Abstract: Targeting methods and devices for non-invasive therapy delivery are disclosed. In one embodiment, a method for targeting an object in a body using ultrasound includes: producing a therapy ultrasound waveform configured to fragment or comminute the object in the body using a therapy transducer of an ultrasound probe; and acquiring a sound waveform by a receiver. The sound waveform is at least in part caused by interactions of the therapy ultrasound with the object. The method also includes generating an indication of a targeting accuracy based on the acquired sound waveform.

Abstract: A power tool includes a motor having a motor shaft that rotates about a motor axis in a first rotational direction. The power tool also includes a fan assembly attachable to the motor shaft for rotation in the first rotational direction. The fan assembly includes a fan body and a bearing having a race that is rotatably affixed to the fan body. The race is freely rotatable relative to the motor shaft in the first rotational direction, and fixed against rotation relative to the motor shaft in a second rotational direction opposite the first rotational direction.

Abstract: Methods and systems for monitoring operation integrity during hydrocarbon production or fluid injection operations by receiving microseismic data; processing the microseismic data to obtain a plurality of data panels corresponding to microseismic data measured over a predetermined time interval; calculating, for each data panel, trigger values for data traces corresponding to sensor receivers of the microseismic monitoring system; selecting, as a triggered data panel, at least one data panel that satisfies predetermined triggering criteria; selecting, as a non-trivial data panel, at least one triggered data panel that satisfies spectral density criteria; calculating a value for each of at least two event attributes of a plurality of event attributes of the event; determining an event score based on the values of the plurality of event attributes; and classifying the event into at least one event category of a plurality of event categories based on the event score.

Abstract: A continuously variable transmission includes two planetary gear sets having two planetary outputs and a planetary output shaft with a first drive gear. A variator drives a ring gear of the second planetary gear set, and a transmission input shaft is driven by the engine, which also drives the variator and the planetary input. Forward and reverse output systems are connected to the planetary output shaft and a transmission output shaft. A first clutch connects the first planetary output to the first drive gear, and a second clutch connects the second planetary output to the first drive gear. A third clutch connects the second planetary output to a second drive gear of the planetary output shaft, with the second drive gear being connected to the forward output system.

Abstract: Provided herein are methods for the production of activated CD26high T cells by co-stimulation with inducible coactivator (ICOS). Further provided are methods for treatment of cancer by administration of the of activated CD26high T cells as an adoptive T cell therapy.

Abstract: A device for treating a damaged tissue includes an expandable scaffold positionable in a portion of a luminal tissue structure of a mammal; and maintained via stent technology, wherein the scaffold is comprised of electrospun fibers composed of a biodegradable compound. The scaffold serves as a temporary template that allows the tissue to be rebuilt.

Abstract: A lighting system for a grid ceiling that includes a plurality of T-bar sections interconnected at an intersection region of the grid ceiling, and includes a lighting module and a connection module. The lighting module and connection module are constructed and arranged to be disposed proximate a first T-bar section of the plurality of T-bar sections and the intersection region of the grid ceiling, respectively. The lighting module has a first end and a second end and includes at least one low voltage light source electrically connected to a conductive surface of a substrate and a connector disposed on the conductive surface of the substrate proximate the first end. The connection module includes a substrate and a connector disposed on a conductive surface of the substrate, and is configured to electrically and mechanically couple to the second end of the lighting module to transfer power to or from the lighting module.

Abstract: Methods for drilling a wellbore within a subsurface region and drilling assemblies and systems that include and/or utilize the methods are disclosed herein. The methods include receiving a plurality of drilling performance indicator maps, normalizing the plurality of drilling performance indicator maps to generate a plurality of normalized maps, adaptive trending of the plurality of drilling performance indicator maps to generate a plurality of trended maps, summing the plurality of trended maps to generate an objective map, selecting a desired operating regime from the objective map, and adjusting at least one drilling operational parameter of a drilling rig based, at least in part, on the desired operating regime.

Abstract: A method to drill a borehole or wellbore through an earthen formation using a drill bit on a drillstring, comprising the steps of: selecting a frequency-domain dynamic model of a drilling assembly that describes the dynamic response of the drilling assembly to excitation at an excitation frequency for operating at a set of selected drilling parameters that include at least rotary speed and weight on bit; calculating a composite vibration index by combining calculated vibration indices for each excitation frequency with the spectral weighting factors for each of the drilling parameter partitions; displaying said composite vibration index for each of the drilling parameter partitions; selecting preferred drilling parameters based on the displayed results, and using the preferred drilling parameters to drill a borehole with the modeled drilling assembly.

Abstract: An airspeed estimation system of an aircraft includes an electronic airspeed rate modeler unit configured to output an estimated airspeed rate signal indicating an estimated airspeed rate of the aircraft. The estimated airspeed rate signal is based on a longitudinal body acceleration of the aircraft and at least one adaptive parametric airspeed model. The airspeed estimation system further includes an electronic airspeed estimator unit in signal communication with the airspeed rate modeler unit. The airspeed estimator unit is configured to determine an estimated airspeed of the aircraft based on the estimated airspeed rate signal.

Abstract: Implantable in vivo sensors used to monitor physical, chemical or electrical parameters within a body. The in vivo sensors are integral with an implantable medical device and are responsive to externally or internally applied energy. Upon application of energy, the sensors undergo a phase change in at least part of the material of the device which is then detected external to the body by conventional techniques such as radiography, ultrasound imaging, magnetic resonance imaging, radio frequency imaging or the like. The in vivo sensors of the present invention may be employed to provide volumetric measurements, flow rate measurements, pressure measurements, electrical measurements, biochemical measurements, temperature, measurements, or measure the degree and type of deposits within the lumen of an endoluminal implant, such as a stent or other type of endoluminal conduit.

Abstract: A metal balloon catheter having a main tubular body, a metal balloon proximate a distal end of the main tubular body, a central annulus extending along an entire longitudinal aspect of the catheter for accommodating a guidewire therethrough and an inflation annulus adjacent the central annulus which extends along the longitudinal axis of the main tubular body and terminates in fluid flow communication with an inflation chamber of the metal balloon. The metal balloon catheter may be either unitary integral metal catheter in which the main tubular body and the balloon are fabricated of metal, or it may consist of a polymeric main tubular body and a metal balloon.

Abstract: A multi-layer friction reducing tape, including: a foil layer including a metal, polymer, or hybrid-metal-polymer; an under layer disposed on the foil layer; an adhesion promoting layer contiguous with a surface of the under layer; a functional layer that includes a fullerene based composite, a diamond based material, diamond-like-carbon (DLC), or combinations thereof, wherein the functional layer is contiguous with a surface of the adhesion promoting layer; and a tape, including an adhesive layer and a backing material, wherein the adhesive layer is attached to a surface of the foil layer opposite the under layer.

Abstract: Methods, computing devices, and a computer-readable medium are described herein related to fragmenting or comminuting an object in a subject using a burst wave lithotripsy (BWL) waveform. A computing device, such a computing device coupled to a transducer, may carry out functions for producing a BWL waveform. The computing device may determine a burst frequency for a number of bursts in the BWL waveform, where the number of bursts includes a number of cycles. Further, the computing device may determine a cycle frequency for the number of cycles. Yet further, the computing device may determine a pressure amplitude for the BWL waveform, where the pressure amplitude is less than or equal to 8 MPa. In addition, the computing device may determine a time period for producing the BWL waveform.

Abstract: Methods, computing devices, and computer-readable medium are described herein related to producing detection signals configured to induce an excited state of an object. A computing device may receive reflection signals, where the reflection signals correspond to at least one detection signals reflected from the object. Based on the received reflection signals, a presence of the object in the excited state may be determined. Further, an output device may provide an indication of the presence of the object in the excited state.

Abstract: A method of correcting an infrared image including a plurality of pixels arranged in an input image array, a first pixel in the plurality of pixels having a first pixel value and one or more neighbor pixel with one or more neighbor pixel values. The first pixel and the one or more neighbor pixels are associated with an object in the image. The method includes providing a correction array having a plurality of correction pixel values, generating a corrected image array by adding the first pixel value to a correction pixel value in the correction array, and detecting edges in the corrected image array. The method also includes masking the detected edges in the corrected image array, updating the correction array, for each correction pixel value in the correction array and providing an output image array based on the correction array and the input image array.

Abstract: Guidewires and thin-film catheter-sheaths, fabricated using vacuum deposition techniques, which are monolayer or plural-layer members having ultra-thin wall thicknesses to provide very-low profile delivery assemblies for introduction and delivery of endoluminal devices.

Abstract: Recycled asphalt shingle pellets having a core pellet, which includes recycled asphalt shingle waste with a softening agent, and a shell coating, which includes a binder with an aggregate blend of virgin recycled asphalt shingle waste and hydrated lime.

Abstract: A method of optimizing drilling ramp-up is provided herein. More specifically, a method of ramping up a drilling operation from a static condition (0, 0) to optimum drilling parameter values (WOB*, RPM*) is provided. The method includes identifying a set of drilling control variables used in forming the wellbore. Examples include weight-on-bit (WOB) and rate of penetration (RPM). The method additionally includes selecting desired control variable values for a first identified drilling stage. The values may be generically referred to as (V1, V2). The method also includes increasing the drilling control variables from (0, 0) to pre-defined drilling control variable values (V1, V2). Preferably, V1 is a WOB value while V2 is a rotation speed value (RPM). The method also comprises monitoring a performance index (PI), wherein (PI) is a combination of torque (TQ) and penetration rate (RPM).

Abstract: Recycled asphalt shingle pellets having a core pellet, which includes recycled asphalt shingle waste with a softening agent, and a shell coating, which includes a binder with an aggregate blend of virgin recycled asphalt shingle waste and hydrated lime.