Patents by Inventor Qun Zhou

Qun Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250108106
    Abstract: This disclosure is directed to a pharmaceutical composition for treating or preventing a disease. The pharmaceutical composition can comprise a polymer-drug nanoaggregate having a polymer and at least one bioactive agent that can comprise STING polypeptide, a nucleic acid encoding said STING polypeptide, a STING inhibitor, a STING activator, a STING agonist, a STING antagonist, a STING modulating molecule, or a combination thereof. The pharmaceutical composition can be a vaccine or an adjuvant for a vaccine. This disclosure is also directed to a method for treating or preventing a disease using the pharmaceutical composition. The disease can include infectious diseases caused by viruses or other pathogens, for example, influenza, rabies, or respiratory illnesses such as severe acute respiratory syndrome (SARS) caused by coronaviruses, such as MERS-CoV, SARS-CoV, and Coronavirus Disease 2019 (COVID-19) caused by the virus SARS-CoV-2 and its variants.
    Type: Application
    Filed: September 10, 2024
    Publication date: April 3, 2025
    Inventors: Lu Lu, Ray Yin, Shibo Jiang, Zezhong Liu, Ming Hsieh, Jie Zhou, Xinling Wang, Qian Wang, Wei XU, Jing Pan, Yubei Zhang, Kai Qi, Qun Sun, Lin Wang, Zhiying Zou, Chunlin Tao
  • Publication number: 20250094887
    Abstract: The present disclosure provides a method for optimizing parameters of a ladder-type carbon trading mechanism based on an improved particle swarm optimization (IPSO) algorithm. The method first obtains information and operating data of a park-level integrated energy system, establishes equipment models and constraints of the park-level integrated energy system, and establishes a ladder-type carbon trading model; then encapsulates a process of optimized low-carbon dispatching of the park-level integrated energy system as a fitness function whose input is parameters of a carbon trading mechanism and output is a carbon emission of the system; and finally, introduces an IPSO algorithm to optimize the fitness function, and outputs optimization result information of the algorithm. The present disclosure verifies effectiveness and rationality of the model and the method that give full play to a role of the ladder-type carbon trading mechanism in the park-level integrated energy system through example analysis.
    Type: Application
    Filed: October 20, 2022
    Publication date: March 20, 2025
    Inventors: Quan Chen, Xuanjun Zong, Sheng Zou, Hongwei Zhou, Tao Peng, Weiliang Wang, Wenjia Zhang, Chen Wu, Qun Zhang, Yuan Shen, Wei Feng, Gaofeng Shen, Min Zhang, Kai Yang, Xinyue Kong
  • Patent number: 12252504
    Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.
    Type: Grant
    Filed: February 14, 2022
    Date of Patent: March 18, 2025
    Assignee: Genzyme Corporation
    Inventors: Luis Z. Avila, Clark Q. Pan, Patrick Finn, John Harrahy, Qun Zhou, Yunxiang Zhu, Paul A. Konowicz, Duncan E. Paterson, Andreas Peer, Joseph P. Kutzko, Michael R. Reardon, James E. Stefano, Xiaoyang Zheng, Robert J. Miller, Lauren Young
  • Publication number: 20250066497
    Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypetpide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
    Type: Application
    Filed: July 29, 2024
    Publication date: February 27, 2025
    Inventors: Clark Pan, Qun Zhou, James Stefano, Pradeep Dhal, Bo Chen, Diego Gianolio, Robert Miller, Huawei Qiu
  • Patent number: 12229360
    Abstract: A display panel, including an active area and a peripheral area, which is located outside of the active area, wherein the active area comprises a base substrate, and a display structure layer and a touch structure layer sequentially arranged on the base substrate; the peripheral area includes an isolation dam, a first ground trace and a second ground trace arranged on the base substrate; and the first ground trace is located at a side of the isolation dam close to the active area, and the second ground trace is located at a side of the isolation dam away from the active area.
    Type: Grant
    Filed: January 9, 2023
    Date of Patent: February 18, 2025
    Assignees: Chengdu BOE Optoelectronics Technology Co., Ltd., BOE Technology Group Co., Ltd.
    Inventors: Chang Luo, Xiping Li, Hongwei Ma, Ming Hu, Wei He, Youngyik Ko, Haijun Qiu, Yi Zhang, Taofeng Xie, Tianci Chen, Qun Ma, Xinghua Li, Ping Wen, Yang Zhou, Yuanqi Zhang, Xiaoyan Yang, Shun Zhang, Pandeng Tang, Yang Zeng, Tong Zhang, Xiaofei Hou, Zhidong Wang, Haoyuan Fan, Jinhwan Hwang
  • Publication number: 20250051328
    Abstract: The present invention relates to salt forms of the Fibroblast Growth Factor Receptors (FGFR) inhibitor 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3?,2?:5,6]pyrido[4,3-d] pyrimidin-2-one, including methods of preparation thereof, where the compound is useful in the treatment of FGFR mediated diseases such as cancer.
    Type: Application
    Filed: May 22, 2024
    Publication date: February 13, 2025
    Inventors: Zhongjiang Jia, Jiacheng Zhou, Qun Li
  • Patent number: 12218289
    Abstract: A light emitting device includes a Chip Scale Packaged (CSP) LED, the CSP LED including an LED chip that generates blue excitation light; and a photoluminescence layer that covers a light emitting face of the LED chip, wherein the photoluminescence layer comprises from 75 wt % to 100 wt % of a manganese-activated fluoride photoluminescence material of the total photoluminescence material content of the layer. The device/CSP LED can further include a further photoluminescence layer that covers the first photoluminescence and that includes a photoluminescence material that generates light with a peak emission wavelength from 500 nm to 650 nm.
    Type: Grant
    Filed: April 18, 2023
    Date of Patent: February 4, 2025
    Assignee: Bridgelux, Inc.
    Inventors: Jun-Gang Zhou, Gang Wang, Yi-Qun Li
  • Publication number: 20250019366
    Abstract: The present invention relates to salt forms of the Pim kinase inhibitor N—{(7R)-4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide, including methods of preparation thereof, and intermediates in the preparation thereof, where the compound is useful in the treatment of Pim kinase-related diseases such as cancer.
    Type: Application
    Filed: June 10, 2024
    Publication date: January 16, 2025
    Inventors: Zhongjiang Jia, Ganfeng Cao, Qiyan Lin, Yongchun Pan, Lei Qiao, Vaqar Sharief, Chongsheng Eric Shi, Michael Xia, Changsheng Zheng, Jiacheng Zhou, Qun Li
  • Publication number: 20240403675
    Abstract: Techniques for stochastic control of at least one load is provided. Electric power generators provide alternating current (AC) to a plurality of consumer premises (CP). Each CP has one or more loads configured to be electrically powered by the AC. The stochastic control is performed at each consumer premises in a distributed manner. The stochastic control is used to maintain or increase the frequency of the AC provided by an AC electrical power distribution grid when such AC frequency falls below a nominal AC frequency of the AC electrical power distribution grid.
    Type: Application
    Filed: April 17, 2024
    Publication date: December 5, 2024
    Applicant: University of Central Florida Research Foundation, Inc.
    Inventors: Guanyu Tian, Qun Zhou Sun
  • Patent number: 12110338
    Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
    Type: Grant
    Filed: August 17, 2021
    Date of Patent: October 8, 2024
    Assignee: Genzyme Corporation
    Inventors: Clark Pan, Qun Zhou, James Stefano, Pradeep Dhal, Bo Chen, Diego Gianolio, Robert Miller, Huawei Qiu
  • Publication number: 20240218051
    Abstract: Engineered antibodies that are stable and can be conjugated to a ligand or drug at a ligand/drug to antibody ratio of above 3, making these conjugates suitable for treatment of a variety of indications, are provided. Methods of producing these engineered antibodies are also provided.
    Type: Application
    Filed: December 8, 2023
    Publication date: July 4, 2024
    Inventors: Qun Zhou, Sunghae Park, Huawei Qiu, Marie-Priscille Brun, Francis Duffieux
  • Publication number: 20240166750
    Abstract: The present disclosure provides glycoengineered Fc domain variants comprising one or more oligomannose-type N-glycans and an Fc domain mutation. The present disclosure also provides nucleic acids encoding Fc domain variants and host cells for making Fc domain variants. Methods for increasing the yield of Fc domain variants, and methods of using Fc domain variants to treat disease, are also provided.
    Type: Application
    Filed: October 25, 2023
    Publication date: May 23, 2024
    Inventors: Julie A. Jaworski, Sagar V. Kathuria, Sunghae Park, Qun Zhou
  • Publication number: 20240117071
    Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
    Type: Application
    Filed: June 21, 2023
    Publication date: April 11, 2024
    Inventors: Luis AVILA, Clark PAN, Huawei QIU, Qun ZHOU
  • Publication number: 20240059793
    Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
    Type: Application
    Filed: May 17, 2023
    Publication date: February 22, 2024
    Inventors: Luis AVILA, Clark PAN, Huawei QIU, Qun ZHOU
  • Patent number: 11879004
    Abstract: Engineered antibodies that are stable and can be conjugated to a ligand or drug at a ligand/drug to antibody ratio of above 3, making these conjugates suitable for treatment of a variety of indications, are provided. Methods of producing these engineered antibodies are also provided.
    Type: Grant
    Filed: February 26, 2021
    Date of Patent: January 23, 2024
    Assignee: GENZYME CORPORATION
    Inventors: Qun Zhou, Sunghae Park, Huawei Qiu, Marie-Priscille Brun, Francis Duffieux
  • Publication number: 20230391849
    Abstract: Engineered antibodies that are stable and can be conjugated to a ligand or drug at a ligand/drug to antibody ratio of above 3, making these conjugates suitable for treatment of a variety of indications, are provided. Methods of producing these engineered antibodies are also provided.
    Type: Application
    Filed: April 19, 2023
    Publication date: December 7, 2023
    Inventors: Qun Zhou, Sunghae Park, Huawei Qiu, Marie-Priscille Brun, Francis Duffieux
  • Publication number: 20230278262
    Abstract: A 3D-configured production structure of rubber products based on an intelligent manufacturing unit and a production method thereof. The structure includes a stereoscopic production warehouse used to store a mobile intelligent manufacturing unit and an ex-warehouse delivery system used to deliver the mobile intelligent manufacturing unit. The mobile intelligent manufacturing unit includes a unit functional assembly, a molding vulcanization apparatus, a blank feeder, a material-delivering apparatus, a product-collecting apparatus and a reclaimer. The molding vulcanization apparatus includes a upper heat plate, a upper mold, a lower mold, a lower heat plate and a support post. The upper mold and the lower mold are arranged on the inner sides of the upper heat plate and the lower heat plate, respectively. The upper heat plate is fixed on one end of the support post, and the lower heat plate is arranged through the support post.
    Type: Application
    Filed: August 26, 2022
    Publication date: September 7, 2023
    Inventors: Jie Zhong, Aimin Zeng, Xiaofeng Zhang, Liang Wang, Xuegang Wu, Qun Zhou, Zanping Zhang, Chen Han, Yu Liu, Zhipeng Li, Gaosheng Guo, Rongqian Mo, Yue Fei
  • Publication number: 20230219302
    Abstract: A device for automatically removing margins of rubber sealing rings in high-precision includes a vibrating plate, an installation platform, a motor assembly and a core rod, wherein the motor assembly is arranged on the lower part of the installation platform, the core rod is arranged above the motor assembly, the core rod is a metal rod, the top of which is tapered, a clamping apparatus, an auxiliary apparatus and a margin-removing apparatus are arranged beside the core rod, a product-conveying belt and a buffer conveyor belt are arranged on the installation platform, one side of the core rod far away from the product-collecting box is further provided with an air-pumping apparatus and an air-blowing apparatus. A method for automatically removing margins of rubber sealing rings in high-precision includes: automatically positioning, removing outer margins, removing inner margins step-by-step and automatically collecting.
    Type: Application
    Filed: August 29, 2022
    Publication date: July 13, 2023
    Inventors: Chen Han, Jicheng Wang, Qun Zhou, Xiaofeng Zhang, Hongzhong Tu, Hansong Zou, Zanping Zhang, Baitao Zhang, Rongqian Mo, Jian Gong, Wenjie Peng, Zhiming Liu, Hong Liu
  • Patent number: 11697690
    Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
    Type: Grant
    Filed: March 29, 2021
    Date of Patent: July 11, 2023
    Assignee: GENZYME CORPORATION
    Inventors: Luis Avila, Clark Pan, Huawei Qiu, Qun Zhou
  • Publication number: 20220242899
    Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.
    Type: Application
    Filed: February 14, 2022
    Publication date: August 4, 2022
    Inventors: Luis Z. AVILA, Clark Q. PAN, Patrick FINN, John HARRAHY, Qun ZHOU, Yunxiang ZHU, Paul A. KONOWICZ, Duncan E. PATERSON, Andreas PEER, Joseph P. KUTZKO, Michael R. REARDON, James E. STEFANO, Xiaoyang ZHENG, Robert J. MILLER, Lauren YOUNG