Patents by Inventor R. Richard Goehring

R. Richard Goehring has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Buprenophine analogs
    Patent number: 8530494
    Abstract: The present invention is directed to Buprenorphine Analog compounds of the Formula I, Formula II or Formula III shown below, wherein R1, R2, R8, R3, R3a, R3b, X, Z and Y are as defined herein. Compounds of the Invention are useful for treating pain and other conditions modulated by activity of opioid and ORL1 receptors.
    Type: Grant
    Filed: July 30, 2009
    Date of Patent: September 10, 2013
    Assignee: Purdue Pharma LP
    Inventors: Donald J. Kyle, R. Richard Goehring, Marian E. Fundytus
  • Nociceptin analogs
    Patent number: 8252815
    Abstract: A compound of the formula (I), (II), (III) or (IV) wherein Z, A, B, C, R, R1, R2, Q, and n are as described herein.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: August 28, 2012
    Assignee: Purdue Pharma L.P.
    Inventors: Qun Sun, R. Richard Goehring, Donald Kyle, Zhengming Chen, Sam Victory, John Whitehead
  • HETEROCYCLIC-SUBSTITUTED PIPERIDINE COMPOUNDS AND THE USES THEREOF
    Publication number: 20120108575
    Abstract: The invention relates to Heterocyclic-Substituted Piperidine Compounds, compositions comprising an effective amount of a Heterocyclic-Substituted Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Heterocyclic-Substituted Piperidine Compound.
    Type: Application
    Filed: January 12, 2012
    Publication date: May 3, 2012
    Applicants: Shionogi & Co., Ltd., Purdue Pharma L.P.
    Inventors: Kevin C. Brown, R, Richard Goehring, Yoshiyasu BABA, Naoki Tsuno
  • NOCICEPTIN ANALOGS
    Publication number: 20120095049
    Abstract: A compound of the formula (I), (II), (III) or (IV) wherein Z, A, B, C, R, R1, R2, Q, and n are as described herein.
    Type: Application
    Filed: March 18, 2011
    Publication date: April 19, 2012
    Applicant: Purdue Pharma L.P.
    Inventors: Qun SUN, R. Richard Goehring, Donald Kyle, Zhengming Chen, Sam Victory, John Whitehead
  • Compounds comprising heterocyclic-substituted piperidine for treating pain
    Patent number: 8110602
    Abstract: The invention relates to Heterocyclic-Substituted Piperidine Compounds, compositions comprising an effective amount of a Heterocyclic-Substituted Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Heterocyclic-Substituted Piperidine Compound.
    Type: Grant
    Filed: July 15, 2009
    Date of Patent: February 7, 2012
    Assignee: Purdue Pharma L.P.
    Inventors: Kevin C. Brown, R. Richard Goehring, Yoshiyasu Baba, Naoki Tsuno
  • Buprenorphine Analogs
    Publication number: 20110136846
    Abstract: The present invention is directed to Buprenorphine Analog compounds of the Formula I, Formula II or Formula III shown below, wherein R1, R2, R8, R3, R3a, R3b, X, Z and Y are as defined herein, R1 H3CO (I) OCH3 OCH3 (III) Compounds of the Invention are useful for treating pain and other conditions modulated by activity of opioid and ORL1 receptors.
    Type: Application
    Filed: July 30, 2009
    Publication date: June 9, 2011
    Applicant: Purdue Pharma L.P.
    Inventors: Donald J. Kyle, R. Richard Goehring, Marian E. Fundytus
  • Aryl substituted pyridines and the use thereof
    Patent number: 7943643
    Abstract: This invention relates aryl substituted pyridines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R1-R4 are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
    Type: Grant
    Filed: August 24, 2009
    Date of Patent: May 17, 2011
    Assignee: Purdue Pharma L.P.
    Inventors: Bin Shao, R. Richard Goehring, Samuel F. Victory
  • Nociceptin analogs
    Patent number: 7939670
    Abstract: A compound of the formula (I), (II), (III) or (IV) wherein Z, A, B, C, R, R1, R2, Q, and n are as described herein.
    Type: Grant
    Filed: February 23, 2009
    Date of Patent: May 10, 2011
    Assignee: Purdue Pharma L.P.
    Inventors: Qun Sun, R. Richard Goehring, Donald Kyle, Zhengming Chen, Sam Victory, John Whitehead
  • Preparation of triazospiro compounds
    Publication number: 20110092704
    Abstract: The present invention relates to processes for producing triazospiro compounds having the formula (IV): wherein A, B, C, R, R1, and W are as defined herein.
    Type: Application
    Filed: October 16, 2003
    Publication date: April 21, 2011
    Inventors: Parvis Gharagozloo, Gary Lee, R. Richard Goehring
  • Substituted-Quinoxaline-Type Piperidine Compounds and the Uses Thereof
    Publication number: 20100216726
    Abstract: The invention relates to Substituted-Quinoxaline-Type Piperidine Compounds, compositions comprising an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound.
    Type: Application
    Filed: February 24, 2010
    Publication date: August 26, 2010
    Applicants: PURDUE PHARMA L.P., SHIONOGI & CO., LTD.
    Inventors: Kouki FUCHINO, R. Richard Goehring, Akira Matsumura, Bin Shao, Yoshiyuki Taoda, Naoki Tsuno, John William Frank Whitehead, Jiangchao Yao
  • Aryl Substituted Pyridines and the Use Thereof
    Publication number: 20100048626
    Abstract: This invention relates aryl substituted pyridines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R1-R4 are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
    Type: Application
    Filed: August 24, 2009
    Publication date: February 25, 2010
    Inventors: Bin SHAO, R. Richard Goehring, Samuel F. Victory, Qun Sun
  • HETEROCYCLIC-SUBSTITUTED PIPERIDINE COMPOUNDS AND THE USES THEREOF
    Publication number: 20100022519
    Abstract: The invention relates to Heterocyclic-Substituted Piperidine Compounds, compositions comprising an effective amount of a Heterocyclic-Substituted Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Heterocyclic-Substituted Piperidine Compound.
    Type: Application
    Filed: July 15, 2009
    Publication date: January 28, 2010
    Inventors: Kevin C. Brown, R. Richard Goehring, Yoshiyasu Baba, Naoki Tsuno
  • NOCICEPTIN ANALOGS
    Publication number: 20090253727
    Abstract: A compound of the having the general formula (I) or general formula (II): wherein Z, A, B, C, R1, R2, Q, W, and n are as described herein.
    Type: Application
    Filed: June 16, 2009
    Publication date: October 8, 2009
    Applicant: Purdue Pharma L.P.
    Inventors: R. Richard Goehring, Zhengming Chen, John Whitehead, Parviz Gharagozloo, Sam Victory, Donald Kyle
  • Aryl substituted pyridines and the use thereof
    Patent number: 7579367
    Abstract: This invention relates aryl substituted pyridines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R1-R4 are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
    Type: Grant
    Filed: September 11, 2006
    Date of Patent: August 25, 2009
    Assignee: Purdue Pharma L.P.
    Inventors: Bin Shao, R. Richard Goehring, Samuel F. Victory
  • Nociceptin analogs
    Patent number: 7563809
    Abstract: The invention relates to benzothiadiazole compounds of formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1, R2, A, B, C, W, Z and n are defined as set forth in the specification. The compounds of the invention have affinity for the nociceptin receptor. The invention is also directed to the use of compounds of Formula (I) to treat a disorder responsive to modulation of the nociceptin receptor. Compounds of the present invention are especially useful for treating pain.
    Type: Grant
    Filed: March 1, 2005
    Date of Patent: July 21, 2009
    Assignee: Purdue Pharma, L.P.
    Inventors: R. Richard Goehring, Zhengming Chen, John Whitehead, Parviz Gharagozloo, Sam Victory, Donald Kyle
  • NOCICEPTIN ANALOGS
    Publication number: 20090156640
    Abstract: A compound of the formula (I), (II), (III) or (IV) wherein Z, A, B, C, R, R1, R2, Q, and n are as described herein.
    Type: Application
    Filed: February 23, 2009
    Publication date: June 18, 2009
    Inventors: Qun SUN, R. Richard Goehring, Donald Kyle, Zhengming Chen, Sam Victory, John Whitehead
  • Nociceptin analogs
    Patent number: 7495109
    Abstract: A compound of the formula (I), (II), (III) or (IV) wherein Z, A, B, C, R, R1, R2, Q, and n are as described herein.
    Type: Grant
    Filed: January 11, 2005
    Date of Patent: February 24, 2009
    Assignee: Purdue Pharma L.P.
    Inventors: Qun Sun, R. Richard Goehring, Donald Kyle, Zhengming Chen, Sam Victory, John Whitehead
  • Benzimidazole compounds having nociceptin receptor affinity
    Patent number: 7456198
    Abstract: Disclosed are compounds of the formula (I) wherein A, R1, R2, R3, R4 and X1 are as disclosed herein. The compounds have affinity for the ORL1 receptor and are useful in the treatment of chronic and acute pain.
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: November 25, 2008
    Assignee: Purdue Pharma L.P.
    Inventors: Donald Kyle, R. Richard Goehring, Bin Shao
  • Synthesis of Cyanoimino-Benzoimidazoles
    Publication number: 20080214827
    Abstract: Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.
    Type: Application
    Filed: February 2, 2005
    Publication date: September 4, 2008
    Applicant: EURO-CELTIQUE S.A.
    Inventors: R. Richard Goehring, John Whitehead, Bin Shao
  • Aryl substituted pyrimidines and the use thereof
    Patent number: 7229993
    Abstract: This invention relates to a method of treating disorders responsive to the blockade of sodium ion channels using novel aryl-substituted pyrimidine compounds of Formula I: or a pharmaceutically acceptable salt, or solvate thereof, wherein A, R1, R2, R3 and R4 are defined in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
    Type: Grant
    Filed: March 13, 2003
    Date of Patent: June 12, 2007
    Assignee: Euro-Celtique S.A.
    Inventors: R. Richard Goehring, Sam F. Victory, Donald J. Kyle