Abstract: Procedures may be performed on the heart after the installation of a mitral valve fixation device. In order to prepare the heart for such procedures, the fixation device may be removed or disabled in minimally invasive ways (e.g., through an endovascular procedure), without requiring open access to the heart. The fixation device may be partitioned so that one portion may remain attached to each leaflet of the mitral valve. In another example, the leaflets may be cut along the edges of the distal element(s) of the fixation device, so as to cut the fixation device from the leaflet(s). Systems and devices for performing such procedures endovascularly are disclosed. Fixation devices with improved access to a release harness are also disclosed.

Abstract: The invention provides devices, systems and methods for tissue approximation and repair at treatment sites. The devices, systems and methods of the invention will find use in a variety of therapeutic procedures, including endovascular, minimally-invasive, and open surgical procedures, and can be used in various anatomical regions, including the abdomen, thorax, cardiovascular system, heart, intestinal tract, stomach, urinary tract, bladder, lung, and other organs, vessels, and tissues. The invention is particularly useful in those procedures requiring minimally-invasive or endovascular access to remote tissue locations, where the instruments utilized must negotiate long, narrow, and tortuous pathways to the treatment site. In addition, many of the devices and systems of the invention are adapted to be reversible and removable from the patient at any point without interference with or trauma to internal tissues.

Abstract: The invention provides devices, systems and methods for tissue approximation and repair at treatment sites. The devices, systems and methods of the invention will find use in a variety of therapeutic procedures, including endovascular, minimally-invasive, and open surgical procedures, and can be used in various anatomical regions, including the abdomen, thorax, cardiovascular system, heart, intestinal tract, stomach, urinary tract, bladder, lung, and other organs, vessels, and tissues. The invention is particularly useful in those procedures requiring minimally-invasive or endovascular access to remote tissue locations, where the instruments utilized must negotiate long, narrow, and tortuous pathways to the treatment site. In addition, many of the devices and systems of the invention are adapted to be reversible and removable from the patient at any point without interference with or trauma to internal tissues.

Abstract: The present invention concerns a flexible connecting device for implantation into the human or animal body and especially for stabilizing the spine with a first rod, which has at least one flexible middle section and at least two connecting sections. At least one part of the flexible middle section includes an adjustment element, such as a flexible element or a stabilization element, which is arranged outside the cross-section of the first rod and connected to the first rod at a first location.

Abstract: A bone anchoring device includes a shaft for anchoring in a bone and a head, the shaft including a first section having a plurality of barb elements, the barb elements being elastically deformable relative to the body of the shaft, and a second section including a bone thread for engagement with the bone. The first section is located near the tip of the shaft and allows insertion by pushing whereas the second section provides enhanced resistance against pull-out.

Abstract: The invention provides devices, systems and methods for tissue approximation and repair at treatment sites. The devices, systems and methods of the invention will find use in a variety of therapeutic procedures, including endovascular, minimally-invasive, and open surgical procedures, and can be used in various anatomical regions, including the abdomen, thorax, cardiovascular system, heart, intestinal tract, stomach, urinary tract, bladder, lung, and other organs, vessels, and tissues. The invention is particularly useful in those procedures requiring minimally-invasive or endovascular access to remote tissue locations, where the instruments utilized must negotiate long, narrow, and tortuous pathways to the treatment site. In addition, many of the devices and systems of the invention are adapted to be reversible and removable from the patient at any point without interference with or trauma to internal tissues.

Abstract: A bone anchoring device includes a shaft for anchoring in a bone and a head, the shaft including a first section having a plurality of barb elements, the barb elements being elastically deformable relative to the body of the shaft, and a second section including a bone thread for engagement with the bone. The first section is located near the tip of the shaft and allows insertion by pushing whereas the second section provides enhanced resistance against pull-out.

Abstract: A bone anchoring device includes a shaft for anchoring in a bone and a head, the shaft including a first section having a plurality of barb elements, the barb elements being elastically deformable relative to the body of the shaft, and a second section including a bone thread for engagement with the bone. The first section is located near the tip of the shaft and allows insertion by pushing whereas the second section provides enhanced resistance against pull-out.

Abstract: Impression devices are provided for making an impression of a desired feature. The impression devices include: a flexible bladder having a cavity formed therein, the flexible bladder being capable of conforming to the details of the desired feature; a rheological material, such as a magnetorheological fluid, disposed in the cavity of the flexible bladder; and an activator for applying an external stimulus to the rheological material to change the state of the rheological material and thereby capture an impression of the desired feature.

Abstract: A bone anchoring device includes a shaft for anchoring in a bone and a head, the shaft including a first section having a plurality of barb elements, the barb elements being elastically deformable relative to the body of the shaft, and a second section including a bone thread for engagement with the bone. The first section is located near the tip of the shaft and allows insertion by pushing whereas the second section provides enhanced resistance against pull-out.

Abstract: An apparatus for sampling tissue includes a tissue engaging member for engaging and retaining a sample of a tissue structure, and a cutter surrounding the tissue engaging member. The tissue engaging member and cutter are both operative to translate longitudinally with respect to one another, and a mechanism prevents the cutter from moving distally, the mechanism being released and the cutter freed to move distally when the tissue engaging member is in a predetermined position, preferably distal of the cutter. Thereby, out of sequence operation, e.g., premature cutting of the tissue before the tissue engaging member is in position, is prevented.

Abstract: Impression devices are provided for making an impression of a desired feature. The impression devices include: a flexible bladder having a cavity formed therein, the flexible bladder being capable of conforming to the details of the desired feature; a rheological material, such as a magnetorheological fluid, disposed in the cavity of the flexible bladder; and an activator for applying an external stimulus to the rheological material to change the state of the rheological material and thereby capture an impression of the desired feature.

Abstract: Methods and apparatus for enhancing the capabilities of ultrasonic techniques through use of ultraharmonics are provided.