Abstract: Described herein are compounds that can arrest mitotic cells and their use in the treatment of disorders such as cancers.

Abstract: There is provided a light emitting device, for example a grow-light, comprising: a first solid-state light source that generates blue light with a blue photon flux; and a second solid-state light source that generates red light with a red photon flux; wherein a ratio of the blue photon flux to red photon flux is from about 1:3 to about 3:1. It may be that the broadband blue light substantially matches at least one of: the absorption peak wavelength of chlorophyll-a; the absorption peak wavelength of chlorophyll-b; and the absorption peak wavelength of carotenoid.

Abstract: Disclosed are a method and device for realizing advanced nitrogen removal of mature landfill leachate and sludge reduction by using sludge fermentation products as carbon source, belonging to the field of biological treatment of sludge of high ammonia nitrogen wastewater.

Abstract: In certain aspects, disclosed herein are methods of treating cancer in a subject, comprising administration to the subject of (1) one or more glucocorticoid receptor agonists and (2) one or more inhibitors of calcineurin. In some embodiments, the administration of the one or more glucocorticoid receptor agonists and the one or more inhibitors of calcineurin results in restoration of contact inhibition, increased formation of intercellular junctions, reduced cell proliferation, and/or increased vacuolization of cells growing in multilayer zones. Included herein are methods for identification of novel compounds that restore contact inhibition in cancer cells.

Abstract: Soyasaponin-related Kompetitive Allele Specific polymerase chain reaction (KASP) markers and an application thereof are provided in the present application, belonging to the technical field of molecular breeding. The KASP markers include one or two of S07_43139773G/T, and S07_43139033A/G; the S07_43139773G/T comprises a base of G/T at a position of 43139773 bp on chromosome 7 of a soybean genome, the S07_43139033A/G comprises a base of A/G at a position of 43139033 bp on the chromosome 7 of the soybean genome. The KASP markers are applied to improve soyasaponin germplasm breeding.

Abstract: The embodiment of the present disclosure discloses a method, an electronic device, and a storage medium for a ship route optimization. The method for the ship route optimization considers a dynamic feature of a multi-functional emergency rescue ship and an interference effect caused by an airflow, uses a movement model with kinematics non-holonomic constraints, such as a ship total cost assessment function to simulate the movement of the ship, and based on a sparrow search algorithm, learns how to apply the algorithm to a route plan of the emergency rescue ship. The method can improve the ship route optimization algorithm, improve an accuracy and practical applicability of a calculated plan. The method can effectively and accurately locate obstacles and hidden reefs, and consider effects of an airflow and a non-holonomic constraint effect, so as to make the route planning of the ship more efficient and intelligent.

Abstract: A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein R1, R2, R3, R4, R5, and n are as defined herein.

Abstract: An orthopedic surgical robot system; the orthopedic surgical robot system comprises: a robotic arm (10), a distal end (170) of the robotic arm (10) being used for providing a locked working point (O) for the orthopedic surgical robot system; a multi-link mechanism (20), wherein the multi-link mechanism (20) comprises: a first link (210), the first link (210) being coupled to the distal end (170) of the robotic arm (10); and a second link (220), a proximal end of the second link (220) being connected to the first link (210) in a movable manner, so that the movement of the second link (220) relative to the first link (210) provides the orthopedic surgical robot system with a locked working plane relative to the locked working point (O); a bone saw (30), the bone saw being coupled to the distal end of the second link (220) and operable in the locked working plane; and a control system (40), the control system (40) being coupled to the robotic arm (10), and controlling, on the basis of a basic control amount of t

Abstract: A light-emitting module and a light-emitting diode are provided. The light-emitting diode includes an epitaxial light-emitting structure to generate a light beam with a broadband blue spectrum. A spectrum waveform of the broadband blue spectrum has a full width at half maximum (FWHM) larger than or equal to 30 nm. The spectrum waveform has a plurality of peak inflection points, and a difference between two wavelength values to which any two adjacent ones of the peak inflection points respectively correspond is less than or equal to 18 nm.

Abstract: Methods and systems are provided for sequence-to-sequence conversion from unstructured search queries to structured database queries, so that lay persons may retrieve information from relational databases without specialized knowledge of database query languages. An encoder module and a decoder module of a learning model are trained to convert an unstructured search query to an intermediate feature vector by computing co-attention and self-attention based on a context string and a database schema, encoding the database schema in the context string by application of self-attention between the context string containing tokens of the database schema with learned structural attention heads which relate the token to logic of the database. Training is performed using labeled training datasets which include structured database queries which are normalized by parsing into a semantic representation thereof, followed by linearization.

Abstract: The present disclosure provides a target identification method, a target identification device, an electronic apparatus, a storage medium and a neuromodulation apparatus. The target identification method includes: acquiring scan data of a subject, the scan data including data obtained from magnetic resonance imaging of the subject's brain; determining the corresponding relationship of regions of interest of a disease type of the subject according to the disease type of the subject; determining at least one disease region of interest and at least one target region of interest of the subject in the scan data according to the corresponding relationship of the regions of interest; determining connectivity between each of voxels in the target region of interest and each disease region of interest in the at least one disease region of interest; and determining the positions of the voxels with the connectivity meeting a preset target connectivity condition in the target region of interest as the targets.

Abstract: The present disclosure provides LPA antagonists, as well as pharmaceutical compositions comprising the compounds disclosed herein. Also provided are methods for treating LPA-associated diseases, disorders, and conditions.

Abstract: This disclosure relates to LPA antagonists of Formula (I): including pharmaceutically acceptable salts and solvates thereof, and pharmaceutical compositions including the same.

Abstract: The present application relates to an optical image stabilization camera module, comprising: a lens; a photosensitive assembly having a photosensitive chip; a first driving part adapted to drive the lens to translate in x-axis and y-axis directions; and a second driving part comprising a second basic portion and a second movable portion, the second driving part having four side surfaces, wherein each side surface is provided with two interlaced SMA wires, and both ends of each SMA line are connected to a fixed end of the second basic portion and a fixed end of the second movable portion, respectively; each of the fixed ends is located at a corner area of the second basic portion or the second movable portion.

Abstract: The present invention is related to the inhibition of the formation of Streptococci biofilms through the inhibition of glucosyl transferase (Gtf). Compounds, compositions and methods for inhibiting Streptococcus biofilm formation, as well as for preventing, inhibiting and/or treating the formation of dental caries, and methods of identifying compounds that prevent, inhibit and/or treat the formation of dental caries are provided.

Abstract: A light-emitting device is provided. The light-emitting device generates a white light and includes at least one light-emitting diode. The at least one light-emitting diode generates a light beam with a broadband blue spectrum and includes a first semiconductor layer, a second semiconductor layer and a multiple quantum well structure. The multiple quantum well structure is located between the first semiconductor layer and the second semiconductor layer, and includes well layers and barrier layers. The well layers include a first well layer, a second well layer and third well layers different in indium concentrations. The first well layer has the largest indium concentration, and the third well layers have the smallest indium concentration.

Abstract: There is provided a light emitting device, for example a grow-light, comprising: a first solid-state light source that generates blue light with a blue photon flux; and a second solid-state light source that generates red light with a red photon flux; wherein a ratio of the blue photon flux to red photon flux is from about 1:3 to about 3:1. It may be that the broadband blue light substantially matches at least one of: the absorption peak wavelength of chlorophyll-a; the absorption peak wavelength of chlorophyll-b; and the absorption peak wavelength of carotenoid.

Abstract: Techniques for MRI pre-scan method may automatically determine and apply a compensation frequency to correct for inhomogeneous magnetic fields, improving the efficiency and quality of clinical examinations. The method may include executing a first pulse sequence with an MRI system, acquiring multiple magnetic resonance signals at different offset frequencies from the same location, and recording corresponding k space data. Variations between the k space data may be calculated and used to determine the compensation frequency. By applying the compensation frequency to correct for inhomogeneous magnetic fields, artifacts in MRI images can be eliminated, resulting in higher quality images. This method offers a quantitative and automated solution for compensating for inhomogeneous magnetic fields during MRI pre-scans, improving the accuracy and efficiency of clinical examinations. The invention also includes a dedicated MRI pre-scan device.