Abstract: The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.

Abstract: Simulating user interactions during dynamic analysis of a sample is disclosed. A sample is received for analysis. Prior to execution of the sample, a baseline screenshot of a system folder is generated by accessing frame buffer data stored on a graphics card. The sample is caused to execute, at least in part using one or more hypervisor instructions to move a pointing device to an icon associated with the sample. A current screenshot of the system folder is generated by accessing current frame buffer data stored on the graphics card.

Abstract: Anchor brackets/tethers may be used to reinforce a vehicle's resin rear door without substantially increasing the mass of the resin rear door. Such anchor brackets hold an interior trim panel(s) in place, and keep the interior trim panel(s) connected to the door structure or portion(s) thereof. The interior trim panel(s) can act as a protective interior shield that eliminates any exposure of the interior cabin/passenger compartment from any outer (and/or interior) door panel cracks/gaps that may be created during an adverse event. Moreover, conventional interior trim panels may, during a collision, break apart, the broken pieces becoming potentially dangerous projectiles. By being attached to the door structure and/or door componentry, the chance that the interior trim panel (or portions thereof) becoming a projectile is negated or at least lessened.

Abstract: Methods for treating joint diseases, disorders, and conditions, such as osteoarthritis, with a composition containing a therapeutically effective amount of tissue inhibitors of matrix metalloproteinases (TIMPs) are provided. The composition can contain TIMPs as part of amniotic fluid, or the TIMPs can be isolated from another source or recombinantly produced. The methods are particularly useful for treating osteoarthritis associated with degradation of articular cartilage by proteases. Also provided are methods of lubricating a joint, such as an osteoarthritic joint.

Abstract: A system that controls a combustion engine stores network vectors in a memory that represent diverse and distinct spiking neural networks. The system decodes the network vectors and trains and evaluates the spiking neural networks. The system duplicates selected network vectors and crosses-over the duplicated network vectors that represent modified spiking neural networks. The system mutates the crossed-over duplicated network vectors by randomly modifying one or more portions of the crossing-over duplicated network vectors. The system meter exhaust gas into an intake manifold when an engine temperature exceeds a threshold, an engine load exceeds a threshold, an engine's rotation-per-minute rate exceeds a threshold, and a fuel flow exceeds a threshold. The system modifies fuel flow into an engine's combustion chamber on a cycle-to-cycle basis by the trained spiking neural network.

Abstract: A system includes a device including one or more sensors that generate one or more signals used to detect whether an unauthorized activity has occurred at the device. The device is configured to transmit the one or more signals generated by the one or more sensors. The central monitoring device is configured to receive the one or more signals and compare the one or more signals with a baseline signal for the device. The baseline signal includes an expected signal for each of the one or more sensors when the unauthorized activity has not occurred. The monitoring device determines whether the unauthorized activity has occurred based on a result of the comparison.

Abstract: A method of content production includes generating a survey of a performance area that includes a point cloud representing a first physical object, in a survey graph hierarchy, constraining the point cloud and a taking camera coordinate system as child nodes of an origin of a survey coordinate system, obtaining virtual content including a first virtual object that corresponds to the first physical object, applying a transformation to the origin of the survey coordinate system so that at least a portion of the point cloud that represents the first physical object is substantially aligned with a portion of the virtual content that represents the first virtual object, displaying the first virtual object on one or more displays from a perspective of the taking camera, capturing, using the taking camera, one or more images of the performance area, and generating content based on the one or more images.

Abstract: A device configured to receive a request for processing a digital document that identifies a target data structure. The device is further configured to obtain the digital document and to process the digital document to identify objects within the digital document. The device is further configured to input the digital document into a machine learning model that is configured to output contextual metadata for the digital document based on the digital document. The contextual metadata describes attributes of the identified objects within the digital document. The device is further configured to populate a first subset of entries in the target data structure with identifiers for the objects identified within the digital document and to populate a second subset of entries in the target data structure with the contextual metadata. The device is further configured to send the populated target data structure to the network device.

Abstract: A spacer for vehicle panels can be shaped such that it absorbs a substantial portion of a first load, the first load applied in a first direction substantially perpendicular to the exterior panel; controllably deforms along a second direction when a second load is applied substantially along the second direction; wherein the second direction is other than the first direction. The spacer need not deform along the second direction when the first load is applied. The spacer can have a shaped member having a channel extending through the spacer perpendicular from the exterior panel, such that the spacer can controllably deform along a width of the channel.

Abstract: Visco-supplement compositions derived from a transcellular fluid, such as human amniotic fluid, human aqueous humor fluid, or human vitreous fluid are described. Also described are methods for treating inflammatory conditions of the musculoskeletal system, such as joint inflammation, and methods of lubricating a joint using the described visco-supplement compositions.

Abstract: An authentication device that is configured to receive an authentication request that includes a device identifier from a user device. The authentication device is further configured to identify a first device that is associated with the device identifier and to send a device fingerprint request to the first device. The authentication device is further configured to receive a first device fingerprint for the first device. The first device fingerprint is uniquely associated with the first device and includes a unique bit string that is generated based on a configuration of the first device. The authentication device is further configured to identify a second device fingerprint that is associated with the first device from among a plurality of device fingerprints stored in a memory, to compare the first device fingerprint to the second device fingerprint, and to send an authentication response to the user device based on the comparison.

Abstract: A system for producing and transmitting encrypted data from data encoded on a storage medium comprises an apparatus configured to receive the storage medium and an encryption chip communicatively coupled to the apparatus. The apparatus comprises a processor, a memory, and a network interface. The processor is configured to receive data encoded into the storage medium, and to decode the received data as the storage medium is at least partially inserted into the apparatus. The processor is further configured to transmit the received data to the memory for storage. The encryption chip comprises an encryption processor configured to access the received data stored in the memory of the apparatus and encrypt the received data with an algorithm to produce the encrypted data. The processor then transmits the encrypted data to an external server communicatively connected to a communication network.

Abstract: Provided are compositions and methods related to the use of apilimod in combination with glutamatergic agents for treating neurological diseases and disorders, and for the treatment of cancer.

Abstract: A system and method design and optimize neural networks. The system and method include a data store that stores a plurality of gene vectors that represent diverse and distinct neural networks and an evaluation queue stored with the plurality of gene vectors. Secondary nodes construct, train, and evaluate the neural network and automatically render a plurality of fitness values asynchronously. A primary node executes a gene amplification on a select plurality of gene vectors, a crossing-over of the amplified gene vectors, and a mutation of the crossing-over gene vectors automatically and asynchronously, which are then transmitted to the evaluation queue. The process continuously repeats itself by processing the gene vectors inserted into the evaluation queue until a fitness level is reached, a network's accuracy level plateaus, a processing time period expires, or when some stopping condition or performance metric is met or exceeded.

Abstract: Apparatus and methods are disclosed for scheduling tasks in a heterogeneous computing environment. Coarse scheduling of a received task-set is performed centrally, with tasks dispatched to respective processing resources including one or more accelerators. At each accelerator, sub-tasks of a received task are identified, scheduled, and executed. Data-transfer and computation sub-tasks can be pipelined. The accelerator operates using small tiles of local data, which are transferred to or from a large shared reservoir of main memory. Sub-task scheduling can be customized to each accelerator; coarse task scheduling can work on larger tasks; both can be efficient. Simulations demonstrate large improvements in makespan and/or circuit area. Disclosed technologies are scalable and can be implemented in varying combinations of hard-wired or software modules. These technologies are widely applicable to high-performance computing, image classification, media processing, wireless coding, encryption, and other fields.

Abstract: A system includes a device including one or more sensors that generate one or more signals used to detect whether an unauthorized activity has occurred at the device. The device is configured to transmit the one or more signals generated by the one or more sensors. The central monitoring device is configured to receive the one or more signals and compare the one or more signals with a baseline signal for the device. The baseline signal includes an expected signal for each of the one or more sensors when the unauthorized activity has not occurred. The monitoring device determines whether the unauthorized activity has occurred based on a result of the comparison.

Abstract: An authentication device that is configured to receive an authentication request that includes a device identifier from a user device. The authentication device is further configured to identify a first device that is associated with the device identifier and to send a device fingerprint request to the first device. The authentication device is further configured to receive a first device fingerprint for the first device. The first device fingerprint is uniquely associated with the first device and includes a unique bit string that is generated based on a configuration of the first device. The authentication device is further configured to identify a second device fingerprint that is associated with the first device from among a plurality of device fingerprints stored in a memory, to compare the first device fingerprint to the second device fingerprint, and to send an authentication response to the user device based on the comparison.

Abstract: An information security system that includes an information security engine configured to detect an attack by a malicious software element in a network. The information security engine is further configured to transfer the malicious software element from the network to the emulated network in response to detecting an attack. The information security engine is further configured to select defense strategies for restricting communications using different port configurations and to implement each defense strategy within the emulated network. The information security engine is further configured to execute a duplicate of the malicious software element in the emulated network and to determine a performance level for each of the defense strategies against the duplicate of the malicious software element. The information security engine is further configured to select a defense strategy with a highest performance level and to implement the selected defense strategy within the network.

Abstract: A device is configured to establish a network connection with a virtual reality device and to identify a user account that is associated with the virtual reality device. The device is further configured to send a virtual simulation survey to the virtual reality device. The virtual simulation survey includes a list of virtual simulations that can be rendered by the virtual reality device. The device is further configured to receive a survey response from the virtual reality device. The survey response identifies one or more virtual simulations from the list of virtual simulations. The device is further configured to determine a cumulative user preference settings value based on the virtual simulations identified in the survey response and to modify user preference settings within the user account based on the cumulative user preference settings value.

Abstract: The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.