Abstract: Systems and methods for multi-domain routing are provided. In some embodiments, a method for determining a path calculation from a source node to a destination node over a multi-domain network is provided. The method may include steps for receiving a predetermined sequence of domains for communicating information from the source node to the destination node, determining a link type for each of a plurality of links in the predetermined sequence of domains, modifying the link type of one or more of the plurality of links such that the plurality of links are unidirectional links towards a destination node, and determining a path along the predetermined sequence of domains based on the modified plurality of links.

Abstract: In accordance with embodiments of the present disclosure, a method for demand aggregation is provided. The method may include routing demands in a ring network such that a length for each routed demand does not exceed a route length maximum, and a load imbalance at each node in the ring network is minimized. The method may also include maximizing optical line card sharing by assigning routed demands sharing common ends to the same wavelength.

Abstract: Systems and methods for finding related terms based on three different sources are disclosed. Generally, a first plurality of distances is determined based on one or more received terms and a first plurality of terms derived from an algorithmic search list. A second plurality of distances is determined based on the one or more received terms and a second plurality of terms derived from a sponsored search list. A third plurality of distances is determined based on the one or more received terms and a third plurality of terms derived from search logs. The first, second, and third pluralities of distances are combined to derive a fourth plurality of distances. Finally, a plurality of related terms related to the one or more received terms is generated based on the fourth plurality of distances.

Abstract: In certain embodiments, minimizing interconnections in a multi-shelf switching system includes receiving a map describing the switching system, where the switching system comprises shelves and input/output (I/O) points. The map is transformed to yield a graph comprising nodes and edges. A node represents an I/O point, and a node weight represents a number of interface cards of the I/O point represented by the node. An edge between a node pair represents traffic demand between the I/O points represented by the node pair, and an edge weight represents the amount of the traffic demand represented by the edge. The graph is partitioned to yield a groups that minimize interconnection traffic among the shelves, where each group represents a shelf of the multi-shelf switching system.

Abstract: Novel pyrimidine derivatives of formula I to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.

Abstract: According to particular embodiments, determining paths in a network with asymmetric switches includes receiving a graph representing the network. Each asymmetric switch has defined degree connectivity between one or more pairs of degrees of the asymmetric switch. The graph is transformed to yield a transformed graph that accounts for the asymmetric switches. A routing process is applied to the transformed graph to yield one or more paths through the network.

Abstract: Novel pyrimidine derivatives of formula I to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.

Abstract: Incremental training data is used to supplement a trained model to provide personalized recommendations for a user. The personalized recommendations can be made by taking into account the user's behavior, such as, without limitation, the user's short and long term web page interactions, to identify item recommendations. A trained model is generated from training data indicative of the web page interaction data collected from a plurality of users. Incremental training data indicative of other web page interaction data can be used to supplement the trained model, or in place of the trained model. Incremental training data can be indicative of user behavior collected more recently than the data used to train the model, for example.

Abstract: According to particular embodiments, determining disjoint paths includes receiving a graph representing a network comprising nodes and links. The graph is transformed such that the number of intermediate nodes of a path indicates the number of regenerators for the path. A set of seed paths from a source node to a destination node of the transformed graph is generated. For each seed path, a shortest path from the source node to the destination node is determined to yield one or more pairs of disjoint paths from the source node to the destination node. An optimized pair of disjoint paths is selected, where the optimized pair of disjoint paths has an optimized number of regenerators.

Abstract: Pair-wise item affinity is based on transaction records. Each transaction record includes an indication of a bucket and an indication of an item transacted corresponding to that bucket. The method comprises a Phase 1 bucket filtering, Phase 2 item count, Phase 3 bucket materialization and Phase 4 pair count and affinity lift/calculation. The phases are ideally suited to be carried out by a computing system in a map-reduce configuration.

Abstract: A network system (10). The system comprises a network (WAN1, LAN1, LAN2) having an architectural model comprising a plurality of layers. The system also comprises a centralized manager node (CM1), coupled to the network. The system also comprises a plurality of routers (ERx) coupled to the network for communicating packets along the network and coupled to communicate with the centralized manager node. The centralized manager is programmed to perform the step (28) of communicating mapping information to each of the plurality of routers, and the mapping information comprises a correspondence of a behavior on a first of the plurality of layers with a behavior on a second of the plurality of layers.

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, PDGF-R, trkB, c-SRC, BMX, FGFR3, b-RAF, ??K, T??2, ???, ?NK2?2, MKK4, c-RAF, MKK6, SAPK2? and SAPK2? kinases.

Abstract: The present invention discloses an asymmetric PCR amplification method, its special primer and application, aims to provide a simple, effective PCR amplification for preparation of single-stranded product. The asymmetric PCR primer of the invention comprises some PCR primer pairs, in which an unrelated nucleic acids sequence to target sequence to be detected is added onto 5?-terminal of one primer. The asymmetric PCR amplification provided includes the steps: 1) preparative denaturing; 2) repetitiously denaturing, primers annealing, extending cycles as the first stage of PCR amplification; 3) repetitiously denaturing, primer extending cycles as the second stage of PCR amplification, wherein an unrelated nucleic acids sequence to target sequence to be detected is added onto 5?-terminal of one PCR primer of each pair in extension.

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, ARG, BCR-Abl, BRK, EphB, Fms, Fyn, KDR, c-Kit, LCK, PDGF-R, b-Raf, c-Raf, SAPK2, Src, Tie2 and TrkB kinases.

Abstract: New substituted heterocyclic compounds, compositions containing them, and methods of using them for the inhibition of Raf kinase activity are provided. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.

Abstract: The present invention provides kits and microarrays containing primer pairs for amplifying drug resistance genes and/or probes for detection of drug resistance genes. Also provided are methods of detecting drug resistance genes using kits and microarrays described herein.

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Lck, IR, IGF-1R, JNK1?, Flt3, Fes, EFGR (Her-1, erbB-1), cSRC, CDK1/cyclinB, c-RAF, BTK, Bmx, Axl, Aurora-A, Abl, BCR-Abl, TrkB, Tie2, Syk, SGK, SAPK2a, Rsk1 and Met kinases.

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, FGFR3, PDGFR? and b-Raf kinases.

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, Bmx, b-RAF, c-RAF, c-SRC, KDR, CSK, FGFR3, JAK2, Lck, Met, PKC?, SAPK2?, Tie2, TrkB and P70S6K kinases.

Abstract: Novel pyrimidine derivatives of formula I to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them