Patents by Inventor Rainer Hahn

Rainer Hahn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220274862
    Abstract: A glass article is designed at least in part in the form of a glass tube element including at least one shell which encloses at least one lumen. For at least one light transmission analysis of the glass article, a ratio of an average amplitude transmission factor and a specific amplitude transmission factor is greater than 1.00001.
    Type: Application
    Filed: May 19, 2022
    Publication date: September 1, 2022
    Applicant: SCHOTT AG
    Inventors: Rainer Erwin Eichholz, Josef Rasp, Michael Hahn, Stefan Knoche
  • Patent number: 10661264
    Abstract: The present invention provides novel methods of cell disruption and release of biomolecules from a cell. The invention comprises the use of positively and/or negatively charged microparticles comprising ground resin. It is particularly useful for purification of biomolecules from cell culture.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: May 26, 2020
    Assignees: BOEHRINGER INGELHEIM RCV GMBH & CO KG, SANDOZ AG
    Inventors: Rainer Hahn, Alois Jungbauer, Alexandru Trefilov
  • Patent number: 10537887
    Abstract: The present invention provides a novel adsorbent composition for recovering biomolecules from a fluid. The composition comprises positively and negatively charged microparticles in the form of ground particles. The adsorbent is particularly useful for purification of biomolecules from the cell culture.
    Type: Grant
    Filed: August 25, 2014
    Date of Patent: January 21, 2020
    Assignees: BOEHRINGER INGELHEIM RCV & GMBH CO KG, SANDOZ AG
    Inventors: Rainer Hahn, Alois Jungbauer, Alexandru Trefilov, Moritz Imendoerffer
  • Publication number: 20190046969
    Abstract: The present invention provides novel methods of cell disruption and release of biomolecules from a cell. The invention comprises the use of positively and/or negatively charged microparticles comprising ground resin. It is particularly useful for purification of biomolecules from cell culture.
    Type: Application
    Filed: August 14, 2018
    Publication date: February 14, 2019
    Inventors: Rainer Hahn, Alois Jungbauer, Alexandru Trefilov
  • Patent number: 10076749
    Abstract: The present invention provides novel methods of cell disruption and release of biomolecules from a cell. The invention comprises the use of positively and/or negatively charged microparticles comprising ground resin. It is particularly useful for purification of biomolecules from cell culture.
    Type: Grant
    Filed: August 25, 2014
    Date of Patent: September 18, 2018
    Assignees: BOEHRINGER INGELHEIM RCV GMBH & CO KG, SANDOZ AG
    Inventors: Rainer Hahn, Alois Jungbauer, Alexandru Trefilov
  • Publication number: 20160340384
    Abstract: Disclosed is a method for refolding recombinantly produced polypeptides comprising the steps of (a)providing inclusion bodies comprising recombinantly produced polypeptides comprising the recombinantly produced polypeptides, (b)dissolving the inclusion bodies under chaotropic conditions in so as to obtain denatured recombinantly produced polypeptides, and (c)refolding the denatured recombinantly produced polypeptides inclusion bodies by addition of a refolding buffer,so as to obtain refolded re-combinantly produced polypeptides, and (d) further processing the refolded recombinantly produced polypeptides by at least one processing step, wherein at least steps (c) and (d) are performed in a tubular reactor in a continuous manner.
    Type: Application
    Filed: December 22, 2014
    Publication date: November 24, 2016
    Applicant: SANDOZ AG
    Inventors: Alois JUNGBAUER, Pan SIQI, Monika ZELGER, Rainer HAHN
  • Publication number: 20160200760
    Abstract: The present invention provides novel methods of cell disruption and release of biomolecules from a cell. The invention comprises the use of positively and/or negatively charged microparticles comprising ground resin. It is particularly useful for purification of biomolecules from cell culture.
    Type: Application
    Filed: August 25, 2014
    Publication date: July 14, 2016
    Inventors: Rainer HAHN, Alois JUNGBAUER, Alexandru TREFILOV
  • Publication number: 20160193598
    Abstract: The present invention provides a novel adsorbent composition for recovering biomolecules from a fluid. The composition comprises positively and negatively charged microparticles in the form of ground particles. The adsorbent is particularly useful for purification of biomolecules from the cell culture.
    Type: Application
    Filed: August 25, 2013
    Publication date: July 7, 2016
    Applicant: Boehringer Ingelhelim RCV GMBH & Co KG
    Inventors: Rainer HAHN, Alois JUNGBAUER, Alexandru TREFILOV, Moritz IMENDOERFFER
  • Patent number: 9248319
    Abstract: The present invention relates to functional composite particles for the oral care sector, more particularly for toothpastes and mouthwashes, which are charged with active ingredients which ensure a long-term antimicrobial or antibacterial effect in the oral cavity and hence reduce the formation of plaque and halitosis. The invention further relates to a process for producing these composite particles and also to their use for producing oral hygiene articles.
    Type: Grant
    Filed: August 6, 2010
    Date of Patent: February 2, 2016
    Assignee: Evonik Degussa
    Inventors: Wojciech Pisula, Stephanie Schäffer, Juri Tschernjaew, Arnold Storeck, Rainer Hahn
  • Patent number: 8372959
    Abstract: Disclosed is a method for the production of a heterologous polypeptide of interest with a homogenous N-terminus, using a fusion polypeptide comprising the polypeptide of interest and N-terminally thereto a polypeptide exhibiting autoproteolytic function, said method comprises the steps of a) binding of the fusion polypeptide in a soluble, autoproteolytically inactive form by an affinity chromatography system, b) refolding of the fusion polypeptide, thereby activating the autoproteolytic function of the fusion polypeptide and causing cleavage of the heterologous polypeptide of interest, and c) subsequently eluting the heterologous polypeptide of interest, wherein the steps are conducted on one affinity chromatography system.
    Type: Grant
    Filed: January 11, 2012
    Date of Patent: February 12, 2013
    Assignees: Sandoz AG, Boehringer Ingelheim RCV GmbH & Co KG
    Inventors: Alois Jungbauer, Rainer Hahn, Anne Tscheliessnig, Waltraud Kaar
  • Publication number: 20120107869
    Abstract: Disclosed is a method for the production of a heterologous polypeptide of interest with a homogenous N-terminus, using a fusion polypeptide comprising the polypeptide of interest and N-terminally thereto a polypeptide exhibiting autoproteolytic function, said method comprising the steps of a) binding of the fusion polypeptide in a soluble, autoproteolytically inactive form by an affinity chromatography system, b) refolding of the fusion polypeptide, thereby activating the autoproteolytic function of the fusion polypeptide and causing cleavage of the heterologous polypeptide of interest, and c) subsequently eluting the heterologous polypeptide of interest, wherein said steps are conducted on one affinity chromatography system.
    Type: Application
    Filed: January 11, 2012
    Publication date: May 3, 2012
    Applicants: BOEHRINGER INGELHEIM RCV GmbH & Co KG, SANDOZ AG
    Inventors: Alois JUNGBAUER, Rainer Hahn, Anne Tscheliessnig, Waltraud Karr
  • Patent number: 8163890
    Abstract: Disclosed is a method for the production of a heterologous polypeptide of interest with a homogenous N-terminus, using a fusion polypeptide comprising the polypeptide of interest and N-terminally thereto a polypeptide exhibiting autoproteolytic function, said method comprising the steps of a) binding of the fusion polypeptide in a soluble, autoproteolytically inactive form by an affinity chromatography system, b) refolding of the fusion polypeptide, thereby activating the autoproteolytic function of the fusion polypeptide and causing cleavage of the heterologous polypeptide of interest, and c) subsequently eluting the heterologous polypeptide of interest, wherein said steps are conducted on one affinity chromatography system.
    Type: Grant
    Filed: April 25, 2006
    Date of Patent: April 24, 2012
    Assignees: Sandoz AG, Boehringer Ingelheim RCV GmbH & Co KG
    Inventors: Alois Jungbauer, Rainer Hahn, Anne Tscheliessnig, Waltraud Kaar
  • Patent number: 8058410
    Abstract: Disclosed is an affinity matrix comprising a solid phase and an affinity ligand comprising peptide bonds coupled to this solid phase, wherein the affinity ligand comprising peptide bond is selected from the following group of ligands: a) peptides comprising the formula X1X2X3X4, wherein X1 to X4 are amino acid residues and at least two of X1 to X4 is W, Y or F; b) peptides comprising the formula X5X6X7X8, wherein X5 to X8 are amino acid residues, at least one of X5 to X8 is W, and at least one of X5 to X8 is E or D; and c) poly-amino acids consisting of an amino acid monomer of the group consisting of R, K, E and D and an amino acid monomer of the group consisting of Y, F and W, preferably poly-KY, poly-KF, poly-KW, poly-RY, poly-RF, poly-RW, poly-EY, poly-DY, poly-EF, poly-EW, poly-DF and poly-DW, with the proviso that the peptides according to a) and b) have a maximum length of 35 amino acid residues and that the poly-amino acids according to c) have a minimum length of 20 amino acid residues.
    Type: Grant
    Filed: April 25, 2006
    Date of Patent: November 15, 2011
    Assignees: Sandoz AG, Boehringer Ingelheim RCV GmbH & Co KG
    Inventors: Alois Jungbauer, Rainer Hahn, Waltraud Kaar, Michael Seifert, Bernhard Auer, Clemens Achmüller, Philipp Wechner
  • Publication number: 20110268997
    Abstract: A battery comprising a cell stack comprising at least one individual cell in a cell housing, an electronic component part, electrical conductors between the cell stack and the electronic component part and an injection-molded part which substantially completely surrounds the electrical conductors and is connected in form-fitting fashion both the cell stack and to the electronic component part and connects the cell stack and the electronic component part to one another, outer contact faces of the battery also being integrated in the electronic component part in addition to at least one electronic circuit.
    Type: Application
    Filed: January 22, 2010
    Publication date: November 3, 2011
    Applicant: VARTA Microbattery GmbH
    Inventors: Christian Gaugler, Kuno Gross, Rainer Hahn
  • Publication number: 20110033511
    Abstract: The present invention relates to functional composite particles for the oral care sector, more particularly for toothpastes and mouthwashes, which are charged with active ingredients which ensure a long-term antimicrobial or antibacterial effect in the oral cavity and hence reduce the formation of plaque and halitosis. The invention further relates to a process for producing these composite particles and also to their use for producing oral hygiene articles.
    Type: Application
    Filed: August 6, 2010
    Publication date: February 10, 2011
    Inventors: Wojciech Pisula, Stephanie Schäffer, Juri Tschernjaew, Arnold Storeck, Rainer Hahn
  • Publication number: 20090306343
    Abstract: Disclosed is an affinity matrix comprising a solid phase and an affinity ligand comprising peptide bonds coupled to this solid phase, wherein the affinity ligand comprising peptide bond is selected from the following group of ligands: a) peptides comprising the formula X1X2X3X4, wherein X1 to X4 are amino acid residues and at least two of X1 to X4 is W, Y or F; b) peptides comprising the formula X5X6X7X8, wherein X5 to X8 are amino acid residues, at least one of X5 to X8 is W, and at least one of X5 to X8 is E or D; and c) poly-amino acids consisting of an amino acid monomer of the group consisting of R, K, E and D and an amino acid monomer of the group consisting of Y, F and W, preferably poly-KY, poly-KF, poly-KW, poly-RY, poly-RF, poly-RW, poly-EY, poly-DY, poly-EF, poly-EW, poly-DF and poly-DW, with the proviso that the peptides according to a) and b) have a maximum length of 35 amino acid residues and that the poly-amino acids according to c) have a minimum length of 20 amino acid residues.
    Type: Application
    Filed: April 25, 2006
    Publication date: December 10, 2009
    Inventors: Alois Jungbauer, Rainer Hahn, Waltraud Kaar, Michael Seifert, Bernhard Auer, Clemens Achmuller, Philipp Wechner
  • Publication number: 20090203069
    Abstract: Disclosed is a method for the production of a heterologous polypeptide of interest with a homogenous N-terminus, using a fusion polypeptide comprising the polypeptide of interest and N-terminally thereto a polypeptide exhibiting autoproteolytic function, said method comprising the steps of a) binding of the fusion polypeptide in a soluble, autoproteolytically inactive form by an affinity chromatography system, b) refolding of the fusion polypeptide, thereby activating the autoproteolytic function of the fusion polypeptide and causing cleavage of the heterologous polypeptide of interest, and c) subsequently eluting the heterologous polypeptide of interest, wherein said steps are conducted on one affinity chromatography system.
    Type: Application
    Filed: April 25, 2006
    Publication date: August 13, 2009
    Applicants: BOEHRINGER INGELHEIM AUSTRIA GMBH, SANDOZ AG
    Inventors: Alois Jungbauer, Rainer Hahn, Anne Tscheliessnig, Waltraud Kaar
  • Patent number: 7365101
    Abstract: A dispersion of pyrogenically produced cerium oxide, which does not contain any particles larger than 1 ?m, is produced by dispersing a pyrogenically produced cerium oxide in water by means of a dissolver, centrifuging it, separating the supernatant from the bottom product, and again dispersing the supernatant by means of ultrasound. The dispersion can be used for chemical-mechanical polishing (CMP).
    Type: Grant
    Filed: September 15, 2004
    Date of Patent: April 29, 2008
    Assignee: Degussa AG
    Inventors: Michael Kröll, Günther Michael, Rainer Hahn, Stipan Katusic, Stefan Heberer, Ralph Brandes
  • Publication number: 20070243201
    Abstract: The invention relates to a method for the selection of epitopes for immunotherapy, peptides obtained by said method, the use of said peptides as vaccines and diagnostics and an immune serum obtainable by said method.
    Type: Application
    Filed: June 2, 2004
    Publication date: October 18, 2007
    Applicant: Igeneon Krebs-Immuntherapie Forschungs-und entwicklungs-AG
    Inventors: Hans Loibner, Gottfried Himmler, Alois Jungbauer, Erich Wasserbauer, Manfred Schuster, Rainer Hahn, Astrid Durauer
  • Patent number: 7163397
    Abstract: An apparatus for applying a viscous modification material includes a material source of the modification material and a needle connected to the source. A material for selectively modifying the optical properties of cells comprises a basic material and a modification substance distributed in the basic material at a prescribed concentration, wherein the basic material comprises a viscous fluid, a gel, a two-dimensional or three-dimensional porous substrate or a material which hardens in situ. A diagnostic apparatus for determining the optical properties of cells which have been exposed to such a material and an apparatus for irradiating cells whose optical properties have been differently modified with such a material are also provided.
    Type: Grant
    Filed: January 8, 2004
    Date of Patent: January 16, 2007
    Assignee: Karl Storz GmbH & Co.
    Inventors: Rainer Hahn, Klaus Irion