Patents by Inventor R. Barry Holtz

R. Barry Holtz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200246787
    Abstract: Biosafety units, methods of making and sealing the same are disclosed herein. The present invention includes a unitary structure able to be validated for pharmaceutical manufacturing comprising: at least one controlled air, sealable, sterilizable cleanroom; a mechanical system room adjacent to and separate from the cleanroom comprising: one or more air handling units that provide conditioned air to the cleanroom; and one or more power busses that provide power to electrical outlets in the cleanroom from two sources, wherein the at least two power supplies are connectable to one or more external electrical power sources; an integrated fire suppression system integral to the cleanroom; and one or more corridor connectors, wherein a corridor can be attached at the corridor connector.
    Type: Application
    Filed: April 21, 2020
    Publication date: August 6, 2020
    Applicant: G-CON Manufacturing, Inc.
    Inventors: R. Barry Holtz, Troy Arledge, Phillip B. Maples, David M. Shanahan
  • Patent number: 10654036
    Abstract: Biosafety units, methods of making and sealing the same are disclosed herein. The present invention includes a unitary structure able to be validated for pharmaceutical manufacturing comprising: at least one controlled air, sealable, sterilizable cleanroom; a mechanical system room adjacent to and separate from the cleanroom comprising: one or more air handling units that provide conditioned air to the cleanroom; and one or more power busses that provide power to electrical outlets in the cleanroom from two sources, wherein the at least two power supplies are connectable to one or more external electrical power sources; an integrated fire suppression system integral to the cleanroom; and one or more corridor connectors, wherein a corridor can be attached at the corridor connector.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: May 19, 2020
    Assignee: G-CON Manufacturing, Inc.
    Inventors: R. Barry Holtz, Troy Arledge, Phillip B. Maples, David M. Shanahan
  • Publication number: 20180043347
    Abstract: Biosafety units, methods of making and sealing the same are disclosed herein. The present invention includes a unitary structure able to be validated for pharmaceutical manufacturing comprising: at least one controlled air, sealable, sterilizable cleanroom; a mechanical system room adjacent to and separate from the cleanroom comprising: one or more air handling units that provide conditioned air to the cleanroom; and one or more power busses that provide power to electrical outlets in the cleanroom from two sources, wherein the at least two power supplies are connectable to one or more external electrical power sources; an integrated fire suppression system integral to the cleanroom; and one or more corridor connectors, wherein a corridor can be attached at the corridor connector.
    Type: Application
    Filed: October 6, 2017
    Publication date: February 15, 2018
    Applicant: G-CON Manufacturing, Inc.
    Inventors: R. Barry Holtz, Troy Arledge, Phillip B. Maples, David M. Shanahan
  • Patent number: 9795957
    Abstract: Biosafety units, methods of making and sealing the same are disclosed herein. The present invention includes a unitary structure able to be validated for pharmaceutical manufacturing comprising: at least one controlled air, sealable, sterilizable cleanroom; a mechanical system room adjacent to and separate from the cleanroom comprising: one or more air handling units that provide conditioned air to the cleanroom; and one or more power busses that provide power to electrical outlets in the cleanroom from two sources, wherein the at least two power supplies are connectable to one or more external electrical power sources; an integrated fire suppression system integral to the cleanroom; and one or more corridor connectors, wherein a corridor can be attached at the corridor connector.
    Type: Grant
    Filed: November 6, 2012
    Date of Patent: October 24, 2017
    Assignee: G-CON MANUFACTURING, INC.
    Inventors: R. Barry Holtz, Troy Arledge, Phillip B. Maples, David M. Shanahan
  • Patent number: 9765980
    Abstract: Biosafety units, methods of making, and sealing the same are disclosed herein. The units comprise at least one controlled air, sealable, sterilizable cleanroom; and a mechanical system room adjacent to the cleanroom comprising: at least two air handling units in a support room adjacent the cleanroom that provide redundant air to the cleanroom with at least Class 100,000 air purity, the air handling units connected to a one or more supply ducts to the cleanroom, and an exhaust duct in communication with the cleanroom and the air handling unit exhaust, wherein a pressure gradient is formed between the cleanroom and the exterior of the structure; and at least two power supplies that provide redundant power to electrical outlets in the cleanroom, wherein the at least two power supplies are connectable to one or more external power sources and the structure is pre-validatable or validated for pharmaceutical manufacturing.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: September 19, 2017
    Assignee: G-CON MANUFACTURING, INC.
    Inventors: R. Barry Holtz, Troy Arledge, Philip B. Maples, David M. Shanahan
  • Patent number: 9518748
    Abstract: Biosafety units, methods of making, and sealing the same are disclosed herein. The units comprise at least one controlled air, sealable, sterilizable cleanroom; and a mechanical system room adjacent to the cleanroom comprising: at least two air handling units in a support room adjacent the cleanroom that provide redundant air to the cleanroom with at least Class 100,000 air purity, the air handling units connected to a one or more supply ducts to the cleanroom, and an exhaust duct in communication with the cleanroom and the air handling unit exhaust, wherein a pressure gradient is formed between the cleanroom and the exterior of the structure; and at least two power supplies that provide redundant power to electrical outlets in the cleanroom, wherein the at least two power supplies are connectable to one or more external power sources and the structure is pre-validatable or validated for pharmaceutical manufacturing.
    Type: Grant
    Filed: August 16, 2010
    Date of Patent: December 13, 2016
    Assignee: G-CON MANUFACTURING INC.
    Inventors: R. Barry Holtz, Troy Arledge, Phillip B. Maples, David M. Shanahan
  • Publication number: 20160010884
    Abstract: Biosafety units, methods of making, and sealing the same are disclosed herein. The units comprise at least one controlled air, sealable, sterilizable cleanroom; and a mechanical system room adjacent to the cleanroom comprising: at least two air handling units in a support room adjacent the cleanroom that provide redundant air to the cleanroom with at least Class 100,000 air purity, the air handling units connected to a one or more supply ducts to the cleanroom, and an exhaust duct in communication with the cleanroom and the air handling unit exhaust, wherein a pressure gradient is formed between the cleanroom and the exterior of the structure; and at least two power supplies that provide redundant power to electrical outlets in the cleanroom, wherein the at least two power supplies are connectable to one or more external power sources and the structure is pre-validatable or validated for pharmaceutical manufacturing.
    Type: Application
    Filed: September 18, 2015
    Publication date: January 14, 2016
    Applicant: G-CON MANUFACTURING, INC.
    Inventors: R. Barry Holtz, Troy Arledge, Philip B. Maples, David M. Shanahan
  • Publication number: 20120192486
    Abstract: A light weight and modular light emitting diode (LED) light bar comprising an extruded aluminum LED fixture frame with integral cooling fins is disclosed herein. The light bar of the present invention is used for high density multi-layer hydroponic grow facilities to greatly improve the uniformity and intensity of light distribution over the plants and at a much reduced energy cost and less heat-to-space compared to conventional lighting used in grow rooms.
    Type: Application
    Filed: November 11, 2011
    Publication date: August 2, 2012
    Applicants: ILLUMITEX, INC., G-CON, LLC
    Inventors: David M. Shanahan, R. Barry Holtz, Paul Winberg
  • Publication number: 20110053486
    Abstract: Biosafety units, methods of making, and sealing the same are disclosed herein. The units comprise at least one controlled air, sealable, sterilizable cleanroom; and a mechanical system room adjacent to the cleanroom comprising: at least two air handling units in a support room adjacent the cleanroom that provide redundant air to the cleanroom with at least Class 100,000 air purity, the air handling units connected to a one or more supply ducts to the cleanroom, and an exhaust duct in communication with the cleanroom and the air handling unit exhaust, wherein a pressure gradient is formed between the cleanroom and the exterior of the structure; and at least two power supplies that provide redundant power to electrical outlets in the cleanroom, wherein the at least two power supplies are connectable to one or more external power sources and the structure is pre-validatable or validated for pharmaceutical manufacturing.
    Type: Application
    Filed: August 16, 2010
    Publication date: March 3, 2011
    Applicant: G-CON, LLC
    Inventors: R. Barry Holtz, Troy Arledge, Phillip B. Maples, David M. Shanahan
  • Patent number: 7048211
    Abstract: A flexible automated apparatus for isolating and purifying viruses, proteins and peptides of interest from a plant material is disclosed, the apparatus being applicable for large scale purification and isolation of such substances from plant material. The flexible automated apparatus provides an efficient apparatus for isolating viruses, proteins and peptides of interest with little waste material. The automated apparatus for isolating viruses, proteins and peptides of interest includes a grinding apparatus for homogenizing a plant to produce a green juice, a means for adjusting the pH of and heating the green juice, a means for separating the target species, either virus or protein/peptide, from other components of the green juice by one or more cycles of centrifugation, resuspension, and ultrafiltration, and finally purifying virus particles by such procedure as PEG-precipitation or purifying proteins and peptides by such procedures as chromatography and/or salt precipitation.
    Type: Grant
    Filed: February 18, 2004
    Date of Patent: May 23, 2006
    Assignee: Large Scale Biology Corporation
    Inventors: Barry Bratcher, Stephen J. Garger, R. Barry Holtz, Michael J. McCulloch
  • Patent number: 7034128
    Abstract: A method for extracting proteins from the intercellular space of plants is provided. The method is applicable to the large scale isolation of many active proteins of interest synthesized by plant cells. The method may be used commercially to recover recombinantly produced proteins from plant hosts thereby making the large scale use of plants as sources for recombinant protein production feasible.
    Type: Grant
    Filed: October 29, 2004
    Date of Patent: April 25, 2006
    Assignee: Large Scale Biology Corporation
    Inventors: Thomas H. Turpen, Stephen J. Garger, Michael J. McCulloch, Terri I. Cameron, Michelle L. Samonek-Potter, R. Barry Holtz
  • Patent number: 6906172
    Abstract: A flexible automated apparatus for isolating and purifying viruses, proteins and peptides of interest from a plant material is disclosed, the apparatus being applicable for large scale purification and isolation of such substances from plant material. The flexible automated apparatus provides an efficient apparatus for isolating viruses, proteins and peptides of interest with little waste material. The automated apparatus for isolating viruses, proteins and peptides of interest includes a grinding apparatus for homogenizing a plant to produce a green juice, a means for adjusting the pH of and heating the green juice, a means for separating the target species, either virus or protein/peptide, from other components of the green juice by one or more cycles of centrifugation, resuspension, and ultrafiltration, and finally purifying virus particles by such procedure as PEG-precipitation or purifying proteins and peptides by such procedures as chromatography and/or salt precipitation.
    Type: Grant
    Filed: October 3, 2001
    Date of Patent: June 14, 2005
    Assignee: Large Scale Biology Corporation
    Inventors: Barry Bratcher, Stephen J. Garger, R. Barry Holtz, Michael J. McCulloch
  • Patent number: 6841659
    Abstract: A method for extracting proteins from the intercellular space of plants is provided. The method is applicable to the large scale isolation of many active proteins of interest synthesized by plant cells. The method may be used commercially to recover recombinantly produced proteins from plant hosts thereby making the large scale use of plants as sources for recombinant protein production feasible.
    Type: Grant
    Filed: August 1, 2003
    Date of Patent: January 11, 2005
    Assignee: Large Scale Biology Corporation
    Inventors: Thomas H. Turpen, Stephen J. Garger, Michael J. McCulloch, Terri I. Cameron, Michelle L. Samonek-Potter, R. Barry Holtz
  • Patent number: 6817970
    Abstract: A centrifuge is provided for recovering material of interest from the interstitial fluids of plant tissues. The centrifuge includes a rotatable centrifuge bowl having a radially outer wall inclined outwardly so that during centrifugation liquid in the bowl climbs the outer wall. The centrifuge bowl is contained in a vacuum sealed housing so that a material of interest contained in the bowl including said liquid can be subjected to a vacuum. A system for automated cleaning of the centrifuge is also provided.
    Type: Grant
    Filed: June 17, 2002
    Date of Patent: November 16, 2004
    Assignee: Large Scale Biology Corporation
    Inventors: Bradley I. Berit, Barry Bratcher, R. Barry Holtz
  • Publication number: 20040171813
    Abstract: The present invention features a method for isolating and purifying proteins and peptides of interest from a plant host, which is applicable on a large scale. Moreover, the present invention provides a more efficient method for isolating proteins and peptides of interest than those methods described in the prior art.
    Type: Application
    Filed: April 20, 2004
    Publication date: September 2, 2004
    Inventors: Stephen J. Garger, R. Barry Holtz, Michael J. McCulloch, Thomas H. Turpen
  • Publication number: 20040166026
    Abstract: A flexible automated apparatus for isolating and purifying viruses, proteins and peptides of interest from a plant material is disclosed, the apparatus being applicable for large scale purification and isolation of such substances from plant material. The flexible automated apparatus provides an efficient apparatus for isolating viruses, proteins and peptides of interest with little waste material. The automated apparatus for isolating viruses, proteins and peptides of interest includes a grinding apparatus for homogenizing a plant to produce a green juice, a means for adjusting the pH of and heating the green juice, a means for separating the target species, either virus or protein/peptide, from other components of the green juice by one or more cycles of centrifugation, resuspension, and ultrafiltration, and finally purifying virus particles by such procedure as PEG-precipitation or purifying proteins and peptides by such procedures as chromatography and/or salt precipitation.
    Type: Application
    Filed: February 18, 2004
    Publication date: August 26, 2004
    Inventors: Barry Bratcher, Stephen J. Garger, R. Barry Holtz, Michael J. McCulloch
  • Patent number: 6740740
    Abstract: The present invention features a method for isolating and purifying proteins and peptides of interest from a plant host, which is applicable on a larger scale. Moreover, the present invention provides a more efficient method for isolating proteins and peptides of interest than those methods described in the prior art. In general, the present method of isolating proteins and peptides of interest comprises the steps of homogenizing a plant to produce a green juice, adjusting the pH of and heating the green juice, separating the target protein/peptide from other components of the green juice by one or more cycles of centrifugation and/or resuspension, and finally purifying proteins and peptides by such procedures as chromatography and/or salt precipitation.
    Type: Grant
    Filed: September 24, 2001
    Date of Patent: May 25, 2004
    Assignee: Large Scale Biology Corporation
    Inventors: Stephen J. Garger, R. Barry Holtz, Michael J. McCulloch, Thomas H. Turpen
  • Publication number: 20040047923
    Abstract: A method for extracting proteins from the intercellular space of plants is provided. The method is applicable to the large scale isolation of many active proteins of interest synthesized by plant cells. The method may be used commercially to recover recombinantly produced proteins from plant hosts thereby making the large scale use of plants as sources for recombinant protein production feasible.
    Type: Application
    Filed: August 1, 2003
    Publication date: March 11, 2004
    Inventors: Thomas H. Turpen, Stephen J. Garger, Michael J. McCulloch, Terri I. Cameron, Michelle L. Samonek-Potter, R. Barry Holtz
  • Publication number: 20030232711
    Abstract: A centrifuge is provided for recovering material of interest from the interstitial fluids of plant tissues. The centrifuge includes a rotatable centrifuge bowl having a radially outer wall inclined outwardly so that during centrifugation liquid in the bowl climbs the outer wall. The centrifuge bowl is contained in a vacuum sealed housing so that a material of interest contained in the bowl including said liquid can be subjected to a vacuum. A system for automated cleaning of the centrifuge is also provided.
    Type: Application
    Filed: June 17, 2002
    Publication date: December 18, 2003
    Inventors: Bradley I. Berit, Barry Bratcher, R. Barry Holtz
  • Patent number: 6617435
    Abstract: A method for extracting proteins from the intercellular space of plants is provided. The method is applicable to the large scale isolation of many active proteins of interest synthesized by plant cells. The method may be used commercially to recover recombinantly produced proteins from plant hosts thereby making the large scale use of plants as sources for recombinant protein production feasible.
    Type: Grant
    Filed: April 8, 2002
    Date of Patent: September 9, 2003
    Assignee: Large Scale Biology Corporation
    Inventors: Thomas H. Turpen, Stephen J. Garger, Michael J. McCulloch, Terri I. Cameron, Michelle L. Samonek-Potter, R. Barry Holtz