Abstract: A ternary composite catalyst of diethylzinc and yttrium trifluoroacetate loaded on chitin for copolymerization of carbon dioxide, epoxy cyclohexane and ethylene oxide is provided. The ternary composite catalyst exhibits strong catalytic activity for the ternary copolymerization of carbon dioxide, cyclohexane oxide and ethylene oxide. A high molecular weight and content of ester chain is maintained. Conventional rare earth ternary catalysts leave residues in the polymer, and the polymer requires rinsing with hydrochloric acid. The ternary composite catalyst can be removed through filtration. The average molecular weight of the resulting polycarbonate is more than 100,000, and the ester chain content is more than 90%. The resulting polymer has a lower metal content. The ternary composite catalyst can be used in agricultural film, disposable packaging and other polymer materials.

Abstract: A method for reducing odor in remediation of pesticide chemical contaminated soil comprises preparing odor control sustained-release particles and evenly covering on the surface of the pesticide chemical contaminated soil according to a certain dosage; preparing odor covering base materials and mixed bacterial solution, and preparing the odor covering soil by mixing the odor covering base materials and mixed bacterial solution in proportion, and then covering the odor covering soil on the surface of the pesticide chemical contaminated soil; and inserting heating rods into the pesticide chemical contaminated soil, and heating the surface layer of the pesticide chemical contaminated soil to 30-40° C.

Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

Abstract: A GNSS emergency monitoring error suppression method for an alpine canyon complex environment is provided. Through three steps of GNSS optimization design of the alpine canyon complex environment, derived error suppression of emergency monitoring criteria in the alpine canyon complex environment, and error suppression measurement and result correction, GNSS measurement errors in the alpine canyons can be effectively suppressed. Through improving measurement accuracy, GNSS technology can be widely applied to the alpine canyons, outstanding advantages of high efficiency and high accuracy in a coordinate transmission process of the GNSS technology are brought into full play, and a cost is effectively reduced. Meanwhile, by processing the errors of the emergency monitoring criteria, it is possible to protect workers from on-site operation risks.

Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

Abstract: Engineered antibodies that are stable and can be conjugated to a ligand or drug at a ligand/drug to antibody ratio of above 3, making these conjugates suitable for treatment of a variety of indications, are provided. Methods of producing these engineered antibodies are also provided.

Abstract: Engineered antibodies that are stable and can be conjugated to a ligand or drug at a ligand/drug to antibody ratio of above 3, making these conjugates suitable for treatment of a variety of indications, are provided. Methods of producing these engineered antibodies are also provided.

Abstract: A 3D-configured production structure of rubber products based on an intelligent manufacturing unit and a production method thereof. The structure includes a stereoscopic production warehouse used to store a mobile intelligent manufacturing unit and an ex-warehouse delivery system used to deliver the mobile intelligent manufacturing unit. The mobile intelligent manufacturing unit includes a unit functional assembly, a molding vulcanization apparatus, a blank feeder, a material-delivering apparatus, a product-collecting apparatus and a reclaimer. The molding vulcanization apparatus includes a upper heat plate, a upper mold, a lower mold, a lower heat plate and a support post. The upper mold and the lower mold are arranged on the inner sides of the upper heat plate and the lower heat plate, respectively. The upper heat plate is fixed on one end of the support post, and the lower heat plate is arranged through the support post.

Abstract: A device for automatically removing margins of rubber sealing rings in high-precision includes a vibrating plate, an installation platform, a motor assembly and a core rod, wherein the motor assembly is arranged on the lower part of the installation platform, the core rod is arranged above the motor assembly, the core rod is a metal rod, the top of which is tapered, a clamping apparatus, an auxiliary apparatus and a margin-removing apparatus are arranged beside the core rod, a product-conveying belt and a buffer conveyor belt are arranged on the installation platform, one side of the core rod far away from the product-collecting box is further provided with an air-pumping apparatus and an air-blowing apparatus. A method for automatically removing margins of rubber sealing rings in high-precision includes: automatically positioning, removing outer margins, removing inner margins step-by-step and automatically collecting.

Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.

Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

Abstract: A method for replacing a native atrioventricular heart valve includes inserting a delivery catheter into the heart with a prosthetic apparatus retained in a compressed state inside of the delivery catheter. The prosthetic apparatus includes an annular anchoring member having a mesh structure made of Nitinol and defining a plurality of circumferentially extending rows of cells. A fabric layer is attached to an inner surface of the anchoring member. An annular support member made of Nitinol is disposed within the anchoring member. The support member is attached to the anchoring member with sutures. A prosthetic valve made of biological tissue is disposed within and secured to the support member. The method further includes allowing the prosthetic apparatus to self-expand to a radially expanded state in which the anchoring member contacts tissue of the native atrioventricular valve.

Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.

Abstract: Techniques are provided for identifying and presenting contextual course recommendations. A browser extension analyzes text within web content that is being displayed on a computing device. The browser extension, as part of the analysis, identifies one or more keywords. The browser extension transmits the one or more keywords over a computer network to a remote computer system. For each keyword, the remote computer system identifies one or more courses and one or more relevance scores, each of which reflects a relevance measure between the keyword and a course of the one or more courses. The remote system transmits, to the browser extension, course identification data that identifies one or more particular courses. The browser extension causes the course identification data to be displayed on the computing device.

Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

Abstract: Systems and methods of the present disclosure generally relate to a partitioned stator. The stator includes a plurality of partitioned iron cores that are identical in shape and connected to each other. Windings are wrapped around the partitioned iron cores. Each partitioned iron core includes a yoke and a tooth. End-face enlargements are symmetrically arranged on two end-faces of the yoke. The yoke is of an arc-shaped structure, and the end-face enlargements extend in a radial direction of the arc-shaped structure.

Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.