Patents by Inventor R. Barry Holtz
R. Barry Holtz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200246787Abstract: Biosafety units, methods of making and sealing the same are disclosed herein. The present invention includes a unitary structure able to be validated for pharmaceutical manufacturing comprising: at least one controlled air, sealable, sterilizable cleanroom; a mechanical system room adjacent to and separate from the cleanroom comprising: one or more air handling units that provide conditioned air to the cleanroom; and one or more power busses that provide power to electrical outlets in the cleanroom from two sources, wherein the at least two power supplies are connectable to one or more external electrical power sources; an integrated fire suppression system integral to the cleanroom; and one or more corridor connectors, wherein a corridor can be attached at the corridor connector.Type: ApplicationFiled: April 21, 2020Publication date: August 6, 2020Applicant: G-CON Manufacturing, Inc.Inventors: R. Barry Holtz, Troy Arledge, Phillip B. Maples, David M. Shanahan
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Patent number: 10654036Abstract: Biosafety units, methods of making and sealing the same are disclosed herein. The present invention includes a unitary structure able to be validated for pharmaceutical manufacturing comprising: at least one controlled air, sealable, sterilizable cleanroom; a mechanical system room adjacent to and separate from the cleanroom comprising: one or more air handling units that provide conditioned air to the cleanroom; and one or more power busses that provide power to electrical outlets in the cleanroom from two sources, wherein the at least two power supplies are connectable to one or more external electrical power sources; an integrated fire suppression system integral to the cleanroom; and one or more corridor connectors, wherein a corridor can be attached at the corridor connector.Type: GrantFiled: October 6, 2017Date of Patent: May 19, 2020Assignee: G-CON Manufacturing, Inc.Inventors: R. Barry Holtz, Troy Arledge, Phillip B. Maples, David M. Shanahan
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Publication number: 20180043347Abstract: Biosafety units, methods of making and sealing the same are disclosed herein. The present invention includes a unitary structure able to be validated for pharmaceutical manufacturing comprising: at least one controlled air, sealable, sterilizable cleanroom; a mechanical system room adjacent to and separate from the cleanroom comprising: one or more air handling units that provide conditioned air to the cleanroom; and one or more power busses that provide power to electrical outlets in the cleanroom from two sources, wherein the at least two power supplies are connectable to one or more external electrical power sources; an integrated fire suppression system integral to the cleanroom; and one or more corridor connectors, wherein a corridor can be attached at the corridor connector.Type: ApplicationFiled: October 6, 2017Publication date: February 15, 2018Applicant: G-CON Manufacturing, Inc.Inventors: R. Barry Holtz, Troy Arledge, Phillip B. Maples, David M. Shanahan
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Patent number: 9795957Abstract: Biosafety units, methods of making and sealing the same are disclosed herein. The present invention includes a unitary structure able to be validated for pharmaceutical manufacturing comprising: at least one controlled air, sealable, sterilizable cleanroom; a mechanical system room adjacent to and separate from the cleanroom comprising: one or more air handling units that provide conditioned air to the cleanroom; and one or more power busses that provide power to electrical outlets in the cleanroom from two sources, wherein the at least two power supplies are connectable to one or more external electrical power sources; an integrated fire suppression system integral to the cleanroom; and one or more corridor connectors, wherein a corridor can be attached at the corridor connector.Type: GrantFiled: November 6, 2012Date of Patent: October 24, 2017Assignee: G-CON MANUFACTURING, INC.Inventors: R. Barry Holtz, Troy Arledge, Phillip B. Maples, David M. Shanahan
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Patent number: 9765980Abstract: Biosafety units, methods of making, and sealing the same are disclosed herein. The units comprise at least one controlled air, sealable, sterilizable cleanroom; and a mechanical system room adjacent to the cleanroom comprising: at least two air handling units in a support room adjacent the cleanroom that provide redundant air to the cleanroom with at least Class 100,000 air purity, the air handling units connected to a one or more supply ducts to the cleanroom, and an exhaust duct in communication with the cleanroom and the air handling unit exhaust, wherein a pressure gradient is formed between the cleanroom and the exterior of the structure; and at least two power supplies that provide redundant power to electrical outlets in the cleanroom, wherein the at least two power supplies are connectable to one or more external power sources and the structure is pre-validatable or validated for pharmaceutical manufacturing.Type: GrantFiled: September 18, 2015Date of Patent: September 19, 2017Assignee: G-CON MANUFACTURING, INC.Inventors: R. Barry Holtz, Troy Arledge, Philip B. Maples, David M. Shanahan
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Patent number: 9518748Abstract: Biosafety units, methods of making, and sealing the same are disclosed herein. The units comprise at least one controlled air, sealable, sterilizable cleanroom; and a mechanical system room adjacent to the cleanroom comprising: at least two air handling units in a support room adjacent the cleanroom that provide redundant air to the cleanroom with at least Class 100,000 air purity, the air handling units connected to a one or more supply ducts to the cleanroom, and an exhaust duct in communication with the cleanroom and the air handling unit exhaust, wherein a pressure gradient is formed between the cleanroom and the exterior of the structure; and at least two power supplies that provide redundant power to electrical outlets in the cleanroom, wherein the at least two power supplies are connectable to one or more external power sources and the structure is pre-validatable or validated for pharmaceutical manufacturing.Type: GrantFiled: August 16, 2010Date of Patent: December 13, 2016Assignee: G-CON MANUFACTURING INC.Inventors: R. Barry Holtz, Troy Arledge, Phillip B. Maples, David M. Shanahan
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Publication number: 20160010884Abstract: Biosafety units, methods of making, and sealing the same are disclosed herein. The units comprise at least one controlled air, sealable, sterilizable cleanroom; and a mechanical system room adjacent to the cleanroom comprising: at least two air handling units in a support room adjacent the cleanroom that provide redundant air to the cleanroom with at least Class 100,000 air purity, the air handling units connected to a one or more supply ducts to the cleanroom, and an exhaust duct in communication with the cleanroom and the air handling unit exhaust, wherein a pressure gradient is formed between the cleanroom and the exterior of the structure; and at least two power supplies that provide redundant power to electrical outlets in the cleanroom, wherein the at least two power supplies are connectable to one or more external power sources and the structure is pre-validatable or validated for pharmaceutical manufacturing.Type: ApplicationFiled: September 18, 2015Publication date: January 14, 2016Applicant: G-CON MANUFACTURING, INC.Inventors: R. Barry Holtz, Troy Arledge, Philip B. Maples, David M. Shanahan
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Publication number: 20120192486Abstract: A light weight and modular light emitting diode (LED) light bar comprising an extruded aluminum LED fixture frame with integral cooling fins is disclosed herein. The light bar of the present invention is used for high density multi-layer hydroponic grow facilities to greatly improve the uniformity and intensity of light distribution over the plants and at a much reduced energy cost and less heat-to-space compared to conventional lighting used in grow rooms.Type: ApplicationFiled: November 11, 2011Publication date: August 2, 2012Applicants: ILLUMITEX, INC., G-CON, LLCInventors: David M. Shanahan, R. Barry Holtz, Paul Winberg
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Publication number: 20110053486Abstract: Biosafety units, methods of making, and sealing the same are disclosed herein. The units comprise at least one controlled air, sealable, sterilizable cleanroom; and a mechanical system room adjacent to the cleanroom comprising: at least two air handling units in a support room adjacent the cleanroom that provide redundant air to the cleanroom with at least Class 100,000 air purity, the air handling units connected to a one or more supply ducts to the cleanroom, and an exhaust duct in communication with the cleanroom and the air handling unit exhaust, wherein a pressure gradient is formed between the cleanroom and the exterior of the structure; and at least two power supplies that provide redundant power to electrical outlets in the cleanroom, wherein the at least two power supplies are connectable to one or more external power sources and the structure is pre-validatable or validated for pharmaceutical manufacturing.Type: ApplicationFiled: August 16, 2010Publication date: March 3, 2011Applicant: G-CON, LLCInventors: R. Barry Holtz, Troy Arledge, Phillip B. Maples, David M. Shanahan
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Patent number: 7048211Abstract: A flexible automated apparatus for isolating and purifying viruses, proteins and peptides of interest from a plant material is disclosed, the apparatus being applicable for large scale purification and isolation of such substances from plant material. The flexible automated apparatus provides an efficient apparatus for isolating viruses, proteins and peptides of interest with little waste material. The automated apparatus for isolating viruses, proteins and peptides of interest includes a grinding apparatus for homogenizing a plant to produce a green juice, a means for adjusting the pH of and heating the green juice, a means for separating the target species, either virus or protein/peptide, from other components of the green juice by one or more cycles of centrifugation, resuspension, and ultrafiltration, and finally purifying virus particles by such procedure as PEG-precipitation or purifying proteins and peptides by such procedures as chromatography and/or salt precipitation.Type: GrantFiled: February 18, 2004Date of Patent: May 23, 2006Assignee: Large Scale Biology CorporationInventors: Barry Bratcher, Stephen J. Garger, R. Barry Holtz, Michael J. McCulloch
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Patent number: 7034128Abstract: A method for extracting proteins from the intercellular space of plants is provided. The method is applicable to the large scale isolation of many active proteins of interest synthesized by plant cells. The method may be used commercially to recover recombinantly produced proteins from plant hosts thereby making the large scale use of plants as sources for recombinant protein production feasible.Type: GrantFiled: October 29, 2004Date of Patent: April 25, 2006Assignee: Large Scale Biology CorporationInventors: Thomas H. Turpen, Stephen J. Garger, Michael J. McCulloch, Terri I. Cameron, Michelle L. Samonek-Potter, R. Barry Holtz
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Patent number: 6906172Abstract: A flexible automated apparatus for isolating and purifying viruses, proteins and peptides of interest from a plant material is disclosed, the apparatus being applicable for large scale purification and isolation of such substances from plant material. The flexible automated apparatus provides an efficient apparatus for isolating viruses, proteins and peptides of interest with little waste material. The automated apparatus for isolating viruses, proteins and peptides of interest includes a grinding apparatus for homogenizing a plant to produce a green juice, a means for adjusting the pH of and heating the green juice, a means for separating the target species, either virus or protein/peptide, from other components of the green juice by one or more cycles of centrifugation, resuspension, and ultrafiltration, and finally purifying virus particles by such procedure as PEG-precipitation or purifying proteins and peptides by such procedures as chromatography and/or salt precipitation.Type: GrantFiled: October 3, 2001Date of Patent: June 14, 2005Assignee: Large Scale Biology CorporationInventors: Barry Bratcher, Stephen J. Garger, R. Barry Holtz, Michael J. McCulloch
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Patent number: 6841659Abstract: A method for extracting proteins from the intercellular space of plants is provided. The method is applicable to the large scale isolation of many active proteins of interest synthesized by plant cells. The method may be used commercially to recover recombinantly produced proteins from plant hosts thereby making the large scale use of plants as sources for recombinant protein production feasible.Type: GrantFiled: August 1, 2003Date of Patent: January 11, 2005Assignee: Large Scale Biology CorporationInventors: Thomas H. Turpen, Stephen J. Garger, Michael J. McCulloch, Terri I. Cameron, Michelle L. Samonek-Potter, R. Barry Holtz
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Patent number: 6817970Abstract: A centrifuge is provided for recovering material of interest from the interstitial fluids of plant tissues. The centrifuge includes a rotatable centrifuge bowl having a radially outer wall inclined outwardly so that during centrifugation liquid in the bowl climbs the outer wall. The centrifuge bowl is contained in a vacuum sealed housing so that a material of interest contained in the bowl including said liquid can be subjected to a vacuum. A system for automated cleaning of the centrifuge is also provided.Type: GrantFiled: June 17, 2002Date of Patent: November 16, 2004Assignee: Large Scale Biology CorporationInventors: Bradley I. Berit, Barry Bratcher, R. Barry Holtz
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Publication number: 20040171813Abstract: The present invention features a method for isolating and purifying proteins and peptides of interest from a plant host, which is applicable on a large scale. Moreover, the present invention provides a more efficient method for isolating proteins and peptides of interest than those methods described in the prior art.Type: ApplicationFiled: April 20, 2004Publication date: September 2, 2004Inventors: Stephen J. Garger, R. Barry Holtz, Michael J. McCulloch, Thomas H. Turpen
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Publication number: 20040166026Abstract: A flexible automated apparatus for isolating and purifying viruses, proteins and peptides of interest from a plant material is disclosed, the apparatus being applicable for large scale purification and isolation of such substances from plant material. The flexible automated apparatus provides an efficient apparatus for isolating viruses, proteins and peptides of interest with little waste material. The automated apparatus for isolating viruses, proteins and peptides of interest includes a grinding apparatus for homogenizing a plant to produce a green juice, a means for adjusting the pH of and heating the green juice, a means for separating the target species, either virus or protein/peptide, from other components of the green juice by one or more cycles of centrifugation, resuspension, and ultrafiltration, and finally purifying virus particles by such procedure as PEG-precipitation or purifying proteins and peptides by such procedures as chromatography and/or salt precipitation.Type: ApplicationFiled: February 18, 2004Publication date: August 26, 2004Inventors: Barry Bratcher, Stephen J. Garger, R. Barry Holtz, Michael J. McCulloch
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Patent number: 6740740Abstract: The present invention features a method for isolating and purifying proteins and peptides of interest from a plant host, which is applicable on a larger scale. Moreover, the present invention provides a more efficient method for isolating proteins and peptides of interest than those methods described in the prior art. In general, the present method of isolating proteins and peptides of interest comprises the steps of homogenizing a plant to produce a green juice, adjusting the pH of and heating the green juice, separating the target protein/peptide from other components of the green juice by one or more cycles of centrifugation and/or resuspension, and finally purifying proteins and peptides by such procedures as chromatography and/or salt precipitation.Type: GrantFiled: September 24, 2001Date of Patent: May 25, 2004Assignee: Large Scale Biology CorporationInventors: Stephen J. Garger, R. Barry Holtz, Michael J. McCulloch, Thomas H. Turpen
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Publication number: 20040047923Abstract: A method for extracting proteins from the intercellular space of plants is provided. The method is applicable to the large scale isolation of many active proteins of interest synthesized by plant cells. The method may be used commercially to recover recombinantly produced proteins from plant hosts thereby making the large scale use of plants as sources for recombinant protein production feasible.Type: ApplicationFiled: August 1, 2003Publication date: March 11, 2004Inventors: Thomas H. Turpen, Stephen J. Garger, Michael J. McCulloch, Terri I. Cameron, Michelle L. Samonek-Potter, R. Barry Holtz
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Publication number: 20030232711Abstract: A centrifuge is provided for recovering material of interest from the interstitial fluids of plant tissues. The centrifuge includes a rotatable centrifuge bowl having a radially outer wall inclined outwardly so that during centrifugation liquid in the bowl climbs the outer wall. The centrifuge bowl is contained in a vacuum sealed housing so that a material of interest contained in the bowl including said liquid can be subjected to a vacuum. A system for automated cleaning of the centrifuge is also provided.Type: ApplicationFiled: June 17, 2002Publication date: December 18, 2003Inventors: Bradley I. Berit, Barry Bratcher, R. Barry Holtz
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Patent number: 6617435Abstract: A method for extracting proteins from the intercellular space of plants is provided. The method is applicable to the large scale isolation of many active proteins of interest synthesized by plant cells. The method may be used commercially to recover recombinantly produced proteins from plant hosts thereby making the large scale use of plants as sources for recombinant protein production feasible.Type: GrantFiled: April 8, 2002Date of Patent: September 9, 2003Assignee: Large Scale Biology CorporationInventors: Thomas H. Turpen, Stephen J. Garger, Michael J. McCulloch, Terri I. Cameron, Michelle L. Samonek-Potter, R. Barry Holtz