Abstract: The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and/or that employ a particular bioreactor having a gas permeable membrane.

Abstract: The lubrication device delivers a lubricant to the perforating device which provides intermittently spaced cuts to a moving web, also referred to as perforations. The lubrication device includes a retaining member, a plenum, and a comb having a plurality of comb channels. The plenum and the plurality of comb channels are in fluid communication with one another and deliver a lubricant to the perforating device. Lubrication of the perforating device in this manner may improve knife life, perforation quality and web handling.

Abstract: A method of producing a polyether alcohol that includes feeding an initiator into a reactor, feeding one or more monomers into the reactor, feeding a polymerization catalyst into the reactor, the polymerization catalyst being a Lewis acid catalyst having a general formula M(R1)1(R2)1(R3)1(R4)0 or 1, separate from feeding the initiator into the reactor, feeding a hydrogen bond acceptor additive into the reactor, the hydrogen bond acceptor additive being a C2 to C20 organic molecule having at least two hydroxyl groups, of which two hydroxyl groups are situated in 1,2-, 1,3-, or 1,4- positions on the organic molecule, and allowing the initiator to react with the one or more monomers in the presence of the polymerization catalyst and the hydrogen bond acceptor additive to form a polyether alcohol having a number average molecular weight greater than a number average molecular weight of the initiator.

Abstract: An embodiment of the invention provides a method of promoting regression of cancer in a mammal comprising obtaining a tumor tissue sample from the mammal; culturing the tumor tissue sample in a first gas permeable container containing cell medium therein; obtaining tumor infiltrating lymphocytes (TIL) from the tumor tissue sample; expanding the number of TIL in a second gas permeable container containing cell medium therein using irradiated allogeneic feeder cells and/or irradiated autologous feeder cells; and administering the expanded number of TIL to the mammal. Methods of obtaining an expanded number of TIL from a mammal for adoptive cell immunotherapy are also provided.

Abstract: An electronic device may have transparent housing structures such as walls formed of glass or sapphire. Housing structures such as transparent housing structures may have a colored coating. The colored coating may include an absorptive layer and a metal layer. The coating may exhibit a color that can be adjusted by adjusting the thickness of the thin absorptive layer. A colored layer such as a layer of colored polymer may be incorporated into the colored coating to further adjust the color of the coating. The colored coating may be formed on an inner or outer housing structure surface. The surface may have a texture to provide the coating with a matte appearance. When formed on an outer surface, a diamond-like carbon layer may protect the colored coating. When formed on an inner surface, a passivation layer may be used to prevent oxidation of the metal layer.

Abstract: An electronic device may include electrical components and other components mounted within an interior of a housing. The device may have a display on a front face of the device and may have a glass layer that forms part of the housing on a rear face of the device. The glass layer may be provided with regions having different appearances. The regions may be textured, may have coatings such as thin-film interference filter coatings formed from stacks of dielectric material having alternating indices of refraction, may have metal coating layers, and/or may have ink coating layers. Textured surfaces may be formed on thin glass layers and polymer films that are coupled to the glass layer. A glass layer may be formed from a pair of coupled glass layers. The coupled layers may have one or more recesses or other structures to visually distinguish different regions of the glass layer.

Abstract: Some embodiments include an integrated assembly having a memory array region, a staircase region, and an intervening region between the staircase region and the memory array region. The intervening region includes first and second slabs of insulative material extending through a stack of alternating insulative and conductive levels. Bridging regions are adjacent to the slabs. First slits are along the bridging regions, and second slits extend through the slabs. First panels are within the first slits, and second panels are within the second slits. The second panels are compositionally different from the first panels. Some embodiments include methods of forming integrated assemblies.

Abstract: This invention relates to methods and devices that improve cell culture efficiency. They include the use of gas permeable culture compartments that reduce the use of space while maintaining uniform culture conditions, and are more suitable for automated liquid handling. They include the integration of gas permeable materials into the traditional multiple shelf format to resolve the problem of non-uniform culture conditions. They include culture devices that use surfaces comprised of gas permeable, plasma charged silicone and can integrate traditional attachment surfaces, such as those comprised of traditional tissue culture treated polystyrene. They include culture devices that integrate gas permeable, liquid permeable membranes. A variety of benefits accrue, including more optimal culture conditions during scale up and more efficient use of inventory space, incubator space, and disposal space. Furthermore, labor and contamination risk are reduced.

Abstract: In selected embodiments a recommendation generator builds a network of interrelationships between venues, reviewers and users based on their attributes and reviewer and user reviews of the venues. Each interrelationship or link may be positive or negative and may accumulate with other links (or anti-links) to provide nodal links the strength of which are based on commonality of attributes among the linked nodes and/or common preferences that one node, such as a reviewer, expresses for other nodes, such as venues. The links may be first order (based on a direct relationship between, for instance, a reviewer and a venue) or higher order (based on, for instance, the fact that two venue are both liked by a given reviewer). The recommendation engine in certain embodiments determines recommended venues based on user attributes and venue preferences by aggregating the link matrices and determining the venues which are most strongly coupled to the user.

Abstract: In accordance with the principles of the present invention a non-biased, computer-implemented financial instrument electronic trading system and electronic central clearinghouse are provided. The electronic trading system and electronic central clearinghouse operate to provide electronic trading of financial instruments that are non-biased in that the electronic trading system and electronic clearing house address at least one of two effects that result from the difference between variation margin on a cleared financial instrument and collateral posted on an uncleared financial instrument, the first effect being a systematic advantage of being short the financial instrument when there is a correlation between the value of the financial instrument and interest rates, referred to as a convexity bias, and the second effect being a distortion in the financial instrument when an underlying asset value of the financial instrument changes, referred to as a net present value (NPV) effect.

Abstract: This disclosure describes methods and compositions for detecting the presence of a Kelch-like protein 11 autoantibody in a biological sample. Also provided are methods of treating subjects with testicular cancer or a premalignant condition and paraneoplastic encephalomyelitis.

Abstract: Relationship management systems in accordance with embodiments of the invention are configured to provide systematic ways for a user to measure, and manage relationships in the user's social network. One embodiment of the invention includes a relationship management server system, and a database. In addition, the relationship management server system is configured to store a user account associated with a user in the database, store information concerning contacts associated with the user in the database, store event information associated with the user and at least one of the stored contacts in the database, store at least one objective in the database, score at least one relationship between the user and a contact based upon stored event information associated with the user and the contact to create a scored relationship graph, and generate a recommendation concerning an action based upon the stored objective and the scored relationship graph.

Abstract: Textured cover assemblies for electronic devices are disclosed. The textured cover assemblies may provide a combination of optical and tactile properties to the electronic devices. In some cases, a textured cover assembly may be provided over decorative coating.

Abstract: An improved method of culturing cells for cell therapy applications that includes growing desired cells in the presence of antigen-presenting cells and/or feeder cells and with medium volume to surface area ratio of up to 1 ml/cm2 if the growth surface is not comprised of gas permeable material and up to 2 ml/cm2 if the growth surface is comprised of gas permeable material. The desired cells are at a surface density of less than 0.5×106 cells/cm2 at the onset of a production cycle, and the surface density of the desired cells plus the surface density of the antigen presenting cells and/or feeder cells are at least about 1.25×105 cells/cm2.

Abstract: The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

Abstract: An amphibious platform vehicle-vessel to support and to move hydraulically operated and controlled earth-moving and lifting equipment, such as excavators and cranes, on solid ground, semi-solid or marshy ground, shallow water, and deeper water. The modular units can be transported to a worksite on separate trailers and assembled and reconfigured on site. Two compartmented pontoon units are mounted to an adaptive cross member that can accommodate different types of moving-lifting equipment through different mounting flanges, and to auxiliary cross members. Propulsion is provided through amphibious cleats on drive chains in chain tracks driven by dual-motor driving drums and over a tension-adjusting passive chain roller, surrounding a sealed pontoon shell internally reinforced with bulkhead partitions, beam shell-bottom stiffeners, and pressed-angle shell-bottom stiffeners. An extendable auxiliary float can be extended outward from each compartmented pontoon for increased stability in floating operations.

Abstract: A blockchain enabled electronic futures trading system and method provided which allows for optional computerized delivery of cryptocurrency. A trade determination system allows a buyer and seller computer system to trade a future on a cryptocurrency such as bitcoin. Additionally, the trade determination system communicates with a central clearing computer system that allows the seller to provide, using the block chain, an amount of bitcoin equal to or greater than the underlying future by transferring the bitcoin from a seller bitcoin wallet associated with the seller computer system to a central clearing bitcoin wallet associated with the central clearing computer system. Upon the expiration date of the future, the seller may optionally select to provide to the buyer the bitcoin that was previously transferred to the central clearing bitcoin wallet instead of fiat currency. Additionally, the future may be associated with an upper boundary price and a lower boundary price.

Abstract: Various embodiments relate to sensing defects associated with a window. Furthermore, various embodiments relate to performing image processing to produce a corrected image of a scene based at least partly on data corresponding to the detected defects. In some examples, one or more lighting modules may be used to illuminate the window to facilitate detection of the defects by one or more sensor devices.

Abstract: An exercise system includes a resistance unit for the performance of a wide variety of exercises including those previously performed using free weights, exercise machines, rowing machines, and/or ski machines. The resistance unit is configured with power rewind such that the resistance for both pull-out and rewind is determined by the resistance developed by a clutch assembly having clutch-plates slipping against friction pads in the clutch-assembly, resulting in the resistance for pulling out and rewinding being virtually the same.

Abstract: A method of testing a data storage system includes maintaining libraries of test routines, a first library including a set of normal-functional tests each operable to test corresponding normal functionality of the data storage system, a second library including a set of fault inserters each being independently operable to induce a corresponding fault condition into the data storage system. Normal-functional tests are executed concurrently with one or more of the fault inserters to cause the normal-functional tests to encounter the corresponding fault conditions during execution and thereby test a response of the normal functionality of the data storage system to the occurrence of the fault conditions.