Abstract: The present invention relates to compositions and methods for inducing an adaptive immune response against Hepatitis C virus (HCV) in a subject. In some embodiments, the present invention provides a composition comprising a nucleoside-modified nucleic acid molecule encoding a HCV antigen, adjuvant, or a combination thereof. For example, in some embodiments, the composition comprises a vaccine comprising a nucleoside-modified nucleic acid molecule encoding a HCV antigen, adjuvant, or a combination thereof.

Abstract: A stator includes insulation including a back insulation portion covering a back stator portion, a first tooth portion covering a first tooth, a second tooth portion covering a second tooth. A first flange portion has a first face that is in facing relationship with the back insulation portion. A second flange portion has a second face that is in facing relationship with the back insulation portion. The first face and the second face together substantially defining a boundary plane, such that a cross-sectional slot area is defined between the back insulation portion, the first tooth portion, the second tooth portion, and the boundary plane. A plurality of conductive wires are arranged in the cross-sectional slot area, the wires defining a cross-sectional winding area within the cross-sectional slot area. A ratio of the cross-sectional winding area to the cross-sectional slot area is greater than or equal to 0.45.

Abstract: The disclosure is directed to, in part, compounds, or pharmaceutically acceptable salts or solvates thereof, for modulating the activity of aldehyde dehydrogenase such as ALDH2 and/or methods for treating and/or preventing an alcohol related disorder such as alcohol use disorder, alcohol induced disorder, alcohol abuse, alcohol dependence, alcohol intoxication, alcohol withdrawal, and the like and/or methods for reducing the amount of alcohol consumed, reducing alcoholic cravings, or increasing the percentage of no heavy drinking days for a subject with alcohol use disorder.

Abstract: An electric vehicle braking system including a braking controller, a front braking system, and a rear braking system. The front braking system includes a front friction brake and a front regenerative braking system. The rear braking system includes a rear regenerative braking system and excludes a friction brake. The braking controller is configured to detect the front regenerative braking has reached a maximum force, detect additional deceleration is required, and, in response to detecting the front regenerative braking has reached the maximum force and detecting additional deceleration is required, apply the front friction brake.

Abstract: The disclosure is directed to, in part, compounds, or pharmaceutically acceptable salts or solvates thereof, for modulating the activity of aldehyde dehydrogenase such as ALDH2 and/or methods for treating and/or preventing an alcohol related disorder such as alcohol use disorder, alcohol induced disorder, alcohol abuse, alcohol dependence, alcohol intoxication, alcohol withdrawal, and the like and/or methods for reducing the amount of alcohol consumed, reducing alcoholic cravings, or increasing the percentage of no heavy drinking days for a subject with alcohol use disorder.

Abstract: Methods and systems for tuning lithotripsy frequency to target size are disclosed. In one embodiment, a lithotripsy system for comminuting a stone in a body includes: a burst wave lithotripsy (BWL) therapy transducer configured to transmit smooth ultrasound waves within a burst of ultrasound waves toward the stone; and a controller configured to determine operating frequency of the ultrasound waves of the therapy transducer. The operating frequency of the ultrasound waves is determined as: f = Const . c d where: d is a diameter of the stone, f is the frequency of the ultrasound waves, c is a wave speed in the stone, and Const. is a predetermined constant.

Abstract: The present disclosure provides novel crystalline forms of a compound that acts as an ALDH2 effector, processes for preparing the crystalline forms of the compound with or without coformer, and uses thereof.

Abstract: The disclosure is directed to cocrystals of fasoracetam, including R-fasoracetam, and various coformers. Crystalline materials comprising fasoracetam, including R-fasoracetam, are also provided. The disclosure further includes pharmaceutical compositions and methods of treatment of the cocrystals and crystalline materials of the disclosure.

Abstract: A power tool includes a housing and an electric motor. The electric motor includes a rotor assembly including a rotor shaft and a stator assembly including a plurality of stator segments. Each stator segment includes a core, an insulator at least partially covering the core, and a coil winding. The insulator includes a mounting portion. The electric motor also includes a printed circuit board assembly configured to direct electric current to each coil winding, and a bus bar assembly attached to at least one of the mounting portions and configured to electrically connect the coil windings to the printed circuit board assembly. The bus bar assembly includes a molded body and a plurality of conductors. The bus bar assembly defines a bearing pocket. The electric motor further includes rotor bearing that is received into the bearing pocket and that supports the rotor shaft for rotation relative to the stator assembly.

Abstract: A method for attempting to fragment or comminute an object in a body using ultrasound includes producing a burst wave lithotripsy (BWL) waveform by a therapy transducer. The BWL waveform is configured to fragment or comminute the object. The BWL waveform includes a first burst of continuous ultrasound cycles and a second burst of continuous ultrasound cycles. A burst frequency corresponds to a frequency of repeating the bursts of the BWL waveform. The method also includes determining a cycle frequency f of the continuous ultrasound cycles within the first burst and the second burst based on a target fragment size D, where the cycle frequency is: f(MHz)=0.47/D(mm).

Abstract: A method includes transmitting a focused ultrasound wave into a medium to form (i) an ultrasound intensity well within the medium that exhibits a first range of acoustic pressure and (ii) a surrounding region of the medium that surrounds the ultrasound intensity well and exhibits a second range of acoustic pressure that exceeds the first range of acoustic pressure. The method further includes confining an object within the ultrasound intensity well. Additionally, an acoustic lens is configured to be acoustically coupled to an acoustic transducer. The acoustic lens has a varying longitudinal thickness that increases proportionally with respect to increasing azimuth angle of the acoustic lens. Another acoustic lens is configured to be acoustically coupled to an acoustic transducer. The acoustic lens includes a plurality of segments. Each of the plurality of segments has a varying longitudinal thickness that increases proportionally with respect to increasing azimuth angle of the segment.

Abstract: Non-planar holographic beam shaping lenses for acoustics are disclosed herein. In one embodiment, an ultrasonic therapy system that is configured to apply ultrasound to a target in a body includes: an ultrasonic transducer configured to generate the ultrasound; and a customizable holographic lens configured to focus the ultrasound onto a focal area of a target that is an object or a portion of the object in the body. The customizable holographic lens is designed and produced based on the target. Furthermore, the customizable holographic lens is curved to mate with a front surface of the ultrasonic transducer.

Abstract: The present disclosure relates generally to the field of drilling operations. More particularly, the present disclosure relates to methods for drilling wells utilizing drilling equipment, more particularly drill string assemblies, and making adjustments to drilling parameters during the drilling operation based on analysis of the drilling data. Included are methods for the selection of modified drilling parameters to mitigate torsional vibration dysfunction.

Abstract: A steering apparatus for a vehicle that utilizes steer-by-wire controls and may selectively be operated in an autonomous mode comprises a body mounted sliding steering column. The body mounted sliding steering column includes an arm that slides between a stowed position and a use position on at least one rail attached to a frame of the vehicle. The arm supports a steering column that may also be adjustable between a retracted position and an extended position. The arm also houses a force feedback motor in force-transmitting communication with the steering column.

Abstract: Provided herein are, inter alia, methods, compositions and kits for HCV antigen and vaccine design. Preferred methods include measuring neutralization of HCV pseudoparticles (HCVpp) by antibodies specific for an HCV in the biological sample, generating a neutralizations profile of each biological sample; deconvoluting the HCV-specific neutralizing antibodies by generating reference antibody neutralization profiles; correlating the reference antibody neutralization profiles to the biological sample's neutralization profile; and, identifying the HCV neutralizing antibodies.

Abstract: Systems and methods generating textiles with repeating design elements based at least in part on Voronoi diagrams are provided. In one example implementation, the method can include generating a plurality of seed points in a graphic area. The seed points are utilized to create a Voronoi diagram. A Voronoi diagram is thereafter propagated within the graphic area based upon the seed points. The method also includes receiving a first user input defining a design area. The design area includes a plurality of boundaries within the graphic area. The design area is then correlated to a textile segment and a textile design is generated by replicating the cells in the design area. The cells that intersect the boundaries of the design area are replicated with identical instances placed at the adjacent sides of the design area and the corners of the design area.

Abstract: A computing device includes a port to allow the computing device to connect to a network, and one or more processors, the one or more processors configured to execute code to cause the one or more processors to determine that a new waveform has been added to a repository connected to the computing device, perform a set of measurements on the new waveform, attach results from the measurements to the new waveform as metadata, and store the new waveform and attached metadata to the repository. A method of managing waveform data includes determining that a new waveform has been added to a repository, performing a set of measurements on the new waveform, attaching results from the measurements to the new waveform as metadata, and storing the new waveform and attached metadata to the repository.

Abstract: A multi-layer friction reducing tape, including: a foil layer including a metal, polymer, or hybrid-metal-polymer; an under layer disposed on the foil layer; an adhesion promoting layer contiguous with a surface of the under layer; a functional layer that includes a fullerene based composite, a diamond based material, diamond-like-carbon (DLC), or combinations thereof, wherein the functional layer is contiguous with a surface of the adhesion promoting layer; and a tape, including an adhesive layer and a backing material, wherein the adhesive layer is attached to a surface of the foil layer opposite the under layer.

Abstract: Systems and methods generating textiles with repeating design elements based at least in part on Voronoi diagrams are provided. In one example implementation, the method can include generating a plurality of seed points in a graphic area. The seed points are utilized to create a Voronoi diagram. A Voronoi diagram is thereafter propagated within the graphic area based upon the seed points. The method also includes receiving a first user input defining a design area. The design area includes a plurality of boundaries within the graphic area. The design area is then correlated to a textile segment and a textile design is generated by replicating the cells in the design area. The cells that intersect the boundaries of the design area are replicated with identical instances placed at the adjacent sides of the design area and the corners of the design area.

Abstract: The disclosure is directed to, in part, compounds, or pharmaceutically acceptable salts or solvates thereof, for modulating the activity of aldehyde dehydrogenase such as ALDH2 and/or methods for treating and/or preventing an alcohol related disorder such as alcohol use disorder, alcohol induced disorder, alcohol abuse, alcohol dependence, alcohol intoxication, alcohol withdrawal, and the like and/or methods for reducing the amount of alcohol consumed, reducing alcoholic cravings, or increasing the percentage of no heavy drinking days for a subject with alcohol use disorder.