Abstract: The present invention relates to methods of reducing liver PD-1-expressing CD8+ T cells using PD-1 Fc fusion proteins that bind Fc receptors, as well as diagnostic, prognostic, therapeutic methods and compositions related thereto.

Abstract: This disclosure relates to the genetic modification of DNMT3A gene in immune cells. In certain embodiments, the modified immune cells may be used in adoptive T cells therapies to enhance immune responses against cancer or chronic infections. In certain embodiments, the disclosure relates to deleting, changing, or inserting nucleotides within the DNMT3A gene in immune cells, e.g., human CD8 T cells, such that the DNMT3A gene product does not function for methylation. In certain embodiments, modification of the DNMT3A gene provides an improvement in antigen-specific T cells functions and/or an enhancement of the longevity of the cells.

Abstract: A one-sided outer-join-based query is rewritten using a materialized view (MV), the definition of which includes the join but does not include a filter predicate from the query. The rewritten query nullifies data from the include-matching table, included in the MV, that does not satisfy the filter predicate. To improve accuracy of the query results, certain rows are removed from intermediate results of the query. To facilitate revising the query results for accuracy, the MV includes a unique column from the include-all table and also an indicator column that indicates whether a given row of the MV is an inner-join-type row or an anti-join-type row. The rewritten query adjusts the indicator values, in the indicator column, of MV rows that do not satisfy the filter to reflect a modified anti-join-type indicator value. Based on the modified indicator values and unique columns from include-all tables, accuracy of query results is attained.

Abstract: This disclosure relates to antibodies and antigen binding fragments that specifically bind Ebola virus particles. In certain embodiments, the antibodies and fragments are capable of treating or preventing an Ebola viral infection. In certain embodiments, the antibodies and antigen binding fragments are also contemplated for diagnostic methods and compositions related thereto.

Abstract: This disclosure relates to the genetic modification of DNMT3A gene in immune cells. In certain embodiments, the modified immune cells may be used in adoptive T cells therapies to enhance immune responses against cancer or chronic infections. In certain embodiments, the disclosure relates to deleting, changing, or inserting nucleotides within the DNMT3A gene in immune cells, e.g., human CD8 T cells, such that the DNMT3A gene product does not function for methylation. In certain embodiments, modification of the DNMT3A gene provides an improvement in antigen-specific T cells functions and/or an enhancement of the longevity of the cells.

Abstract: A one-sided outer-join-based query is rewritten using a materialized view (MV), the definition of which includes the join but does not include a filter predicate from the query. The rewritten query nullifies data from the include-matching table, included in the MV, that does not satisfy the filter predicate. To improve accuracy of the query results, certain rows are removed from intermediate results of the query. To facilitate revising the query results for accuracy, the MV includes a unique column from the include-all table and also an indicator column that indicates whether a given row of the MV is an inner-join-type row or an anti-join-type row. The rewritten query adjusts the indicator values, in the indicator column, of MV rows that do not satisfy the filter to reflect a modified anti-join-type indicator value. Based on the modified indicator values and unique columns from include-all tables, accuracy of query results is attained.

Abstract: Definitions of material views are automatically generated. In general, Automated MV generation identifies a set of candidates MVs by examining a working set of query blocks. Once the candidates are formed, the candidate MVs are further evaluated to calculate a benefit to the candidate MVs. An improved approach for generating a candidate set of MVs is described herein. The improved approach is referred to as the extended covering subexpression technique (ECSE). Under ECSE, various relationships between join sets other than strict equivalence are used to generate new resultant join sets. Such relationships include subset, intersection, superset, and union, which shall be described in further detail below. In some cases, relationships among resultant join sets and initial join sets are considered to generate new resultant join sets. The final resultant join sets are then used to form a candidate set of MVs.

Abstract: This disclosure relates to HPV proteins, antibodies, and uses in managing abnormal epithelial cell growth. In certain embodiments, this disclosure relates to detecting an HPV protein in a sample and correlating the presence as an indication that a subject is at risk of developing an HPV-related disease or condition. In certain embodiments, the HPV protein is E2 and/or E6. In certain embodiments, this disclosure relates to vaccinating or treating a subject for an HPV infection or related condition optionally in combination with immune-checkpoint inhibitors. In certain embodiments, this disclosure relates to HPV protein specific antibodies and binding agents for uses reported herein.

Abstract: A method, apparatus, and stored instructions are provided for transforming a query representation by unnesting a predicate condition that is based on whether or not a result exists for a subquery of the predicate condition. An initial query representation is received. The initial query representation represents an initial query that includes an EXISTS-equivalent predicate or a NOT-EXISTS-equivalent predicate and at least one other predicate in a disjunction. The initial query representation is transformed into a semantically equivalent transformed query representation that represents a transformed query. The transformed query includes, instead of the EXISTS-equivalent predicate or a NOT-EXISTS-equivalent predicate, a join operator that references the data object.

Abstract: PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced using these PD-1 antagonists in conjunction with an antigen from the infectious agent or tumor. Thus, subjects with infections, such as persistent infections can be treated using PD-1 antagonists. In addition, subjects with tumors can be treated using the PD-1 antagonists. In several examples, subjects can be treated by transplanting a therapeutically effective amount of activated T cells that recognize an antigen of interest and by administering a therapeutically effective amount of a PD-1 antagonist.

Abstract: The present invention is based, in part, on the identification of novel human anti-PD-1, PD-L1, and PD-L2 antibodies. Accordingly, the invention relates to compositions and methods for diagnosing, prognosing, and treating conditions that would benefit from modulating PD-1, PD-L1, and/or PD-L2 activity (e.g., persistent infections diseases, autoimmune diseases, asthma, transplant rejection, inflammatory disorders and tumors) using the novel human anti-PD-1, PD-L1, and PD-L2 antibodies described herein.

Abstract: This disclosure relates to antibodies and antigen binding fragments that specifically bind Ebola virus particles. In certain embodiments, the antibodies and fragments are capable of treating or preventing an Ebola viral infection. In certain embodiments, the antibodies and antigen binding fragments are also contemplated for diagnostic methods and compositions related thereto.

Abstract: Techniques herein optimize sort-merge join method for a band join. In an embodiment, for a query comprising a query block specifying a join between a first table and a second table, a band join condition is detected between the first table and the second table. Once the band join condition in detected, an execution plan is generated and executed. The execution of the execution plan includes: for a first row of at least a subset of first sorted rows, scanning second rows from a set of second sorted rows, joining each of said second rows with said first row, and ceasing to scan when encountering a row from the second sorted rows that falls outside a bound of said band join condition. Techniques also include parallelizing a workload by overlapping the distribution of rows to the same slave process and computing cost and cardinality estimation for enhanced band join.

Abstract: Attributes and semantics of duplicate insignificance that are inherent or inferred in a database language statement are detected. Also, a join operation that is inherent or inferred in the database language statement is detected and examined for join semantics. The join semantics specifies or refers to a driving table to be subjected to a hash join operation that may populate one or more hash buckets. The optimizer and the execution layers may use cost estimation or heuristics to assign the left and right table roles to the tables involved in the join. The hash join operation removes left table duplicates during population of the hash buckets, resulting in full or partial duplicate elimination that occurs during the hash join operation.

Abstract: A method, apparatus, and stored instructions are provided for the removal of redundant GROUP BY and/or DISTINCT. Every table in the FROM clause of the query block must be a qualified table for the GROUP-BY clause or the DISTINCT keyword in the SELECT clause of the query block to be removed. A table Tx that satisfies at least one of the following two conditions is referred to as a qualified table: (1) Tx has a non-null unique column Tx.u that appears on the GROUP BY clause or the SELECT clause that contains a DISTINCT keyword and (2) There is a qualified table Ty and Ty has a filtering join with Tx.

Abstract: This disclosure relates to specific binding agents to varicella-zoster virus proteins or glycoproteins. In certain embodiments the specific binding agents are antibodies and binding fragments thereof disclosed herein. In certain embodiments, this disclosure relates to methods of treating or preventing a varicella-zoster infection comprising administering an effective amount of a specific binding agent disclosed herein to a subject in need thereof.

Abstract: The present invention provides methods and compositions for the treatment, prevention, or reduction of persistent infections, such as chronic infections, latent infections, and slow infections and cancer. The methods and compositions of the invention are also useful for the alleviation of one or more symptoms associated with such infections and cancer.

Abstract: The present invention provides methods and compositions for the treatment, prevention, or reduction of persistent infections, such as chronic infections, latent infections, and slow infections and cancer. The methods and compositions of the invention are also useful for the alleviation of one or more symptoms associated with such infections and cancer.

Abstract: The present invention is based, in part, on the identification of novel human anti-PD-1, PD-L1, and PD-L2 antibodies. Accordingly, the invention relates to compositions and methods for diagnosing, prognosing, and treating conditions that would benefit from modulating PD-1, PD-1, and/or PD-L2 activity (e.g., persistent infectious diseases autoimmune diseases, asthma, transplant rejection, inflammatory disorders and tumors) using the novel human anti-PD-1, PD-L1, and PD-L2 antibodies described herein.

Abstract: Antibodies that specifically bind influenza virus hemagglutinin A (HA), and antigen binding fragments thereof are disclosed herein. In several embodiments, these antibodies are broadly neutralizing. Nucleic acids encoding these monoclonal antibodies, vectors including these nucleic acids, and host cells transformed with these vectors are also disclosed. Compositions are disclosed that include these antibodies, antigen binding fragments, nucleic acids, vectors and host cells. Method of using these antibodies, and antigen binding fragments, nucleic acids, vectors and host cells, such as for diagnosis and treatment of an influenza virus infection are also provided.