Abstract: It is disclosed herein that treatment of a subject with an mTOR inhibitor enhances antigen-specific T cell immune responses. Thus, provided herein is a method of enhancing an antigen-specific T cell response in a subject by administering to the subject a therapeutically effective amount of an mTOR inhibitor. The antigen can be any antigen, such as an antigen from a pathogen or a vaccine, or a tumor antigen. In some embodiments, the method further comprises administering to the subject a vaccine, such as a virus vaccine or a cancer vaccine. The mTOR inhibitor can be administered either before or after vaccination to enhance the quantity and quality of the T cell immune response and immunological memory. In some examples, the mTOR inhibitor is rapamycin or a rapamycin analog.

Abstract: The present invention provides methods and compositions for the treatment, prevention, or reduction of persistent infections, such as chronic infections, latent infections, and slow infections and cancer. The methods and compositions of the invention are also useful for the alleviation of one or more symptoms associated with such infections and cancer.

Abstract: A method, apparatus, and stored instructions are provided for transforming a query representation by unnesting a predicate condition that is based on whether or not a result exists for a subquery of the predicate condition. An initial query representation is received. The initial query representation represents an initial query that includes an EXISTS-equivalent predicate or a NOT-EXISTS-equivalent predicate and at least one other predicate in a disjunction. The initial query representation is transformed into a semantically equivalent transformed query representation that represents a transformed query. The transformed query includes, instead of the EXISTS-equivalent predicate or a NOT-EXISTS-equivalent predicate, a join operator that references the data object.

Abstract: The present invention provides methods and compositions for the treatment, prevention, or reduction of persistent infections, such as chronic infections, latent infections, and slow infections and cancer. The methods and compositions of the invention are also useful for the alleviation of one or more symptoms associated with such infections and cancer.

Abstract: Antibodies or antibody fragments, wherein the antibody or the fragment binds HA domain of influenza virus (e.g. H1N1, H5N1, or both).

Abstract: The present invention is based, in part, on the identification of novel human anti-PD-1, PD-L1, and PD-L2 antibodies. Accordingly, the invention relates to compositions and methods for diagnosing, prognosing, and treating conditions that would benefit from modulating PD-1, PD-L1, and/or PD-L2 activity (e.g., persistent infectious diseases, autoimmune diseases, asthma, transplant rejection, inflammatory disorders and tumors) using the novel human anti-PD-1, PD-L1, and PD-L2 antibodies described herein.

Abstract: High efficient methods for producing an antibody molecule that binds an antigen are described. The methods include obtaining a population of PBMC enriched for CD19highCD3negCD20low to negCD38highCD27high cells from a mammal exposed to an antigen from sample of cells enriched for PBMC. The cells are isolated from a sample obtained at a time that the fraction of PBMC expressing antibody reactive to the antigen is at a high level. Sequences encoding heavy and light chain variable domains are prepared in a manner that allow production of molecules with natural heavy and light chain pairing.

Abstract: Methods, computing devices, and computer-readable media are provided for transforming an initial query with a single-table outer join predicate to a second, semantically equivalent query that includes a multi-table predicate instead of the single-table outer join predicate. Because the second query does not include the single-table outer join predicate, the second query may be available for further transformations or optimization techniques, may produce a more efficient or otherwise different execution plan, or may be executed more efficiently or differently. The single-table outer join predicate may be in a full outer join ON clause of the initial query or nested in a left outer-joined LATERAL VIEW of the initial query. The multi-table predicate may be in a WHERE clause of the second query. Unlike the initial query, the second query allows use of a temporary organization of data from multiple tables for evaluation of multiple rows of the left outer join.

Abstract: The present invention is based, in part, on the identification of novel human anti-PD-1, PD-L1, and PD-L2 antibodies. Accordingly, the invention relates to compositions and methods for diagnosing, prognosing, and treating conditions that would benefit from modulating PD-1, PD-L1, and/or PD-L2 activity (e.g., persistent infectious diseases, autoimmune diseases, asthma, transplant rejection, inflammatory disorders and tumors) using the novel human anti-PD-1, PD-L1, and PD-L2 antibodies described herein.

Abstract: Methods, computer-readable media, and machines are provided for transforming a query by removing a correlated predicate from a lateral view in an initial query. A query processor may transform the lateral view into a regular view such that a transformed query with the regular view is semantically equivalent to the initial query. The transformed query may support a larger set of access paths, join methods, and join permutations, may qualify for other transformations or optimizations, or may otherwise be executed or optimized differently from the initial query. The lateral view may reference an aggregation function, and the query processor may add a GROUP BY operator to the transformed query to preserve, after the correlated predicate has been pulled out of the lateral view, an interaction that was present between the aggregation function and the correlated predicate when the correlated predicate was in the lateral view.

Abstract: A method, apparatus, and stored instructions are provided for transforming an initial query having a scalar subquery with correlated predicates into a transformed query having transformed predicates that are not in the scalar subquery. The transformed predicates correspond to the correlated predicates, but the transformed predicates are no longer correlated. The transformed predicates reference an outer join operation to preserve null values that may have been generated by the correlated predicates that were in the scalar subquery of the initial query. The transformed query is semantically equivalent to the initial query. When creating an execution plan for the transformed query, the query processor may choose from a much larger set of access paths, join methods, and join permutations than those that were available for the initial query. The transformed query may qualify for other transformations or optimizations, or may otherwise be executed or optimized differently from the initial query.

Abstract: Methods for transforming a query to simulate a bushy tree execution plan for queries containing joins in series are provided. Left deep tree execution plans are supported by most relational database systems but are inefficient at processing queries directed to databases with snowstorm schema. A snowstorm schema contains several large fact tables and many smaller dimension tables, which make reference to one another. Bushy tree execution plans can be much more efficient for processing queries to snowstorm schema. The decision to choose between left-deep and bushy tree execution plans are based on the relative costs of the two execution plans. The methods provided transform queries which are otherwise executed with left deep tree execution plans into queries which are executed with simulated bushy tree execution plans.

Abstract: Methods for transforming a query to remove redundant tables and eliminate superfluous join operations is provided. The methods provided transform queries to remove redundant tables and anti-joins, semi-joins, and outer-joins. Whether a table is redundant is determined based on a set of criteria which, if fulfilled, indicates that the removal of the table and the anti-join, semi-join, or outer-join operation does not impact query results. The removal of a redundant table from a query also results in the elimination of the anti-join, semi-join, or outer-join operation that references the removed table.

Abstract: Antibodies that bind with high affinity to swine H1N1 virus are described. In vivo experiments showed that one such antibody is able to fully protect mice challenged with a lethal dose of swine H1N1 virus. The antibody is also able to cure mice in a therapeutic setting when treated as late as up to 60 hours (2.5 days) after infection with swine H1N1 virus. Also described are recombinant forms of this antibody.

Abstract: PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced using these PD-1 antagonists in conjunction with an antigen from the infectious agent or tumor. Thus, subjects with infections, such as persistent infections can be treated using PD-1 antagonists. In addition, subjects with tumors can be treated using the PD-1 antagonists. In several examples, subjects can be treated by transplanting a therapeutically effective amount of activated T cells that recognize an antigen of interest and by administering a therapeutically effective amount of a PD-1 antagonist.

Abstract: Techniques for optimizing queries are provided. In one technique, a query optimizer determines that two tables involved in equi-joins with one other table return unique rows. The query optimizer further determines that the rows returned by one of the tables is a subset of the rows returned by the other table. The query optimizer then determines that one of the two tables involved in the equi-joins can be eliminated. In another technique, a query optimizer determines that group-by placement may be used on a query that specifies a table. The query optimizer further determines that a view that (1) replaces the table and (2) results from the group-by placement is a subset of an existing view. The query optimizer further determines that each view is unique. The query optimizer selects an execution plan that does not join any tables or views with the resulting view or with the specified table.

Abstract: Methods for transforming queries that contain EXISTS and NOT EXISTS subqueries are provided. The methods provided transform original queries that contain EXISTS and/or NOT EXISTS subqueries in conjunctive or disjunctive combinations into transformed queries that coalesce the original EXISTS and/or NOT EXISTS subqueries into a reduced number of EXISTS and/or NOT EXISTS subqueries, thereby eliminating duplicative table accesses and join operations.

Abstract: The present invention is based, in part, on the identification of novel human anti-PD-1, PD-L1, and PD-L2 antibodies. Accordingly, the invention relates to compositions and methods for diagnosing, prognosing, and treating conditions that would benefit from modulating PD-1, PD-L1, and/or PD-L2 activity (e.g., persistent infectious diseases, autoimmune diseases, asthma, transplant rejection, inflammatory disorders and tumors) using the novel human anti-PD-1, PD-L1, and PD-L2 antibodies described herein.

Abstract: It is disclosed herein that treatment of a subject with an mTOR inhibitor enhances antigen-specific T cell immune responses. Thus, provided herein is a method of enhancing an antigen-specific T cell response in a subject by administering to the subject a therapeutically effective amount of an mTOR inhibitor. The antigen can be any antigen, such as an antigen from a pathogen or a vaccine, or a tumor antigen. In some embodiments, the method further comprises administering to the subject a vaccine, such as a virus vaccine or a cancer vaccine. The mTOR inhibitor can be administered either before or after vaccination to enhance the quantity and quality of the T cell immune response and immunological memory. In some examples, the mTOR inhibitor is rapamycin or a rapamycin analog.

Abstract: Methods for transforming a query to remove redundant subqueries in HAVING clauses are provided. The methods provided transform queries that contain subqueries in HAVING clauses with tables and join conditions and filter conditions equal to tables, join conditions and filter conditions in outer query to queries that eliminate the original subquery and retain the original outer query with a single inline view using window functions. Whether this transformation can be performed depends on which tables and join and filter conditions are in the outer query and the subquery. The transformation eliminates duplicative table accesses and join operations from queries.