Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.

Abstract: Techniques are provided for identifying and presenting contextual course recommendations. A browser extension analyzes text within web content that is being displayed on a computing device. The browser extension, as part of the analysis, identifies one or more keywords. The browser extension transmits the one or more keywords over a computer network to a remote computer system. For each keyword, the remote computer system identifies one or more courses and one or more relevance scores, each of which reflects a relevance measure between the keyword and a course of the one or more courses. The remote system transmits, to the browser extension, course identification data that identifies one or more particular courses. The browser extension causes the course identification data to be displayed on the computing device.

Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

Abstract: Systems and methods of the present disclosure generally relate to a partitioned stator. The stator includes a plurality of partitioned iron cores that are identical in shape and connected to each other. Windings are wrapped around the partitioned iron cores. Each partitioned iron core includes a yoke and a tooth. End-face enlargements are symmetrically arranged on two end-faces of the yoke. The yoke is of an arc-shaped structure, and the end-face enlargements extend in a radial direction of the arc-shaped structure.

Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

Abstract: Engineered antibodies that are stable and can be conjugated to a ligand or drug at a ligand/drug to antibody ratio of above 3, making these conjugates suitable for treatment of a variety of indications, are provided. Methods of producing these engineered antibodies are also provided.

Abstract: The disclosure claims a magnetizing device and method for preparing magnetized water for dust fall of an underground coal mine. The device is formed by a plurality of magnetic drums in a parallel connection with connecting elbows in a “U”-shaped arrangement manner. Each magnetic drum consists of an external magnet, an internal magnet, a hollow pressure pipe, a spiral blade, a screen magnet cover, a connecting steel column, a pressure pipe, a closed nut and a flange plate. According to the disclosure, the internal and external magnets are arranged on a spiral flow channel consisting of the hollow pressure pipe, the spiral blade and the pressure blade by means of an alternating arrangement, thereby building an efficient magnetization environment combined by pulse cutting magnetization and spiral turbulence, enabling that the water for dust fall flowing through is magnetized continuously and efficiently.

Abstract: An apparatus is provided for replacing a native cardiac valve. The native cardiac valve has at least one leaflet and is surrounded by a native cardiac valve annulus having superior and inferior aspects. The apparatus comprises a barbell-shaped, expandable anchoring member including first, second, and main body portions extending between the end portions. The main body portion includes a channel defined by inner and outer surfaces. Each of the first and second end portions has a diameter greater than the diameter of the main body portion. The first and second end portions are sized to respectively contact the superior and inferior aspects of the native cardiac valve annulus when the expandable anchoring member is in an expanded configuration. The apparatus also includes an expandable support member operably disposed within the main body portion of the expandable anchoring member, and a prosthetic cardiac valve secured within the expandable support member.

Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

Abstract: A method for managing account data and handling account recovery requests are disclosed. The method comprises a multi-level identity verification process, including a first level where a specific computing device requesting recovery of an electronic account is requested to identify a trusted contact for the electronic account and a second level where the specific computing device is requested to provide a dynamically generated security code that has been communicated to a trusted contact identified by the specific computing device.

Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.

Abstract: A method for managing account data and handling account recovery requests are disclosed. The method comprises a multi-level identity verification process, including a first level where a specific computing device requesting recovery of an electronic account is requested to identify a trusted contact for the electronic account and a second level where the specific computing device is requested to provide a dynamically generated security code that has been communicated to a trusted contact identified by the specific computing device.

Abstract: A signal collection assembly and a power battery module are provided. The signal collection assembly includes: a substrate; a signal collection line including a sheet-like metal conductive element disposed on the substrate; a signal collection member disposed on the substrate and connected with the signal collection line; and a signal collection terminal disposed on the substrate. The signal collection terminal includes a first terminal connected with the signal collection line and a second terminal connected with a power connection member of the power battery module.

Abstract: Techniques are provided for identifying and presenting contextual course recommendations. A browser extension analyzes text within web content that is being displayed on a computing device. The browser extension, as part of the analysis, identifies one or more keywords. The browser extension transmits the one or more keywords over a computer network to a remote computer system. For each keyword, the remote computer system identifies one or more courses and one or more relevance scores, each of which reflects a relevance measure between the keyword and a course of the one or more courses. The remote system transmits, to the browser extension, course identification data that identifies one or more particular courses. The browser extension causes the course identification data to be displayed on the computing device.

Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.

Abstract: A method of self-healing power grids after power outages includes providing an Adaptive Restoration Decision Support System (ARDSS) for generating a restoration solution using static and dynamic input data from power generator(s) powering transmission lines, from the transmission lines and loads. At a beginning of a restoration period a two-stage problem is solved including a first and second-stage problem with an optimal planning (OP) function as a mixed-integer linear programming (MILP) problem using initial static and dynamic data to determine start-up times for the power generator and energization sequences for transmission lines involved in the power outage. Only the second-stage problem is again solved with an optimal real-time (OR) function using the start-up times and energization sequences along with updated static and dynamic data to determine operating parameters for the grid.

Abstract: A method and system for determining a separation distance between a first object and a second object comprises using a search module associated with a first object comprising a first transponder having a unique address. The method includes using a reply module associated with a second object comprising a second transponder having a different, unique address. The method includes the search module transmitting a search signal on a first frequency, said search signal including the address of the first transponder and the address of the second transponder. The reply module receives the search signal and locally validates the address included in said received search signal for the second transponder, whereby, if the validation is positive; the reply module transmits a reply signal on a second, different frequency.

Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypetpide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.