Patents by Inventor Rainer Sobotta

Rainer Sobotta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing 1,3-dialkyl-5-hydroxyoxindoles and the ether derivatives thereof
    Patent number: 5614637
    Abstract: The invention is directed to a process for preparing a 1,3-dialkyl-5-hydroxyoxindole of formula 1: ##STR1## comprising heating an N-alkyl-p-alkoxy-(.alpha.-haloacyl)anilide of formula 2: ##STR2## wherein the substituents are as defined herein, in the presence of an anhydrous zinc halide to a temperature in the range from about 120.degree. C. to about 160.degree. C., and isolating the 1,3-dialkyl-5-hydroxyoxindole prepared.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: March 25, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Rainer Sobotta, Rainer Schwarz, Manfred Psiorz
  • Process for preparing 1,2-5,6-diacetone-D-glucose
    Patent number: 5565037
    Abstract: The present invention relates to an improved process for preparing 1,2-5,6-diacetone-D-glucose from D-glucose and diketene or the adduct of diketene with acetone.
    Type: Grant
    Filed: June 24, 1994
    Date of Patent: October 15, 1996
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Rainer Sobotta, Franz D. Klingler
  • Process for preparing enantiomerically pure diarylprolinols
    Patent number: 5527923
    Abstract: The present invention relates to a new process for preparing enantiomerically pure diarylprolinols, especially (R)-(+)- or (S)-(-)-2-(diphenylhydroxymethyl)-pyrrolidine (R)-(+)- or (S)-(-)-.alpha.,.alpha.-diphenyl-(2-pyrrolidinyl)-methanol) starting from proline.
    Type: Grant
    Filed: May 4, 1995
    Date of Patent: June 18, 1996
    Assignee: Boehringer Ingelheim KG
    Inventors: Franz D. Klingler, Rainer Sobotta
  • Process for the racemization of nonracemic 3-oxyocylopentane- or -hexanecarboxylic acids or their esters with C.sub.1 -C.sub.6 -alcohols
    Patent number: 5488136
    Abstract: Racemates are obtained from non-racemic 3-oxocyclopentane or 3-oxocyclohexane carboxylic acids or their esters by esterification and ketalization of the non-racemic acid with orthoformic acid ester in an alocohol, racemization and hydrolysis of the product obtained with an alcoholate and isolation of the racemate.
    Type: Grant
    Filed: April 16, 1993
    Date of Patent: January 30, 1996
    Assignee: Boehringer Ingelheim KG
    Inventor: Rainer Sobotta
  • Certain 3-bromo-2,6-dimethoxybenzamides and pharmaceutical use thereof
    Patent number: 5006533
    Abstract: 3-Bromo-2,6-dimethoxybenzamides useful as neuroleptic agents are described.
    Type: Grant
    Filed: November 22, 1989
    Date of Patent: April 9, 1991
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Rainer Sobotta, Adolf Langbein, Herbert Merz, Rudolf Bauer, Joachim Mierau
  • Tetrahydrobenzothiazoles, and the preparation and use thereof
    Patent number: 4981862
    Abstract: Tetrahydrobenzothiazole derivatives of the formula ##STR1## wherein n is 1, 2 or 3 and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are defined substituents, said derivatives (I) being suitable as active compounds for treating parkinsonism or Parkinson's Disease.
    Type: Grant
    Filed: December 20, 1988
    Date of Patent: January 1, 1991
    Assignee: Boehringer Ingelheim KG
    Inventors: Claus Schneider, Herbert Merz, Rainer Sobotta, Rudolf Bauer, Joachim Mierau, Gunter Schingnitz
  • 8-Arylalkyl-3-phenyl-3-nortropanols and salts thereof
    Patent number: 4393069
    Abstract: Compounds of the formula ##STR1## wherein Ar is ##STR2## R.sub.1 is hydrogen, fluorine, bromine, methyl or methoxy; X is .dbd.CO, .dbd.CH--CN, .dbd.CH--OH, --O--, --S--, --NH--, ##STR3## and R is hydrogen, 4-fluoro, 4-chloro, 4-trifluoromethyl, 3-trifluoromethyl, 3-trifluoromethyl-4-chloro, 4-methyl or 4-methoxy;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as neuroleptics.
    Type: Grant
    Filed: November 25, 1981
    Date of Patent: July 12, 1983
    Assignee: C. H. Boehringer Sohn
    Inventors: Adolf Langbein, Herbert Merz, Rainer Sobotta, Rudolf Bauer, Hans M. Jennewein, Joachim Mierau