Patents by Inventor Qun Zhou

Qun Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11507823
    Abstract: A method of adaptive quantization for a convolutional neural network, includes at least one of receiving an acceptable model accuracy, determining a float value multiply accumulate for the layer based on a float value weight and a float value input, quantizing the float value weight at multiple weight quantization precisions, quantizing the float value input at multiple input quantization precisions, determining a multiply accumulate at multiple multiply accumulate quantization precisions based on the weight quantization precisions and the input quantization precisions, determining multiple quantization errors based on differences between the float value multiply accumulate and the multiple multiply accumulate quantization precisions and selecting one of the multiple weight quantization precisions, one of the multiple input quantization precisions and one of the multiple multiply accumulate quantization precisions based on the predetermined acceptable model accuracy and the multiple quantization errors.
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: November 22, 2022
    Assignee: Black Sesame Technologies Inc.
    Inventors: Zuoguan Wang, Tian Zhou, Qun Gu
  • Patent number: 11472801
    Abstract: The present disclosure relates to solid forms of N-{[2?-(2,6-difluoro-3,5-dimethoxyphenyl)-3?-oxo-2?,3?-dihydro-1?H-spiro[cyclopropane-1,4?-[2,7]naphthyridin]-6?-yl]methyl}acrylamide, methods of preparation thereof, and intermediates in the preparation thereof, which are useful in the treatment of the FGFR-associated or mediated diseases such as cancer.
    Type: Grant
    Filed: February 6, 2020
    Date of Patent: October 18, 2022
    Assignee: Incyte Corporation
    Inventors: Yongchun Pan, Chongsheng Eric Shi, Ming Tao, Wayne Han, Michael Xia, Dengjin Wang, Zhongjiang Jia, Jiacheng Zhou, Qun Li
  • Publication number: 20220310722
    Abstract: Provided are a display motherboard, a preparation method thereof, a display substrate and a display device. The display motherboard includes a plurality of display substrate regions and a cutting region located at a periphery of each of the plurality of display substrate regions; the display motherboard includes a driving structure layer arranged in each of the plurality of display substrate regions and a marking structure layer arranged in each cutting region, wherein the marking structure layer includes a cutting mark layer; and a planarization layer arranged on the driving structure layer and the marking structure layer, and covering the marking structure layer.
    Type: Application
    Filed: December 29, 2020
    Publication date: September 29, 2022
    Inventors: Linhong HAN, Yi ZHANG, Guangzhou ZHAO, Yiyang ZHANG, Yuqing YANG, Tingliang LIU, Pengfei YU, Yang ZHOU, Qun MA, Xiping LI, Shikai QIN, Weiyun HUANG, Yue LONG
  • Publication number: 20220306628
    Abstract: The present application relates to crystalline solid forms of an inhibitor of BET proteins such as BRD2, BRD3, BRD4, and BRD-t, including methods of preparation thereof, and intermediates in the preparation thereof, where the compound is useful in the treatment of diseases such as cancer.
    Type: Application
    Filed: June 2, 2022
    Publication date: September 29, 2022
    Inventors: Shili Chen, Zhongjiang Jia, Pingli Liu, Lei Qiao, Yongzhong Wu, Jiacheng Zhou, Qun Li
  • Publication number: 20220242899
    Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.
    Type: Application
    Filed: February 14, 2022
    Publication date: August 4, 2022
    Inventors: Luis Z. AVILA, Clark Q. PAN, Patrick FINN, John HARRAHY, Qun ZHOU, Yunxiang ZHU, Paul A. KONOWICZ, Duncan E. PATERSON, Andreas PEER, Joseph P. KUTZKO, Michael R. REARDON, James E. STEFANO, Xiaoyang ZHENG, Robert J. MILLER, Lauren YOUNG
  • Publication number: 20220227770
    Abstract: The present application provides salt forms of N-(4-(4-Amino-7-(1-isobutyrylpiperidin-4-yl)pyrrolo[1,2-f][1,2,4]triazin-5-yl)phenyl)-1-isopropyl-2,4-dioxo-3-(pyridin-2-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide and N-(4-(4-Amino-7-(1-isobutyrylpiperidin-4-yl)pyrrolo[1,2-f][1,2,4]triazin-5-yl)phenyl)-1-isopropyl-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxamide, which are useful as inhibitors of TAM kinases, as well as processes and intermediates related thereto.
    Type: Application
    Filed: August 13, 2021
    Publication date: July 21, 2022
    Inventors: Zhongjiang Jia, Yongzhong Wu, Yongchun Pan, Jiacheng Zhou, Qun Li
  • Patent number: 11384638
    Abstract: An apparatus for controllably unfolding a flexible mesh for a continuous miner includes a mesh roll storage rack, a height adjustment post, a mesh rolling shaft and a flexible mesh. The flexible mesh includes a mesh roll and an unfolded mesh. The mesh roll and the unfolded mesh are an integrated structure. The mesh roll is located on the mesh roll storage rack. The unfolded mesh is clamped on the mesh rolling shaft, and is pressed on a cut un-supported tunnel roof via a roof bolt. The mesh rolling shaft is rotatably connected to a top portion of the height adjustment post. The mesh roll storage rack and the height adjustment post are both mounted on the continuous miner. The mesh rolling shaft is located at a back end of the mesh roll storage rack. A limit mechanism and a damping mechanism are disposed on the mesh rolling shaft.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: July 12, 2022
    Assignee: CHINA UNIVERSITY OF MINING AND TECHNOLOGY
    Inventors: Nong Zhang, Zhengzheng Xie, Qun Wei, Junyao Zhou
  • Patent number: 11377446
    Abstract: The present application relates to crystalline solid forms of an inhibitor of BET proteins such as BRD2, BRD3, BRD4, and BRD-t, including methods of preparation thereof, and intermediates in the preparation thereof, where the compound is useful in the treatment of diseases such as cancer.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: July 5, 2022
    Assignee: Incyte Corporation
    Inventors: Shili Chen, Zhongjiang Jia, Pingli Liu, Lei Qiao, Yongzhong Wu, Jiacheng Zhou, Qun Li
  • Publication number: 20220119547
    Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
    Type: Application
    Filed: March 29, 2021
    Publication date: April 21, 2022
    Inventors: Luis AVILA, Clark PAN, Huawei QIU, Qun ZHOU
  • Publication number: 20220110748
    Abstract: A method for replacing a native atrioventricular heart valve includes inserting a delivery catheter into the heart with a prosthetic apparatus retained in a compressed state inside of the delivery catheter. The prosthetic apparatus includes an annular anchoring member having a mesh structure made of Nitinol and defining a plurality of circumferentially extending rows of cells. A fabric layer is attached to an inner surface of the anchoring member. An annular support member made of Nitinol is disposed within the anchoring member. The support member is attached to the anchoring member with sutures. A prosthetic valve made of biological tissue is disposed within and secured to the support member. The method further includes allowing the prosthetic apparatus to self-expand to a radially expanded state in which the anchoring member contacts tissue of the native atrioventricular valve.
    Type: Application
    Filed: December 20, 2021
    Publication date: April 14, 2022
    Applicants: The Cleveland Clinic Foundation, Edwards Lifesciences Corporation
    Inventors: Jose Luis Navia, Ji-Feng Chen, Qun Zhou
  • Publication number: 20220088214
    Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
    Type: Application
    Filed: August 16, 2021
    Publication date: March 24, 2022
    Inventors: Luis Z. Avila, Qun Zhou
  • Publication number: 20220089763
    Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
    Type: Application
    Filed: August 17, 2021
    Publication date: March 24, 2022
    Inventors: Clark Pan, Qun Zhou, James Stefano, Pradeep Dhal, Bo Chen, Diego Gianolio, Robert Miller, Huawei Qiu
  • Patent number: 11279725
    Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.
    Type: Grant
    Filed: September 24, 2019
    Date of Patent: March 22, 2022
    Assignee: Genzyme Corporation
    Inventors: Luis Z. Avila, Clark Q. Pan, Patrick Finn, John Harrahy, Qun Zhou, Yunxiang Zhu, Paul A. Konowicz, Duncan E. Paterson, Andreas Peer, Joseph P. Kutzko, Michael R. Reardon, James E. Stefano, Xiaoyang Zheng, Robert J. Miller, Lauren Young
  • Patent number: 11250716
    Abstract: Techniques are provided for identifying and presenting contextual course recommendations. A browser extension analyzes text within web content that is being displayed on a computing device. The browser extension, as part of the analysis, identifies one or more keywords. The browser extension transmits the one or more keywords over a computer network to a remote computer system. For each keyword, the remote computer system identifies one or more courses and one or more relevance scores, each of which reflects a relevance measure between the keyword and a course of the one or more courses. The remote system transmits, to the browser extension, course identification data that identifies one or more particular courses. The browser extension causes the course identification data to be displayed on the computing device.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: February 15, 2022
    Assignee: Microsoft Technology Licensing, LLC
    Inventors: Yi Qun Zhou, Yayuan Hu, Haowen Cao, Ibraheem Abdul Malik
  • Patent number: 11160874
    Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: November 2, 2021
    Assignee: GENZYME CORPORATION
    Inventors: Luis Z. Avila, Qun Zhou
  • Publication number: 20210328465
    Abstract: Systems and methods of the present disclosure generally relate to a partitioned stator. The stator includes a plurality of partitioned iron cores that are identical in shape and connected to each other. Windings are wrapped around the partitioned iron cores. Each partitioned iron core includes a yoke and a tooth. End-face enlargements are symmetrically arranged on two end-faces of the yoke. The yoke is of an arc-shaped structure, and the end-face enlargements extend in a radial direction of the arc-shaped structure.
    Type: Application
    Filed: August 3, 2020
    Publication date: October 21, 2021
    Applicant: Zhe Jiang Cheering Sewing Machine Co., LTD.
    Inventors: Qianlin Zhao, Wen Liu, Qun Zhou, Yi Zhao, Xiuyu Guan, Qianli Huang, Bingping Fang, Qing Cheng
  • Patent number: 11130816
    Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: September 28, 2021
    Assignee: GENZYME CORPORATION
    Inventors: Clark Pan, Qun Zhou, James Stefano, Pradeep Dhal, Bo Chen, Diego Gianolio, Robert Miller, Huawei Qiu
  • Publication number: 20210292391
    Abstract: Engineered antibodies that are stable and can be conjugated to a ligand or drug at a ligand/drug to antibody ratio of above 3, making these conjugates suitable for treatment of a variety of indications, are provided. Methods of producing these engineered antibodies are also provided.
    Type: Application
    Filed: February 26, 2021
    Publication date: September 23, 2021
    Inventors: Qun Zhou, Sunghae Park, Huawei Qiu, Marie-Priscille Brun, Francis Duffieux
  • Publication number: 20210253453
    Abstract: The disclosure claims a magnetizing device and method for preparing magnetized water for dust fall of an underground coal mine. The device is formed by a plurality of magnetic drums in a parallel connection with connecting elbows in a ā€œUā€-shaped arrangement manner. Each magnetic drum consists of an external magnet, an internal magnet, a hollow pressure pipe, a spiral blade, a screen magnet cover, a connecting steel column, a pressure pipe, a closed nut and a flange plate. According to the disclosure, the internal and external magnets are arranged on a spiral flow channel consisting of the hollow pressure pipe, the spiral blade and the pressure blade by means of an alternating arrangement, thereby building an efficient magnetization environment combined by pulse cutting magnetization and spiral turbulence, enabling that the water for dust fall flowing through is magnetized continuously and efficiently.
    Type: Application
    Filed: August 19, 2017
    Publication date: August 19, 2021
    Inventors: Botao QIN, Qun ZHOU, Jun WANG, Hongjun LIANG, Anliang WANG, Ang GAO, Yuan GAO, Jin HOU
  • Publication number: 20210161657
    Abstract: An apparatus is provided for replacing a native cardiac valve. The native cardiac valve has at least one leaflet and is surrounded by a native cardiac valve annulus having superior and inferior aspects. The apparatus comprises a barbell-shaped, expandable anchoring member including first, second, and main body portions extending between the end portions. The main body portion includes a channel defined by inner and outer surfaces. Each of the first and second end portions has a diameter greater than the diameter of the main body portion. The first and second end portions are sized to respectively contact the superior and inferior aspects of the native cardiac valve annulus when the expandable anchoring member is in an expanded configuration. The apparatus also includes an expandable support member operably disposed within the main body portion of the expandable anchoring member, and a prosthetic cardiac valve secured within the expandable support member.
    Type: Application
    Filed: October 9, 2020
    Publication date: June 3, 2021
    Inventors: Jose Luis Navia, Ji-Feng Chen, Qun Zhou