Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.

Abstract: In one or more embodiments, one or more systems, methods, and/or processes may determine one or more auxiliary edges that bypass at least one vertex of vertices that represent physical nodes of a network domain; evaluate at least one edge, that includes the one or more auxiliary edges and that interconnect the vertices, to evaluate a portion of the vertices that excludes the at least one vertex that was bypassed to identify at least one vertex that is associated with at least one service function of a service function chain request specifying service functions to be performed via at least a portion of physical nodes of network domains; and configure a first physical node of the physical nodes of the network domain and associated with the at least one vertex that is associated with the at least one service function to process data via the at least one service function.

Abstract: The invention relates to a composite substrate for light emitting device and a LED module equipped with the composite substrate for light emitting device. The composite substrate for light emitting device includes a metal substrate, an insulating carrier and an electrode, the metal substrate and the insulating carrier respectively have a front side and a back side that are opposite, the insulating carrier is disposed on the periphery of the metal substrate and connected to the metal substrate, the electrode is disposed on the insulating carrier, the electrode penetrates the insulating carrier, the electrode has a front side and a back side that are opposite, the heights of the back sides of the insulating carrier and the electrode are less than that of the back side of the metal substrate. The present invention also provides a LED module. The composite substrate for light emitting device can reduce costs.

Abstract: Systems, methods and devices for evaluating an earth formation intersected by a borehole. Method embodiments may include using a downhole tool in the borehole to generate a plurality of signal pulses responsive to detected radiation; using at least one signal quality characteristic of each pulse of the plurality of pulses to classify each pulse as belonging to at least one subset of a plurality of pulse subsets; and using one of more of the plurality of pulse subsets to estimate a value of a parameter of interest. The signal quality characteristic may be indicative of a pulse pile-up condition being associated with the respective pulse. The signal quality characteristic may include at least one of: i) rising time (slope) of the respective pulse; ii) time between a peak of the respective pulse and a peak of a closest following pulse; iii) pulse width; and iv) skewness of the pulse.

Abstract: This invention relates generally to the field of nucleic acid detection. In particular, the invention provides a lab-on-chip system for analyzing a nucleic acid, which system comprises, inter alia, controllably closed space, and a target nucleic acid can be prepared and/or amplified, and hybridized to a nucleic acid probe, and the hybridization signal can be acquired if desirable, in the controllably closed space without any material exchange between the controllably closed space and the outside environment. Methods for analyzing a nucleic acid using the lab-on-chip system is also provided.

Abstract: A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein R1, R2, R3, R4, R5, and n are as defined herein.

Abstract: Object-oriented network virtualization may involve creating and operating virtual network objects (VNO) using a software-programmed networking operating system (SPN OS). A VNO may be a complete representation of a virtual network service provided under the SPN OS. A VNO may have a unique identity and properties, along with an internal set of methods for executing functionality encapsulated by the VNO. A VNO may exhibit persistence and autonomous control to enable improved virtual network services.

Abstract: Methods and systems are provided for determining a shortest path with a constraint in an optical network. The method includes identifying a permitted number of events defined by the constraint. The method further includes creating virtual nodes for each node in the optical network, the virtual nodes corresponding with the permitted number of events. The method also includes traversing the virtual nodes from a source node to a destination node with a shortest path algorithm, wherein traversing the virtual nodes comprises creating virtual links between the virtual nodes when the constraint is not violated, the virtual link corresponding with a physical link; and identifying a shortest path between the source node and the destination node from the virtual links, the shortest path not violating the constraint.

Abstract: Methods and systems are provided for determining a shortest minimum regeneration path in an optical network. The method includes creating a virtual node at a source node, the source node communicatively coupled to a destination node through a plurality of nodes and links. The method includes traversing the virtual nodes, wherein traversing the virtual nodes comprises selecting an unvisited virtual node at a node; identifying a candidate virtual node from the unvisited virtual node; determining whether the candidate virtual node exceeds a maximum permitted weight; determining whether the candidate virtual node violates a shortest minimum regeneration path condition; and creating the new virtual node from the candidate virtual node if the candidate virtual node does not exceed the maximum permitted weight and if the candidate virtual node does not violate the shortest minimum regeneration path condition.

Abstract: The present invention provides techniques for use in association with online advertising, relating to use of serving thresholds, associated with predicted click through rates, and delivery policies, associated with advertising inventory serving and distribution. An offline-trained machine learning-based model may be utilized in advertising serving decision-making in connection with serving opportunities. However, serving thresholds and delivery policies, for use in association with the model in serving decision-making, may be adjusted online, such as in real-time or near real-time, based on information obtained online affecting factors such as predicted click through rates and advertising inventory distribution.

Abstract: In one or more embodiments, one or more systems of a physical optical network that may implement and/or manage a virtual optical network (VON) that interconnects multiple data centers. Virtual nodes based the multiple data centers to be interconnected may be determined, and each of the virtual nodes may be mapped to at least two physical nodes of the physical optical network. Virtual links for pairs of the virtual nodes may be determined, and each virtual link may be mapped to at least one optical network connection of the physical optical network. At least one of a physical node impairment and an optical network connection impairment that is associated with a first physical node implementing a first virtual node may be detected, and the first virtual node may be implemented via a second physical node.

Abstract: In a method and magnetic resonance (MR) apparatus for heart diffusion imaging, when an ECG trigger signal by a computer that operates an MR scanner, the MR scanner is operated to acquire a navigator echo before a stimulated echo sequence, in order to detect diaphragm position information. When the first diaphragm position information is not located in an acquisition window, the stimulated echo sequence is not executed, and the computer waits to receive the next ECG trigger signal. The detection time of the navigator echo after the stimulated echo sequence as well as the acquisition time of the stimulated echo sequence, are thus eliminated when the first diaphragm position information does not meet requirements, so can significantly reduce scanning time, and increase the image SNR.

Abstract: Methods, systems, and devices for evaluating an earth formation intersected by a borehole using information from standard resolution measurements. Methods include generating an image representative of the formation over an interval of borehole depth, the image having a second resolution greater than the first resolution. Generating the image may be carried out by identifying layers corresponding to lithotype facies within the interval, the layers defined by boundaries having boundary locations along the borehole; and using a unified characterization of the formation within the interval determined from the standard resolution measurements and the boundary locations within the interval to solve for a value for the formation parameter corresponding to each layer consistent with the unified characterization of the interval. The unified characterization may be an average value for the formation parameter within the interval.

Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.

Abstract: The present invention provides techniques for use in association with online advertising, relating to use of serving thresholds, associated with predicted click through rates, and delivery policies, associated with advertising inventory serving and distribution. An offline-trained machine learning-based model may be utilized in advertising serving decision-making in connection with serving opportunities. However, serving thresholds and delivery policies, for use in association with the model in serving decision-making, may be adjusted online, such as in real-time or near real-time, based on information obtained online affecting factors such as predicted click through rates and advertising inventory distribution.

Abstract: An isolated power control device that includes an auxiliary isolated power circuit and a voltage level identification unit is provided. The auxiliary isolated power circuit includes a transformer module, a control module, and a switch module. The transformer module includes a primary side and a secondary side. The control module generates a switch control signal according to a primary side remote on/off control signal. The switch module is conducted according to the switch control signal to transmit an input auxiliary power signal to the primary side of the transformer module such that the auxiliary isolated power circuit generates a target voltage signal having a plurality of voltage levels. The voltage level identification unit receives the target voltage signal to output a secondary side remote on-off control signal to control a main isolated power device.

Abstract: A method of identifying barite in a subterranean annulus that surrounds a wellbore, where the method includes detecting gamma rays in the wellbore that are generated from the annulus, obtaining a count rate of the detected gamma rays, comparing the count rate with reference data, and determining the presence of barite in the wellbore based on the comparison. The count rate can be a ratio of counts of detected gamma rays obtained from spaced apart receivers on a downhole tool, or a ratio of detected inelastic and capture gamma rays. The reference data is obtained by using a simulation algorithm.

Abstract: A method of identifying barite in a subterranean annulus that surrounds a wellbore, where the method includes detecting gamma rays in the wellbore that are generated from the annulus, obtaining a count rate of the detected gamma rays, comparing the count rate with reference data, and determining the presence of barite in the wellbore based on the comparison. The count rate can be a ratio of counts of detected gamma rays obtained from spaced apart receivers on a downhole tool, or a ratio of detected inelastic and capture gamma rays. The reference data is obtained by using a simulation algorithm.

Abstract: Optical transceiver sharing methods may be based on different ROADM node architectures for shared restoration in flexible grid optical networks. A ROADM node architecture with a pool of transceivers may improve transceiver utilization for backup optical paths, compared to a conventional ROADM node architecture. Sharing of transceivers in the pool for working and backup optical paths may further improve transceiver utilization. The methods disclosed herein may be used for multiple bit rates and different modulation formats.

Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.