Abstract: The present invention is directed to novel heteroaryl sulfone-based conjugation handles of the formula: (wherein R1, R2, Het, D, E, X, Y, Z, m, n, p, q, r, s and t are as defined herein), methods for their preparation, their use in synthesizing antibody drig conjugates, and the resulting antibody drig conjugates made with components having heteroaryl sulfone-based conjugation handles.

Abstract: A device may receive content data identifying content created by users and metadata associated with the content. The device may receive rules data identifying rules associated with utilization of the content. The device may utilize the metadata to generate digital DNA signatures for the content in near-real time. The device may store, in a repository, the rules data, the content, the digital DNA signatures, and relationships between the digital DNA signatures. The device may receive, from a client device, new content that is generated based on particular content of the content data and new metadata associated with the new content. The device may utilize the new metadata to generate a new digital DNA signature for the new content. The device may process the new digital DNA signature, the rules data, and the digital DNA signatures to determine whether the new content violates one or more rules of the rules data.

Abstract: A blister strip advance mechanism includes: an indexing gear train; drive mechanism configured to drive the indexing gear train; and a hub including a recess shaped to engage a first blister of a blister strip, the hub being rotatable by the indexing gear train to engage the first blister in the recess and move the engaged blister strip such that a second blister is moved to a dosing position at which the second blister can be emptied; wherein the indexing gear train is configured to temporarily disengage the drive mechanism from the hub when the second blister is in the dosing position. Also disclosed is a dosing mechanism including the blister strip advance mechanism; an inhaler including the dosing mechanism; a method for advancing a blister strip; and a method for dosing a medicament including the method for advancing a blister strip.

Abstract: Aspects of the present disclosure include a system for turbo-compression cooling. The system may be aboard a marine vessel. The system includes a power cycle and a cooling cycle. The power cycle includes a first working fluid, a waste heat boiler configured to evaporate the working fluid, a turbine, and a condenser. The condenser condenses the working fluid to a saturated or subcooled liquid. The cooling cycle includes a second working fluid, a first compressor configured to increase the pressure of the second working fluid, a condenser configured to condense the second working fluid to a saturated or subcooled liquid after exiting the first compressor, an expansion valve, and an evaporator. The turbine and first compressor are coupled one to the other. The waste heat boiler receives waste heat from engine jacket water and lubricating oil from a ship service generator. The evaporator cools water in a shipboard cooling loop.

Abstract: The present invention provides a method and system for manufacturing cement wherein ground particles of cement and calcium sulfate are subjected to infrared sensors, laser sensors, or both, so that emanated, irradiated, transmitted, and/or absorbed energy having wavelengths principally within the range of 700 nanometers to 1 millimeter can be monitored and compared to stored data previously obtained from ground cement and sulfate particles and preferably correlated with stored strength, calorimetric, or other data values, such that adjustments can be made to the mill processing conditions, such as the form or amounts of calcium sulfate (e.g., gypsum, plaster, anhydride), or cement additive levels. The strength and other properties of cement can be thus adjusted, and its quality can be more uniform.

Abstract: The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic gent to attract a desired cell.

Abstract: An adapter includes a substantially rigid body having a distal portion, a proximal portion, a central opening formed at least in part by an inner wall of the body, and a longitudinal axis extending substantially centrally through the opening. The distal portion includes an annular ring having a top surface and a ridge disposed opposite the top surface, the ridge extending substantially perpendicular to the longitudinal axis. The distal. The adapter also includes a seal configured to form a substantially fluid-tight seal with a surface of a fitting removably attachable to the adapter.

Abstract: A storage and charging station for storing and charging a plurality of mobile electronic devices communicable with a remote electronic device. The station comprises a storage assembly and an electrical system coupled to the storage assembly. The storage assembly comprises a frame and a plurality of storage bays supported by the frame. The plurality of storage bays is to receive the plurality of mobile electronic devices. The electrical system comprises a power component, a communication component, a logic component, a memory component, and a plurality of ports electrically coupled to the power component and the communication component. When a first mobile electronic device connects with a first port, the power component powers the first mobile electronic device via the first port, and the station communicates with the remote electronic device via the first port and the first mobile electronic device.

Abstract: New or improved lead acid batteries with vapor pressure barriers and/or improved battery separators, as well as systems, vehicles, and/or methods of manufacture and/or use thereof are disclosed herein. In at least select embodiments, the instant disclosure provides new or improved lead acid batteries with a vapor pressure barrier. In at least select embodiments, the instant disclosure provides new or improved lead acid battery vapor pressure barriers along with new or improved battery separators, and/or methods of manufacture and/or use thereof. In at least select embodiments, the instant disclosure provides a new or improved lead acid battery with a vapor pressure barrier that reduces the water loss from the battery. In at least select embodiments, a method of reducing the water loss of a lead acid battery may include providing a vapor pressure barrier, such as a layer of oil, inside the lead acid battery along with an improved battery separator.

Abstract: Disclosed are exemplary process and system for managing a mix design catalog of a concrete producer that involves collecting slump curve data obtained during in-transit monitoring of delivered concrete loads made from a plurality of various mix designs, wherein each mix design is identified by a different identification code (regardless of whether components are different), clustering slump curve data having same movement characteristics according to assigned strength value, and selecting a mix design to produce, to display, or both to produce and to display, from among the two or more slump data curves of individual mix designs within the same data curve cluster. The selection is based on same movement characteristic and assigned strength value, and at least one factor relative to cost, performance, physical aspect, quality, or other characteristic of the concrete mix or its components. Exemplary methods for generating new mix designs are also disclosed.

Abstract: An example device is configured to capture an image of a patient. The devices includes a camera configured to capture the image of the patient. The device further: captures contextual data associated with the image; allows a caregiver to select the image to be stored; forwards the image and the contextual data to a remote server for processing using artificial intelligence; and receives a proposed diagnosis from the remote server based upon the image and the contextual data.

Abstract: An adapter includes a substantially rigid body having a distal portion, a proximal portion, a central opening formed at least in part by an inner wall of the body, and a longitudinal axis extending substantially centrally through the opening. The distal portion includes an annular ring having a top surface and a ridge disposed opposite the top surface, the ridge extending substantially perpendicular to the longitudinal axis. The distal. The adapter also includes a seal configured to form a substantially fluid-tight seal with a surface of a fitting removably attachable to the adapter.

Abstract: A medical device includes a handle portion downwardly extending from an examination portion. The handle portion has opposing upper and lower open ends and a through cavity extending therebetween. An illumination assembly mounted within the open upper end of cavity includes a housing, at least one battery disposed within the housing, and an LED disposed at the distal end of an arm extending from the housing. The housing is mounted through the open upper end of the through cavity. According to at least one version, the at least one battery can be removed without removing the housing from the handle portion. The extending arm is supported by the examination portion and configured to provide illumination to a medical target. The medical device can include a vaginal speculum, sigmoidoscope, laryngoscope, anoscope, or other hand-held medical device.

Abstract: The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic gent to attract a desired cell.

Abstract: Disclosed herein are improved separators for lead acid batteries, improved batteries, and related methods. The separators may include a porous membrane, rubber and/or latex, and at least one performance enhancing additive or surfactant.

Abstract: The invention relates to compositions containing the non-salt form of the herbicide fomesafen solubilized with at least one surfactant selected from the group consisting of fatty amine, alkanolamine, fatty amine alkoxylate and alkoxylated quaternary ammonium compounds. Advantages provided by these compositions include higher active ingredient levels, improved cold temperature stability, and enhanced weed control performance.

Abstract: The invention relates to compositions containing the non-salt form of the herbicide fomesafen solubilized with at least one surfactant. Advantages provided by these compositions include higher active ingredient levels, improved cold temperature stability, and enhanced weed control performance.

Abstract: A system and process for detecting dynamic segregation in concrete rotated within a mixer drum, such as mounted on a delivery truck. A system processor is programmed to monitor an instantaneous and averaged rheology parameter and to deploy protocols for detecting segregation. A first protocol comprises monitoring the averaged slump during and immediately after a jump in drum speed of at least plus or minus four rotations per minute and detecting when a change in the averaged slump value meets or exceeds a threshold; and a second protocol comprises monitoring the instantaneous slump when the mixer drum is rotating at a constant speed for at least three successive rotations and detecting when the instantaneous slump value meets or exceeds a threshold limit. Once segregation is detected, one or more operations can be initiated, such as initiating an alarm or adjusting the mix.

Abstract: A storage and management assembly for a plurality of portable electronic devices is provided. The assembly includes a tower assembly to define a vertical channel along a first side of the tower assembly. A plurality of shelves are removably coupled to a second side of the tower assembly, each of the shelves includes a storage bay defined by a bottom portion provided perpendicular to the first member, and opposing raised edge portions provided about a portion of the perimeter of the bottom portion, the plurality of shelves provided in a stacked vertical arrangement along the tower assembly. Rear support shelves protrude rearwardly from the shelf bottom portion and through tower support first receiving slots to support electrical apparatus within the channel for powering portable electronic devices placed on the shelf bottom portions.

Abstract: A device for forming a random set of playing cards comprises a card in-feed area, a shuffling system, a card removal area, and a card reading system located within the device, the card reading system employing a complementary metal-oxide semiconductor (CMOS) sensor and a hardware component, the hardware component capable of converting signals from the CMOS sensor into vector sets and comparing the vector sets to known vectors to determine rank and suit.