordination.

Abstract: Disclosed is an echelon utilization battery pack with good seismic resistance. The echelon utilization battery pack involves a battery pack body and a battery, wherein the battery pack body is of a hollow cuboid structure, fixed seats are fixed at two ends of the inner bottom of the battery pack body, first fixed shafts are fixed between the two fixed seats, the first fixed shafts are slidably connected with a mounting seat in a sleeving mode, a first sliding groove is formed in the top of the mounting seat, second fixed shafts are fixed in the first sliding groove, and the two ends of the second fixed shafts are slidably connected with first sliding blocks.

Abstract: A communication system comprises a set of specialized backend servers 100 and groups of terminals (210, 220) connected through the Internet. Users of the communication system can make video calls and share text messages, images and video clips through the terminals (210, 220). The terminals in this system are organized into private terminal groups 200 of varying sizes. Each group has only one controller terminal 210 and one or more display terminals 220. Both types of terminals provide an easy-to-use graphic user interface for the user to access the communication services provided by the system. Communication and information sharing between any display terminals must be pre-authorized by their controllers. This communication system, while ensuring security and privacy, addresses the needs of caregiver groups that include caregiver professionals, family members and care receivers, to facilitate private conference calls, information sharing and caring activity coordination.

Abstract: A computer-implemented method includes positioning a sliding window over a string of data and calculating a hash value using a rolling hash function for data encompassed by the sliding window. The method includes determining whether the calculated hash value for the data encompassed by the sliding window matches the value of an element in a cut point candidate (CPC) array by comparing the calculated hash value to the value of a first element in the CPC array. In response to the calculated hash value being equal to the value of the first element in the CPC array, the method includes defining an index of the sliding window as the cutting point for a data block.

Abstract: An unmanned aerial vehicle (UAV)-based intelligent anomaly identification method for petroleum pipeline inspection is provided. The precise UAV cruise technology is combined with a target detection algorithm to design an intelligent petroleum pipeline inspection method, which realizes fast anomaly detection for petroleum pipeline inspection based on the existing computer processing capability. In addition, a lot of optimization algorithms and improvements are made for target detection under special working conditions of UAV inspection, and a dedicated target detection network model adapted to these conditions is trained. The UAV-based intelligent anomaly identification method realizes accurate, real-time anomaly reporting for petroleum pipeline inspection, reduces the blindness of manual inspection, greatly improves inspection efficiency, reduces labor costs, and has practicability.

Abstract: A method for the treatment and/or reduction of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) is disclosed. The method uses active amino-aryl-benzamide compounds and methods for the preparation thereof.