Abstract: Disclosed are anti-CD45 antibodies and antibody drug conjugates (ADCs) useful in therapeutic methods, including targeting CD45 expressing hematopoietic stem cells (HSCs) or immune cells prior to transplantation.

Abstract: The presently claimed invention relates to a novel, highly efficient and general process for the preparation of UV absorbers.

Abstract: A memory subsystem and method for performing calibrations therein is disclosed. A memory subsystem includes a memory controller coupled to a memory by a plurality of signal paths. The memory controller is configured to perform an initial calibration to determine respective eye patterns corresponding to the ones of the plurality of signal paths. For a subsequent calibration, updated eye patterns are determined for a subset of the plurality of signal paths. Remaining ones of the plurality of signal paths (not included in the subset), are not active during the subsequent calibrations. Updated eye patterns for the remaining ones of the plurality of signal paths are determined based on information obtained during the initial calibration and information from signal paths in the subset designated proxies for the remaining ones of the plurality of signal paths.

Abstract: The present disclosure is directed to 3-D stacked architecture for Programmable Fabrics and Central Processing Units (CPUs). The 3-D stacked orientation enables reconfigurability of the fabric, and allows the fabric to function using coarse-grained and fine-grained acceleration for offloading CPU processing. Additionally, the programmable fabric may be able to function to interface with multiple other compute chiplet components in the 3-D stacked orientation. This enables multiple compute components to communicate without the need for offloading the data communications between the compute chiplets.

Abstract: Generating object morphisms during object search includes obtaining object-search request data, wherein the object-search request data includes object-search terms, obtaining resolved-request data representing the object-search terms, determining that a first analytical object partially consistent with the resolved-request data is available, wherein the first analytical object is consistent with a first portion of the resolved-request data, generating candidate object-morphism data with respect to the first analytical object in accordance with a second portion of the resolved-request data, outputting object-search response data including the candidate object-morphism data for presentation to a user, obtaining data indicating a selected object morphism from the candidate object-morphism data, generating a second analytical object in accordance with the first analytical object and the selected object morphism, wherein the second analytical object differs from the first analytical object, and outputting response

Abstract: The present disclosure encompasses solid state forms of Trilaciclib and Trilaciclib citrate salt, in embodiments poly-morphs of Trilaciclib and Trilaciclib citrate salt, processes for preparation thereof, pharmaceutical compositions and uses thereof.

Abstract: An ostomy device includes an implant formed of a flexible material and shaped so that the implant is capable of transitioning between a first shape and a second shape. The implant includes a tubular body sized and shaped for insertion within a lumen extending through a hole in an abdominal wall, a flared portion extending radially outward and away from the body when the implant is in the first shape, and a transition region between the body and the flared portion. The transition region and the flared portion are bendable so that transitioning the implant from the first shape into the second shape comprises inverting the flared portion so that a surface of the flared portion can be brought into contact with an outer surface of patient anatomy, whereupon the implant can be attached to the patient anatomy in the second shape.

Abstract: A computing system is disclosed that includes a processor and memory. The memory stores instructions that, when executed by the processor, cause the processor to perform several acts. The acts include receiving, by a generative model, input set forth by a user of a client computing device that is in network communication with the computing system. The acts also include generating, by the generative model, a query based upon the input set forth by the user; providing the query to a search engine. The acts further include receiving, by the generative model and from the search engine, content identified by the search engine based upon the query. The acts additionally include generating, by the generative model, an output based upon a prompt, where the prompt includes the content identified by the search engine based upon the query. The acts also include transmitting the output to the client computing device for presentment to the user.

Abstract: The disclosed technology relates to methods, transcriptomics systems, and non-transitory computer readable media for enabling natural language transcriptomics analysis. In some examples, genomic data including gene expression profiles for cells is transformed into sequences of genes ordered by expression level for each of the cells. The sequences of genes are annotated with metadata in a natural language format. A large language model (LLM) is then fine-tuned using the annotated sequences. The LLM is pretrained for natural language processing (NLP) tasks. The fine-tuned LLM is applied to generate and output a result in response to a received prompt in the natural language format. Thus, the LLMs of this technology advantageously both generate and interpret transcriptomics data and interact in natural language to generate meaningful text from cells and valid genes, among many other types of results.

Abstract: A method, computer system, and a computer program product for dynamic indoor navigation is provided. The present invention may include receiving a set of sensor data from at least one distance measuring sensor located in an enclosed environment. The present invention may include generating a baseline map of the enclosed environment based on the received set of sensor data. The present invention may include detecting at least one object in the enclosed environment based on the received set of sensor data. The present invention may include generating an obstacle map of the enclosed environment by plotting the detected at least one object in the generated baseline map of the enclosed environment. The present invention may include determining a movement path through the enclosed environment that avoids the detected at least one object in the generated obstacle map.

Abstract: A computer-implemented method for adjusting agents staffing levels of a successive work-shift of a preassigned ongoing work-shift, during the preassigned ongoing work-shift, in a contact center. The computer-implemented method includes: (i) during the preassigned ongoing work-shift, determining a number of agents to handle inbound-interactions that require one or more skills for the successive work-shift; (ii) comparing the number of agents to handle inbound-interactions that require one or more skills to a threshold; (iii) when the number of agents to handle inbound-interactions that require one or more skills is above the threshold, calculating a number of extra-agents; and (iv) operating a shift-extension module to: (a) select the calculated number of extra-agents from agents having the one or more skills which are assigned to the preassigned ongoing work-shift; and (b) update corresponding schedules of the selected number of extra-agents, in a database of a Workforce Management (WFM) system.

Abstract: The present invention relates to a single photon avalanche diodes-based time-of-flight sensor (100). The single photon avalanche diodes (SPADs) based time-of-flight (ToF) sensor (100) includes an Nx N single photon avalanche diode (SPAD) photodetector (101), a front-end (FE) unit (103), a pulse shaping (PS) unit (105), a pulse store unit (107), a peak detection unit (109), a digital logic unit (111), a timing processing circuitry unit (113), and memory elements unit (115). Due to integration of multiple units in single photon avalanche diodes (SPADs) based time-of-flight (ToF) sensor (100), the single photon avalanche diodes-based time-of-flight (ToF) sensor (100) accurately measures distance by adequate, suitable, and efficient elimination of background light.

Abstract: Generally disclosed herein are electronic circuits with high bandwidth interfaces (HBI) for multi-directional die-to-die communications. The HBIs are designed to allow for sharing of data between all sides of the memory chiplets. By using all sides of the memory chiplets and multiplexing the data between the multiple connected chiplets, the total bandwidth of the memory available to the connected chiplets can increase. The sharing and multiplexing of the data can also be dynamically configured to accommodate various options for the allocation of performance levels and the associated cost.

Abstract: A medical error reduction system may include a medical error reduction software for use in creating and revising at least one drug library. The software configured to provide one of a plurality of sets of privileges to each of a plurality of sets of users. Each of the plurality of sets of privileges arranged to allocate a degree of software functionality to one of the plurality of sets of users. The degree of software functionality configured to define the ability of a user to alter the at least one drug library. The medical error reduction system may include at least one server. The medical error reduction system may include at least one editor computer each of the at least one editor computer comprising a processor in communication with a display. The at least one editor computer and at least one server may be configured to communicate via a network in a client-server based model. Each of the at least one drug library may be for use in at least one medical device.

Abstract: An ostomy device includes an implant shaped in a ring and sized for placement in or adjacent to a hole in an abdominal wall, the implant including a surface for contacting a lumen. The implant includes a first part including the surface for contacting the lumen, the first part, when placed in or adjacent to the hole in the abdominal wall, extending in a direction orthogonal to the abdominal wall to support the lumen. The implant includes a region for attaching an ostomy bag.

Abstract: The present subject matter relates to a solid oral pharmaceutical composition comprising combination of meloxicam and rizatriptan or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable excipient. The present subject matter also relates to a fixed dose pharmaceutical composition comprising meloxicam and rizatriptan or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable excipient. Furthermore, it also relates to methods for manufacturing such compositions and use thereof.

Abstract: Techniques for low power indoor/outdoor detection are disclosed. In the illustrative embodiment, an integrated sensor hub receives data from an accelerometer. The sensor hub processes the accelerometer data to determine an activity of the user. Depending on the activity of the user, the sensor hub may determine whether the compute device is indoors or outdoors or may receive data from additional sensors, such as a magnetometer, a gyroscope, or an ambient light sensor. The additional sensor data may be used to determine whether the compute device is inside or outside.

Abstract: An industrial alarm monitoring system leverages generative artificial intelligence (AI) to perform dynamic monitoring and analysis of a customer's industrial processes, identify potential or active performance issues or alarm conditions, and assist users in resolving these issues. The system monitors and collects operational and status data from industrial devices and assets of industrial automation systems and stores information regarding active and historical alarm conditions indicated by this data in an alarm repository. Users can submit natural language requests for assistance with, or information about, active or historical alarms to the system, which leverages trained custom models and a generative AI model to process these requests. The system can formulate natural language alarm resolution guidance based on analysis of the user's request, content of the custom models, responses prompted from the generative AI model, and relevant information about the alarm condition obtained from the alarm repository.

Abstract: A method, apparatus, and computer-readable medium are described that gather information from subnets of a virtual private cloud, compare the information of the subnets to criteria of components of a service, and identify selected subnets that comport with the criteria. The subnets may be associated with different availability zones. The selection of any subnet may affect the subnets available for the next selection. The process may dynamically adjust for previous subnet selections and may be available as a service. Based on a call to the service with criteria of the components, the service may request information regarding the subnets and return an identified list of subnets for the components. The process may accommodate services during development stages and during deployment stages and/or account for primary and secondary subnet assignments. By dynamically adjusting the available subnets, delays in subnet selection and subsequent deployment may be reduced.