Patents by Inventor R. Freeman

R. Freeman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12103972
    Abstract: The present invention is based, in part, on the discovery of monoclonal antibodies, and antigen-binding fragments thereof, that specifically bind to HHLA2, as well as immunoglobulins, polypeptides, nucleic acids thereof, and methods of using such antibodies for diagnostic, prognostic, and therapeutic purposes.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: October 1, 2024
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Gordon J. Freeman, Antonio R. Arulanandam
  • Publication number: 20240245656
    Abstract: Methods of using glucokinase (GK) activators are generally disclosed herein, particularly in combination with insulin or insulin analogs. In certain aspects, the disclosure provides methods of treating type 1 diabetes that include administering a GK activator in combination with insulin or insulin analogs. Uses of GK activators as a medicament are also disclosed herein, as well as the manufacture of a medicament for such uses.
    Type: Application
    Filed: April 5, 2024
    Publication date: July 25, 2024
    Inventors: Jennifer L.R. FREEMAN, Maria Carmen VALCARCE LOPEZ
  • Patent number: 11974989
    Abstract: Methods of using glucokinase (GK) activators are generally disclosed herein, particularly in combination with insulin or insulin analogs. In certain aspects, the disclosure provides methods of treating type 1 diabetes that include administering a GK activator in combination with insulin or insulin analogs. Uses of GK activators as a medicament are also disclosed herein, as well as the manufacture of a medicament for such uses.
    Type: Grant
    Filed: February 18, 2021
    Date of Patent: May 7, 2024
    Assignee: VTV THERAPEUTICS LLC
    Inventors: Jennifer L. R. Freeman, Maria Carmen Valcarce Lopez
  • Patent number: 11833136
    Abstract: Methods of using glucokinase (GK) activators are generally disclosed herein, particularly in combination with insulin or insulin analogs. In certain aspects, the disclosure provides methods of treating type 1 diabetes that include administering a GK activator in combination with insulin or insulin analogs. Uses of GK activators as a medicament are also disclosed herein, as well as the manufacture of a medicament for such uses.
    Type: Grant
    Filed: February 18, 2021
    Date of Patent: December 5, 2023
    Assignee: VTV THERAPEUTICS LLC
    Inventors: Jennifer L. R. Freeman, Maria Carmen Valcarce Lopez
  • Publication number: 20230248538
    Abstract: Technologies for aligning an acetabular prosthetic component in a patient's surgically prepared acetabulum include a reference sensor module securable to the patient's bony anatomy, an inserter sensor module securable to an acetabular prosthetic component inserter, and a display module. Each sensor module generates sensor data indicative of the orientation of the sensor module and/or structures to which the sensor module is coupled. The display module receives the sensor data from the sensor modules, determines the orientation of the acetabular prosthetic component relative to the patient's bony anatomy, and displays indicia of the determined orientation on a display.
    Type: Application
    Filed: April 19, 2023
    Publication date: August 10, 2023
    Inventors: Jason T. Sherman, Alec A. Birkbeck, Robert R. Freeman
  • Patent number: 11660209
    Abstract: Technologies for aligning an acetabular prosthetic component in a patient's surgically prepared acetabulum include a reference sensor module securable to the patient's bony anatomy, an inserter sensor module securable to an acetabular prosthetic component inserter, and a display module. Each sensor module generates sensor data indicative of the orientation of the sensor module and/or structures to which the sensor module is coupled. The display module receives the sensor data from the sensor modules, determines the orientation of the acetabular prosthetic component relative to the patient's bony anatomy, and displays indicia of the determined orientation on a display.
    Type: Grant
    Filed: April 28, 2021
    Date of Patent: May 30, 2023
    Assignee: DEPUY SYNTHES PRODUCTS, INC.
    Inventors: Jason T. Sherman, Alec A. Birkbeck, Robert R. Freeman
  • Patent number: 11589945
    Abstract: A surgical restraint is disclosed including a body strap, a sling, and a connecting strap. The body strap is arranged and disposed to wrap over patient's torso and around a support disposed below the patient, restraining the patient against the support. The sling is arranged and disposed to cradle an upper arm, an elbow and a forearm of a patient's arm. The connecting strap includes a first attachment site associated with a brace and a second attachment site associated with the sling. The connecting strap is arranged and disposed to cross over the patient's shoulder between the first attachment site and the second attachment site. The surgical restraint is arranged and disposed to restrain the patient's arm against the patient's torso and removed from a surgical site.
    Type: Grant
    Filed: June 3, 2019
    Date of Patent: February 28, 2023
    Inventor: Carl R Freeman
  • Patent number: 11206863
    Abstract: Disclosed are compositions suitable for use as alternatives or substitutes for natural tobacco. Disclosed compositions include combustible products comprising leafy material from one or more plants classified in the brassicaceae or spinnacia plant family. Also disclosed are methods for the manufacture and use of the disclosed compositions.
    Type: Grant
    Filed: December 6, 2011
    Date of Patent: December 28, 2021
    Inventor: Steven R. Freeman
  • Publication number: 20210244549
    Abstract: Technologies for aligning an acetabular prosthetic component in a patient's surgically prepared acetabulum include a reference sensor module securable to the patient's bony anatomy, an inserter sensor module securable to an acetabular prosthetic component inserter, and a display module. Each sensor module generates sensor data indicative of the orientation of the sensor module and/or structures to which the sensor module is coupled. The display module receives the sensor data from the sensor modules, determines the orientation of the acetabular prosthetic component relative to the patient's bony anatomy, and displays indicia of the determined orientation on a display.
    Type: Application
    Filed: April 28, 2021
    Publication date: August 12, 2021
    Inventors: Jason T. Sherman, Alec A. Birkbeck, Robert R. Freeman
  • Patent number: 11084537
    Abstract: An access panel for a body of a vehicle is provided that includes a dome portion, a flat portion, and an extension portion. The dome portion has a reinforcing element. The extension portion extends from the flat portion. A floor panel structure for a vehicle is also provided that includes a metal sheet and an access panel. The metal sheet includes an aperture. The access panel includes a dome portion, a flat portion, and an extension portion. The access panel is coupled to the metal sheet over the aperture, and the flat portion and the extension portion are configured to transmit a downward force applied to the access panel to the metal sheet.
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: August 10, 2021
    Assignee: Honda Motor Co., Ltd.
    Inventors: Christopher R. Freeman, Patrick J. Ellison
  • Publication number: 20210169857
    Abstract: Methods of using glucokinase (GK) activators are generally disclosed herein, particularly in combination with insulin or insulin analogs. In certain aspects, the disclosure provides methods of treating type 1 diabetes that include administering a GK activator in combination with insulin or insulin analogs. Uses of GK activators as a medicament are also disclosed herein, as well as the manufacture of a medicament for such uses.
    Type: Application
    Filed: February 18, 2021
    Publication date: June 10, 2021
    Inventors: Jennifer L.R. FREEMAN, Maria Carmen VALCARCE LOPEZ
  • Publication number: 20210169858
    Abstract: Methods of using glucokinase (GK) activators are generally disclosed herein, particularly in combination with insulin or insulin analogs. In certain aspects, the disclosure provides methods of treating type 1 diabetes that include administering a GK activator in combination with insulin or insulin analogs. Uses of GK activators as a medicament are also disclosed herein, as well as the manufacture of a medicament for such uses.
    Type: Application
    Filed: February 18, 2021
    Publication date: June 10, 2021
    Inventors: Jennifer L.R. FREEMAN, Maria Carmen VALCARCE LOPEZ
  • Patent number: 11026811
    Abstract: Technologies for aligning an acetabular prosthetic component in a patient's surgically prepared acetabulum include a reference sensor module securable to the patient's bony anatomy, an inserter sensor module securable to an acetabular prosthetic component inserter, and a display module. Each sensor module generates sensor data indicative of the orientation of the sensor module and/or structures to which the sensor module is coupled. The display module receives the sensor data from the sensor modules, determines the orientation of the acetabular prosthetic component relative to the patient's bony anatomy, and displays indicia of the determined orientation on a display.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: June 8, 2021
    Assignee: DEPUY SYNTHES PRODUCTS, INC.
    Inventors: Jason T. Sherman, Alec A. Birkbeck, Robert R. Freeman
  • Patent number: 10952993
    Abstract: Methods of using glucokinase (GK) activators are generally disclosed herein, particularly in combination with insulin or insulin analogs. In certain aspects, the disclosure provides methods of treating type 1 diabetes that include administering a GK activator in combination with insulin or insulin analogs. Uses of GK activators as a medicament are also disclosed herein, as well as the manufacture of a medicament for such uses.
    Type: Grant
    Filed: January 13, 2020
    Date of Patent: March 23, 2021
    Assignee: vTv Therapeutics LLC
    Inventors: Jennifer L. R. Freeman, Maria Carmen Valcarce Lopez
  • Publication number: 20210023072
    Abstract: Methods of using glucagon-like peptide 1 receptor (GLP1R) agonists are generally disclosed herein. In certain aspects, the disclosure provides methods of treating type 2 diabetes that include administering a GLP1R agonist according to certain dosage regimens. In certain other aspects, the disclosure provides methods of treating obesity that include administering a GLP1R agonist according to certain dosage regimens. In certain other aspects, the disclosure provides methods of lowering glycated hemoglobin (for example, lowering HbA1c) that include administering a GLP1R agonist according to certain dosage regimens. Compositions containing GLP1R agonists and their manufacture, for example, for use as a medicament are also disclosed herein.
    Type: Application
    Filed: October 13, 2020
    Publication date: January 28, 2021
    Inventors: Jennifer L.R. Freeman, Maria Carmen Valcarce Lopez
  • Patent number: 10864947
    Abstract: A rear support structure for a vehicle includes a parcel cross-member and a brace assembly. The parcel cross-member extends from a first side structure to a second side structure of the vehicle and includes a first vertical member, a second vertical member, and an upper horizontal member that at least partially define an opening between the cargo area and the passenger compartment. The brace assembly includes a first brace extending across the opening and including a first end secured to the upper horizontal member adjacent a longitudinal centerline of the vehicle and a second brace extending across the opening and including a first end secured to the upper horizontal member adjacent to the longitudinal centerline. The first brace further includes a second end secured to the first vertical member and the second brace includes a second end secured to the first vertical member.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: December 15, 2020
    Assignee: Honda Motor Co., Ltd.
    Inventors: Timothy J. Palesano, Kevin A. Veverka, Christopher R. Freeman, Rafael Teran, Jr., Christopher Hinz
  • Publication number: 20200307712
    Abstract: A rear support structure for a vehicle includes a parcel cross-member and a brace assembly. The parcel cross-member extends from a first side structure to a second side structure of the vehicle and includes a first vertical member, a second vertical member, and an upper horizontal member that at least partially define an opening between the cargo area and the passenger compartment. The brace assembly includes a first brace extending across the opening and including a first end secured to the upper horizontal member adjacent a longitudinal centerline of the vehicle and a second brace extending across the opening and including a first end secured to the upper horizontal member adjacent to the longitudinal centerline. The first brace further includes a second end secured to the first vertical member and the second brace includes a second end secured to the first vertical member.
    Type: Application
    Filed: March 27, 2019
    Publication date: October 1, 2020
    Inventors: Timothy J. PALESANO, Kevin A. VEVERKA, Christopher R. FREEMAN, Rafael TERAN, JR., Christopher HINZ
  • Publication number: 20200307717
    Abstract: An access panel for a body of a vehicle is provided that includes a dome portion, a flat portion, and an extension portion. The dome portion has a reinforcing element. The extension portion extends from the flat portion. A floor panel structure for a vehicle is also provided that includes a metal sheet and an access panel. The metal sheet includes an aperture. The access panel includes a dome portion, a flat portion, and an extension portion. The access panel is coupled to the metal sheet over the aperture, and the flat portion and the extension portion are configured to transmit a downward force applied to the access panel to the metal sheet.
    Type: Application
    Filed: March 25, 2019
    Publication date: October 1, 2020
    Inventors: Christopher R. Freeman, Patrick J. Ellison
  • Publication number: 20200200362
    Abstract: Light modules for converting the wavelength of light are described herein along with methods for using and making such modules and devices incorporating such modules.
    Type: Application
    Filed: December 18, 2019
    Publication date: June 25, 2020
    Inventors: Gregory MILLER, William R. FREEMAN
  • Publication number: 20200147052
    Abstract: Methods of using glucokinase (GK) activators are generally disclosed herein, particularly in combination with insulin or insulin analogs. In certain aspects, the disclosure provides methods of treating type 1 diabetes that include administering a GK activator in combination with insulin or insulin analogs. Uses of GK activators as a medicament are also disclosed herein, as well as the manufacture of a medicament for such uses.
    Type: Application
    Filed: January 13, 2020
    Publication date: May 14, 2020
    Inventors: Jennifer L.R. FREEMAN, Maria Carmen VALCARCE LOPEZ