Abstract: Compositions based on low toxicity solvents, in particular coating formulations, having reduced viscosity are disclosed. The compositions contain polyamideimide polymers having well-defined molecular weight distribution.

Abstract: Systems and methods for neuronavigation in accordance with embodiments of the invention are illustrated. Targeting systems and methods as described herein can generate personalized stimulation targets for the treatment of mental conditions. In many embodiments, direct stimulation of a personalized the stimulation target indirectly impacts a brain structure that is more difficult to reach via the stimulation modality. In various embodiments, the mental condition is major depressive disorder. In a number of embodiments, the mental condition is suicidal ideation.

Abstract: Antibacterial compounds are shown and described. In one aspect, a pharmaceutical composition includes a therapeutically effective amount of an antibacterial compound and a pharmaceutically acceptable vehicle therefor. In another aspect, a method of treating a bacterial infection involves administering the pharmaceutical composition to an individual in need thereof.

Abstract: Systems and methods for treatment verification and re-treatment with iboga alkaloids in accordance with embodiments of the invention are illustrated. One embodiment includes obtaining a first arterial spin labeling (ASL) scan of a patient's brain pre-treatment with an iboga-alkaloid for a neuropsychiatric condition, obtaining a second ASL scan of the patient's brain post-treatment, measuring changes in regional cerebral blood flow (rCBF) in a left orbitofrontal cortex, left insula, right cingulate cortex, and left putamen of the patient's brain based on the first ASL scan and the second ASL scan, determining that the treatment succeeded when either (i) rCBF increased by at least 0.1 in the left orbitofrontal cortex, or (ii) rCBF increased by any amount in the left orbitofrontal cortex and in at least two of the left insula, right cingulate cortex, and left putamen, and determining that the treatment failed when it is not determined that the treatment succeeded.

Abstract: Pharmaceutical compounds having anticancer activity are disclosed. A pharmaceutical composition may include a therapeutically effective amount of the compound(s) and a pharmaceutically acceptable vehicle. A method of treating a cancer or other disorders involves administering the pharmaceutical composition to an individual in need thereof.

Abstract: Pharmaceutical compounds have anti-inflammatory activity. A pharmaceutical composition may include a therapeutically effective amount of the compound(s) and a pharmaceutically acceptable vehicle. A method of treating a disorder associated with chronic inflammation involves administering the pharmaceutical composition to an individual in need thereof.

Abstract: In one aspect, an artificial sweetener compound is disclosed. In another aspect, a sweetened composition includes the sweetener compound. In some aspects, the sweetened composition is combined with a product such as a food product, beverage product, or a pharmaceutical product.

Abstract: Pharmaceutical compounds are described for treating hair loss, promoting hair growth, and/or improving the appearance of hair. In one aspect, a method of increasing hair growth includes administering to an individual in need thereof a pharmaceutical composition containing a therapeutically effective amount of a compound or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable vehicle therefor. In another aspect, a method of improving the appearance of hair includes administering to an individual in need thereof a pharmaceutical composition containing a therapeutically effective amount of a compound or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable vehicle therefor.

Abstract: A wire grid polarizer (WGP) can include an array of support-ribs on a substrate. Sides of the support-ribs can be inclined to one side. A wire can be applied on an upper-side and distal end of each support-rib, each wire being separate from wires on adjacent support-ribs. The WGP can be made with reduced or no etching.

Abstract: Compounds disclosed herein may exhibit antibacterial and anti-inflammatory properties. Pharmaceutical compositions containing the compound(s) may be used to treat bacterial infections, such as urinary tract infections, and/or disorders associated with chronic inflammation.

Abstract: A fiber-based optical amplifier is formed to exhibit a reflective architecture in a particular configuration where a single pump source is shared among several individual reflective amplifier elements. A passive, non-variable power splitter is used to direct sub-beams of sufficient power into the rare-earth doped fiber contained within individual amplifiers. Since the reflective architecture results in an optical signal passing through the doped fiber coil (gain medium) twice, a lower pump power (compared to a conventional single-pass structure) may be used to obtain the same target output power level and the single pump source is considered as sufficient to provide enough output power to pass through a power splitting arrangement and deliver enough pump power to provide amplification of a propagating optical signal in each of the individual amplifiers.

Abstract: Pharmaceutical compounds have anti-inflammatory activity. A pharmaceutical composition may include a therapeutically effective amount of the compound(s) and a pharmaceutically acceptable vehicle. A method of treating a disorder associated with chronic inflammation, such as arthritis, involves administering the pharmaceutical composition to an individual in need thereof.

Abstract: A watercraft includes: a deck; and a first pontoon coupled with the deck, the first pontoon including: a first body; a first marine propulsion device coupled with the first body; and a first electric motor operably coupled with the first marine propulsion device and disposed within the first body.

Abstract: Compounds disclosed herein may be useful for treating a glucose and lipid metabolism disorders, such as hyperlipidemia, diabetes, fatty liver, obesity, and arteriosclerotic cardiovascular and cerebrovascular diseases. In some aspects, a pharmaceutical composition contains a glucose and lipid metabolism regulating agent(s) and a pharmaceutically acceptable vehicle therefor.

Abstract: An oral irrigator handle including a housing and a first fitting, the first fitting including a first fitting inlet in fluid communication with a handle inlet in fluid communication with a fluid source and a first fitting outlet in fluid communication with the first fitting inlet. The handle includes a seal positioned around the first fitting and between the first fitting inlet and the first fitting outlet. A second fitting includes a second fitting inlet in fluid communication with the first fitting outlet and a second fitting outlet in fluid communication with the second fitting inlet. A bottom portion of the second fitting seats on a portion of the first fitting so that the seal engages an interior surface of the second fitting, a flow passage is coupled to the second fitting and in fluid communication with the second fitting outlet.

Abstract: A surgical instrument assembly comprises a guide tube and a first instrument. The first instrument includes a first elongated shaft and a first proximal arm link coupled by a first shoulder joint, the first proximal arm link and a first distal arm link coupled by a first elbow joint, and the first distal arm link and a first end effector coupled by a first wrist joint. The surgical instrument assembly also comprises a second instrument that includes a second elongated shaft and a second proximal arm link coupled by a second shoulder joint, the second proximal arm link and a second distal arm link coupled by a second elbow joint, and the second distal arm link and a second end effector coupled by a second wrist joint. The surgical instrument assembly also includes an imaging assembly. The first and second end effectors are within the imaging assembly's field of view.

Abstract: Implants, systems and methods for correcting bone deformities and fractures in the lower extremity are disclosed. Specifically, implants, systems and methods used for correcting bone deformities and/or fractures in the foot using compression are disclosed. A nail system including a first member with a first deformable member positioned at a first end of the first member and a second member received within the first member.

Abstract: A method of making a polarizer can include applying a liquid with solid inorganic nanoparticles dispersed throughout a continuous phase, then forming this into a different phase including a solid, interconnecting network of the inorganic nanoparticles. This method can improve manufacturability and reducing manufacturing cost. This method can be used to provide an antireflective coating, to provide a protective coating on polarization structures, to provide thin films for optical properties, or to form the polarization structures themselves.

Abstract: An autonomous coverage robot detection system includes an emitter configured to emit a directed beam, a detector configured to detect the directed beam and a controller configured to direct the robot in response to a signal detected by the detector. In some examples, the detection system detects a stasis condition of the robot. In some examples, the detection system detects a wall and can follow the wall in response to the detected signal.