Abstract: The invention relates to a process for preparing the compound of formula 1, a valuable intermediate product in the synthesis of the pharmaceutical active substance dabigatran etexilate.

Abstract: The invention relates to a process for preparing the compound of formula 1, a valuable intermediate product in the synthesis of the pharmaceutical active substance dabigatran etexilate.

Abstract: The invention relates to a process for preparing the compound of formula 1, a valuable intermediate product in the synthesis of the pharmaceutical active substance dabigatran etexilate.

Abstract: Ethyl 3-[(2-{[4-(hexyloxycarbonylaminoiminomethyl)phenylamino]methyl}-1-methyl-1H-benzimidazole-5-carbonyl)pyridin-2-ylamino]propionate methanesulfonate in the crystalline modifications I and II and as the hemihydrate and the use thereof as a pharmaceutical composition.

Abstract: The invention relates to a process for preparing the compound of formula 1, a valuable intermediate product in the synthesis of the pharmaceutical active substance dabigatran etexilate.

Abstract: The present invention relates to a shortened process for preparing L-lobeline by rhodium-catalysed asymmetric hydrogenation on an industrial scale.

Abstract: Ethyl 3-[(2-{[4-(hexyloxycarbonylaminoiminomethyl)phenylamino]methyl}-1-methyl-1H-benzimidazole-5-carbonyl)pyridin-2-ylamino]propionate methanesulfonate in the crystalline modifications I and II and as the hemihydrate and the use thereof as a pharmaceutical composition.

Abstract: The invention relates to a process for preparing N-substituted 3?-aminonortropanes of formula I wherein R1 has the meaning given in the claims, from the corresponding 3-oxonortropane or the corresponding 3?-aminonortropane, in which the latter is converted with an arylmethylamine or an arylaldehyde into the corresponding imines which are then tautomerised or isomerised and then hydrolysed. The invention also relates to the new compounds of formula V wherein R1 and Ar have the meanings given in the claims.

Abstract: The invention relates to a process for obtaining and purifying pure ?-mangostin from the rind of the fruit (mangosteen) of Garcinia mangostana.

Abstract: Disclosed are polymorphs of the active substance 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazole-5-carbonyl)-pyridin-2 -yl-amino]-propionic acid ethyl ester, the preparation thereof and the use thereof as pharmaceutical compositions.

Abstract: The present invention relates to a shortened process for preparing L-lobeline by rhodium-catalysed asymmetric hydrogenation on an industrial scale.

Abstract: The invention relates to a process for obtaining and purifying pure ?-mangostin from the rind of the fruit (mangosteen) of Garcinia mangostana.

Abstract: Ethyl 3-[(2-{[4-(hexyloxycarbonylaminoiminomethyl)phenylamino]methyl}-1-methyl-1H-benzimidazole-5-carbonyl)pyridin-2-ylamino]propionate methanesulfonate in the crystalline modifications I and II and as the hemihydrate and the use thereof as a pharmaceutical composition.

Abstract: The invention relates to a process for preparing N-substituted 3?-aminonortropanes of formula I wherein R1 has the meaning given in the claims, from the corresponding 3-oxonortropane or the corresponding 3 ?-aminonortropane, in which the latter is converted with an arylmethylamine or an arylaldehyde into the corresponding imines which are then tautomerised or isomerised and then hydrolysed. The invention also relates to the new compounds of formula V wherein R1 and Ar have the meanings given in the claims.

Abstract: A process for preparing tropenol (I) or an acid addition salt thereof, the process comprising: (a) reducing a scopine ester of formula (II)  wherein R is C1-C4-alkyl or C1-C4-alkylene-phenyl, each optionally substituted by hydroxy or C1-C4-alkoxy, or an acid addition salt or hydrate thereof, using zinc in a suitable solvent in the presence of an activating metal salt; and (b) saponifying the product of (a) using a suitable base to obtain the tropenol of formula (I) or the acid addition salt thereof.

Abstract: A process for preparing tropenol (I) 1

Abstract: A process for purifying 20(S)-camptothecin, the process comprising: (a) combining an aqueous base and a starting material containing 20(S)-camptothecin to convert the lactone ring of the 20(S)-camptothecin into a carboxylate salt; (b) hydrogenating to the product of step (a) in the presence of a transition metal catalyst; (c) acidifying the aqueous phase of the product of step (b) to form 20(S)-camptothecin crystals; (d) adding at least one polar aprotic solvent to the product of step (c); and (e) separating off the purified 20(S)-camptothecin crystals.

Abstract: A process for purifying 20(S)-camptothecin, the process comprising:

Abstract: The present invention relates to a new and improved process for preparing 2-amino-6-chloropurine comprising the step of reacting guanine in the presence of ammonium sulphate with hexamethyldisilazane. The process of this invention advantageously results in a high yield of 2-amino-6-chloropurine and may be carried out on a laboratory or an industrial scale.

Abstract: A method of preparing sugar acetonides, such as for example 1,2:5,6-Di-O-isopropylidene-.alpha.-D-glucofuranose, by reacting the corresponding sugar, e.g. D-(+)-glucose, with acetone in the presence of a Lewis acid and a carboxylic acid derivative of general formula ##STR1## wherein X is a leaving group which may be readily replaced by a hydroxyl group.