Patents by Inventor R. Rox Anderson

R. Rox Anderson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6511475
    Abstract: Methods and apparatus for dermatology treatment are provided which involve the use of continuous wave (CW) radiation, preheating of the treatment volume, precooling, cooling during treatment and post-treatment cooling of the epidermis above the treatment volume, various beam focusing techniques to reduce scattering and/or other techniques for reducing the cost and/or increasing the efficacy of optical radiation for use in hair removal and other dermatological treatments. A number of embodiments are included for achieving the various objectives indicated above.
    Type: Grant
    Filed: August 9, 2000
    Date of Patent: January 28, 2003
    Assignees: The General Hospital Corporation, Palomar Medical Technologies, Inc.
    Inventors: Gregory B. Altshuler, R. Rox Anderson
  • Publication number: 20020161357
    Abstract: A method and apparatus are provided for performing a therapeutic treatment on a patient's skin by concentrating applied radiation of at least one selected wavelength at a plurality of selected, three-dimensionally located, treatment portions, which treatment portions are within non-treatment portions. The ratio of treatment portions to the total volume may vary from 0.1% to 90%, but is preferably less than 50%. Various techniques, including wavelength, may be utilized to control the depth to which radiation is concentrated and suitable optical systems may be provided to concentrate applied radiation in parallel or in series for selected combinations of one or more treatment portions.
    Type: Application
    Filed: December 27, 2001
    Publication date: October 31, 2002
    Inventors: R. Rox Anderson, Gregory B. Altshuler, Dieter Manstein, Sergey B. Biruchinsky, Andrei V. Erofeev
  • Publication number: 20020091377
    Abstract: A method and apparatus are provided for performing a medical procedure on a patient, for example a dermatological procedure, by use of electromagnetic radiation (EMR) having a relatively low peak power, and in particular a peak power low enough so as not to result in a phase change in the heater or chromophore absorbing radiation which would result in a significant reduction in its absorption, and of relatively long duration which is generally greater than, sometimes significantly greater than, the thermal relaxation time of the irradiated target.
    Type: Application
    Filed: January 25, 2001
    Publication date: July 11, 2002
    Inventors: R. Rox Anderson, Dieter Manstein, Eliot Battle, Gregory B. Altshuler, Michael Smotrich, Henry H. Zenzie, Michael Z. Smimov
  • Publication number: 20020065533
    Abstract: The present invention relates to methods and devices used for the formation of microconduits in a tissue. The term “microconduit” refers to a small opening, channel, or hole into, or through, a tissue, that allows transfer of materials by liquid flow, and by electrophoresis, the microconduit being formed upon impact of a plurality of accelerated microparticles with the surface of the tissue. A method is described for forming at least one microconduit in tissue including the steps of: accelerating a plurality of microparticles to a velocity that causes the microparticles to penetrate a region of tissue surface upon impingement of the microparticles on the tissue surface; and directing the microparticle towards the region of tissue surface, thereby causing the microparticles to penetrate the tissue and form a microconduit in the tissue. According to an embodiment, microparticles are accelerated by being hit with a moving, solid surface.
    Type: Application
    Filed: June 7, 2001
    Publication date: May 30, 2002
    Applicant: Massachusetts Institute of Technology
    Inventors: James C. Weaver, R. Rox Anderson, Terry O. Herndon, T. R. Gowrishankar, Elizabeth A. Gift, Salvador Gonzalez
  • Patent number: 6350261
    Abstract: The invention features methods and systems for selectively delivering or coupling laser radiation into a first material or substrate, e.g., a first biological tissue, having a first index of refraction and not into a second material or substrate, e.g., a second biological tissue, having a second index of refraction. The system determines whether a target area corresponds to the first material or the second material by monitoring the reflection of a probe beam incident on the target area through an optical coupler at a non-normal incident angle. The monitored reflection of the probe beam is a control signal for a feedback controller that causes a treatment beam to be delivered to the target area based on the monitored reflection.
    Type: Grant
    Filed: April 11, 2000
    Date of Patent: February 26, 2002
    Assignee: The General Hospital Corporation
    Inventors: Yacov Domankevitz, R. Rox Anderson
  • Publication number: 20020022827
    Abstract: The invention encompasses methods and apparatus for pumping fluid from one location to another through the repetitive expansion and collapse of bubbles generated as a result of the absorption of repetitive pulses of radiation in a fluid. This pumping phenomenon can be used to aid removal of a total or partial occlusion in a body passage by emulsifying the occlusion with acoustic shock and pressure waves or by causing mechanically disrupting the occlusive material.
    Type: Application
    Filed: September 6, 2001
    Publication date: February 21, 2002
    Inventors: Victor C. Esch, Quang Q. Tran, R. Rox Anderson
  • Patent number: 6273884
    Abstract: Methods and apparatus for dermatology treatment are provided which involve the use of continuous wave (CW) radiation, preheating of the treatment volume, precooling, cooling during treatment and post-treatment cooling of the epidermis above the treatment volume, various beam focusing techniques to reduce scattering and/or other techniques for reducing the cost and/or increasing the efficacy of optical radiation for use in hair removal and other dermatological treatments. A number of embodiments are included for achieving the various objectives indicated above.
    Type: Grant
    Filed: May 13, 1998
    Date of Patent: August 14, 2001
    Assignees: Palomar Medical Technologies, Inc., General Hospital Corporation
    Inventors: Gregory B. Altshuler, R. Rox Anderson
  • Patent number: 6139543
    Abstract: The invention encompasses methods and apparatus for pumping fluid from one location to another through the repetitive expansion and collapse of bubbles generated as a result of the absorption of repetitive pulses of radiation in a fluid. This pumping phenomenon can be used to aid removal of a total or partial occlusion in a body passage by emulsifying the occlusion with acoustic shock and pressure waves or by mechanically disrupting the occlusive material.
    Type: Grant
    Filed: July 22, 1998
    Date of Patent: October 31, 2000
    Assignee: EndoVasix, Inc.
    Inventors: Victor C. Esch, Quang Q. Tran, R. Rox Anderson, Stephen J. Hebert, Marc-Alan Levine, Eduardo U. Sucgang
  • Patent number: 6129723
    Abstract: An apparatus and method for superficially ablating and/or photochemically altering a substrate, e.g., a biological tissue, having a first refractive index, e.g., to a desired configuration, including a laser energy source which provides laser energy to an energy coupling wave generator which generates laser energy waves from the laser energy, the generator having a surface adapted to contact and form an interface with the substrate and having a second refractive index higher than the first refractive index, wherein laser energy entering the wave generator impinges on the surface at an angle of incidence greater than or equal to a critical angle for total internal reflection when the surface is not contacting the substrate, and wherein the wave generator couples the laser energy waves, e.g., refracted or evanescent waves, into the substrate at the interface to superficially ablate the substrate when contacting the substrate.
    Type: Grant
    Filed: November 28, 1995
    Date of Patent: October 10, 2000
    Assignee: The General Hospital Corporation
    Inventors: R. Rox Anderson, Yacov Domankevitz
  • Patent number: 6126655
    Abstract: The invention features a probe for selectively delivering laser radiation to a first tissue having a first index of refraction relative to a second tissue having a second index of refraction less than the first index. The probe includes a laser transmitting medium having an optical axis and a tissue-contacting surface. In some embodiments, the optical axis contacts the tissue-contacting surface at an angle that is less than the critical angle for an interface between the tissue-contacting surface and the first tissue and greater than or equal to the critical angle for an interface between the tissue-contacting surface and the second tissue, wherein during operation the probe directs the laser radiation along the optical axis to the tissue-contacting surface.
    Type: Grant
    Filed: August 11, 1998
    Date of Patent: October 3, 2000
    Assignee: The General Hospital Corporation
    Inventors: Yacov Domankevitz, R. Rox Anderson
  • Patent number: 6120497
    Abstract: A method for treating wrinkles in skin involves the use of a beam of pulsed, scanned or gated continuous wave laser or incoherent radiation. The method comprises generating a beam of radiation, directing the beam of radiation to a targeted dermal region between 100 microns and 1.2 millimeters below a wrinkle in the skin, and thermally injuring collagen in the targeted dermal region. The beam of radiation has a wavelength of between 1.3 and 1.8 microns. The method may include cooling an area of the skin above the targeted dermal region while partially denaturing the collagen in the targeted dermal region. The method may also include cooling an area of the skin above the targeted dermal region prior to thermally injuring collagen in the targeted dermal region.
    Type: Grant
    Filed: September 15, 1998
    Date of Patent: September 19, 2000
    Assignees: Massachusetts General Hospital, Candela Corporation, United States of America
    Inventors: R. Rox Anderson, Edward Victor Ross, Jr., James C. Hsia, Kathleen McMillan
  • Patent number: 6066130
    Abstract: A method for conducting laser energy to a site includes steps of bringing the proximal end of a flexible tube near the site, filling at least a proximal portion of the tube with a liquid by introducing the liquid into the tube, allowing a portion of the liquid to flow out from the proximal end of the tube toward the site, and directing laser energy from a laser energy source into the distal end of the tube, whereby a portion of the laser energy emerges from the proximal end of the tube at the site. Also, such a method in which the liquid is a radiographic contrast medium. Also, such a method for removing an obstruction from a blood vessel in an animal.
    Type: Grant
    Filed: October 24, 1988
    Date of Patent: May 23, 2000
    Assignee: The General Hospital Corporation
    Inventors: Kenton W. Gregory, R. Rox Anderson
  • Patent number: 5995283
    Abstract: A confocal microscope for generating an image of a sample includes a first scanning element for scanning a light beam along a first axis, and a second scanning element for scanning the light beam at a predetermined amplitude along a second axis perpendicular to the first axis. A third scanning element scans the light beam at a predetermined amplitude along a third axis perpendicular to an imaging plane defined by the first and second axes. The second and third scanning element are synchronized to scan at the same frequency. The second and third predetermined amplitudes are percentages of their maximum amplitudes. A selector determines the second and third predetermined amplitudes such that the sum of the percentages is equal to one-hundred percent.
    Type: Grant
    Filed: November 12, 1998
    Date of Patent: November 30, 1999
    Assignee: General Hospital Corporation
    Inventors: R. Rox Anderson, Robert H. Webb, Milind Rajadhyaksha
  • Patent number: 5925078
    Abstract: A method of permanently joining a first collagen-containing material to a second collagen-containing material, each material having free ends of collagen fibrils at a surface, by bringing the free ends of collagen fibrils at the surfaces of the first and second materials into contact, heating the first and second materials for a time and to a temperature sufficient to permanently join the first and second materials at an area of contact of the free ends, wherein the temperature is above a melting temperature of the collagen fibril free ends, and below a melting temperature of intact collagen fibrils, such that collagen fibrils in the first and second materials are not denatured except at their free ends, and optionally thereafter crosslinking the collagen along the area of contact.
    Type: Grant
    Filed: November 4, 1996
    Date of Patent: July 20, 1999
    Assignee: The General Hospital Corporation
    Inventor: R. Rox Anderson
  • Patent number: 5911718
    Abstract: An apparatus and method is disclosed for treating vascular lesions. In the preferred embodiment, an intracavity, frequency doubled Nd:YAG laser is used to generate output pulses having a duration of 0.5 to 10.0 milliseconds. This laser output is used to irradiate the lesions. The laser energy is absorbed in the blood of the vein, causing it to coagulate and collapse. The long pulse duration helps to minimize bleeding while controlling thermal damage to surrounding tissue.
    Type: Grant
    Filed: May 8, 1998
    Date of Patent: June 15, 1999
    Assignee: Coherent, Inc.
    Inventors: J. Michael Yarborough, R. Rox Anderson, George Marcellino, Gerald M. Mitchell
  • Patent number: 5880880
    Abstract: A confocal microscope for generating an image of a sample includes a first scanning element for scanning a light beam along a first axis, and a second scanning element for scanning the light beam at a predetermined amplitude along a second axis perpendicular to the first axis. A third scanning element scans the light beam at a predetermined amplitude along a third axis perpendicular to an imaging plane defined by the first and second axes. The second and third scanning element are synchronized to scan at the same frequency. The second and third predetermined amplitudes are percentages of their maximum amplitudes. A selector determines the second and third predetermined amplitudes such that the sum of the percentages is equal to one-hundred percent.
    Type: Grant
    Filed: July 15, 1996
    Date of Patent: March 9, 1999
    Assignee: The General Hospital Corp.
    Inventors: R. Rox Anderson, Robert H. Webb, Milind Rajadhyaksha
  • Patent number: 5879326
    Abstract: A method and apparatus for mechanically disrupting a layer of skin having a known thickness without substantially disrupting underlying dermis layers below the layer of skin in question so as to facilitate the delivery of compounds across the disrupted layer. The apparatus includes a cutter having a plurality of microprotrusions having a height chosen with respect to the layer of skin that is to be disrupted and a stop for preventing the apparatus from penetrating the skin beyond a predetermined distance. In the preferred embodiment of the present invention, the microprotrusions include blades that generate cuts in the layer of skin. The cuts are generated by moving the apparatus parallel to the surface of the skin either at the time of application, during the normal movements of the individual wearing the apparatus, or both. In the preferred embodiment of the present invention, the appropriate length of blade is determined for each individual and delivery site on that individual.
    Type: Grant
    Filed: April 25, 1997
    Date of Patent: March 9, 1999
    Inventors: Ned Allen Godshall, R. Rox Anderson
  • Patent number: 5814041
    Abstract: An illuminator including a differential optical radiator and a laser fiber disposed within the differential optical radiator. The differential optical radiator includes a first region that has a first level of reflectivity and a first level of transmissivity and a second region that has a second, higher level of reflectivity and a second, lower level of transmissivity. The first and second regions are positioned such and their reflectivities and transmissivities are chosen such that the radiator produces a substantially uniform pattern of illumination from the first and second regions. In another embodiment, the illuminator includes an expandable radiator and a laser fiber disposed within the expandable radiator. The reflectivity of the expandable radiator is such that the illumination at the outer surface of the expandable radiator is substantially uniform.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 29, 1998
    Assignee: The General Hospital Corporation
    Inventors: R. Rox Anderson, Nayantara Bhatta, Scott Prahl
  • Patent number: 5810801
    Abstract: A method for treating wrinkles in skin involves the use of a beam of puls scanned or gated continuous wave laser or incoherent radiation. The method comprises generating a beam of radiation, directing the beam of radiation to a targeted dermal region between 100 microns and 1.2 millimeters below a wrinkle in the skin, and thermally injuring collagen in the targeted dermal region. The beam of radiation has a wavelength of between 1.3 and 1.8 microns. The method may include cooling an area of the skin above the targeted dermal region while partially denaturing the collagen in the targeted dermal region. The method may also include cooling an area of the skin above the targeted dermal region prior to thermally injuring collagen in the targeted dermal region.
    Type: Grant
    Filed: February 5, 1997
    Date of Patent: September 22, 1998
    Assignees: Candela Corporation, The United States of America as represented by the Secretary of the Navy
    Inventors: R. Rox Anderson, Edward Victor Ross, Jr., James C. Hsia, Kathleen McMillan
  • Patent number: 5754573
    Abstract: An apparatus and method is disclosed for treating vascular lesions. In the preferred embodiment, an intracavity, frequency doubled Nd:YAG laser is used to generate output pulses having a duration of 0.5 to 10.0 milliseconds. This laser output is used to irradiate the lesions. The laser energy is absorbed in the blood of the vein, causing it to coagulate and collapse. The long pulse duration helps to minimize bleeding while controlling thermal damage to surrounding tissue.
    Type: Grant
    Filed: July 9, 1996
    Date of Patent: May 19, 1998
    Assignee: Coherent, Inc.
    Inventors: J. Michael Yarborough, R. Rox Anderson, George Marcellino, Gerald M. Mitchell